PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 7948035-7 1994 The amounts of p47-phox and p67-phox translocated to the plasma membrane in response to phorbol myristate acetate (PMA) increased with increasing amounts of cytochrome b-558 in the membrane. Tetradecanoylphorbol Acetate 115-118 neutrophil cytosolic factor 1 Homo sapiens 15-23 7744791-7 1995 Moreover, although phorbol 12-myristate 13-acetate stimulated both the stable translocation of p47phox and p67phox and sustained NADPH oxidase activity, it did not stimulate p21rac2 translocation. Tetradecanoylphorbol Acetate 19-50 neutrophil cytosolic factor 1 Homo sapiens 95-102 7948035-7 1994 The amounts of p47-phox and p67-phox translocated to the plasma membrane in response to phorbol myristate acetate (PMA) increased with increasing amounts of cytochrome b-558 in the membrane. Tetradecanoylphorbol Acetate 88-113 neutrophil cytosolic factor 1 Homo sapiens 15-23 7797495-0 1995 The fatty acid bimodal action on superoxide anion production by human adherent monocytes under phorbol 12-myristate 13-acetate or diacylglycerol activation can be explained by the modulation of protein kinase C and p47phox translocation. Tetradecanoylphorbol Acetate 95-126 neutrophil cytosolic factor 1 Homo sapiens 215-222 8673625-13 1995 Further investigations in HAM led us to examine the UEFA capacity at modulating the translocation of PKC, on the one hand, and the endogenous phosphorylation and membrane translocation of p47phox, on the other, in the presence of PMA or DAG. Tetradecanoylphorbol Acetate 230-233 neutrophil cytosolic factor 1 Homo sapiens 188-195 8257426-2 1993 Evidence has been accumulated that in phorbol 12-myristate 13-acetate (PMA)-stimulated neutrophils, the translocation to the plasma membrane of the cytosolic components p47phox and p67phox and the phosphorylation of p47phox are essential steps in activation of NADPH oxidase. Tetradecanoylphorbol Acetate 38-69 neutrophil cytosolic factor 1 Homo sapiens 169-176 8182143-4 1994 In PMA-stimulated neutrophils and in a cell-free translocation assay with neutrophil membranes and cytosol, the association of the cytosolic proteins p47-phox and p67-phox with the membrane fraction of the patient was strongly disturbed. Tetradecanoylphorbol Acetate 3-6 neutrophil cytosolic factor 1 Homo sapiens 150-158 8144669-7 1994 In addition, we show that protein kinase C (PKC) also undergoes an extensive redistribution to the Triton X-100-insoluble fraction in 4 beta-phorbol 12-myristate 13-acetate-stimulated cells, the extent of which is diminished significantly in neutrophils from chronic granulomatous disease patients who lack either p47-phox or cytochrome b558. Tetradecanoylphorbol Acetate 136-172 neutrophil cytosolic factor 1 Homo sapiens 314-322 8141770-3 1994 Activation of superoxide production by phorbol 12-myristate 13-acetate or formylmethionyl-leucyl-phenylalanine in whole cells, and by SDS in the cell-free assay, led to the dissociation of some of the p21rac2 from rhoGDI and its movement to the plasma membrane together with p47phox and p67phox. Tetradecanoylphorbol Acetate 39-70 neutrophil cytosolic factor 1 Homo sapiens 275-282 8257426-2 1993 Evidence has been accumulated that in phorbol 12-myristate 13-acetate (PMA)-stimulated neutrophils, the translocation to the plasma membrane of the cytosolic components p47phox and p67phox and the phosphorylation of p47phox are essential steps in activation of NADPH oxidase. Tetradecanoylphorbol Acetate 38-69 neutrophil cytosolic factor 1 Homo sapiens 216-223 8257426-2 1993 Evidence has been accumulated that in phorbol 12-myristate 13-acetate (PMA)-stimulated neutrophils, the translocation to the plasma membrane of the cytosolic components p47phox and p67phox and the phosphorylation of p47phox are essential steps in activation of NADPH oxidase. Tetradecanoylphorbol Acetate 71-74 neutrophil cytosolic factor 1 Homo sapiens 169-176 8257426-2 1993 Evidence has been accumulated that in phorbol 12-myristate 13-acetate (PMA)-stimulated neutrophils, the translocation to the plasma membrane of the cytosolic components p47phox and p67phox and the phosphorylation of p47phox are essential steps in activation of NADPH oxidase. Tetradecanoylphorbol Acetate 71-74 neutrophil cytosolic factor 1 Homo sapiens 216-223 8270871-3 1994 Stimulation of human neutrophils with PMA greatly increased O2(-)-generating activity and caused considerable translocation of the cytosolic components p47phox and p67phox. Tetradecanoylphorbol Acetate 38-41 neutrophil cytosolic factor 1 Homo sapiens 152-159 8407934-6 1993 After activation of neutrophils with phorbol 12-myristate 13-acetate or formyl-methionyl-leucyl-phenylalanine, Rac was translocated from the cytosol to the plasma membrane, and this translocation corresponded temporally with the translocation of p47-phox and p67-phox and with the generation of superoxide. Tetradecanoylphorbol Acetate 37-68 neutrophil cytosolic factor 1 Homo sapiens 246-254 1848559-6 1991 Using the PKC activator phorbol myristate acetate (PMA) as the agonist, we found that activation of the respiratory burst oxidase was associated with translocation of cytosolic p47-phox and p67-phox to the plasma membrane as well as redistribution of p47-phox to the Triton-insoluble cytoskeleton. Tetradecanoylphorbol Acetate 24-49 neutrophil cytosolic factor 1 Homo sapiens 177-185 1332032-5 1992 We report here that O2- production was partly restored to phorbol 12-myristate 13-acetate-stimulated Epstein-Barr virus-transformed B lymphocytes from a patient with p47phox-deficient chronic granulomatous disease by transfection with an expression plasmid containing a p47phox cDNA inserted in the sense direction. Tetradecanoylphorbol Acetate 58-89 neutrophil cytosolic factor 1 Homo sapiens 166-173 1848559-6 1991 Using the PKC activator phorbol myristate acetate (PMA) as the agonist, we found that activation of the respiratory burst oxidase was associated with translocation of cytosolic p47-phox and p67-phox to the plasma membrane as well as redistribution of p47-phox to the Triton-insoluble cytoskeleton. Tetradecanoylphorbol Acetate 51-54 neutrophil cytosolic factor 1 Homo sapiens 177-185 19521892-9 2009 Treatment with rHDL induced disruption of the lipid raft structures and blunted PMA-induced redistribution of p47phox into lipid rafts. Tetradecanoylphorbol Acetate 80-83 neutrophil cytosolic factor 1 Homo sapiens 110-117 20178640-11 2010 The NCF1 pseudogene expression responded robustly to PMA induction during macrophage differentiation. Tetradecanoylphorbol Acetate 53-56 neutrophil cytosolic factor 1 Homo sapiens 4-8 26116564-12 2015 TPA-induced induction of MMP-7 expression was suppressed by AP-1, NF-kappaB, and MAPK (ERK, p38, and JNK) inhibitors, whereas TPA-induced expression of NOX2 and its regulators, p47phox and p67phox, was blocked by p38 and NF-kappaB inhibitors. Tetradecanoylphorbol Acetate 0-3 neutrophil cytosolic factor 1 Homo sapiens 177-184 26116564-12 2015 TPA-induced induction of MMP-7 expression was suppressed by AP-1, NF-kappaB, and MAPK (ERK, p38, and JNK) inhibitors, whereas TPA-induced expression of NOX2 and its regulators, p47phox and p67phox, was blocked by p38 and NF-kappaB inhibitors. Tetradecanoylphorbol Acetate 126-129 neutrophil cytosolic factor 1 Homo sapiens 177-184 23119229-2 2012 Phosphorylation of the NOX2 cytosolic subunit p47phox is required for phorbol myristate acetate (PMA)-induced NOX2 activation in EBV-transformed B lymphocytes, however the role of this process in receptor-mediated NOX2 activation is not known. Tetradecanoylphorbol Acetate 70-95 neutrophil cytosolic factor 1 Homo sapiens 46-53 23119229-2 2012 Phosphorylation of the NOX2 cytosolic subunit p47phox is required for phorbol myristate acetate (PMA)-induced NOX2 activation in EBV-transformed B lymphocytes, however the role of this process in receptor-mediated NOX2 activation is not known. Tetradecanoylphorbol Acetate 97-100 neutrophil cytosolic factor 1 Homo sapiens 46-53 34068760-10 2021 However, they only decreased PMA-induced p47phox phosphorylation. Tetradecanoylphorbol Acetate 29-32 neutrophil cytosolic factor 1 Homo sapiens 41-48 27809835-10 2016 Moreover, Anv-polysaccharides strongly inhibited PMA-induced PKCbeta and p47phox translocation to membranes and p47phox phosphorylation on Ser328, a main PKC target. Tetradecanoylphorbol Acetate 49-52 neutrophil cytosolic factor 1 Homo sapiens 73-80 27809835-10 2016 Moreover, Anv-polysaccharides strongly inhibited PMA-induced PKCbeta and p47phox translocation to membranes and p47phox phosphorylation on Ser328, a main PKC target. Tetradecanoylphorbol Acetate 49-52 neutrophil cytosolic factor 1 Homo sapiens 112-119 15328001-2 2004 AMPK activated with either 5"-aminoimidazole-4-carboxamide ribonucleoside (AICAR) or with 5"-AMP significantly attenuated both phorbol 12-myristate 13-acetate (PMA) and formyl methionyl leucyl phenylalanine-stimulated superoxide anion O2- release by human neutrophils, consistently with a reduced translocation to the cell membrane and phosphorylation of a cytosolic component of NADPH oxidase, namely p47phox. Tetradecanoylphorbol Acetate 127-158 neutrophil cytosolic factor 1 Homo sapiens 402-409 15828232-5 2005 In addition, the phorbol myristate acetate (PMA)-stimulated 22 kDa-subunit (p22phox) protein levels and 47 kDa-subunit (p47phox) protein levels in NADPH (superoxide generating enzyme nicotinamide adenine dinucleotide phosphate (reduced form)) oxidase were decreased by treatment with PPARalpha and PPARgamma ligands/activators. Tetradecanoylphorbol Acetate 17-42 neutrophil cytosolic factor 1 Homo sapiens 120-127 15828232-5 2005 In addition, the phorbol myristate acetate (PMA)-stimulated 22 kDa-subunit (p22phox) protein levels and 47 kDa-subunit (p47phox) protein levels in NADPH (superoxide generating enzyme nicotinamide adenine dinucleotide phosphate (reduced form)) oxidase were decreased by treatment with PPARalpha and PPARgamma ligands/activators. Tetradecanoylphorbol Acetate 44-47 neutrophil cytosolic factor 1 Homo sapiens 120-127 19687351-6 2009 In addition, EXP3179 inhibited (P<0.05) both phorbol myristate acetate-stimulated p47phox translocation from cytosol to membranes and protein kinase C activity. Tetradecanoylphorbol Acetate 48-73 neutrophil cytosolic factor 1 Homo sapiens 85-92 19559082-7 2009 These results indicated that BaP induced NCF1/p47(phox) expression and subsequently enhanced superoxide anion production in PMA-treated human macrophages, in an AhR-dependent manner; such an NCF1/NADPH oxidase regulation by polycyclic aromatic hydrocarbons may participate in deleterious effects toward human health triggered by these environmental contaminants, including atherosclerosis and smoking-related diseases. Tetradecanoylphorbol Acetate 124-127 neutrophil cytosolic factor 1 Homo sapiens 191-195 15328001-2 2004 AMPK activated with either 5"-aminoimidazole-4-carboxamide ribonucleoside (AICAR) or with 5"-AMP significantly attenuated both phorbol 12-myristate 13-acetate (PMA) and formyl methionyl leucyl phenylalanine-stimulated superoxide anion O2- release by human neutrophils, consistently with a reduced translocation to the cell membrane and phosphorylation of a cytosolic component of NADPH oxidase, namely p47phox. Tetradecanoylphorbol Acetate 160-163 neutrophil cytosolic factor 1 Homo sapiens 402-409 10993214-4 2000 Although translocation of p47phox and p67phox to the membrane fraction by PMA-stimulation of intact and GCSF-treated neutrophils occurred in parallel with O2- production, that of CB-treated neutrophils by PMA-stimulation was not always proportional to O2- production. Tetradecanoylphorbol Acetate 74-77 neutrophil cytosolic factor 1 Homo sapiens 26-33 11200061-5 2001 In cells treated with TPA, the burst in ROS at 48 h was preceded by accumulation at 12 h of gp91phox (8.8-fold) and p47phox mRNA (threefold), whereas untreated cells contained steady-state levels of both transcripts. Tetradecanoylphorbol Acetate 22-25 neutrophil cytosolic factor 1 Homo sapiens 116-123 9862721-5 1998 Moreover, PMA was able to induce a normal phosphorylation of the cytosolic factor p47phox and to fully activate extracellular signal-regulated kinases (Erk1/2). Tetradecanoylphorbol Acetate 10-13 neutrophil cytosolic factor 1 Homo sapiens 82-89 10540223-10 1999 In subcellular fractions, Rac2 was found to translocate, along with p47phox and p67phox, from cytosol to plasma membrane-associated fractions following phorbol myristate acetate stimulation, while RhoGDI remained within cytosolic fractions. Tetradecanoylphorbol Acetate 152-177 neutrophil cytosolic factor 1 Homo sapiens 68-75 8655638-5 1996 On the other hand, PMA-induced phosphorylation and translocation of p47phox were not affected by such a low dose of okadaic acid. Tetradecanoylphorbol Acetate 19-22 neutrophil cytosolic factor 1 Homo sapiens 68-75 9794432-4 1998 Dexamethasone down-regulated the NADPH oxidase system of cytokine-differentiated THP-1 cells as assessed by an inhibition on the PMA-stimulated superoxide release, cytochrome b558 content, and expression of the gp91-phox and p47-phox genes. Tetradecanoylphorbol Acetate 129-132 neutrophil cytosolic factor 1 Homo sapiens 225-233 9794433-6 1998 4) In PMA-stimulated B cells from an X91+ CGD patient in which p22phox was normally expressed and gp91phox was present but lacked five amino acids, translocation of p47phox to the membranes was unaffected, but p67phox and p40phox were poorly translocated, and the production of O2- was greatly reduced with respect to that by normal B cells. Tetradecanoylphorbol Acetate 6-9 neutrophil cytosolic factor 1 Homo sapiens 165-172 8558059-5 1996 The PMA-induced translocation of p47phox to the plasma membrane was diminished in neutrophils loaded with peptide 4. Tetradecanoylphorbol Acetate 4-7 neutrophil cytosolic factor 1 Homo sapiens 33-40