PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
9374665-4	1997	Treatments with forskolin, phorbol 12-myristate 13-acetate, staurosporine, and genistein also induced cell shape change and decreased F-actin staining and ET-1 mRNA levels.	Tetradecanoylphorbol Acetate	27-58	endothelin 1	Bos taurus	155-159	
2164911-7	1990	Since ET-1 action involves activation of protein kinase-C (PKC), we studied the effect of a phorbol ester (PMA) on the down-regulation of ET-1 receptors.	Tetradecanoylphorbol Acetate	107-110	endothelin 1	Bos taurus	138-142	
8392184-3	1993	The treatment of endothelial cells with either phorbol 12-myristate 13-acetate (100 nM) to activate protein kinase C (PKC) or forskolin (10 microM) to stimulate adenylate cyclase sharply decreased ET-1 mRNA.	Tetradecanoylphorbol Acetate	47-78	endothelin 1	Bos taurus	197-201	
1744120-4	1991	Moreover, the effects of phorbol 12-myristate 13-acetate (PMA) and insulin were additive in the induction of ET-1 gene expression.	Tetradecanoylphorbol Acetate	25-56	endothelin 1	Bos taurus	109-113	
1744120-4	1991	Moreover, the effects of phorbol 12-myristate 13-acetate (PMA) and insulin were additive in the induction of ET-1 gene expression.	Tetradecanoylphorbol Acetate	58-61	endothelin 1	Bos taurus	109-113	
1744120-5	1991	When protein kinase C in the bovine aortic endothelial cells was down-regulated by preincubation with 8 x 10(-7) M PMA for 24 or 48 h, insulin was still able to increase ET-1 mRNA levels whereas PMA was ineffective.	Tetradecanoylphorbol Acetate	115-118	endothelin 1	Bos taurus	170-174	
1858892-9	1991	By contrast, the protein kinase C activator phorbol myristate acetate only enhanced preproET-1 mRNA expression at 30 min and suppressed expression thereafter.	Tetradecanoylphorbol Acetate	44-69	endothelin 1	Bos taurus	84-94