PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 22009531-6 2011 Exposure to DMBA and TPA activated p53 and decreased MnSOD expression via p53-mediated suppression of Sp1 binding to the MnSOD promoter in normal-appearing skin and benign papillomas. Tetradecanoylphorbol Acetate 21-24 superoxide dismutase 2 Homo sapiens 53-58 22009531-6 2011 Exposure to DMBA and TPA activated p53 and decreased MnSOD expression via p53-mediated suppression of Sp1 binding to the MnSOD promoter in normal-appearing skin and benign papillomas. Tetradecanoylphorbol Acetate 21-24 superoxide dismutase 2 Homo sapiens 121-126 21077177-4 2011 Recently, the reduction of Cu/Zn-SOD and the induction of Mn-SOD by TPA in leukemic cells have been reported; however, the regulation of EC-SOD by TPA remains poorly understood. Tetradecanoylphorbol Acetate 68-71 superoxide dismutase 2 Homo sapiens 58-64 21705328-0 2011 Dual function of protein kinase C (PKC) in 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced manganese superoxide dismutase (MnSOD) expression: activation of CREB and FOXO3a by PKC-alpha phosphorylation and by PKC-mediated inactivation of Akt, respectively. Tetradecanoylphorbol Acetate 43-79 superoxide dismutase 2 Homo sapiens 94-124 21705328-0 2011 Dual function of protein kinase C (PKC) in 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced manganese superoxide dismutase (MnSOD) expression: activation of CREB and FOXO3a by PKC-alpha phosphorylation and by PKC-mediated inactivation of Akt, respectively. Tetradecanoylphorbol Acetate 43-79 superoxide dismutase 2 Homo sapiens 126-131 21705328-0 2011 Dual function of protein kinase C (PKC) in 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced manganese superoxide dismutase (MnSOD) expression: activation of CREB and FOXO3a by PKC-alpha phosphorylation and by PKC-mediated inactivation of Akt, respectively. Tetradecanoylphorbol Acetate 81-84 superoxide dismutase 2 Homo sapiens 94-124 21705328-0 2011 Dual function of protein kinase C (PKC) in 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced manganese superoxide dismutase (MnSOD) expression: activation of CREB and FOXO3a by PKC-alpha phosphorylation and by PKC-mediated inactivation of Akt, respectively. Tetradecanoylphorbol Acetate 81-84 superoxide dismutase 2 Homo sapiens 126-131 21705328-1 2011 12-O-tetradecanoylphorbol-13-acetate (TPA) has been shown to induce transcriptional activation of human manganese superoxide dismutase (MnSOD) mRNA in human lung carcinoma cells, A549, mediated by a protein kinase C (PKC)-dependent activation of cAMP-responsive element-binding protein (CREB)-1/ATF-1-like factors. Tetradecanoylphorbol Acetate 0-36 superoxide dismutase 2 Homo sapiens 104-134 21705328-1 2011 12-O-tetradecanoylphorbol-13-acetate (TPA) has been shown to induce transcriptional activation of human manganese superoxide dismutase (MnSOD) mRNA in human lung carcinoma cells, A549, mediated by a protein kinase C (PKC)-dependent activation of cAMP-responsive element-binding protein (CREB)-1/ATF-1-like factors. Tetradecanoylphorbol Acetate 0-36 superoxide dismutase 2 Homo sapiens 136-141 21705328-1 2011 12-O-tetradecanoylphorbol-13-acetate (TPA) has been shown to induce transcriptional activation of human manganese superoxide dismutase (MnSOD) mRNA in human lung carcinoma cells, A549, mediated by a protein kinase C (PKC)-dependent activation of cAMP-responsive element-binding protein (CREB)-1/ATF-1-like factors. Tetradecanoylphorbol Acetate 38-41 superoxide dismutase 2 Homo sapiens 104-134 21705328-1 2011 12-O-tetradecanoylphorbol-13-acetate (TPA) has been shown to induce transcriptional activation of human manganese superoxide dismutase (MnSOD) mRNA in human lung carcinoma cells, A549, mediated by a protein kinase C (PKC)-dependent activation of cAMP-responsive element-binding protein (CREB)-1/ATF-1-like factors. Tetradecanoylphorbol Acetate 38-41 superoxide dismutase 2 Homo sapiens 136-141 21705328-2 2011 In this study, we showed that MnSOD protein expression was elevated in response to TPA or TNF-alpha, but not to hydrogen peroxide treatment. Tetradecanoylphorbol Acetate 83-86 superoxide dismutase 2 Homo sapiens 30-35 21705328-4 2011 Small interfering RNA (siRNA) experiments indicated that knocking down the NADPH oxidase components e.g. Rac1, p22(phox), p67(phox), and NOXO1 in A549 cells impaired TPA-induced MnSOD expression. Tetradecanoylphorbol Acetate 166-169 superoxide dismutase 2 Homo sapiens 178-183 21705328-5 2011 To identify the PKC isozyme involved, we used a sod2 gene response reporter plasmid, pSODLUC-3340-I2E-C, capable of sensing the effect of TNF-alpha and TPA, to monitor the effects of PKC isozyme-specific inhibitors and siRNA-induced knockdown of specific PKC isozyme. Tetradecanoylphorbol Acetate 152-155 superoxide dismutase 2 Homo sapiens 48-52 21705328-6 2011 Our data indicate that TPA-induced MnSOD expression was independent of p53 and most likely mediated by PKC-alpha-, and -epsilon-dependent signaling pathways. Tetradecanoylphorbol Acetate 23-26 superoxide dismutase 2 Homo sapiens 35-40 21705328-7 2011 Furthermore, siRNA-induced knock-down of CREB and Forkhead box class O (FOXO) 3a led to a reduction in TPA-induced MnSOD gene expression. Tetradecanoylphorbol Acetate 103-106 superoxide dismutase 2 Homo sapiens 115-120 21705328-8 2011 Together, our results revealed that TPA up-regulates, in part, two PKC-dependent transcriptional pathways to induce MnSOD expression. Tetradecanoylphorbol Acetate 36-39 superoxide dismutase 2 Homo sapiens 116-121 21045076-7 2011 Differentiated HL60 cells were stimulated with phorbol-12-myristate-7-acetate (PMA) after inhibition of SOD2 by small interfering RNA followed by respiratory burst assessment using flow cytometry. Tetradecanoylphorbol Acetate 79-82 superoxide dismutase 2 Homo sapiens 104-108 21045076-10 2011 Inhibition of SOD2 reduced the PMA-induced respiratory burst and IL1A, IL-1R1, IL-1R2 and IL8RA gene expression in neutrophil-differentiated HL60 cells. Tetradecanoylphorbol Acetate 31-34 superoxide dismutase 2 Homo sapiens 14-18 15862717-4 2005 Our recent studies demonstrated that overexpression of MnSOD reduced tumor incidence in the two-stage 7,12-dimethylbenz(a)-anthracene (DMBA)/12-O-tetradecanoylphorbol-13-acetate (TPA) skin carcinogenesis model. Tetradecanoylphorbol Acetate 141-177 superoxide dismutase 2 Homo sapiens 55-60 16740634-10 2006 Using ChIP assays and immunoprecipitation, we further demonstrated that p53 interacts with Sp1 to suppress both the constitutive and 12-O-tetradecanoylphorbol-13-acetate-stimulated expression of the MnSOD gene. Tetradecanoylphorbol Acetate 133-169 superoxide dismutase 2 Homo sapiens 199-204 17652337-0 2007 Chronic exposure to 12-O-tetradecanoylphorbol-13-acetate represses sod2 induction in vivo: the negative role of p50. Tetradecanoylphorbol Acetate 20-56 superoxide dismutase 2 Homo sapiens 67-71 17652337-1 2007 It is well documented that the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) can activate manganese superoxide dismutase (MnSOD) expression. Tetradecanoylphorbol Acetate 46-82 superoxide dismutase 2 Homo sapiens 102-132 17652337-1 2007 It is well documented that the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) can activate manganese superoxide dismutase (MnSOD) expression. Tetradecanoylphorbol Acetate 46-82 superoxide dismutase 2 Homo sapiens 134-139 17652337-1 2007 It is well documented that the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) can activate manganese superoxide dismutase (MnSOD) expression. Tetradecanoylphorbol Acetate 84-87 superoxide dismutase 2 Homo sapiens 102-132 17652337-1 2007 It is well documented that the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) can activate manganese superoxide dismutase (MnSOD) expression. Tetradecanoylphorbol Acetate 84-87 superoxide dismutase 2 Homo sapiens 134-139 17652337-3 2007 We generated transgenic mice expressing human MnSOD promoter- and enhancer-driven luciferase reporter gene and used a non-invasive imaging system to investigate the effects of TPA on MnSOD expression in vivo. Tetradecanoylphorbol Acetate 176-179 superoxide dismutase 2 Homo sapiens 183-188 17652337-4 2007 Our data indicate that TPA initially activates MnSOD expression, but this positive effect declines after repeated applications. Tetradecanoylphorbol Acetate 23-26 superoxide dismutase 2 Homo sapiens 47-52 17652337-6 2007 Using chromatin immunoprecipitation coupled to Western analysis of the transcription factors known to be essential for the constitutive and TPA-induced transcription of MnSOD, we found that TPA treatment leads to both activation and inactivation of MnSOD gene transcription. Tetradecanoylphorbol Acetate 140-143 superoxide dismutase 2 Homo sapiens 169-174 17652337-6 2007 Using chromatin immunoprecipitation coupled to Western analysis of the transcription factors known to be essential for the constitutive and TPA-induced transcription of MnSOD, we found that TPA treatment leads to both activation and inactivation of MnSOD gene transcription. Tetradecanoylphorbol Acetate 140-143 superoxide dismutase 2 Homo sapiens 249-254 17652337-6 2007 Using chromatin immunoprecipitation coupled to Western analysis of the transcription factors known to be essential for the constitutive and TPA-induced transcription of MnSOD, we found that TPA treatment leads to both activation and inactivation of MnSOD gene transcription. Tetradecanoylphorbol Acetate 190-193 superoxide dismutase 2 Homo sapiens 169-174 17652337-6 2007 Using chromatin immunoprecipitation coupled to Western analysis of the transcription factors known to be essential for the constitutive and TPA-induced transcription of MnSOD, we found that TPA treatment leads to both activation and inactivation of MnSOD gene transcription. Tetradecanoylphorbol Acetate 190-193 superoxide dismutase 2 Homo sapiens 249-254 17652337-8 2007 Sustained treatments with TPA lead to further increase of p50 but not p65, Sp1 or NPM, suggesting that excess p50 may have inhibitory effects leading to the suppression of MnSOD. Tetradecanoylphorbol Acetate 26-29 superoxide dismutase 2 Homo sapiens 172-177 17652337-10 2007 These findings identify p50 as having a negative effect on MnSOD induction upon repeated applications of TPA and provide an insight into a cause for the reduction of MnSOD expression during early stages of skin carcinogenesis. Tetradecanoylphorbol Acetate 105-108 superoxide dismutase 2 Homo sapiens 59-64 15862717-4 2005 Our recent studies demonstrated that overexpression of MnSOD reduced tumor incidence in the two-stage 7,12-dimethylbenz(a)-anthracene (DMBA)/12-O-tetradecanoylphorbol-13-acetate (TPA) skin carcinogenesis model. Tetradecanoylphorbol Acetate 179-182 superoxide dismutase 2 Homo sapiens 55-60 15330761-9 2004 Western blot analysis indicated the presence of several PKC isoforms in the VA-13 cell line; however, PMA pre-treatment specifically down-regulated alpha and betaI, suggesting a role for one or more of these proteins in SOD2 induction. Tetradecanoylphorbol Acetate 102-105 superoxide dismutase 2 Homo sapiens 220-224 15118344-3 2004 YS 51 also showed synergistic effects on the induction of Mn-SOD mRNA with phorbol-12-myristate-13-acetate (TPA) and/or tumor necrosis factor-alpha (TNF-alpha). Tetradecanoylphorbol Acetate 75-106 superoxide dismutase 2 Homo sapiens 58-64 15330761-2 2004 Using the VA-13 cell line, we studied the regulation of SOD2 upon treatment with PMA. Tetradecanoylphorbol Acetate 81-84 superoxide dismutase 2 Homo sapiens 56-60 15087454-2 2004 We have reported that NF-kappaB is essential but not sufficient for the synergistic induction of MnSOD by phorbol 12-myristate 13-acetate and cytokines. Tetradecanoylphorbol Acetate 106-137 superoxide dismutase 2 Homo sapiens 97-102 15087454-10 2004 These results identify NPM as a partner of the NF-kappaB transcription complex in the induction of MnSOD by phorbol 12-myristate 13-acetate and cytokines. Tetradecanoylphorbol Acetate 108-139 superoxide dismutase 2 Homo sapiens 99-104 15118344-3 2004 YS 51 also showed synergistic effects on the induction of Mn-SOD mRNA with phorbol-12-myristate-13-acetate (TPA) and/or tumor necrosis factor-alpha (TNF-alpha). Tetradecanoylphorbol Acetate 108-111 superoxide dismutase 2 Homo sapiens 58-64 10601319-1 1999 Transcriptional activation of human manganese superoxide dismutase (MnSOD) mRNA induced by a phorbol ester, 12-O-tetradecanoylphorbol-13-acetate (TPA), was examined to identify the responsive transcriptional regulator. Tetradecanoylphorbol Acetate 108-144 superoxide dismutase 2 Homo sapiens 68-73 11553022-8 2001 Incubation with phorbol 12-myristate 13-acetate, the PKC activator, enhanced the increase in Mn-SOD gene expression in response to transient hypoxia. Tetradecanoylphorbol Acetate 16-47 superoxide dismutase 2 Homo sapiens 93-99 11560779-0 2001 TPA-activated transcription of the human MnSOD gene: role of transcription factors Sp-1 and Egr-1. Tetradecanoylphorbol Acetate 0-3 superoxide dismutase 2 Homo sapiens 41-46 11560779-6 2001 We also found that the basal promoter is responsive to 12-O-tetradecanoylphorbol-13-acetate (TPA)-activated hMnSOD transcription in the human hepatocarcinoma cell line HepG2. Tetradecanoylphorbol Acetate 55-91 superoxide dismutase 2 Homo sapiens 108-114 11560779-6 2001 We also found that the basal promoter is responsive to 12-O-tetradecanoylphorbol-13-acetate (TPA)-activated hMnSOD transcription in the human hepatocarcinoma cell line HepG2. Tetradecanoylphorbol Acetate 93-96 superoxide dismutase 2 Homo sapiens 108-114 11560779-7 2001 The contributions of these binding sites and the roles of the transcription factors Egr-1, AP-2, and Sp1 in the activation of hMnSOD transcription by TPA were investigated by site-directed mutation analysis, Western blotting, and overexpression of transcription factors. Tetradecanoylphorbol Acetate 150-153 superoxide dismutase 2 Homo sapiens 126-132 11560779-8 2001 The results showed that Sp1 plays a positive role for both basal and TPA-activated hMnSOD transcription, whereas overexpression of Egr-1 has a negative role in the basal promoter activity without any effect on TPA-mediated activation of hMnSOD transcription. Tetradecanoylphorbol Acetate 69-72 superoxide dismutase 2 Homo sapiens 83-89 10601319-0 1999 Transcriptional activation of the human manganese superoxide dismutase gene mediated by tetradecanoylphorbol acetate. Tetradecanoylphorbol Acetate 88-116 superoxide dismutase 2 Homo sapiens 40-70 10601319-1 1999 Transcriptional activation of human manganese superoxide dismutase (MnSOD) mRNA induced by a phorbol ester, 12-O-tetradecanoylphorbol-13-acetate (TPA), was examined to identify the responsive transcriptional regulator. Tetradecanoylphorbol Acetate 108-144 superoxide dismutase 2 Homo sapiens 36-66 10601319-1 1999 Transcriptional activation of human manganese superoxide dismutase (MnSOD) mRNA induced by a phorbol ester, 12-O-tetradecanoylphorbol-13-acetate (TPA), was examined to identify the responsive transcriptional regulator. Tetradecanoylphorbol Acetate 146-149 superoxide dismutase 2 Homo sapiens 36-66 10601319-1 1999 Transcriptional activation of human manganese superoxide dismutase (MnSOD) mRNA induced by a phorbol ester, 12-O-tetradecanoylphorbol-13-acetate (TPA), was examined to identify the responsive transcriptional regulator. Tetradecanoylphorbol Acetate 146-149 superoxide dismutase 2 Homo sapiens 68-73 10601319-4 1999 The region between -1292 and -1202 contains a cAMP-responsive element-like sequence, TGACGTCT, which we identified as the manganese superoxide dismutase TPA-responsive element, MSTRE. Tetradecanoylphorbol Acetate 153-156 superoxide dismutase 2 Homo sapiens 122-152 10601319-8 1999 These results led us to conclude that the human MnSOD gene having the promoter construct used in this study is induced by TPA via activation of a CREB-1/ATF-1-like factor and not via either NF-kappaB or AP-1. Tetradecanoylphorbol Acetate 122-125 superoxide dismutase 2 Homo sapiens 48-53 9837861-8 1998 Since TPA induces differentiation in human breast cancer cells and up-regulates MnSOD gene in HeLa cells, MnSOD expression and AP-1 and NF-kappaB activity were measured under TPA treatment. Tetradecanoylphorbol Acetate 6-9 superoxide dismutase 2 Homo sapiens 80-85 9852137-10 1998 Down-regulation of PKC by prolonged treatment with phorbol 12-myristate 13-acetate (PMA) also inhibited induction of MnSOD by anticancer drugs, indicating an important role of PKC in MnSOD signaling by these agents. Tetradecanoylphorbol Acetate 51-82 superoxide dismutase 2 Homo sapiens 117-122 9852137-10 1998 Down-regulation of PKC by prolonged treatment with phorbol 12-myristate 13-acetate (PMA) also inhibited induction of MnSOD by anticancer drugs, indicating an important role of PKC in MnSOD signaling by these agents. Tetradecanoylphorbol Acetate 51-82 superoxide dismutase 2 Homo sapiens 183-188 9852137-10 1998 Down-regulation of PKC by prolonged treatment with phorbol 12-myristate 13-acetate (PMA) also inhibited induction of MnSOD by anticancer drugs, indicating an important role of PKC in MnSOD signaling by these agents. Tetradecanoylphorbol Acetate 84-87 superoxide dismutase 2 Homo sapiens 117-122 9852137-10 1998 Down-regulation of PKC by prolonged treatment with phorbol 12-myristate 13-acetate (PMA) also inhibited induction of MnSOD by anticancer drugs, indicating an important role of PKC in MnSOD signaling by these agents. Tetradecanoylphorbol Acetate 84-87 superoxide dismutase 2 Homo sapiens 183-188 9837861-9 1998 The results showed that TPA induced endogenous MnSOD expression and inhibited both AP-1 and NF-kappaB. Tetradecanoylphorbol Acetate 24-27 superoxide dismutase 2 Homo sapiens 47-52 9498574-5 1997 Pretreatment with tumor necrosis factor (TNF) or phorbol ester (TPA), which increases the Mn-SOD level, prevented the apoptosis. Tetradecanoylphorbol Acetate 64-67 superoxide dismutase 2 Homo sapiens 90-96 9434740-6 1997 Induction of the MnSOD mRNA by phorbol-12-myristate-13-acetate (PMA) was only slightly diminished in the presence of PDTC, which in contrast virtually eliminated induction of the NF kappa B-dependent transcript I kappa B-alpha by PMA. Tetradecanoylphorbol Acetate 31-62 superoxide dismutase 2 Homo sapiens 17-22 9434740-6 1997 Induction of the MnSOD mRNA by phorbol-12-myristate-13-acetate (PMA) was only slightly diminished in the presence of PDTC, which in contrast virtually eliminated induction of the NF kappa B-dependent transcript I kappa B-alpha by PMA. Tetradecanoylphorbol Acetate 64-67 superoxide dismutase 2 Homo sapiens 17-22 9434740-10 1997 In vitro DNA binding studies confirmed strong AP-1 activation under conditions where NF kappa B is blocked but the MnSOD transcript is strongly induced (e.g., PMA treatment in the presence of PDTC). Tetradecanoylphorbol Acetate 159-162 superoxide dismutase 2 Homo sapiens 115-120 9651816-10 1998 Although the addition of 12-o-tetradecanoylphorbol-13-acetate (TPA) singly to the incubation medium had no effect on either Mn-, or Cu,Zn-SOD activity, it significantly augmented the IFN-gamma-dependent induction of Mn-SOD activity by anti-Fas antibody or by TNF-alpha. Tetradecanoylphorbol Acetate 25-61 superoxide dismutase 2 Homo sapiens 216-222 9651816-10 1998 Although the addition of 12-o-tetradecanoylphorbol-13-acetate (TPA) singly to the incubation medium had no effect on either Mn-, or Cu,Zn-SOD activity, it significantly augmented the IFN-gamma-dependent induction of Mn-SOD activity by anti-Fas antibody or by TNF-alpha. Tetradecanoylphorbol Acetate 63-66 superoxide dismutase 2 Homo sapiens 216-222 9651816-11 1998 The protein kinase C inhibitor, 1-(5-isoquinoline-sulfonyl)-2-methyl piperazine dihydrochloride (H-7), significantly inhibited the TPA-dependent increase in Mn-SOD activity. Tetradecanoylphorbol Acetate 131-134 superoxide dismutase 2 Homo sapiens 157-163 8702551-8 1996 The effect of Mn-SOD overexpression on IL-1alpha expression can be overcome by treatment with the protein kinase C activator, phorbol 12-myristate 13-acetate. Tetradecanoylphorbol Acetate 126-157 superoxide dismutase 2 Homo sapiens 14-20 9067545-4 1997 Compared with the parental and vector-transfected (gpt) control cells, MnSOD-overexpressing cells had a slower growth rate and their ability to form colonies in soft agar was significantly decreased in response to 12-O-tetradecanoylphorbol-13-acetate (TPA) treatment. Tetradecanoylphorbol Acetate 214-250 superoxide dismutase 2 Homo sapiens 71-76 9067545-4 1997 Compared with the parental and vector-transfected (gpt) control cells, MnSOD-overexpressing cells had a slower growth rate and their ability to form colonies in soft agar was significantly decreased in response to 12-O-tetradecanoylphorbol-13-acetate (TPA) treatment. Tetradecanoylphorbol Acetate 252-255 superoxide dismutase 2 Homo sapiens 71-76 9067545-6 1997 Overexpression of MnSOD led to a significant decrease in c-jun and c-fos expression in response to treatment with TPA or the oxidant promoter superoxide. Tetradecanoylphorbol Acetate 114-117 superoxide dismutase 2 Homo sapiens 18-23 8037686-1 1994 We have reported that the phorbol ester phorbol 12-myristate 13-acetate (PMA) enhances the expression of manganese superoxide dismutase (Mn-SOD) mRNA [Fujii and Taniguchi (1991) J. Biol. Tetradecanoylphorbol Acetate 40-71 superoxide dismutase 2 Homo sapiens 105-135 8037686-1 1994 We have reported that the phorbol ester phorbol 12-myristate 13-acetate (PMA) enhances the expression of manganese superoxide dismutase (Mn-SOD) mRNA [Fujii and Taniguchi (1991) J. Biol. Tetradecanoylphorbol Acetate 40-71 superoxide dismutase 2 Homo sapiens 137-143 8037686-1 1994 We have reported that the phorbol ester phorbol 12-myristate 13-acetate (PMA) enhances the expression of manganese superoxide dismutase (Mn-SOD) mRNA [Fujii and Taniguchi (1991) J. Biol. Tetradecanoylphorbol Acetate 73-76 superoxide dismutase 2 Homo sapiens 105-135 8037686-1 1994 We have reported that the phorbol ester phorbol 12-myristate 13-acetate (PMA) enhances the expression of manganese superoxide dismutase (Mn-SOD) mRNA [Fujii and Taniguchi (1991) J. Biol. Tetradecanoylphorbol Acetate 73-76 superoxide dismutase 2 Homo sapiens 137-143 1616052-6 1992 The time course and extent of increased MnSOD gene transcription by TNF-alpha and TPA were distinct. Tetradecanoylphorbol Acetate 82-85 superoxide dismutase 2 Homo sapiens 40-45 8238402-2 1993 The Mn-SOD in human endothelial cells was markedly induced by the cytokines tumor necrosis factor (TNF), interleukin-1, and lipopolysaccharide as well as by phorbol esters [12-O-tetradecanoylphorbol 13-acetate (TPA)]. Tetradecanoylphorbol Acetate 173-209 superoxide dismutase 2 Homo sapiens 4-10 8238402-2 1993 The Mn-SOD in human endothelial cells was markedly induced by the cytokines tumor necrosis factor (TNF), interleukin-1, and lipopolysaccharide as well as by phorbol esters [12-O-tetradecanoylphorbol 13-acetate (TPA)]. Tetradecanoylphorbol Acetate 211-214 superoxide dismutase 2 Homo sapiens 4-10 1744113-1 1991 The effects of phorbol ester (TPA) and other known stimulators such as tumor necrosis factor (TNF), interleukin-1, and lipopolysaccharide on induction of mRNA for manganese-superoxide dismutase (Mn-SOD) were investigated in various cell lines. Tetradecanoylphorbol Acetate 30-33 superoxide dismutase 2 Homo sapiens 163-193 1744113-2 1991 TPA enhanced Mn-SOD mRNA expression in TNF-resistant cell lines including HeLa cells, in which the other reagents also induced expression of the gene, but did not affect TNF-sensitive cells, in which the other stimulators did not alter expression of the gene. Tetradecanoylphorbol Acetate 0-3 superoxide dismutase 2 Homo sapiens 13-19 1744113-3 1991 HeLa cells which had been desensitized to TPA by pretreatment with TPA for 24 h expressed Mn-SOD mRNA at a slightly higher level than the cells without TPA treatment. Tetradecanoylphorbol Acetate 42-45 superoxide dismutase 2 Homo sapiens 90-96 1744113-3 1991 HeLa cells which had been desensitized to TPA by pretreatment with TPA for 24 h expressed Mn-SOD mRNA at a slightly higher level than the cells without TPA treatment. Tetradecanoylphorbol Acetate 67-70 superoxide dismutase 2 Homo sapiens 90-96 1744113-3 1991 HeLa cells which had been desensitized to TPA by pretreatment with TPA for 24 h expressed Mn-SOD mRNA at a slightly higher level than the cells without TPA treatment. Tetradecanoylphorbol Acetate 67-70 superoxide dismutase 2 Homo sapiens 90-96 1744113-4 1991 TPA-pretreated cells stimulated with TNF, however, expressed Mn-SOD mRNA at about twice the level of TNF-stimulated, TPA-untreated cells. Tetradecanoylphorbol Acetate 0-3 superoxide dismutase 2 Homo sapiens 61-67 32673443-7 2020 We collected the conditioned medium from lipopolysaccharide-activated phorbol myristate acetate-induced THP1 (M1) cells to stimulate A549 and H1299 cells and observed that THP1-M1 upregulated SOD-2 by secreting TNF-alpha. Tetradecanoylphorbol Acetate 70-95 superoxide dismutase 2 Homo sapiens 192-197