PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 2138160-2 1990 Phorbol 12-myristate 13-acetate (PMA) has been reported to induce maturation-like changes, including the loss of TdT, in many leukemic cell lines. Tetradecanoylphorbol Acetate 0-31 DNA nucleotidylexotransferase Homo sapiens 113-116 8528190-5 1995 Phorbol myristate acetate can cause an increase, at 4 and 8 hours of differentiation, of intracellular levels of putrescine as well as a decrease in terminal deoxynucleotidyl transferase synthesis showing the probable involvement that polyamines have in the differentiation process. Tetradecanoylphorbol Acetate 0-25 DNA nucleotidylexotransferase Homo sapiens 149-186 8392417-2 1993 KM-3 cells are lymphoblastoid cells expressing the TdT and when induced to differentiate by phorbol ester (PMA) they loose this enzyme. Tetradecanoylphorbol Acetate 107-110 DNA nucleotidylexotransferase Homo sapiens 51-54 8244198-1 1993 Culture of two lymphoid leukemia cell lines with 5 x 10(-9) to 10(-7) M 12-0-tetradecanoyl-phorbol 13-acetate (TPA) induced the significant increase in sialyltransferase, acid phosphatase and butyrate esterase activities, the decrease in poly(A) polymerase and terminal deoxynucleotidyl transferase (TdT) activities. Tetradecanoylphorbol Acetate 111-114 DNA nucleotidylexotransferase Homo sapiens 261-298 8244198-1 1993 Culture of two lymphoid leukemia cell lines with 5 x 10(-9) to 10(-7) M 12-0-tetradecanoyl-phorbol 13-acetate (TPA) induced the significant increase in sialyltransferase, acid phosphatase and butyrate esterase activities, the decrease in poly(A) polymerase and terminal deoxynucleotidyl transferase (TdT) activities. Tetradecanoylphorbol Acetate 111-114 DNA nucleotidylexotransferase Homo sapiens 300-303 8244198-2 1993 B4-, J5-, TdT- or PNA-positive cells were decreased in TPA-treated cells, while B1-positive cells were increased. Tetradecanoylphorbol Acetate 55-58 DNA nucleotidylexotransferase Homo sapiens 10-13 2110502-2 1990 Incubation of leukemic cells in the presence of the phorbol esters, 12-O-tetradecanoyl-phorbol-13-acetate or phorbol 12,13-dibutyrate, resulted in reduction of ADA and TdT mRNA levels, while PNP mRNA levels increased under the same treatment. Tetradecanoylphorbol Acetate 68-105 DNA nucleotidylexotransferase Homo sapiens 168-171 2110502-4 1990 TPA caused a 40% decrease in ADA and a 60% decrease in TdT enzyme activity, after 6 h of treatment. Tetradecanoylphorbol Acetate 0-3 DNA nucleotidylexotransferase Homo sapiens 55-58 2138160-2 1990 Phorbol 12-myristate 13-acetate (PMA) has been reported to induce maturation-like changes, including the loss of TdT, in many leukemic cell lines. Tetradecanoylphorbol Acetate 33-36 DNA nucleotidylexotransferase Homo sapiens 113-116 2138160-4 1990 At a concentration of 8 nM, PMA caused both repression of TdT synthesis and arrest of proliferation. Tetradecanoylphorbol Acetate 28-31 DNA nucleotidylexotransferase Homo sapiens 58-61 2789262-3 1989 To investigate the regulation of TdT gene expression, pre-B and pre-T cells were treated with PMA or three of its analogs and its effects on steady-state TdT mRNA levels determined. Tetradecanoylphorbol Acetate 94-97 DNA nucleotidylexotransferase Homo sapiens 33-36 2789262-3 1989 To investigate the regulation of TdT gene expression, pre-B and pre-T cells were treated with PMA or three of its analogs and its effects on steady-state TdT mRNA levels determined. Tetradecanoylphorbol Acetate 94-97 DNA nucleotidylexotransferase Homo sapiens 154-157 7051778-0 1982 Disappearance of nuclear TdT in RPMI-8402 following TPA treatment. Tetradecanoylphorbol Acetate 52-55 DNA nucleotidylexotransferase Homo sapiens 25-28 6601131-4 1983 As a consequence of TPA treatment, resistance to dGuo is observed in 8402, as well as in two other TdT+ lymphoid T cell lines, Molt-4 and CEM-10. Tetradecanoylphorbol Acetate 20-23 DNA nucleotidylexotransferase Homo sapiens 99-102 6319830-2 1983 Phorbol ester (TPA) promotes differentiation of human leukaemic lymphoblasts as assessed by changes in phenotypic surface markers and terminal deoxynucleotidyl transferase (TdT) activity. Tetradecanoylphorbol Acetate 15-18 DNA nucleotidylexotransferase Homo sapiens 134-171 6319830-2 1983 Phorbol ester (TPA) promotes differentiation of human leukaemic lymphoblasts as assessed by changes in phenotypic surface markers and terminal deoxynucleotidyl transferase (TdT) activity. Tetradecanoylphorbol Acetate 15-18 DNA nucleotidylexotransferase Homo sapiens 173-176 7035564-5 1982 TPA-treated cells also underwent a concomitant decrease in the expression of TdT when analyzed enzymatically or by immunofluorescence. Tetradecanoylphorbol Acetate 0-3 DNA nucleotidylexotransferase Homo sapiens 77-80 6951664-6 1982 In one of these three ALL cases the population of TdT-positive cells and the TdT activity of the blasts decreased significantly after culture with TPA. Tetradecanoylphorbol Acetate 147-150 DNA nucleotidylexotransferase Homo sapiens 50-53 6951664-6 1982 In one of these three ALL cases the population of TdT-positive cells and the TdT activity of the blasts decreased significantly after culture with TPA. Tetradecanoylphorbol Acetate 147-150 DNA nucleotidylexotransferase Homo sapiens 77-80 6967217-10 1980 Terminal transferase activities and percentages of terminal-transferase-positive cells in these cultures were reduced to as low as 1/10th in 4 days in the presence of 16 nM TPA. Tetradecanoylphorbol Acetate 173-176 DNA nucleotidylexotransferase Homo sapiens 0-20 6967217-10 1980 Terminal transferase activities and percentages of terminal-transferase-positive cells in these cultures were reduced to as low as 1/10th in 4 days in the presence of 16 nM TPA. Tetradecanoylphorbol Acetate 173-176 DNA nucleotidylexotransferase Homo sapiens 51-71 6976970-2 1981 It was found that the induction process by TPA, which included increase in cells with receptors to sheep red blood cells (E--rosette positive--E+) and decrease in the levels of the marker enzyme terminal deoxynucleotidyl transferase (TdT) was not affected by the presence of DNA synthesis inhibitor arabinofuranosylcytosine (Ara-C). Tetradecanoylphorbol Acetate 43-46 DNA nucleotidylexotransferase Homo sapiens 234-237 6976970-4 1981 The kinetics of the increased in E+ cells, decrease in the levels of TdT in these cells, or decrease in the ability to proliferate as measured by colony formation were similar with exposure to TPA for 1, 6, 24, or 96 hours. Tetradecanoylphorbol Acetate 193-196 DNA nucleotidylexotransferase Homo sapiens 69-72