PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 19195490-4 2009 We also designed a chimera that had an additional N-terminal TPA leader sequence (pTPA.GPI-PA63) with an aim to target GPI-PA63 to ER where new CD1 molecules are synthesized. Tetradecanoylphorbol Acetate 61-64 glucose-6-phosphate isomerase Homo sapiens 87-90 2650613-4 1989 Intracellular pH (pHi) was increased by TPA treatment; however, while the alkalinization of K-562 cells was dependent on the presence of extracellular Na+, the response of U-937 cells was unaffected by the removal of this cation. Tetradecanoylphorbol Acetate 40-43 glucose-6-phosphate isomerase Homo sapiens 18-21 2650613-5 1989 In each cell type the protein kinase C (PKC) inhibitor H-7 largely attenuated the TPA induced increase of pHi. Tetradecanoylphorbol Acetate 82-85 glucose-6-phosphate isomerase Homo sapiens 106-109 2535694-6 1989 In contrast, other agents such as phorbol 12-myristate 13-acetate known to induce differentiation in this cell line do cause an increase in pHi. Tetradecanoylphorbol Acetate 34-65 glucose-6-phosphate isomerase Homo sapiens 140-143 2455658-2 1988 12-O-Tetradecanoyl phorbol-13-acetate (PMA), butyrate, interferon, retinoic acid and 1,25-dihydroxyvitamin D3 all increased pHi. Tetradecanoylphorbol Acetate 0-37 glucose-6-phosphate isomerase Homo sapiens 124-127 2455658-2 1988 12-O-Tetradecanoyl phorbol-13-acetate (PMA), butyrate, interferon, retinoic acid and 1,25-dihydroxyvitamin D3 all increased pHi. Tetradecanoylphorbol Acetate 39-42 glucose-6-phosphate isomerase Homo sapiens 124-127 3566711-2 1987 Stimulation of platelets by thrombin or 12-O-tetradecanoylphorbol 13-acetate increased pHi by about 0.11 pH unit above the resting value. Tetradecanoylphorbol Acetate 40-76 glucose-6-phosphate isomerase Homo sapiens 87-90 3040449-1 1987 The effect of the tumor-promoting phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) on cytoplasmic pH (pHi) and H+ extrusion was studied in the human monoblastic cell line U-937. Tetradecanoylphorbol Acetate 48-84 glucose-6-phosphate isomerase Homo sapiens 110-113 3040449-1 1987 The effect of the tumor-promoting phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) on cytoplasmic pH (pHi) and H+ extrusion was studied in the human monoblastic cell line U-937. Tetradecanoylphorbol Acetate 86-89 glucose-6-phosphate isomerase Homo sapiens 110-113 3040449-2 1987 About 2 min after addition of TPA, pHi started to increase and reached a steady state 10-15 min later. Tetradecanoylphorbol Acetate 30-33 glucose-6-phosphate isomerase Homo sapiens 35-38 3040449-4 1987 The TPA-induced increase in pHi was independent of the presence of extracellular Na+. Tetradecanoylphorbol Acetate 4-7 glucose-6-phosphate isomerase Homo sapiens 28-31 3793878-6 1986 Addition of TPA caused no change in [Ca2+]i but a biphasic change in pHi. Tetradecanoylphorbol Acetate 12-15 glucose-6-phosphate isomerase Homo sapiens 69-72 15729714-5 2005 On the other hand, monensin, a Na+/H+ ionophore mimicking NHE activation, and phorbol 12-myristate 13-acetate (PMA), which stimulates NHE, significantly increased the pHi and decreased the drug accumulation in HT29 cells to values similar to those observed in control HT29-dx cells. Tetradecanoylphorbol Acetate 78-109 glucose-6-phosphate isomerase Homo sapiens 167-170 17188004-2 2007 In the present study, we investigated the pH-dependence of phorbol myristate acetate (PMA)-induced PMN spreading. Tetradecanoylphorbol Acetate 59-84 glucose-6-phosphate isomerase Homo sapiens 42-44 17188004-2 2007 In the present study, we investigated the pH-dependence of phorbol myristate acetate (PMA)-induced PMN spreading. Tetradecanoylphorbol Acetate 86-89 glucose-6-phosphate isomerase Homo sapiens 42-44 17013814-10 2007 The reduced burst effectiveness of GPI-defective granulocytes was maintained after treatment with phorbol 12-myristate 13-acetate, a pharmacological stimulus able to extensively recruit and to trigger intracellular protein kinase C (PKC). Tetradecanoylphorbol Acetate 98-129 glucose-6-phosphate isomerase Homo sapiens 35-38 15729714-5 2005 On the other hand, monensin, a Na+/H+ ionophore mimicking NHE activation, and phorbol 12-myristate 13-acetate (PMA), which stimulates NHE, significantly increased the pHi and decreased the drug accumulation in HT29 cells to values similar to those observed in control HT29-dx cells. Tetradecanoylphorbol Acetate 111-114 glucose-6-phosphate isomerase Homo sapiens 167-170 8804438-15 1996 PMA, an activator of PKC, dramatically decreased pH(i) but did not impair the spreading of neutrophils. Tetradecanoylphorbol Acetate 0-3 glucose-6-phosphate isomerase Homo sapiens 49-54 8973715-6 1996 Although addition of phorbol 12-myristate 13-acetate (TPA) had no effect on pHi in unstimulated conditions, the pHi recovery from an acid load was enhanced by exposure to TPA. Tetradecanoylphorbol Acetate 171-174 glucose-6-phosphate isomerase Homo sapiens 112-115 1659231-8 1991 The pHi increase was abolished by 1) blockade of the Na(+)-H+ exchanger by ethyl isopropyl amiloride and 2) inhibition of protein kinase C (PKC) activity via pretreatment with staurosporine or prolonged incubation with 4 beta-phorbol 12-myristate 13-acetate. Tetradecanoylphorbol Acetate 221-257 glucose-6-phosphate isomerase Homo sapiens 4-7 8203529-8 1994 The tumor promotor phorbol 12-myristate 13-acetate (PMA) stimulated recovery rate from acid load and also increased resting pHi. Tetradecanoylphorbol Acetate 19-50 glucose-6-phosphate isomerase Homo sapiens 124-127 8203529-8 1994 The tumor promotor phorbol 12-myristate 13-acetate (PMA) stimulated recovery rate from acid load and also increased resting pHi. Tetradecanoylphorbol Acetate 52-55 glucose-6-phosphate isomerase Homo sapiens 124-127 1332693-4 1992 Addition of ionomycin in Ca(2+)-containing buffer did not cause a rise in basal pHi; however, addition of the phorbol ester phorbol 12-myristate 13-acetate (PMA) did cause a slowly developing rise in resting pHi of 0.14 +/- 0.02 unit over 4-5 min. Tetradecanoylphorbol Acetate 124-155 glucose-6-phosphate isomerase Homo sapiens 208-211 1332693-4 1992 Addition of ionomycin in Ca(2+)-containing buffer did not cause a rise in basal pHi; however, addition of the phorbol ester phorbol 12-myristate 13-acetate (PMA) did cause a slowly developing rise in resting pHi of 0.14 +/- 0.02 unit over 4-5 min. Tetradecanoylphorbol Acetate 157-160 glucose-6-phosphate isomerase Homo sapiens 208-211 1332693-6 1992 In nigericin-pretreated cells, PMA caused a rapid rise in pHi without changing the [Ca2+]i. Tetradecanoylphorbol Acetate 31-34 glucose-6-phosphate isomerase Homo sapiens 58-61 8760139-3 1996 Treatment of type II cells with 80 nM phorbol 12-myristate 13-acetate (PMA) increased the resting pHi in a time-dependent manner. Tetradecanoylphorbol Acetate 38-69 glucose-6-phosphate isomerase Homo sapiens 98-101 8760139-3 1996 Treatment of type II cells with 80 nM phorbol 12-myristate 13-acetate (PMA) increased the resting pHi in a time-dependent manner. Tetradecanoylphorbol Acetate 71-74 glucose-6-phosphate isomerase Homo sapiens 98-101 1591268-3 1992 The set point of control platelets (7.28 +/- 0.01) is shifted rapidly (discernibly less than or equal to 30 s) and markedly to alkaline pHi (7.62 +/- 0.03) by PMA, that activates protein kinase C and is shifted to acidic pHi (7.05 +/- 0.01) by staurosporine, which inhibits protein kinases. Tetradecanoylphorbol Acetate 159-162 glucose-6-phosphate isomerase Homo sapiens 136-139 1591268-3 1992 The set point of control platelets (7.28 +/- 0.01) is shifted rapidly (discernibly less than or equal to 30 s) and markedly to alkaline pHi (7.62 +/- 0.03) by PMA, that activates protein kinase C and is shifted to acidic pHi (7.05 +/- 0.01) by staurosporine, which inhibits protein kinases. Tetradecanoylphorbol Acetate 159-162 glucose-6-phosphate isomerase Homo sapiens 221-224 2168414-4 1990 Furthermore, when thrombin (0.1 unit/ml) or the phorbol ester 12-O-tetradecanoylphorbol 13-acetate (TPA) had raised pHi from 7.13 +/- 0.05 to 7.35 +/- 0.07 (n = 30), addition of NaF (2.5-10 mM) rapidly restored pHi to values found before stimulation. Tetradecanoylphorbol Acetate 100-103 glucose-6-phosphate isomerase Homo sapiens 116-119 2168414-4 1990 Furthermore, when thrombin (0.1 unit/ml) or the phorbol ester 12-O-tetradecanoylphorbol 13-acetate (TPA) had raised pHi from 7.13 +/- 0.05 to 7.35 +/- 0.07 (n = 30), addition of NaF (2.5-10 mM) rapidly restored pHi to values found before stimulation. Tetradecanoylphorbol Acetate 100-103 glucose-6-phosphate isomerase Homo sapiens 211-214 2316641-6 1990 TPA (a tumor-promoting phorbol ester) and OAG (synthetic diacylglycerol), both potent activators of protein kinase C, imitate the action of EGF in rapidly elevating pHi and stimulating cell growth in thyroid cells. Tetradecanoylphorbol Acetate 0-3 glucose-6-phosphate isomerase Homo sapiens 165-168 2155021-9 1990 In both RES and ELI MOs, stimulation with TPA resulted in a biphasic pHi response: an initial acidification followed by a sustained alkalinization to a new steady-state pHi. Tetradecanoylphorbol Acetate 42-45 glucose-6-phosphate isomerase Homo sapiens 69-72 2155021-9 1990 In both RES and ELI MOs, stimulation with TPA resulted in a biphasic pHi response: an initial acidification followed by a sustained alkalinization to a new steady-state pHi. Tetradecanoylphorbol Acetate 42-45 glucose-6-phosphate isomerase Homo sapiens 169-172 2155021-11 1990 The new steady-state pHi attained after TPA stimulation was equivalent in RES and ELI MOs (7.28 +/- 0.04 and 7.31 +/- 0.06, respectively), indicating comparable stimulated Na+/H+ antiport activity. Tetradecanoylphorbol Acetate 40-43 glucose-6-phosphate isomerase Homo sapiens 21-24 2155021-14 1990 This suggested that the TPA-induced pHi reduction was due in part to acid produced via the respiratory burst, and in part to other acid-generating pathways stimulated by TPA. Tetradecanoylphorbol Acetate 24-27 glucose-6-phosphate isomerase Homo sapiens 36-39 2155021-14 1990 This suggested that the TPA-induced pHi reduction was due in part to acid produced via the respiratory burst, and in part to other acid-generating pathways stimulated by TPA. Tetradecanoylphorbol Acetate 170-173 glucose-6-phosphate isomerase Homo sapiens 36-39