PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 10775036-5 2000 PMA treatment rapidly (10 min) induced phosphorylation of MAPK kinase (MEK and p44/42 MAPK), which persisted for at least 24 h. p44/42 MAPK immunoprecipitates from lysates of PMA-treated cells had increased ability to phosphorylate the transcription factor Elk-1. Tetradecanoylphorbol Acetate 0-3 ETS transcription factor ELK1 Homo sapiens 257-262 15806162-11 2005 RNAi-mediated knockdown of endogenous SRF, ELK1 and c-JUN protein expression significantly reduced TPA-stimulated FRA-1 promoter activity. Tetradecanoylphorbol Acetate 99-102 ETS transcription factor ELK1 Homo sapiens 43-47 15910736-4 2005 Expression experiments using mitogen-activated protein kinase phosphatase-1 or a dominant-negative mutant of the ternary complex factor Elk-1 revealed that the distal cluster of serum response elements is essential in the TPA-induced enhancement of Egr-1 promoter activity, encompassing two independent TPA-responsive elements. Tetradecanoylphorbol Acetate 222-225 ETS transcription factor ELK1 Homo sapiens 136-141 10775036-5 2000 PMA treatment rapidly (10 min) induced phosphorylation of MAPK kinase (MEK and p44/42 MAPK), which persisted for at least 24 h. p44/42 MAPK immunoprecipitates from lysates of PMA-treated cells had increased ability to phosphorylate the transcription factor Elk-1. Tetradecanoylphorbol Acetate 175-178 ETS transcription factor ELK1 Homo sapiens 257-262 9341140-4 1997 Reporter gene assays also demonstrated that gastrin and PMA stimulated Elk-1- and c-Myc-dependent transactivation, consistent with gastrin- and PMA-induced activation of ERKs. Tetradecanoylphorbol Acetate 56-59 ETS transcription factor ELK1 Homo sapiens 71-76 10637505-5 1999 Analysis of cells stably expressing Elk-1 in vivo shows that following serum or TPA stimulation, residues T353, T363, T368, S383, S389 and T417 become phosphorylated with similar kinetics. Tetradecanoylphorbol Acetate 80-83 ETS transcription factor ELK1 Homo sapiens 36-41 9880563-6 1999 Serum response factor (SRF), Elk-1, and Sp1 bound to cognate sites within this segment, SRF and Elk-1 acting coordinately to affect both basal activity and TPA inducibility, whereas Sp1 affected basal activity only. Tetradecanoylphorbol Acetate 156-159 ETS transcription factor ELK1 Homo sapiens 29-34 9880563-6 1999 Serum response factor (SRF), Elk-1, and Sp1 bound to cognate sites within this segment, SRF and Elk-1 acting coordinately to affect both basal activity and TPA inducibility, whereas Sp1 affected basal activity only. Tetradecanoylphorbol Acetate 156-159 ETS transcription factor ELK1 Homo sapiens 96-101 9880563-7 1999 Thus, the mechanism of the TPA-induced increase in MCL1 expression seen in myelomonocytic cells at early stages of differentiation involves signal transduction through ERKs and transcriptional activation through SRF/Elk-1. Tetradecanoylphorbol Acetate 27-30 ETS transcription factor ELK1 Homo sapiens 216-221 9341140-4 1997 Reporter gene assays also demonstrated that gastrin and PMA stimulated Elk-1- and c-Myc-dependent transactivation, consistent with gastrin- and PMA-induced activation of ERKs. Tetradecanoylphorbol Acetate 144-147 ETS transcription factor ELK1 Homo sapiens 71-76 9202001-7 1997 This differential substrate specificity of MKP-1 can be functionally extended to nuclear transcriptional events in that PMA-induced c-Jun transcriptional activity was more sensitive to inhibition by MKP-1 than either Elk-1 or c-Myc. Tetradecanoylphorbol Acetate 120-123 ETS transcription factor ELK1 Homo sapiens 217-222 8970984-7 1996 However, the TPA responsiveness of both CMV elements proved to involve synergistic interactions between the core SRF binding site (CCATATATGG) and the adjacent inverted ETS binding motifs (TTCC), which correlated directly with formation of a bound tripartite complex containing both the cellular SRF and ELK-1 proteins. Tetradecanoylphorbol Acetate 13-16 ETS transcription factor ELK1 Homo sapiens 304-309 23940030-6 2013 In addition, FBXO25 overexpression suppressed induction of two ELK-1 target genes, c-fos and egr-1, in response to phorbol 12-myristate 13-acetate. Tetradecanoylphorbol Acetate 115-146 ETS transcription factor ELK1 Homo sapiens 63-68 26786102-5 2016 We show that androgen signaling suppresses TPA-induced c-Fos expression through repressing a PKC/MEK/ERK/ELK-1 signaling pathway. Tetradecanoylphorbol Acetate 43-46 ETS transcription factor ELK1 Homo sapiens 105-110 21186251-6 2011 BAS 02104951 also inhibited 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced Elk-1 phosphorylation in HeLa cells, translocation of PKCepsilon and PKCeta to the membrane following treatment of PC3 cells with TPA. Tetradecanoylphorbol Acetate 28-64 ETS transcription factor ELK1 Homo sapiens 79-84 21186251-6 2011 BAS 02104951 also inhibited 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced Elk-1 phosphorylation in HeLa cells, translocation of PKCepsilon and PKCeta to the membrane following treatment of PC3 cells with TPA. Tetradecanoylphorbol Acetate 66-69 ETS transcription factor ELK1 Homo sapiens 79-84 20025870-7 2010 In contrast, treatment of HASM by PMA induces phosphorylation and activation of Ra, MEK1/2, ERK1/2, JNK, Elk-1, and c-Jun. Tetradecanoylphorbol Acetate 34-37 ETS transcription factor ELK1 Homo sapiens 105-110 19168130-7 2009 Treatment with doxycycline/TPA or TPA alone increased phosphorylations of Elk-1(S383), PDK1(S241), Rb(S807/S811), PKCdelta(T505), p38MAPK(T180/Y182), MEK1/2(S217/S221) and ERK2(T185/T187). Tetradecanoylphorbol Acetate 27-30 ETS transcription factor ELK1 Homo sapiens 74-79 19168130-7 2009 Treatment with doxycycline/TPA or TPA alone increased phosphorylations of Elk-1(S383), PDK1(S241), Rb(S807/S811), PKCdelta(T505), p38MAPK(T180/Y182), MEK1/2(S217/S221) and ERK2(T185/T187). Tetradecanoylphorbol Acetate 34-37 ETS transcription factor ELK1 Homo sapiens 74-79