PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
16774932-3	2007	PMA selectively causes the degradation of IkappaB kinases (IKKs) including IKK-gamma and IKK-beta, and subsequent inhibition of tumor necrosis factor (TNF) induced IKK and NF-kappaB activation in human colon cancer cell line HCT-116, but not in other gastrointestinal tract cells.	Tetradecanoylphorbol Acetate	0-3	inhibitor of nuclear factor kappa B kinase subunit beta	Homo sapiens	89-97	
25460026-7	2015	AM404 also inhibited NF-kappaB activation induced by PMA/Ionomycin in SK-N-SH cells by targeting IKKbeta phosphorylation and activation.	Tetradecanoylphorbol Acetate	53-56	inhibitor of nuclear factor kappa B kinase subunit beta	Homo sapiens	97-104	
24747121-9	2014	In addition, the blockade of ERK1/2 activation negated the catalytic activity of IKKalpha, but not that of IKKbeta, whereas silencing NAK by specific siRNA abrogated the IKKbeta activity in TPA-treated cells.	Tetradecanoylphorbol Acetate	190-193	inhibitor of nuclear factor kappa B kinase subunit beta	Homo sapiens	170-177	
24747121-10	2014	Taken together, sulforaphane inhibits TPA-induced NF-kappaB activation and COX-2 expression in MCF-10A cells by blocking two distinct signaling pathways mediated by ERK1/2-IKKalpha and NAK-IKKbeta.	Tetradecanoylphorbol Acetate	38-41	inhibitor of nuclear factor kappa B kinase subunit beta	Homo sapiens	189-196	
20541543-6	2010	Moreover, palmitate treatment induced activation of protein kinase Ctheta (PKCtheta) while blocking PKCtheta significantly inhibited JNK and IKKbeta activation induced by palmitate or phorbol 12-myristate 13-acetate (PKC activator, PMA), and attenuated the palmitate-induced defects in insulin action.	Tetradecanoylphorbol Acetate	184-215	inhibitor of nuclear factor kappa B kinase subunit beta	Homo sapiens	141-148	
20584749-10	2010	In conclusion, our results show that direct modification of IKKbeta by PIC, presumably at the cysteine 179 residue, blocks NF-kappaB activation signaling and COX-2 induction in TPA-treated MCF-10A cells and also migration and transformation of these cells.	Tetradecanoylphorbol Acetate	177-180	inhibitor of nuclear factor kappa B kinase subunit beta	Homo sapiens	60-67	
19258426-5	2009	Pretreatment with NSC 676914 is here shown to repress 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced IkappaB-alpha phosphorylation and translocation of p65/50 to the nucleus but not the processing of p52 from p100, suggesting the inhibition of NF-kappaB regulator IKKbeta rather than IKKalpha.	Tetradecanoylphorbol Acetate	54-90	inhibitor of nuclear factor kappa B kinase subunit beta	Homo sapiens	268-275	
19258426-5	2009	Pretreatment with NSC 676914 is here shown to repress 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced IkappaB-alpha phosphorylation and translocation of p65/50 to the nucleus but not the processing of p52 from p100, suggesting the inhibition of NF-kappaB regulator IKKbeta rather than IKKalpha.	Tetradecanoylphorbol Acetate	92-95	inhibitor of nuclear factor kappa B kinase subunit beta	Homo sapiens	268-275	
11483407-13	2001	TNF-alpha- or TPA-induced ICAM-1 promoter activity was inhibited by dominant negative PKCalpha or IKK2, but not IKK1 mutant.	Tetradecanoylphorbol Acetate	14-17	inhibitor of nuclear factor kappa B kinase subunit beta	Homo sapiens	98-102	
12645577-10	2003	Substitution of these residues with phenylalanines abolished ICAM-1 promoter activity and c-Src-dependent phosphorylation of IKKbeta induced by TNF-alpha or TPA.	Tetradecanoylphorbol Acetate	157-160	inhibitor of nuclear factor kappa B kinase subunit beta	Homo sapiens	125-132	
14630700-3	2004	PMA induced the phosphorylation of IKKbeta and the subsequent degradation of IkappaBalpha.	Tetradecanoylphorbol Acetate	0-3	inhibitor of nuclear factor kappa B kinase subunit beta	Homo sapiens	35-42	
12707358-10	2003	Substitution of these residues with phenylalanines attenuated COX-2 promoter activity and c-Src-dependent phosphorylation of IKKbeta induced by TNF-alpha or TPA.	Tetradecanoylphorbol Acetate	157-160	inhibitor of nuclear factor kappa B kinase subunit beta	Homo sapiens	125-132	
10022904-8	1999	We also show that cell stimulation with phorbol 12-myristate 13-acetate activates IKKbeta, which is entirely dependent on the activity of alphaPKC but not that of the atypical isoforms.	Tetradecanoylphorbol Acetate	40-71	inhibitor of nuclear factor kappa B kinase subunit beta	Homo sapiens	82-89	
11093788-10	2000	Dominant-negative PKCalpha, NIK, or IKK2, but not IKK1 mutant, inhibited IL-1beta- or TPA-induced ICAM-1 promoter activity.	Tetradecanoylphorbol Acetate	86-89	inhibitor of nuclear factor kappa B kinase subunit beta	Homo sapiens	36-40