PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 10472804-2 1999 AFB1 inhibited the phorbol-12myristate-13-acetate/i6nomycin (PMA/Io)-induced IL-2 mRNA expression in the murine thymocytes and Jurkat E6-1 cells as determined by qualitative RT-PCR, while no effect was observed in the EL4.IL-2 cells. Tetradecanoylphorbol Acetate 19-49 epilepsy 4 Mus musculus 218-221 26981393-3 2016 We used the mouse EL4 T cell as a model system to study genes that are induced as a result of T cell activation using phorbol myristate acetate (PMA) and calcium ionomycin (I) as stimuli. Tetradecanoylphorbol Acetate 118-143 epilepsy 4 Mus musculus 18-21 26981393-3 2016 We used the mouse EL4 T cell as a model system to study genes that are induced as a result of T cell activation using phorbol myristate acetate (PMA) and calcium ionomycin (I) as stimuli. Tetradecanoylphorbol Acetate 145-148 epilepsy 4 Mus musculus 18-21 21533871-1 2011 The murine EL4 lymphoma cell line exists in variants that are either sensitive or resistant to phorbol 12-myristate 13-acetate (PMA). Tetradecanoylphorbol Acetate 95-126 epilepsy 4 Mus musculus 11-14 21533871-1 2011 The murine EL4 lymphoma cell line exists in variants that are either sensitive or resistant to phorbol 12-myristate 13-acetate (PMA). Tetradecanoylphorbol Acetate 128-131 epilepsy 4 Mus musculus 11-14 19263515-1 2009 The EL4 murine lymphoma cell line exists in variant phenotypes that differ with respect to responses to the tumor promoter phorbol 12-myristate 13-acetate (PMA1). Tetradecanoylphorbol Acetate 123-154 epilepsy 4 Mus musculus 4-7 17630204-4 2007 Isoeugenol inhibited phorbol 12-myristate 13-acetate (PMA) plus ionomycin (Io)-induced IL-2 mRNA expression and protein secretion in B6C3F1 mouse splenocytes, and in EL4.IL-2 mouse T-cells, as determined by real-time RT-PCR and ELISA, respectively. Tetradecanoylphorbol Acetate 21-52 epilepsy 4 Mus musculus 166-169 17630204-4 2007 Isoeugenol inhibited phorbol 12-myristate 13-acetate (PMA) plus ionomycin (Io)-induced IL-2 mRNA expression and protein secretion in B6C3F1 mouse splenocytes, and in EL4.IL-2 mouse T-cells, as determined by real-time RT-PCR and ELISA, respectively. Tetradecanoylphorbol Acetate 54-57 epilepsy 4 Mus musculus 166-169 17065239-1 2007 The murine EL4 lymphoma cell line exists in variants that are either sensitive or resistant to the tumor promoter phorbol 12-myristate 13-acetate (PMA). Tetradecanoylphorbol Acetate 114-145 epilepsy 4 Mus musculus 11-14 17065239-1 2007 The murine EL4 lymphoma cell line exists in variants that are either sensitive or resistant to the tumor promoter phorbol 12-myristate 13-acetate (PMA). Tetradecanoylphorbol Acetate 147-150 epilepsy 4 Mus musculus 11-14 10472804-2 1999 AFB1 inhibited the phorbol-12myristate-13-acetate/i6nomycin (PMA/Io)-induced IL-2 mRNA expression in the murine thymocytes and Jurkat E6-1 cells as determined by qualitative RT-PCR, while no effect was observed in the EL4.IL-2 cells. Tetradecanoylphorbol Acetate 61-64 epilepsy 4 Mus musculus 218-221 9406065-7 1997 Upon stimulation of EL-4.IL-2 with phorbol-12-myristate-13-acetate, there were variable increases in interleukin-2 secretion (up to 2.4-fold for 10(6) Bifidobacterium Bf-1/ml) and interleukin-5 secretion (up to 4.6-fold for 10(8) B. adolescentis M101-4). Tetradecanoylphorbol Acetate 35-66 epilepsy 4 Mus musculus 20-24 9678170-7 1998 Upon concurrent stimulation of EL4.IL-2 cells with phorbol 12-myristate-13-acetate, seven of the eight strains displayed significant enhancement of IL-2 and IL-5 production, with S. thermophilus being most effective. Tetradecanoylphorbol Acetate 51-82 epilepsy 4 Mus musculus 31-34 31207793-9 1997 Upon stimulation of EL4.IL-2 cells with phorbol 12-myristate-13-acetate, IL-2 secretion increased up to 1.9-fold in the presence of 106 L. bulgaricus Lr 79 cells per ml whereas this cytokine decreased in the presence of 107 or 108 lactobacilli per ml. Tetradecanoylphorbol Acetate 40-71 epilepsy 4 Mus musculus 20-23 8887449-3 1996 When EL-4 thymoma cells were stimulated with phorbol 12-myristate 13-acetate plus ionomycin in the presence of 500 ng/ml VT, DNA binding activity by NF-kappaB/Rel in nuclear extracts was increased from 2 to 48 hr when compared to controls employing no VT. VT preferentially induced a slower migrating electrophoretic band of the NF-kappaB/Rel complex particularly in later time points (8-48 hr). Tetradecanoylphorbol Acetate 45-76 epilepsy 4 Mus musculus 5-9 8999961-2 1997 In this report, we show that in EL4, a murine T-lymphoma cell line, stimulation with concanavalin A or treatment with phorbol 13-myristate 12-acetate (PMA) inhibit growth, due to cell cycle arrest at both the G1 and the G2/M phases. Tetradecanoylphorbol Acetate 151-154 epilepsy 4 Mus musculus 32-35 9328180-1 1997 Phorbol ester-sensitive EL4 murine thymoma cells respond to phorbol 12-myristate 13-acetate with activation of ERK mitogen-activated protein kinases, synthesis of interleukin-2, and death, whereas phorbol ester-resistant variants of this cell line do not exhibit these responses. Tetradecanoylphorbol Acetate 60-91 epilepsy 4 Mus musculus 24-27 8950029-4 1996 PMA, but not Ara-C or ceramides, activated ERK MAPKS, in Jurkat and EL4. Tetradecanoylphorbol Acetate 0-3 epilepsy 4 Mus musculus 68-71 8691508-2 1996 EL-4 cells were stimulated with phorbol 12-myristate 12-acetate (PMA) in the presence of mycotoxins at various concentrations for 5 d and culture supernatants were analyzed for interleukins (IL) IL-2 and IL-5 by enzyme-linked immunosorbent assay (ELISA). Tetradecanoylphorbol Acetate 65-68 epilepsy 4 Mus musculus 0-4 8710683-3 1996 Cell-conditioned media (CM) from EL-4 cells treated with 0.2 ng/ml phorbol myristate acetate (PMA) + 0.1 microgram/ml VES contained increased amounts of IL-2, as determined by the murine cytotoxic T cell IL-2-dependent CTLL-2 bioassay. Tetradecanoylphorbol Acetate 67-92 epilepsy 4 Mus musculus 33-37 8710683-3 1996 Cell-conditioned media (CM) from EL-4 cells treated with 0.2 ng/ml phorbol myristate acetate (PMA) + 0.1 microgram/ml VES contained increased amounts of IL-2, as determined by the murine cytotoxic T cell IL-2-dependent CTLL-2 bioassay. Tetradecanoylphorbol Acetate 94-97 epilepsy 4 Mus musculus 33-37 7499370-2 1995 The tyrosine kinase inhibitor herbimycin A was found to block NF-kappa B stimulation in response to interleukin-1 and phorbol 12-myristate 13-acetate in EL4.NOB-1 thymoma cells and phorbol 12-myristate 13-acetate in Jurkat T lymphoma cells. Tetradecanoylphorbol Acetate 118-149 epilepsy 4 Mus musculus 153-156 1966941-5 1990 EL-4 feeder activity was strictly dependent on the presence of phorbol-myristate-acetate (PMA) and supernatant from stimulated T-lymphocytes (T-SN). Tetradecanoylphorbol Acetate 63-88 epilepsy 4 Mus musculus 0-4 8396935-4 1993 Phorbol myristate acetate (PMA), another activator of EL4.NOB-1 cells, had an opposite effect to IL-1 in that it increased binding site expression dramatically suggesting different mechanisms of action for these two effectors. Tetradecanoylphorbol Acetate 0-25 epilepsy 4 Mus musculus 54-57 8396935-4 1993 Phorbol myristate acetate (PMA), another activator of EL4.NOB-1 cells, had an opposite effect to IL-1 in that it increased binding site expression dramatically suggesting different mechanisms of action for these two effectors. Tetradecanoylphorbol Acetate 27-30 epilepsy 4 Mus musculus 54-57 8374508-6 1993 Vitamin E succinate plus suboptimal levels of the protein kinase C (PKC) activator phorbol myristate acetate (PMA) induced the highest levels of IL-2 by EL-4 cells. Tetradecanoylphorbol Acetate 83-108 epilepsy 4 Mus musculus 153-157 8374508-6 1993 Vitamin E succinate plus suboptimal levels of the protein kinase C (PKC) activator phorbol myristate acetate (PMA) induced the highest levels of IL-2 by EL-4 cells. Tetradecanoylphorbol Acetate 110-113 epilepsy 4 Mus musculus 153-157 7730629-1 1995 cAMP inhibits PMA-induced IL-2 production at the transcriptional level in EL-4, a mouse lymphoma line. Tetradecanoylphorbol Acetate 14-17 epilepsy 4 Mus musculus 74-78 1966941-5 1990 EL-4 feeder activity was strictly dependent on the presence of phorbol-myristate-acetate (PMA) and supernatant from stimulated T-lymphocytes (T-SN). Tetradecanoylphorbol Acetate 90-93 epilepsy 4 Mus musculus 0-4 2138520-0 1990 TPA induction of EL4 resistance to macrophage-released TNF: role of ADP-ribosylation in tumoricidal activities of TNF and other factors. Tetradecanoylphorbol Acetate 0-3 epilepsy 4 Mus musculus 17-20 2646299-1 1989 Macrophage activation activity was characterized from a PMA-induced subclone of the murine EL-4 leukaemic cell line. Tetradecanoylphorbol Acetate 56-59 epilepsy 4 Mus musculus 91-95 2788092-2 1989 Here we show that IL4 and phorbol 12-myristate 13-acetate (PMA) induce, on a per cell basis, very high IgE secretion in purified human B cells by using a mouse thymoma (EL4) co-culture method. Tetradecanoylphorbol Acetate 26-57 epilepsy 4 Mus musculus 169-172 2788092-2 1989 Here we show that IL4 and phorbol 12-myristate 13-acetate (PMA) induce, on a per cell basis, very high IgE secretion in purified human B cells by using a mouse thymoma (EL4) co-culture method. Tetradecanoylphorbol Acetate 59-62 epilepsy 4 Mus musculus 169-172 2784444-0 1989 Comparison of phorbol-12-myristate-13-acetate and dioctanoyl-sn-glycerol in the activation of EL4/6.1 thymoma cells. Tetradecanoylphorbol Acetate 14-45 epilepsy 4 Mus musculus 94-99 2522880-4 1989 In the presence of the tumor promoter phorbol 12-myristate 13-acetate IL 1 augments IL 2 secretion and IL 2R expression of EL4 5D3 but not of EL4 D6/76 cells. Tetradecanoylphorbol Acetate 38-69 epilepsy 4 Mus musculus 123-126 2138520-6 1990 A tumor-promoting phorbol ester, TPA, rendered TNF-sensitive and -insensitive EL4 cells resistant to M phi-mediated lysis. Tetradecanoylphorbol Acetate 33-36 epilepsy 4 Mus musculus 78-81 3265048-9 1988 The role of protein kinase C translocation and degradation in the PMA-induced responses in EL4 cells is unknown. Tetradecanoylphorbol Acetate 66-69 epilepsy 4 Mus musculus 91-94 6089211-1 1984 Supernatants from phorbol 12-myristate 13-acetate-activated cultures of the mouse EL4 thymoma, or of several mouse T-cell hybridomas stimulated either by their specific antigen or by concanavalin A, induced primary splenic B cells to proliferate and differentiate to antibody-secreting cells. Tetradecanoylphorbol Acetate 18-49 epilepsy 4 Mus musculus 82-85 3192268-1 1988 Pretreatment of EL4 cells with 12-O-tetradecanoyl phorbol-13-acetate (TPA) for 30 min renders them resistant to lysis by activated macrophages (M phi). Tetradecanoylphorbol Acetate 31-68 epilepsy 4 Mus musculus 16-19 3192268-1 1988 Pretreatment of EL4 cells with 12-O-tetradecanoyl phorbol-13-acetate (TPA) for 30 min renders them resistant to lysis by activated macrophages (M phi). Tetradecanoylphorbol Acetate 70-73 epilepsy 4 Mus musculus 16-19 3192268-2 1988 This resistance was augmented two to three-fold when TPA-treated EL4 cells were incubated for 2-6 hr prior to co-culture with M phi. Tetradecanoylphorbol Acetate 53-56 epilepsy 4 Mus musculus 65-68 3133307-1 1988 Supernatants from phorbol myristate acetate (PMA)-stimulated EL4.IL2 cells (EL4.PMA), but not recombinant IL-2 (rIL-2), induced the production of cytotoxic T lymphocytes (CTL) in low density murine spleen cell cultures. Tetradecanoylphorbol Acetate 18-43 epilepsy 4 Mus musculus 61-64 3133307-1 1988 Supernatants from phorbol myristate acetate (PMA)-stimulated EL4.IL2 cells (EL4.PMA), but not recombinant IL-2 (rIL-2), induced the production of cytotoxic T lymphocytes (CTL) in low density murine spleen cell cultures. Tetradecanoylphorbol Acetate 18-43 epilepsy 4 Mus musculus 76-79 3133307-1 1988 Supernatants from phorbol myristate acetate (PMA)-stimulated EL4.IL2 cells (EL4.PMA), but not recombinant IL-2 (rIL-2), induced the production of cytotoxic T lymphocytes (CTL) in low density murine spleen cell cultures. Tetradecanoylphorbol Acetate 45-48 epilepsy 4 Mus musculus 61-64 3133307-1 1988 Supernatants from phorbol myristate acetate (PMA)-stimulated EL4.IL2 cells (EL4.PMA), but not recombinant IL-2 (rIL-2), induced the production of cytotoxic T lymphocytes (CTL) in low density murine spleen cell cultures. Tetradecanoylphorbol Acetate 45-48 epilepsy 4 Mus musculus 76-79 3496224-3 1987 TPA stimulation of an interleukin 2 (IL 2)-producing variant, EL4+, induced a 3-4-fold increase in TCR beta, but not alpha, chain mRNA. Tetradecanoylphorbol Acetate 0-3 epilepsy 4 Mus musculus 62-65 3496224-6 1987 TPA stimulation of EL4+ cells also induced de novo expression of the IL 2 gene and subsequent secretion of this lymphokine. Tetradecanoylphorbol Acetate 0-3 epilepsy 4 Mus musculus 19-22 3082993-1 1986 The murine T lymphoma EL4 subline produces large amounts of interleukin 2 (IL-2) upon stimulation with phorbol myristate acetate (PMA). Tetradecanoylphorbol Acetate 103-128 epilepsy 4 Mus musculus 22-25 3082993-1 1986 The murine T lymphoma EL4 subline produces large amounts of interleukin 2 (IL-2) upon stimulation with phorbol myristate acetate (PMA). Tetradecanoylphorbol Acetate 130-133 epilepsy 4 Mus musculus 22-25 3082993-6 1986 The reverted EL4 cells were again able to produce large amounts of IL-2 upon restimulation with PMA. Tetradecanoylphorbol Acetate 96-99 epilepsy 4 Mus musculus 13-16 3109744-1 1987 A cloned variant of the EL-4 murine T-cell line treated with phorbol myristate acetate (PMA) releases a factor that activates macrophages for nonspecific tumor cytotoxicity. Tetradecanoylphorbol Acetate 61-86 epilepsy 4 Mus musculus 24-28 3109744-1 1987 A cloned variant of the EL-4 murine T-cell line treated with phorbol myristate acetate (PMA) releases a factor that activates macrophages for nonspecific tumor cytotoxicity. Tetradecanoylphorbol Acetate 88-91 epilepsy 4 Mus musculus 24-28 6092699-1 1984 cDNA libraries from EL-4 cells treated with 12-O-tetradecanoyl phorbol-13-acetate (TPA) were screened for TPA-inducible sequences by differential hybridization. Tetradecanoylphorbol Acetate 44-81 epilepsy 4 Mus musculus 20-24 6368713-1 1984 Culture fluids from a phorbol myristate acetate-stimulated EL-4 thymoma cell line were previously found to activate mouse macrophages to become nonspecifically tumoricidal. Tetradecanoylphorbol Acetate 22-47 epilepsy 4 Mus musculus 59-63 6233008-3 1984 (1) When GF-containing fluids from cultures of phorbol myristic acetate (PMA)-activated EL4 thymoma were fractionated by a variety of biochemical techniques. Tetradecanoylphorbol Acetate 73-76 epilepsy 4 Mus musculus 88-91 6202789-1 1984 Factors obtained from phorbol myristate acetate (PMA)-stimulated EL-4 thymoma cells, a continuous T cell line, suppressed lymphokine-induced macrophage activation to kill intracellular Leishmania tropica amastigotes. Tetradecanoylphorbol Acetate 22-47 epilepsy 4 Mus musculus 65-69 6202789-1 1984 Factors obtained from phorbol myristate acetate (PMA)-stimulated EL-4 thymoma cells, a continuous T cell line, suppressed lymphokine-induced macrophage activation to kill intracellular Leishmania tropica amastigotes. Tetradecanoylphorbol Acetate 49-52 epilepsy 4 Mus musculus 65-69 6085623-1 1984 Treatment of resident murine peritoneal macrophages with 12-O-tetradecanoyl phorbol-13-acetate (TPA) rapidly converted the cells to tumour cytostatic and cytolytic effector cells, as determined by growth inhibition or lysis of T-lymphoma cells (Eb, EL4) in vitro. Tetradecanoylphorbol Acetate 57-94 epilepsy 4 Mus musculus 249-252 6085623-1 1984 Treatment of resident murine peritoneal macrophages with 12-O-tetradecanoyl phorbol-13-acetate (TPA) rapidly converted the cells to tumour cytostatic and cytolytic effector cells, as determined by growth inhibition or lysis of T-lymphoma cells (Eb, EL4) in vitro. Tetradecanoylphorbol Acetate 96-99 epilepsy 4 Mus musculus 249-252 6813857-4 1982 Production of interferon by phorbol myristate acetate-stimulated BFS cell cultures was synergistically increased by the addition of EL4 thymoma cell culture supernatants. Tetradecanoylphorbol Acetate 28-53 epilepsy 4 Mus musculus 132-135 6352806-1 1983 A subline of the C57BL/6 mouse EL-4 thymoma produces upon stimulation with phorbol myristate acetate (PMA) a B cell growth factor (BCGF) that co-stimulates anti-IgM-stimulated splenic B cells. Tetradecanoylphorbol Acetate 75-100 epilepsy 4 Mus musculus 31-35 6352806-1 1983 A subline of the C57BL/6 mouse EL-4 thymoma produces upon stimulation with phorbol myristate acetate (PMA) a B cell growth factor (BCGF) that co-stimulates anti-IgM-stimulated splenic B cells. Tetradecanoylphorbol Acetate 102-105 epilepsy 4 Mus musculus 31-35 6982943-1 1982 Supernatant culture fluids from a phorbol myristate acetate (PMA) stimulated variant of the murine EL-4 thymoma cell line activated inflammatory macrophages for nonspecific tumoricidal activity in vitro; active supernatants fluids were not directly toxic to tumor target cells in the absence of macrophages. Tetradecanoylphorbol Acetate 34-59 epilepsy 4 Mus musculus 99-103 6982943-1 1982 Supernatant culture fluids from a phorbol myristate acetate (PMA) stimulated variant of the murine EL-4 thymoma cell line activated inflammatory macrophages for nonspecific tumoricidal activity in vitro; active supernatants fluids were not directly toxic to tumor target cells in the absence of macrophages. Tetradecanoylphorbol Acetate 61-64 epilepsy 4 Mus musculus 99-103 6975322-1 1981 A variant line of murine T lymphoma EL4 produces high levels of the lymphokine Interleukin 2 (IL 2) when it is stimulated with phorbol myristate acetate. Tetradecanoylphorbol Acetate 127-152 epilepsy 4 Mus musculus 36-39 6975322-6 1981 The IL 2 produced by injected oocytes from a given preparation of mRNA is about 1% of the amount produced by the EL4 cells stimulated originally with phorbol myristate acetate. Tetradecanoylphorbol Acetate 150-175 epilepsy 4 Mus musculus 113-116 6975322-8 1981 We conclude that IL 2 is essentially protein in nature, that the protein is coded for by poly A+ mRNA, and that the amount of this mRNA increases significantly after stimulation of the variant EL4 cells with the inducer phorbol myristate acetate. Tetradecanoylphorbol Acetate 220-245 epilepsy 4 Mus musculus 193-196