PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
21292826-6	2011	The SRF site alone is sufficient for induction by GnRH, whereas induction by 12-tetradecanoylphorbol-13-acetate (TPA) requires both the ELK1 and SRF sites.	Tetradecanoylphorbol Acetate	113-116	ELK1, member of ETS oncogene family	Mus musculus	136-140	
22461904-6	2012	The further mechanistic studies showed that JWA deficiency blocked TPA-induced activation of MAPKs and its downstream transcription factor Elk1 both in vitro and in vivo.	Tetradecanoylphorbol Acetate	67-70	ELK1, member of ETS oncogene family	Mus musculus	139-143	
22461904-7	2012	JWA(Delta2/Delta2) mice are resistance to tumorigenesis induced by DMBA/TPA probably through inhibition of transcription factor Elk1 via MAPKs.	Tetradecanoylphorbol Acetate	72-75	ELK1, member of ETS oncogene family	Mus musculus	128-132	
16515541-0	2006	Up-regulation of tyrosine hydroxylase gene transcription by tetradecanoylphorbol acetate is mediated by the transcription factors Ets-like protein-1 (Elk-1) and Egr-1.	Tetradecanoylphorbol Acetate	60-88	ELK1, member of ETS oncogene family	Mus musculus	130-148	
21292826-6	2011	The SRF site alone is sufficient for induction by GnRH, whereas induction by 12-tetradecanoylphorbol-13-acetate (TPA) requires both the ELK1 and SRF sites.	Tetradecanoylphorbol Acetate	77-111	ELK1, member of ETS oncogene family	Mus musculus	136-140	
16515541-0	2006	Up-regulation of tyrosine hydroxylase gene transcription by tetradecanoylphorbol acetate is mediated by the transcription factors Ets-like protein-1 (Elk-1) and Egr-1.	Tetradecanoylphorbol Acetate	60-88	ELK1, member of ETS oncogene family	Mus musculus	150-155	
16515541-3	2006	We have analysed the stimulation of tyrosine hydroxylase gene transcription by the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) in noradrenergic locus coeruleus-like CATH.a cells and observed a striking enhancement of the transcriptional activation potential of the ternary complex factor Ets-like protein-1 (Elk-1), a key transcriptional regulator of serum response element-driven gene transcription.	Tetradecanoylphorbol Acetate	135-138	ELK1, member of ETS oncogene family	Mus musculus	301-319	
16515541-3	2006	We have analysed the stimulation of tyrosine hydroxylase gene transcription by the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) in noradrenergic locus coeruleus-like CATH.a cells and observed a striking enhancement of the transcriptional activation potential of the ternary complex factor Ets-like protein-1 (Elk-1), a key transcriptional regulator of serum response element-driven gene transcription.	Tetradecanoylphorbol Acetate	135-138	ELK1, member of ETS oncogene family	Mus musculus	321-326	
16515541-7	2006	Expression of dominant-negative mutants of Elk-1 or Egr-1 impaired TPA-induced stimulation of a tyrosine hydroxylase promoter/reporter gene transcription.	Tetradecanoylphorbol Acetate	67-70	ELK1, member of ETS oncogene family	Mus musculus	43-48	
10722731-5	2000	Surprisingly, we observed that expression of N17Ras inhibited the activity and phosphorylation of Elk-1, a physiological substrate of MAP kinases, in response to phorbol myristate acetate.	Tetradecanoylphorbol Acetate	162-187	ELK1, member of ETS oncogene family	Mus musculus	98-103	
11050045-6	2000	Interestingly, Elk-1 activities were further enhanced by the tumor promoter, 12-O-tetradecanoyl phorbol 13-acetate (TPA), but not by hepatocyte mitogens (epidermal growth factor [EGF] and transforming growth factor alpha [TGF-alpha]) in NIH3T3 cells and HepG2 cells expressing HCV core protein.	Tetradecanoylphorbol Acetate	77-114	ELK1, member of ETS oncogene family	Mus musculus	15-20	
11050045-6	2000	Interestingly, Elk-1 activities were further enhanced by the tumor promoter, 12-O-tetradecanoyl phorbol 13-acetate (TPA), but not by hepatocyte mitogens (epidermal growth factor [EGF] and transforming growth factor alpha [TGF-alpha]) in NIH3T3 cells and HepG2 cells expressing HCV core protein.	Tetradecanoylphorbol Acetate	116-119	ELK1, member of ETS oncogene family	Mus musculus	15-20	
9891065-8	1999	TPA-induced activation of the SRE was partially inhibited by dominant negative c-Raf, ERK1, or ERK2, and constitutively active mutants of PKC-alpha and PKC-epsilon activated the transactivation domain of Elk-1.	Tetradecanoylphorbol Acetate	0-3	ELK1, member of ETS oncogene family	Mus musculus	204-209