PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 15625014-0 2004 Regulation of alternative splicing of Bcl-x by IL-6, GM-CSF and TPA. Tetradecanoylphorbol Acetate 64-67 BCL2 like 1 Homo sapiens 38-43 15625014-4 2004 In U251 glioma cells, however, TPA efficiently increased the Bcl-xL level. Tetradecanoylphorbol Acetate 31-34 BCL2 like 1 Homo sapiens 61-67 15563463-4 2005 Even when apoptosis was prevented by the overexpression of Bcl-XL, activated Notch signals still inhibited TPA-induced megakaryocytic differentiation. Tetradecanoylphorbol Acetate 107-110 BCL2 like 1 Homo sapiens 59-65 15968086-11 2005 Moreover, activation of PKC by phorbol 12-myristate 13-acetate markedly attenuated cell death induced by Abeta and induced elevation in BclxL levels. Tetradecanoylphorbol Acetate 31-62 BCL2 like 1 Homo sapiens 136-141 12082637-4 2002 A RNase-protection analysis showed that PMA stimulated the expression of several known anti-apoptotic genes (TRAF1, TRAF4, c-IAP-1, c-IAP-2, Bfl-1, Bcl-xl). Tetradecanoylphorbol Acetate 40-43 BCL2 like 1 Homo sapiens 148-154 15625014-7 2004 As for the TPA effect, only nucleotides 1-76 are required in the downstream intron, Thus UK-6, GM-CSF and TPA differentially regulate Bcl-x splicing and require specific intronic pre-mRNA sequences for their respective effects. Tetradecanoylphorbol Acetate 106-109 BCL2 like 1 Homo sapiens 134-139 12430000-5 2002 Levels of expression of two genes, human flavoprotein subunit of complex II and JKTBP, were downregulated by TPA, and expression of two genes, human golgin p245 and bcl-xL, was upregulated. Tetradecanoylphorbol Acetate 109-112 BCL2 like 1 Homo sapiens 165-171 12430000-6 2002 Moreover, we found that the changes in expression of flavo-protein, JKTBP and bcl-xL induced by TPA were blocked by treatment with protein kinase C (PKC) or mitogen-activated protein (MAP) kinase inhibitors that prevent TPA-induced differentiation of TSU-Pr1 cells. Tetradecanoylphorbol Acetate 96-99 BCL2 like 1 Homo sapiens 78-84 12430000-6 2002 Moreover, we found that the changes in expression of flavo-protein, JKTBP and bcl-xL induced by TPA were blocked by treatment with protein kinase C (PKC) or mitogen-activated protein (MAP) kinase inhibitors that prevent TPA-induced differentiation of TSU-Pr1 cells. Tetradecanoylphorbol Acetate 220-223 BCL2 like 1 Homo sapiens 78-84 12118374-12 2002 Taken together, our data demonstrate that PMA-mediated inhibition of apoptosis is a complex process that is integrated at both the transcriptional and post-transcriptional level and point out to the potential role of Mcl-1, Bcl-x, c-Myc and survivin in this process. Tetradecanoylphorbol Acetate 42-45 BCL2 like 1 Homo sapiens 224-229 11526432-4 2001 The results show that TPA induces the association of SAPK with the mitochondrial anti-apoptotic Bcl-x(L) protein. Tetradecanoylphorbol Acetate 22-25 BCL2 like 1 Homo sapiens 96-104 10696432-5 1999 By the treatment with phorbol 12-myristate 13-acetate (PMA) and ionomycin, normal CD4+ T cells were induced to express bcl-xS which can promote apoptosis, while bcl-xL was constitutively expressed in MD cell lines. Tetradecanoylphorbol Acetate 22-53 BCL2 like 1 Homo sapiens 161-167 11526432-5 2001 Overexpression of Bcl-x(L) attenuated the apoptotic response to TPA treatment. Tetradecanoylphorbol Acetate 64-67 BCL2 like 1 Homo sapiens 18-26 11526432-6 2001 Moreover, expression of Bcl-x(L) mutated at sites of SAPK phosphorylation (Thr-47, -115) was more effective than wild-type Bcl-x(L) in abrogating TPA-induced cytochrome c release and apoptosis. Tetradecanoylphorbol Acetate 146-149 BCL2 like 1 Homo sapiens 24-32 11526432-6 2001 Moreover, expression of Bcl-x(L) mutated at sites of SAPK phosphorylation (Thr-47, -115) was more effective than wild-type Bcl-x(L) in abrogating TPA-induced cytochrome c release and apoptosis. Tetradecanoylphorbol Acetate 146-149 BCL2 like 1 Homo sapiens 24-29 10954916-7 2000 NF-kappaB activation induced by serum-activated lipopolysaccharide (SALPS), ceramide, and okadaic acid was also inhibited by overexpression of Bcl-x(L), whereas that by phorbol myristate acetate (PMA) and H2O2 was unaffected. Tetradecanoylphorbol Acetate 196-199 BCL2 like 1 Homo sapiens 143-151 10696432-5 1999 By the treatment with phorbol 12-myristate 13-acetate (PMA) and ionomycin, normal CD4+ T cells were induced to express bcl-xS which can promote apoptosis, while bcl-xL was constitutively expressed in MD cell lines. Tetradecanoylphorbol Acetate 55-58 BCL2 like 1 Homo sapiens 161-167 10381626-5 1999 Exposure of TPA-differentiated U937 cells to 0.8 microg/ml cycloheximide for 24 h, that triggers apoptosis in 50% cells, activates procaspase-2L, -3 and -8, induces the mitochondrial release of cytochrome c and decreases Bcl-xL expression without modifying Bcl-2, Mcl-1 and Bax protein levels. Tetradecanoylphorbol Acetate 12-15 BCL2 like 1 Homo sapiens 221-227 9419420-7 1997 Treatment with Epo or 12-O-tetradecanoyl-phorbol-13-acetate (TPA) up-regulated expression of GATA-2 and Bcl-xL, and these elevations were inhibited by inhibitors of protein kinase C (PKC), H7 and H8. Tetradecanoylphorbol Acetate 22-59 BCL2 like 1 Homo sapiens 104-110 9317114-8 1997 In this system, Fas ligation also triggers Bcl-2/Bcl-x down-regulation, an effect inhibited by sIgG cross-linking, the cysteine protease inhibitor acetyl-Tyr-Val-Ala-Asp-chloromethyl ketone, and PMA treatment. Tetradecanoylphorbol Acetate 195-198 BCL2 like 1 Homo sapiens 49-54 9419420-7 1997 Treatment with Epo or 12-O-tetradecanoyl-phorbol-13-acetate (TPA) up-regulated expression of GATA-2 and Bcl-xL, and these elevations were inhibited by inhibitors of protein kinase C (PKC), H7 and H8. Tetradecanoylphorbol Acetate 61-64 BCL2 like 1 Homo sapiens 104-110 8635587-4 1996 We report here that apoptosis induced by PMA, sphingosine, and N,N-dimethylsphingosine (DMS) was accompanied by a concomitant decrease of bcl-2 expression in both RNA and protein levels in HL-60 cells, while expression of bcl-XL and bax mRNA did not change, and neither sphingosine nor DMS induced differentiation of HL-60 cells. Tetradecanoylphorbol Acetate 41-44 BCL2 like 1 Homo sapiens 222-228 7747803-4 1995 Immunohistochemical staining and flow cytometry analysis revealed that normal cultured keratinocytes express low levels of Fas, CD40, and Bcl-x that was enhanced by cytokines including gamma-interferon (IFN-gamma) and a phorbol ester tumor promoter, TPA. Tetradecanoylphorbol Acetate 250-253 BCL2 like 1 Homo sapiens 138-143