PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 19232538-2 2009 Induction of THP-1 monocyte differentiation by phorbol 12-myristate 13-acetate (PMA) markedly increased SVCT2 mRNA, protein, and function. Tetradecanoylphorbol Acetate 47-78 solute carrier family 23 member 2 Homo sapiens 104-109 19232538-2 2009 Induction of THP-1 monocyte differentiation by phorbol 12-myristate 13-acetate (PMA) markedly increased SVCT2 mRNA, protein, and function. Tetradecanoylphorbol Acetate 80-83 solute carrier family 23 member 2 Homo sapiens 104-109 19232538-3 2009 When ascorbate was present during PMA-induced differentiation, the increase in SVCT2 protein expression was inhibited, but differentiation was enhanced. Tetradecanoylphorbol Acetate 34-37 solute carrier family 23 member 2 Homo sapiens 79-84 19232538-4 2009 PMA-induced SVCT2 protein expression was blocked by inhibitors of protein kinase C (PKC), with most of the affect due to the PKCbetaI and betaII isoforms. Tetradecanoylphorbol Acetate 0-3 solute carrier family 23 member 2 Homo sapiens 12-17 19232538-8 2009 In conclusion, PMA-induced monocyte-macrophage differentiation is enhanced by ascorbate and associated with increased expression and function of the SVCT2 protein through a pathway involving sustained activation of PKCbetaI/II, MAP kinase, NADPH oxidase, and NF-kappaB. Tetradecanoylphorbol Acetate 15-18 solute carrier family 23 member 2 Homo sapiens 149-154