PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
11591175-0	2001	p21(WAF1) is associated with CDK2 and CDK4 protein during HL-60 cell differentiation by TPA treatment.	Tetradecanoylphorbol Acetate	88-91	cyclin dependent kinase 2	Homo sapiens	29-33	
16156860-8	2005	Sustained CDK2 catalytic activity, typically associated with megakaryocyte endomitosis, was dramatically decreased in TPA-stimulated Evi1-expressing HEL cells because of significantly reduced levels of cyclin A.	Tetradecanoylphorbol Acetate	118-121	cyclin dependent kinase 2	Homo sapiens	10-14	
9615391-9	1998	Co-administration of bryostatin 1 with PMA antagonized the latter"s differentiation-inducing capacity and anti-proliferative effects, actions that were accompanied by a reduction in PMA-mediated p21CIP1/WAF1 induction, CDK2 inhibition, pRb dephosphorylation, and c-Myc downregulation.	Tetradecanoylphorbol Acetate	39-42	cyclin dependent kinase 2	Homo sapiens	219-223	
7589260-13	1995	These results demonstrate that TPA blocks the G1/S transition in Demel melanoma cells in late G1 by mechanisms which regulate phosphorylation and activation of the CDK2 kinase.	Tetradecanoylphorbol Acetate	31-34	cyclin dependent kinase 2	Homo sapiens	164-168	
9345026-5	1997	During the PMA-induced differentiation, cyclin E-associated cdk2 activity drops markedly.	Tetradecanoylphorbol Acetate	11-14	cyclin dependent kinase 2	Homo sapiens	60-64	
9345026-6	1997	Furthermore, the amount of p27(Kip1) protein associated with cyclin E/cdk2 greatly increases 24 to 72 hours after PMA treatment.	Tetradecanoylphorbol Acetate	114-117	cyclin dependent kinase 2	Homo sapiens	70-74	
8626531-5	1996	PMA inhibited the histone H1 kinase activity of Cdk2, which increased from about 9 h, whereas PMA did not inhibit the pRb kinase activities of cyclin D-associated kinase(s) and Cdk4, detectable from 0-3 h. These results suggested that the PMA-induced inhibition of pRb phosphorylation is not mediated by suppressing cyclin D-associated kinase(s) including Cdk4, but involves the suppression of Cdk2 activity that results from the reduced expression of cyclins E and A.	Tetradecanoylphorbol Acetate	0-3	cyclin dependent kinase 2	Homo sapiens	48-52	
9345026-4	1997	In contrast, the level of cyclin E protein remains unchanged and in a complex with cdk2 during the entire course of PMA treatment.	Tetradecanoylphorbol Acetate	116-119	cyclin dependent kinase 2	Homo sapiens	83-87	
8078506-0	1994	Changes of G1 cyclins, cdk2, and cyclin A during the differentiation of HL60 cells induced by TPA.	Tetradecanoylphorbol Acetate	94-97	cyclin dependent kinase 2	Homo sapiens	23-27	
7589260-0	1995	Inhibition of the melanoma cell cycle and regulation at the G1/S transition by 12-O-tetradecanoylphorbol-13-acetate (TPA) by modulation of CDK2 activity.	Tetradecanoylphorbol Acetate	79-115	cyclin dependent kinase 2	Homo sapiens	139-143	
7589260-0	1995	Inhibition of the melanoma cell cycle and regulation at the G1/S transition by 12-O-tetradecanoylphorbol-13-acetate (TPA) by modulation of CDK2 activity.	Tetradecanoylphorbol Acetate	117-120	cyclin dependent kinase 2	Homo sapiens	139-143	
7589260-3	1995	To investigate the mechanism by which TPA arrests melanoma cell growth at the G1/S transition we have examined its effects on the levels of cyclins and cyclin dependent kinases (CDKs) and activation of CDK2 kinase activity.	Tetradecanoylphorbol Acetate	38-41	cyclin dependent kinase 2	Homo sapiens	202-206	
7589260-5	1995	When TPA was added in G1, it inhibited the mobility shift of CDK2 reflecting a change in phosphorylation state.	Tetradecanoylphorbol Acetate	5-8	cyclin dependent kinase 2	Homo sapiens	61-65	
7641182-2	1995	Both bryostatin 1 and PMA induced inhibition of cyclin-dependent kinase 2 (cdk2) activity.	Tetradecanoylphorbol Acetate	22-25	cyclin dependent kinase 2	Homo sapiens	48-73	
7641182-2	1995	Both bryostatin 1 and PMA induced inhibition of cyclin-dependent kinase 2 (cdk2) activity.	Tetradecanoylphorbol Acetate	22-25	cyclin dependent kinase 2	Homo sapiens	75-79	
7641182-5	1995	The level of growth inhibition induced by these two compounds correlated with the degree of cdk2 dephosphorylation as follows: bryostatin 1, 60%; PMA, 100%.	Tetradecanoylphorbol Acetate	146-149	cyclin dependent kinase 2	Homo sapiens	92-96	
8078506-5	1994	TPA-treated cells accumulated in G1 phase within 24 h and most of the cells were arrested in this phase at 36 h. The expression of cyclins and cdk2 was studied by Northern blot hybridization of the reverse-transcription polymerase chain reaction (RT-PCR).	Tetradecanoylphorbol Acetate	0-3	cyclin dependent kinase 2	Homo sapiens	143-147