PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34359010-0 2021 A novel commentary: Investigation of the role of a balance between neurotrophic and apoptotic proteins in the pathogenesis of psychosis via the tPA-BDNF pathway. Tetradecanoylphorbol Acetate 144-147 brain derived neurotrophic factor Homo sapiens 148-152 9003041-3 1997 We found that when the active beta from of 4 beta-12-O-tetradecanoylphorbol 13-acetate (TPA), but not the inactive alpha analogue, was incubated in the presence of aFGF, basic FGF, or brain-derived neurotrophic factor, TH expression was initiated. Tetradecanoylphorbol Acetate 88-91 brain derived neurotrophic factor Homo sapiens 184-217 10980241-3 2000 This effect was mimicked by co-treatment with a growth factor (aFGF, bFGF or BDNF; but not GDNF, IGF-1, EGF or TGF) and the neurotransmitter 5-HT (but not GABA, dopamine, glutamate) and/or a protein kinase activator (IBMX, forskolin, TPA). Tetradecanoylphorbol Acetate 234-237 brain derived neurotrophic factor Homo sapiens 77-81 7747595-9 1994 Treatment with 12-O-tetradecanoyl phorbol-13-acetate (TPA) transiently suppressed BDNF mRNA. Tetradecanoylphorbol Acetate 15-52 brain derived neurotrophic factor Homo sapiens 82-86 7747595-9 1994 Treatment with 12-O-tetradecanoyl phorbol-13-acetate (TPA) transiently suppressed BDNF mRNA. Tetradecanoylphorbol Acetate 54-57 brain derived neurotrophic factor Homo sapiens 82-86 7747595-10 1994 Treatment with both serum and TPA first stimulated and then transiently suppressed BDNF mRNA. Tetradecanoylphorbol Acetate 30-33 brain derived neurotrophic factor Homo sapiens 83-87 26021525-8 2015 Treatment of HUVEC and EA.hy 926 cells with PKC-activating phorbol esters (phorbol-12-myristate-13-acetate, PMA or phorbol-12,13-dibutyrate) resulted in a downregulation of BDNF expression, whereas the inactive 4alpha-phorbol-12,13-didecanoate was without effect. Tetradecanoylphorbol Acetate 75-106 brain derived neurotrophic factor Homo sapiens 173-177 26021525-10 2015 BDNF downregulation by PMA could be prevented by PKC inhibitors Go 6983 and rottlerin, but not by Go 6976. Tetradecanoylphorbol Acetate 23-26 brain derived neurotrophic factor Homo sapiens 0-4 26021525-11 2015 Thus, a Go 6983/rottlerin-sensitive PKC isoform is likely to be responsible for PMA-induced BDNF downregulation. Tetradecanoylphorbol Acetate 80-83 brain derived neurotrophic factor Homo sapiens 92-96