PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
24441674-0	2014	Requirement and epigenetics reprogramming of Nrf2 in suppression of tumor promoter TPA-induced mouse skin cell transformation by sulforaphane.	Tetradecanoylphorbol Acetate	83-86	nuclear factor, erythroid derived 2, like 2	Mus musculus	45-49	
35197329-0	2022	Aberrant HO-1/NQO1-Reactive Oxygen Species-ERK Signaling Pathway Contributes to Aggravation of TPA-Induced Irritant Contact Dermatitis in Nrf2-Deficient Mice.	Tetradecanoylphorbol Acetate	95-98	nuclear factor, erythroid derived 2, like 2	Mus musculus	138-142	
35197329-4	2022	In this article, we elucidated the role of Nrf2 in 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced acute ICD.	Tetradecanoylphorbol Acetate	89-92	nuclear factor, erythroid derived 2, like 2	Mus musculus	43-47	
35197329-10	2022	Taken together, the findings illustrate the key role of the Nrf2/ROS/ERK signaling pathway in TPA-induced acute ICD.	Tetradecanoylphorbol Acetate	94-97	nuclear factor, erythroid derived 2, like 2	Mus musculus	60-64	
24441674-9	2014	Collectively, these results suggest that the anti-cancer effect of SFN against TPA-induced neoplastic transformation of mouse skin could involve the epigenetic reprogramming of anti-cancer genes such as Nrf2, leading to the epigenetic reactivation of Nrf2 and the subsequent induction of downstream target genes involved in cellular protection.	Tetradecanoylphorbol Acetate	79-82	nuclear factor, erythroid derived 2, like 2	Mus musculus	203-207	
24441674-9	2014	Collectively, these results suggest that the anti-cancer effect of SFN against TPA-induced neoplastic transformation of mouse skin could involve the epigenetic reprogramming of anti-cancer genes such as Nrf2, leading to the epigenetic reactivation of Nrf2 and the subsequent induction of downstream target genes involved in cellular protection.	Tetradecanoylphorbol Acetate	79-82	nuclear factor, erythroid derived 2, like 2	Mus musculus	251-255	
24441674-3	2014	In this study, we investigated the inhibitory role and epigenetics of Nrf2 on tumor transformation induced by 12-O-tetradecanoylphorbol-13-acetate (TPA) in mouse skin epidermal JB6 (JB6 P+) cells and the anticancer effect of sulforaphane (SFN), an isothiocyanate found in cruciferous vegetables.	Tetradecanoylphorbol Acetate	110-146	nuclear factor, erythroid derived 2, like 2	Mus musculus	70-74	
24441674-3	2014	In this study, we investigated the inhibitory role and epigenetics of Nrf2 on tumor transformation induced by 12-O-tetradecanoylphorbol-13-acetate (TPA) in mouse skin epidermal JB6 (JB6 P+) cells and the anticancer effect of sulforaphane (SFN), an isothiocyanate found in cruciferous vegetables.	Tetradecanoylphorbol Acetate	148-151	nuclear factor, erythroid derived 2, like 2	Mus musculus	70-74	
24441674-5	2014	Knockdown of Nrf2 attenuated the induction of Nrf2, HO-1 and NQO1 by SFN, enhanced TPA-induced colony formation and dampened the inhibitory effect of SFN on TPA-induced JB6 transformation.	Tetradecanoylphorbol Acetate	83-86	nuclear factor, erythroid derived 2, like 2	Mus musculus	13-17	
24441674-5	2014	Knockdown of Nrf2 attenuated the induction of Nrf2, HO-1 and NQO1 by SFN, enhanced TPA-induced colony formation and dampened the inhibitory effect of SFN on TPA-induced JB6 transformation.	Tetradecanoylphorbol Acetate	157-160	nuclear factor, erythroid derived 2, like 2	Mus musculus	13-17	
16912211-3	2006	7,12-Dimethylbenz(a)anthracene/12-O-tetradecanoylphorbol-13-acetate treatments resulted in an increase in the incidence of skin tumors and tumor numbers per mouse in both genotypes; however, both indices were markedly higher in Nrf2(-/-) mice as compared with Nrf2(+/+) mice.	Tetradecanoylphorbol Acetate	31-67	nuclear factor, erythroid derived 2, like 2	Mus musculus	228-232	
16912211-3	2006	7,12-Dimethylbenz(a)anthracene/12-O-tetradecanoylphorbol-13-acetate treatments resulted in an increase in the incidence of skin tumors and tumor numbers per mouse in both genotypes; however, both indices were markedly higher in Nrf2(-/-) mice as compared with Nrf2(+/+) mice.	Tetradecanoylphorbol Acetate	31-67	nuclear factor, erythroid derived 2, like 2	Mus musculus	260-264