PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 16553792-5 2006 Prior administration of PD98059 also antagonized the enhancing effect of 12-O-tetradecanoylphorbol-13-acetate (TPA), a protein kinase C activator that also causes ERK activation, on SGK phosphorylation and cAMP response element binding protein (CREB) phosphorylation. Tetradecanoylphorbol Acetate 73-109 Eph receptor B1 Rattus norvegicus 163-166 32095918-5 2020 PMA mediated activation of both PKC and ERK and either inhibition of PKC by Go6983 or ERK by the MEK inhibitor Trametinib attenuated both P-ERK and P-PKC in both cardiac fibroblasts isolated from AF rats or from healthy rats but transduced with PKC-delta. Tetradecanoylphorbol Acetate 0-3 Eph receptor B1 Rattus norvegicus 40-43 21323644-4 2011 The importance of ERK with respect to downstream NF-kappaB signalling was underscored by the finding that PMA, a potent ERK activator, enhanced IKK phosphorylation. Tetradecanoylphorbol Acetate 106-109 Eph receptor B1 Rattus norvegicus 18-21 21323644-4 2011 The importance of ERK with respect to downstream NF-kappaB signalling was underscored by the finding that PMA, a potent ERK activator, enhanced IKK phosphorylation. Tetradecanoylphorbol Acetate 106-109 Eph receptor B1 Rattus norvegicus 120-123 21323644-5 2011 Strikingly, both palmitate- and PMA-induced activation of IKK/NF-kappaB were antagonized by AMPK (AMP-activated protein kinase) activators because of reduced ERK signalling. Tetradecanoylphorbol Acetate 32-35 Eph receptor B1 Rattus norvegicus 158-161 21212180-12 2011 PMA-stimulated ERK activity was also inhibited by 1-butanol. Tetradecanoylphorbol Acetate 0-3 Eph receptor B1 Rattus norvegicus 15-18 20207737-6 2010 Isoproterenol also blocked ERK downstream of phorbol 12-myristate 13-acetate and the P2X(7) and epidermal growth factor receptors. Tetradecanoylphorbol Acetate 45-76 Eph receptor B1 Rattus norvegicus 27-30 19020135-5 2008 We also examined the effects of nicorandil on the ERK activation induced by 4beta-phorbol 12-myristate 13-acetate, an activator of protein kinase C, or ionomycin, a calcium ionophore. Tetradecanoylphorbol Acetate 76-113 Eph receptor B1 Rattus norvegicus 50-53 16553792-5 2006 Prior administration of PD98059 also antagonized the enhancing effect of 12-O-tetradecanoylphorbol-13-acetate (TPA), a protein kinase C activator that also causes ERK activation, on SGK phosphorylation and cAMP response element binding protein (CREB) phosphorylation. Tetradecanoylphorbol Acetate 111-114 Eph receptor B1 Rattus norvegicus 163-166 15178807-0 2004 The tumor promoter 12-O-tetradecanoylphorbol 13-acetate (TPA) provokes a prolonged morphologic response and ERK activation in Tsc2-null renal tumor cells. Tetradecanoylphorbol Acetate 19-55 Eph receptor B1 Rattus norvegicus 108-111 15178807-11 2004 The selective PKC inhibitor, bisindolylmaleimide VIII, however, inhibited TPA-induced changes in morphology and ERK activation. Tetradecanoylphorbol Acetate 74-77 Eph receptor B1 Rattus norvegicus 112-115 15178807-12 2004 These results imply that TPA-induced changes in morphology and ERK activation are mediated primarily through PKC and not Rap1 in renal epithelial cells. Tetradecanoylphorbol Acetate 25-28 Eph receptor B1 Rattus norvegicus 63-66 15178807-13 2004 These data also imply that Tsc2 expression modulates TPA-induced changes in renal epithelial cell morphology via an ERK-independent mechanism. Tetradecanoylphorbol Acetate 53-56 Eph receptor B1 Rattus norvegicus 116-119 15271671-15 2004 However, AdV-DN PKC-alpha partially blocked PMA-induced ERK activation. Tetradecanoylphorbol Acetate 44-47 Eph receptor B1 Rattus norvegicus 56-59 15178807-0 2004 The tumor promoter 12-O-tetradecanoylphorbol 13-acetate (TPA) provokes a prolonged morphologic response and ERK activation in Tsc2-null renal tumor cells. Tetradecanoylphorbol Acetate 57-60 Eph receptor B1 Rattus norvegicus 108-111 15178807-9 2004 TPA treatment rapidly increased phosphorylation of ERK, a reported downstream effector of both PKC and Rap1, in ERC-18 cells, but induced weak Rap1 activation. Tetradecanoylphorbol Acetate 0-3 Eph receptor B1 Rattus norvegicus 51-54 15178807-10 2004 TPA-induced ERK phosphorylation was prolonged in ERC-18 cells compared to NRK-52E cells and expression of Tsc2 in ERC-18 cells did not inhibit prolonged ERK activation. Tetradecanoylphorbol Acetate 0-3 Eph receptor B1 Rattus norvegicus 12-15 12210750-2 2002 The aim of the present study was to investigate the effect of PKA and PKC activities on the distribution of perilipin and ADRP in primary cultured adrenal cells, and the role of ERK in PMA- and calphostin C-induced steroidogenesis. Tetradecanoylphorbol Acetate 185-188 Eph receptor B1 Rattus norvegicus 178-181 15048868-6 2004 In addition, inhibition of conventional and novel PKC isoforms by chronic (24 h) exposure to phorbol 12-myristate 13-acetate (PMA) inhibited AVP-induced activation of ERK and p70S6 kinase as well as EGF-R phosphorylation. Tetradecanoylphorbol Acetate 93-124 Eph receptor B1 Rattus norvegicus 167-170 15048868-6 2004 In addition, inhibition of conventional and novel PKC isoforms by chronic (24 h) exposure to phorbol 12-myristate 13-acetate (PMA) inhibited AVP-induced activation of ERK and p70S6 kinase as well as EGF-R phosphorylation. Tetradecanoylphorbol Acetate 126-129 Eph receptor B1 Rattus norvegicus 167-170 12898704-5 2003 Although PMA increased phosphorylation in all three major MAP kinase pathways (ERK, p38 MAP kinase, and JNK), only inhibition of the ERK pathway by the MEK/ERK inhibitor U0126 (0.1-10 microM) significantly reduced MMP-9 upregulation, even when treatment was delayed for 4 h after PMA exposure. Tetradecanoylphorbol Acetate 9-12 Eph receptor B1 Rattus norvegicus 79-82 12794177-8 2003 Both phorbol-12-myristate-13-acetate (PMA), which activates PKC and, in turn, ERK, and caffeine, which increases intracellular Ca2+ without eliciting contraction, increased HSL activity. Tetradecanoylphorbol Acetate 5-36 Eph receptor B1 Rattus norvegicus 78-81 12794177-8 2003 Both phorbol-12-myristate-13-acetate (PMA), which activates PKC and, in turn, ERK, and caffeine, which increases intracellular Ca2+ without eliciting contraction, increased HSL activity. Tetradecanoylphorbol Acetate 38-41 Eph receptor B1 Rattus norvegicus 78-81 12210750-6 2002 We further demonstrated that ERK pathway was involved in PMA-induced steroidogenesis, since PD98059, specific inhibitor of MEK, blocked the increases in steroidogenesis and phosphorylation of ERK caused by PMA, but not by cAMP-PKA. Tetradecanoylphorbol Acetate 57-60 Eph receptor B1 Rattus norvegicus 29-32 12210750-6 2002 We further demonstrated that ERK pathway was involved in PMA-induced steroidogenesis, since PD98059, specific inhibitor of MEK, blocked the increases in steroidogenesis and phosphorylation of ERK caused by PMA, but not by cAMP-PKA. Tetradecanoylphorbol Acetate 57-60 Eph receptor B1 Rattus norvegicus 192-195 12210750-6 2002 We further demonstrated that ERK pathway was involved in PMA-induced steroidogenesis, since PD98059, specific inhibitor of MEK, blocked the increases in steroidogenesis and phosphorylation of ERK caused by PMA, but not by cAMP-PKA. Tetradecanoylphorbol Acetate 206-209 Eph receptor B1 Rattus norvegicus 29-32 12210750-6 2002 We further demonstrated that ERK pathway was involved in PMA-induced steroidogenesis, since PD98059, specific inhibitor of MEK, blocked the increases in steroidogenesis and phosphorylation of ERK caused by PMA, but not by cAMP-PKA. Tetradecanoylphorbol Acetate 206-209 Eph receptor B1 Rattus norvegicus 192-195 11500965-0 2001 Inhibition of connexin43 gap junctional intercellular communication by TPA requires ERK activation. Tetradecanoylphorbol Acetate 71-74 Eph receptor B1 Rattus norvegicus 84-87 11509543-10 2001 Downregulation of PKC with phorbol myristate acetate (5 micromol/l) markedly reduced LDL-induced ERK phosphorylation. Tetradecanoylphorbol Acetate 27-52 Eph receptor B1 Rattus norvegicus 97-100 11152962-3 2000 In agreement with our previous finding that p90(rsk1) is essential for TPA-induced activation of NF-kappaB in Adenovirus 5E1-transformed Baby Rat Kidney cells, we now report that the MEK/ERK/p90(rsk1) inhibitor U0126 efficiently blocks TPA-induced IkappaBalpha processing in these cells. Tetradecanoylphorbol Acetate 71-74 Eph receptor B1 Rattus norvegicus 187-190 11152962-3 2000 In agreement with our previous finding that p90(rsk1) is essential for TPA-induced activation of NF-kappaB in Adenovirus 5E1-transformed Baby Rat Kidney cells, we now report that the MEK/ERK/p90(rsk1) inhibitor U0126 efficiently blocks TPA-induced IkappaBalpha processing in these cells. Tetradecanoylphorbol Acetate 236-239 Eph receptor B1 Rattus norvegicus 187-190 10342885-6 1999 D3 induction by TPA was blocked by GF 109203X, an inhibitor of protein kinase C. In addition, the effects of TPA and bFGF were partially prevented by PD 98059, a specific inhibitor of MEK and the Erk signaling cascade. Tetradecanoylphorbol Acetate 16-19 Eph receptor B1 Rattus norvegicus 196-199 10342885-6 1999 D3 induction by TPA was blocked by GF 109203X, an inhibitor of protein kinase C. In addition, the effects of TPA and bFGF were partially prevented by PD 98059, a specific inhibitor of MEK and the Erk signaling cascade. Tetradecanoylphorbol Acetate 109-112 Eph receptor B1 Rattus norvegicus 196-199 10342885-8 1999 In addition, the stimulatory effects of TPA and bFGF on D3 mRNA and activity appear to be mediated at least in part by activation of the MEK/Erk signaling cascade. Tetradecanoylphorbol Acetate 40-43 Eph receptor B1 Rattus norvegicus 141-144 9419349-5 1998 ITF also decreased activation of ERK activity induced by either transforming growth factor-alpha, which links extracellular stimuli to the Ras/Raf/MEK/ERK pathway via the epidermal growth factor receptor, or phorbol 12-myristate 13-acetate, which activates Raf through protein kinase C. ITF-induced inhibition of ERK activity was blocked by an inhibitor of tyrosine and dual-specific phosphatases, sodium orthovanadate. Tetradecanoylphorbol Acetate 208-239 Eph receptor B1 Rattus norvegicus 33-36 10673387-8 2000 Moreover, pretreatment with PMA to downregulate PKC abolished the activation of ERK. Tetradecanoylphorbol Acetate 28-31 Eph receptor B1 Rattus norvegicus 80-83 10519505-9 1999 Both ERKs were also activated by 4beta-phorbol 12-myristate 13-acetate, an activator of protein kinase C, and fluoroaluminate (AlF4-), respectively, but procaine did not affect ERK activation induced by these two substances. Tetradecanoylphorbol Acetate 33-70 Eph receptor B1 Rattus norvegicus 5-8 9312114-7 1997 The role of the extracellular signal-related kinase (ERK) signaling pathway in the HMGI-C induction was highlighted by the result that the MAP kinase kinase (MEK) inhibitor, PD 98059, blocked DeltaRaf-1:ER- and 12-O-tetradecanoylphorbol-13-acetate-stimulated HMGI-C induction. Tetradecanoylphorbol Acetate 211-247 Eph receptor B1 Rattus norvegicus 16-51 9312114-7 1997 The role of the extracellular signal-related kinase (ERK) signaling pathway in the HMGI-C induction was highlighted by the result that the MAP kinase kinase (MEK) inhibitor, PD 98059, blocked DeltaRaf-1:ER- and 12-O-tetradecanoylphorbol-13-acetate-stimulated HMGI-C induction. Tetradecanoylphorbol Acetate 211-247 Eph receptor B1 Rattus norvegicus 53-56