PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 29271701-6 2018 Furthermore, RGO induced the nuclear factor erythroid 2-related factor 2 (Nrf2)-mediated antioxidant enzyme heme oxygenase-1 (HO-1) expression, and effectively blocked the overproduction of TPA-induced reactive oxygen species. Tetradecanoylphorbol Acetate 190-193 NFE2 like bZIP transcription factor 2 Homo sapiens 74-78 30776542-3 2019 To further reveal the mediated mechanism that Nrf2 active state was affected by protein kinase C (PKC), here we evaluated SVCV replication in host cells by treated with a strong activator of PKC phorbol-12-myristate-13-acetate (PMA) and an inhibitor staurosporine. Tetradecanoylphorbol Acetate 195-226 NFE2 like bZIP transcription factor 2 Homo sapiens 46-50 30776542-3 2019 To further reveal the mediated mechanism that Nrf2 active state was affected by protein kinase C (PKC), here we evaluated SVCV replication in host cells by treated with a strong activator of PKC phorbol-12-myristate-13-acetate (PMA) and an inhibitor staurosporine. Tetradecanoylphorbol Acetate 228-231 NFE2 like bZIP transcription factor 2 Homo sapiens 46-50 31181187-5 2019 Knockdown of nuclear factor E2-related factor 2 (Nrf2) in shNrf2 JB6 P+ cells enhanced TPA-induced colony formation and attenuated pelargonidin"s blocking effect. Tetradecanoylphorbol Acetate 87-90 NFE2 like bZIP transcription factor 2 Homo sapiens 49-53 25941985-6 2015 We further confirmed that CPT inhibits PMA-induced MMP-9 and VEGF expression by upregulating nuclear factor-erythroid related factor-2 (Nrf2)-mediated heme oxygenase-1 (HO-1) induction. Tetradecanoylphorbol Acetate 39-42 NFE2 like bZIP transcription factor 2 Homo sapiens 93-134 25724683-2 2015 Here, we aim to investigate the relative capacity of Toc isoforms to modify the stress-activated NfkappaB and Nrf-2 signaling pathways that regulate the expression of pro-inflammatory cytokines and antioxidant enzymes, respectively, in this well-established in vitro model of the small intestine The modulation of IFNgamma/phorbol myristate acetate (PMA)-induced inflammatory responses, determined by the expression of IL8 mRNA and protein, corresponded to the extent by which different Toc isoforms altered intracellular oxidative status in Caco-2 cells. Tetradecanoylphorbol Acetate 350-353 NFE2 like bZIP transcription factor 2 Homo sapiens 110-115 29603113-8 2018 In summary, our results show that FX activates the Nrf2 signaling pathway, induces the epigenetic demethylation of CpG sites in Nrf2 and blocks the TPA-induced transformation of JB6 P+ cells, indicating the potential health-promoting effects of FX in skin cancer prevention. Tetradecanoylphorbol Acetate 148-151 NFE2 like bZIP transcription factor 2 Homo sapiens 51-55 29603113-8 2018 In summary, our results show that FX activates the Nrf2 signaling pathway, induces the epigenetic demethylation of CpG sites in Nrf2 and blocks the TPA-induced transformation of JB6 P+ cells, indicating the potential health-promoting effects of FX in skin cancer prevention. Tetradecanoylphorbol Acetate 148-151 NFE2 like bZIP transcription factor 2 Homo sapiens 128-132 26988984-10 2016 Moreover, reserpine induced Nrf2 expression via an epigenetic pathway in skin epidermal JB6 P+ cells, enhancing the protective antioxidant activity and decreasing TPA-induced cell transformation. Tetradecanoylphorbol Acetate 163-166 NFE2 like bZIP transcription factor 2 Homo sapiens 28-32 26222138-0 2015 NRF2 Signaling Negatively Regulates Phorbol-12-Myristate-13-Acetate (PMA)-Induced Differentiation of Human Monocytic U937 Cells into Pro-Inflammatory Macrophages. Tetradecanoylphorbol Acetate 36-67 NFE2 like bZIP transcription factor 2 Homo sapiens 0-4 26222138-0 2015 NRF2 Signaling Negatively Regulates Phorbol-12-Myristate-13-Acetate (PMA)-Induced Differentiation of Human Monocytic U937 Cells into Pro-Inflammatory Macrophages. Tetradecanoylphorbol Acetate 69-72 NFE2 like bZIP transcription factor 2 Homo sapiens 0-4 26222138-7 2015 In addition, PMA-inducible secretion of monocyte chemotactic protein 1 (MCP-1) was significantly high in NRF2-silenced U937. Tetradecanoylphorbol Acetate 13-16 NFE2 like bZIP transcription factor 2 Homo sapiens 105-109 26222138-10 2015 Taken together, our results suggest that the NRF2 system functions to suppress PMA-stimulated U937 cell differentiation into pro-inflammatory macrophages and provide evidence that the ROS-PKCalpha-ERK-NFkB axis is involved in PMA-facilitated differentiation of NRF2-silenced U937 cells. Tetradecanoylphorbol Acetate 79-82 NFE2 like bZIP transcription factor 2 Homo sapiens 45-49 26222138-10 2015 Taken together, our results suggest that the NRF2 system functions to suppress PMA-stimulated U937 cell differentiation into pro-inflammatory macrophages and provide evidence that the ROS-PKCalpha-ERK-NFkB axis is involved in PMA-facilitated differentiation of NRF2-silenced U937 cells. Tetradecanoylphorbol Acetate 79-82 NFE2 like bZIP transcription factor 2 Homo sapiens 261-265 25941985-6 2015 We further confirmed that CPT inhibits PMA-induced MMP-9 and VEGF expression by upregulating nuclear factor-erythroid related factor-2 (Nrf2)-mediated heme oxygenase-1 (HO-1) induction. Tetradecanoylphorbol Acetate 39-42 NFE2 like bZIP transcription factor 2 Homo sapiens 136-140 24753527-5 2014 Mitochondrial dysfunction in children with autism was accompanied by a lower (26% of TD children) oxidative burst by PMA-stimulated reduced nicotinamide-adenine dinucleotide phosphate (NADPH) oxidase and by a lower gene expression (45% of TD children"s mean values) of the nuclear factor erythroid 2-related factor 2 transcription factor involved in the antioxidant response. Tetradecanoylphorbol Acetate 117-120 NFE2 like bZIP transcription factor 2 Homo sapiens 273-316 12446695-3 2003 Nrf2 has previously been found to undergo nuclear translocation by a phosphorylation-dependent mechanism mediated by protein kinase C in HepG2 cells treated with tert-butylhydroquinone, beta-naphthoflavone, or 12-O-tetradecanoylphorbol-13-acetate. Tetradecanoylphorbol Acetate 210-246 NFE2 like bZIP transcription factor 2 Homo sapiens 0-4 19573594-4 2009 Retinoic acid (RA) and 12-O-tetradecanoylphorbol 13-acetate, two well-studied inducers of neuronal differentiation, are able to induce Nrf2 and its target gene NAD(P)H quinone oxidoreductase 1 in a dose- and time-dependent manner. Tetradecanoylphorbol Acetate 23-59 NFE2 like bZIP transcription factor 2 Homo sapiens 135-139 35043283-7 2022 The suppressive effects of FX on TPA-enhancedSAM/SAH was abrogated by Nfe2l2 KD indicating Nfe2l2 plays a critical role in FX-mediated metabolic rewiring and its potential consequences on epigenetic reprogramming. Tetradecanoylphorbol Acetate 33-36 NFE2 like bZIP transcription factor 2 Homo sapiens 70-76 35043283-7 2022 The suppressive effects of FX on TPA-enhancedSAM/SAH was abrogated by Nfe2l2 KD indicating Nfe2l2 plays a critical role in FX-mediated metabolic rewiring and its potential consequences on epigenetic reprogramming. Tetradecanoylphorbol Acetate 33-36 NFE2 like bZIP transcription factor 2 Homo sapiens 91-97 35043283-9 2022 Transcriptomic RNA-seq showed that FX abrogated TPA-induced differentially expressed genes (DEGs) of Nfe2l2-related genes Nqo1, Ho1, and Keap1. Tetradecanoylphorbol Acetate 48-51 NFE2 like bZIP transcription factor 2 Homo sapiens 101-107 35043283-12 2022 In this context, FX/Nfe2l2"s redox signaling drives metabolic rewiring causing epigenetic and transcriptomic reprogramming potentially contributing to the protection of TPA-induced JB6 cellular transformation skin cancer model. Tetradecanoylphorbol Acetate 169-172 NFE2 like bZIP transcription factor 2 Homo sapiens 20-26