PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 11594749-1 2001 Interleukin-1 (IL-1) regulation of tPA in hepatocytes was studied in mouse hepatocyte line AML12. Tetradecanoylphorbol Acetate 35-38 interleukin 1 complex Mus musculus 0-13 11594749-1 2001 Interleukin-1 (IL-1) regulation of tPA in hepatocytes was studied in mouse hepatocyte line AML12. Tetradecanoylphorbol Acetate 35-38 interleukin 1 complex Mus musculus 15-19 11594749-2 2001 IL-1 induced transient accumulation of tPA mRNA as high as threefold by 2 h after the start of treatment. Tetradecanoylphorbol Acetate 39-42 interleukin 1 complex Mus musculus 0-4 11594749-7 2001 These results revealed that low-density lipoprotein receptor-related protein (LRP), which is known to be a receptor for tPA and to be blocked by RAP, was up-regulated by IL-1. Tetradecanoylphorbol Acetate 120-123 interleukin 1 complex Mus musculus 170-174 10960082-8 2000 In addition, PKC-depleted astrocyte cultures by overnight treatment with PMA no longer responded to PMA or IL-1. Tetradecanoylphorbol Acetate 73-76 interleukin 1 complex Mus musculus 107-111 11125308-3 2000 Concanavalin A or phorbol myristate acetate/calcium ionophore/anti-CD3 stimulation of spleen cells from H2(b) congenic mice induced less IL-1, IL-2, IFN-gamma and MIF mRNA and/or protein than the equivalent cells from H2(d) mice. Tetradecanoylphorbol Acetate 18-43 interleukin 1 complex Mus musculus 137-141 7675040-2 1995 IL-1 synergistically enhances the stimulatory effect of TPA on AP-1-mediated gene expression in this cell line. Tetradecanoylphorbol Acetate 56-59 interleukin 1 complex Mus musculus 0-4 9452447-7 1998 Phorbol 12-myristate 13-acetate, an agonist of PKC, mimics glucose-induced inhibition of IL-1 release. Tetradecanoylphorbol Acetate 0-31 interleukin 1 complex Mus musculus 89-93 7675040-4 1995 We found that IL-1 + TPA-treated cells contain significantly higher Jun B protein levels than cells treated with TPA alone. Tetradecanoylphorbol Acetate 21-24 interleukin 1 complex Mus musculus 14-18 7675040-4 1995 We found that IL-1 + TPA-treated cells contain significantly higher Jun B protein levels than cells treated with TPA alone. Tetradecanoylphorbol Acetate 113-116 interleukin 1 complex Mus musculus 14-18 7675040-9 1995 Thus, the stimulation of AP-1-mediated gene expression by IL-1 in EL4 cells is due to the promotion of Jun B protein accumulation that, in turn, facilitates Jun B heterodimerization with TPA-induced Fra-1 protein, thereby forming an active AP-1 complex. Tetradecanoylphorbol Acetate 187-190 interleukin 1 complex Mus musculus 58-62 7948425-6 1994 In the IL-1-responsive cell line OA strongly synergized with phorbol myristate acetate (PMA) and IL-1. Tetradecanoylphorbol Acetate 61-86 interleukin 1 complex Mus musculus 7-11 7948425-6 1994 In the IL-1-responsive cell line OA strongly synergized with phorbol myristate acetate (PMA) and IL-1. Tetradecanoylphorbol Acetate 88-91 interleukin 1 complex Mus musculus 7-11 7948425-7 1994 In the IL-1-nonresponsive cell line OA synergized with PMA but not with IL-1. Tetradecanoylphorbol Acetate 55-58 interleukin 1 complex Mus musculus 7-11 7510523-5 1994 However, 8-Br-cAMP and TPA acted synergistically to induce PGE2 production equal to that of IL-1. Tetradecanoylphorbol Acetate 23-26 interleukin 1 complex Mus musculus 92-96 1560050-1 1992 EL 4-6.1 cells, variants of the murine EL4 thymoma cell line, can be activated by interleukin 1 (IL-1) or phorbol 12-myristate-13-acetate (PMA), or PMA+IL-1 to secrete interleukin 2 (IL-2) and interleukin 4 (IL-4) and to express the IL-2 receptor (IL-2R). Tetradecanoylphorbol Acetate 139-142 interleukin 1 complex Mus musculus 152-156 8396935-4 1993 Phorbol myristate acetate (PMA), another activator of EL4.NOB-1 cells, had an opposite effect to IL-1 in that it increased binding site expression dramatically suggesting different mechanisms of action for these two effectors. Tetradecanoylphorbol Acetate 0-25 interleukin 1 complex Mus musculus 97-101 1530793-10 1992 In EL-4 cells, IL-1 potentiates PMA-mediated release of IL-2 at suboptimal concentrations of PMA. Tetradecanoylphorbol Acetate 32-35 interleukin 1 complex Mus musculus 15-19 1530793-10 1992 In EL-4 cells, IL-1 potentiates PMA-mediated release of IL-2 at suboptimal concentrations of PMA. Tetradecanoylphorbol Acetate 93-96 interleukin 1 complex Mus musculus 15-19 2157204-2 1990 Desensitization of protein kinase C (PKC) by pretreatment with phorbol ester [phorbol 12-tetradecanoate 13-acetate (TPA)] for 8 hr abolished the secretion induced by TPA as well as the enhancement of TPA-induced beta-endorphin release produced by IL-1. Tetradecanoylphorbol Acetate 78-114 interleukin 1 complex Mus musculus 247-251 2059661-5 1991 First, the protein kinase C inhibitor 1-(5-isoquinolinesulfonyl)-2-methylpiperazine (H-7) strongly inhibited PMA-induced activation of NF-kappa B in 70Z/3 cells but had no effect on NF-kappa B activated by IL-1 or LPS. Tetradecanoylphorbol Acetate 109-112 interleukin 1 complex Mus musculus 206-210 2268359-1 1990 Interleukin 1 (IL-1) has been shown to potentiate the release of beta-endorphin induced by secretagogues, including corticotropin releasing factor (CRF) and phorbol ester (TPA), in the mouse AtT-20 pituitary tumor cell line (Fagarasan et al., PNAS, 1989, 86, 2070-2073). Tetradecanoylphorbol Acetate 172-175 interleukin 1 complex Mus musculus 0-13 2268359-1 1990 Interleukin 1 (IL-1) has been shown to potentiate the release of beta-endorphin induced by secretagogues, including corticotropin releasing factor (CRF) and phorbol ester (TPA), in the mouse AtT-20 pituitary tumor cell line (Fagarasan et al., PNAS, 1989, 86, 2070-2073). Tetradecanoylphorbol Acetate 172-175 interleukin 1 complex Mus musculus 15-19 2268359-4 1990 However, treatment of AtT-20 cells with IL-1 induced the expression of vasopressin-mediated beta-endorphin release; this effect of IL-1 was reduced after depletion of protein kinase C by prolonged treatment with TPA. Tetradecanoylphorbol Acetate 212-215 interleukin 1 complex Mus musculus 40-44 2268359-4 1990 However, treatment of AtT-20 cells with IL-1 induced the expression of vasopressin-mediated beta-endorphin release; this effect of IL-1 was reduced after depletion of protein kinase C by prolonged treatment with TPA. Tetradecanoylphorbol Acetate 212-215 interleukin 1 complex Mus musculus 131-135 1652466-4 1991 Interleukin-2 was ineffective in promoting either cell proliferation or enhanced opioid binding, but the effects of IL-1 could be mimicked by phorbol myristate acetate (PMA), suggesting the involvement of tyrosine phosphorylation. Tetradecanoylphorbol Acetate 142-167 interleukin 1 complex Mus musculus 116-120 1652466-4 1991 Interleukin-2 was ineffective in promoting either cell proliferation or enhanced opioid binding, but the effects of IL-1 could be mimicked by phorbol myristate acetate (PMA), suggesting the involvement of tyrosine phosphorylation. Tetradecanoylphorbol Acetate 169-172 interleukin 1 complex Mus musculus 116-120 1692959-3 1990 Although IL-1 induction of the IL-2 promoter in these cells required costimulus with phorbol myristate acetate, the signal induced by IL-1 was qualitatively different. Tetradecanoylphorbol Acetate 85-110 interleukin 1 complex Mus musculus 9-13 2157204-2 1990 Desensitization of protein kinase C (PKC) by pretreatment with phorbol ester [phorbol 12-tetradecanoate 13-acetate (TPA)] for 8 hr abolished the secretion induced by TPA as well as the enhancement of TPA-induced beta-endorphin release produced by IL-1. Tetradecanoylphorbol Acetate 116-119 interleukin 1 complex Mus musculus 247-251 2157204-2 1990 Desensitization of protein kinase C (PKC) by pretreatment with phorbol ester [phorbol 12-tetradecanoate 13-acetate (TPA)] for 8 hr abolished the secretion induced by TPA as well as the enhancement of TPA-induced beta-endorphin release produced by IL-1. Tetradecanoylphorbol Acetate 166-169 interleukin 1 complex Mus musculus 247-251 2157204-2 1990 Desensitization of protein kinase C (PKC) by pretreatment with phorbol ester [phorbol 12-tetradecanoate 13-acetate (TPA)] for 8 hr abolished the secretion induced by TPA as well as the enhancement of TPA-induced beta-endorphin release produced by IL-1. Tetradecanoylphorbol Acetate 166-169 interleukin 1 complex Mus musculus 247-251 2329998-7 1990 The effects of IL-1 were mimicked by the tumor promoter phorbol 12-myristate 13-acetate (PMA) at 1-100 nM, which inhibited CDP and reduced procollagen alpha 1(I) mRNA levels to a similar extent. Tetradecanoylphorbol Acetate 56-87 interleukin 1 complex Mus musculus 15-19 2329998-7 1990 The effects of IL-1 were mimicked by the tumor promoter phorbol 12-myristate 13-acetate (PMA) at 1-100 nM, which inhibited CDP and reduced procollagen alpha 1(I) mRNA levels to a similar extent. Tetradecanoylphorbol Acetate 89-92 interleukin 1 complex Mus musculus 15-19 3116092-7 1987 In contrast, PMA was able to induce IL-1 production by both C3H/He and C3H/HeJ macrophages without increasing intracellular Ca2+. Tetradecanoylphorbol Acetate 13-16 interleukin 1 complex Mus musculus 36-40 2307488-4 1990 In contrast, macrophages from ACM-injected mice only increased their IL-1 production after the first 24-h incubation with PMA, and not after the second 24-h incubation. Tetradecanoylphorbol Acetate 122-125 interleukin 1 complex Mus musculus 69-73 2530580-6 1989 Activation of phospholipid/Ca2+-dependent protein kinase, protein kinase C, by phorbol 12-myristate 13-acetate (PMA) greatly reduced the number of IL-1 binding sites on 70Z/3. Tetradecanoylphorbol Acetate 79-110 interleukin 1 complex Mus musculus 147-151 2530580-6 1989 Activation of phospholipid/Ca2+-dependent protein kinase, protein kinase C, by phorbol 12-myristate 13-acetate (PMA) greatly reduced the number of IL-1 binding sites on 70Z/3. Tetradecanoylphorbol Acetate 112-115 interleukin 1 complex Mus musculus 147-151 2785869-5 1989 Lipopolysaccharide (LPS)-triggered release of IL-1 and TNF was determined in culture supernatants of splenic MPs from phorbol ester-sensitive (SENCAR) and resistant (B6C3F1) mice following topical application of 8 micrograms of TPA twice in one week. Tetradecanoylphorbol Acetate 228-231 interleukin 1 complex Mus musculus 46-58 2540858-7 1989 However, a mixture of hrIL-1 alpha and hrIL-1 beta reproduced the ability of mIL-1 to inhibit the oxidative response to suboptimal doses of phorbol myristate acetate (PMA). Tetradecanoylphorbol Acetate 140-165 interleukin 1 complex Mus musculus 77-82 2540858-7 1989 However, a mixture of hrIL-1 alpha and hrIL-1 beta reproduced the ability of mIL-1 to inhibit the oxidative response to suboptimal doses of phorbol myristate acetate (PMA). Tetradecanoylphorbol Acetate 167-170 interleukin 1 complex Mus musculus 77-82 2522880-4 1989 In the presence of the tumor promoter phorbol 12-myristate 13-acetate IL 1 augments IL 2 secretion and IL 2R expression of EL4 5D3 but not of EL4 D6/76 cells. Tetradecanoylphorbol Acetate 38-69 interleukin 1 complex Mus musculus 70-74 3262467-2 1988 When stimulated with suboptimal concentrations of ionomycin and phorbol myristate acetate (PMA), the immature subpopulation of Lyt2-,L3T4- (2-4-) thymocytes responded to exogenous, purified IL-1 in a dose-dependent manner. Tetradecanoylphorbol Acetate 64-89 interleukin 1 complex Mus musculus 190-194 3262467-2 1988 When stimulated with suboptimal concentrations of ionomycin and phorbol myristate acetate (PMA), the immature subpopulation of Lyt2-,L3T4- (2-4-) thymocytes responded to exogenous, purified IL-1 in a dose-dependent manner. Tetradecanoylphorbol Acetate 91-94 interleukin 1 complex Mus musculus 190-194 2574679-5 1989 Similarly to plastic-adsorbed antibodies, phorbol myristic acetate (PMA) or a combination of PMA and the calcium ionophore Ionomycin also induces secretion of growth factors without inducing proliferation, but in this case addition of IL 1 is ineffective in inducing AK-8 proliferation. Tetradecanoylphorbol Acetate 68-71 interleukin 1 complex Mus musculus 235-239 2787874-7 1989 In conditioned media from LPS-PMA-stimulated macrophages, IL-1 levels were significantly greater than in media from unstimulated macrophages and peaked on Postsurgical Day 3. Tetradecanoylphorbol Acetate 30-33 interleukin 1 complex Mus musculus 58-62 2565932-3 1989 Although the latter cells strongly proliferate in response to phorbol myristate acetate (PMA) + ionomycin, DETC, when exposed to interleukin-1 (IL-1), interleukin-3 (IL-3), concanavalin A (ConA), PMA, and ionomycin used either alone or in combination, do not exhibit significant mitotic activity. Tetradecanoylphorbol Acetate 89-92 interleukin 1 complex Mus musculus 144-148 2977423-2 1988 Although 12-O-tetradecanoylphorbol-13-acetate (TPA) was capable of replacing IL-1 as an activating stimulus under certain conditions, biologic studies indicated that TPA failed to synergize with Ti-CD3-dependent stimuli under conditions in which IL-1 was clearly active. Tetradecanoylphorbol Acetate 47-50 interleukin 1 complex Mus musculus 77-81 3878827-1 1985 4 beta-phorbol 12-myristate 13-acetate (PMA), a potent tumor promoter, was found to have a dual effect on interleukin 1-(IL 1) stimulated murine thymocyte cultures. Tetradecanoylphorbol Acetate 0-38 interleukin 1 complex Mus musculus 121-125 3029093-3 1987 The activation signals provided by PHA and IL1 were replaced by the Ca2+ ionophore, ionomycin, and the phorbol ester, 12-O-tetradecanoylphorbol 13-acetate (TPA), respectively. Tetradecanoylphorbol Acetate 156-159 interleukin 1 complex Mus musculus 43-46 3100060-6 1986 Il-1 required the simultaneous presence of ionomycin and TPA to have any demonstrable effect on T lymphocytes from spleen and on thymocytes. Tetradecanoylphorbol Acetate 57-60 interleukin 1 complex Mus musculus 0-4 3100060-7 1986 However, on EL4 cells which were also partially responsive to TPA alone, Il-1 showed strong synergy with TPA to induce Il-2 secretion and Il-2 receptor expression. Tetradecanoylphorbol Acetate 62-65 interleukin 1 complex Mus musculus 73-77 3100060-8 1986 The effect of Il-1 on EL4 cells was dose dependent where increasingly higher concentrations of Il-1 in the presence of a fixed concentration of TPA caused higher percentage of EL4 cells to become Il-2 receptor positive. Tetradecanoylphorbol Acetate 144-147 interleukin 1 complex Mus musculus 14-18 3100060-8 1986 The effect of Il-1 on EL4 cells was dose dependent where increasingly higher concentrations of Il-1 in the presence of a fixed concentration of TPA caused higher percentage of EL4 cells to become Il-2 receptor positive. Tetradecanoylphorbol Acetate 144-147 interleukin 1 complex Mus musculus 95-99 3090144-5 1986 In the presence of either suboptimal levels of phorbol ester (PMA) or Ionomycin, the addition of IL 1 resulted in up to an 80-fold enhancement in the amount of IL 2 secreted. Tetradecanoylphorbol Acetate 62-65 interleukin 1 complex Mus musculus 97-101 3878827-1 1985 4 beta-phorbol 12-myristate 13-acetate (PMA), a potent tumor promoter, was found to have a dual effect on interleukin 1-(IL 1) stimulated murine thymocyte cultures. Tetradecanoylphorbol Acetate 40-43 interleukin 1 complex Mus musculus 121-125 3930604-2 1985 In the rat liver cells that had been prelabeled with [3H]arachidonic acid, the release of 6-keto-PGF1 alpha and arachidonic acid also was stimulated by the IL 1, and this release was synergistic in the presence of TPA. Tetradecanoylphorbol Acetate 214-217 interleukin 1 complex Mus musculus 156-160