PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
8655632-3	1996	In sharp contrast, when cells were first treated with 1 microM TPA at 37 degrees C for 24 h or with 5 microM sphingosine at 37 degrees C for 30 min to down-regulate cellular PKC, the heat induction on kinase FA/GSK-3 alpha was found to be reversely promoted up to approximately 250% of control level, demonstrating that kinase FA/GSK-3 alpha may not represent a constitutively active/mitogen-inactivated protein kinase as previously conceived.	Tetradecanoylphorbol Acetate	63-66	glycogen synthase kinase 3 alpha	Homo sapiens	211-222	
8825421-2	1996	In sharp contrast, down-regulation of PKC by 0.05 microM calphostin C (IC50, approximately 0.05 microM for inhibiting PKC in cells) or by tumor promoter phorbol ester TPA was found to have stimulatory effect on the cellular activity of kinase FA/GSK-3 alpha, when processed under identical conditions.	Tetradecanoylphorbol Acetate	167-170	glycogen synthase kinase 3 alpha	Homo sapiens	246-257	
8655632-3	1996	In sharp contrast, when cells were first treated with 1 microM TPA at 37 degrees C for 24 h or with 5 microM sphingosine at 37 degrees C for 30 min to down-regulate cellular PKC, the heat induction on kinase FA/GSK-3 alpha was found to be reversely promoted up to approximately 250% of control level, demonstrating that kinase FA/GSK-3 alpha may not represent a constitutively active/mitogen-inactivated protein kinase as previously conceived.	Tetradecanoylphorbol Acetate	63-66	glycogen synthase kinase 3 alpha	Homo sapiens	330-341	
8655632-4	1996	Taken together, the results provide initial evidence that TPA/sphingosine and okadaic acid could reversibly modulate the heat induction on kinase FA/GSK-3 alpha in A431 cells, suggesting that phosphorylation/dephosphorylation mechanisms are involved in the regulation of the heat-shock induction of kinase FA/GSK-3 alpha, representing a new mode of signal transduction for the regulation of this multisubstrate protein kinase and a new mode of signaling pathway modulating the heat-induction process.	Tetradecanoylphorbol Acetate	58-61	glycogen synthase kinase 3 alpha	Homo sapiens	149-160	
8655632-4	1996	Taken together, the results provide initial evidence that TPA/sphingosine and okadaic acid could reversibly modulate the heat induction on kinase FA/GSK-3 alpha in A431 cells, suggesting that phosphorylation/dephosphorylation mechanisms are involved in the regulation of the heat-shock induction of kinase FA/GSK-3 alpha, representing a new mode of signal transduction for the regulation of this multisubstrate protein kinase and a new mode of signaling pathway modulating the heat-induction process.	Tetradecanoylphorbol Acetate	58-61	glycogen synthase kinase 3 alpha	Homo sapiens	309-320	
7890813-3	1994	Conversely, when cells were chronically treated with 1 microM TPA at 37 degrees C for 24 h and processed under identical conditions, kinase FA/GSK-3 alpha was found to be rephosphorylated on tyrosine residue and reactivated to approximately 130% of the original control level.	Tetradecanoylphorbol Acetate	62-65	glycogen synthase kinase 3 alpha	Homo sapiens	143-154	
7890813-4	1994	Taken together, the results provide initial evidence that the phosphotyrosine content and cellular activity of kinase FA/GSK-3 alpha can be modulated in a reversible manner by short-term and long-term exposure of A431 cells to TPA.	Tetradecanoylphorbol Acetate	227-230	glycogen synthase kinase 3 alpha	Homo sapiens	121-132	
31939617-8	2020	Taken together, these results demonstrated that morin hydrate reduced the metastatic potential in TPA-treated MCF-7 human breast cancer cells via the inhibition of MMPs, uPA and uPAR, and the underlying Akt/GSK-3beta/c-Fos pathway.	Tetradecanoylphorbol Acetate	98-101	glycogen synthase kinase 3 alpha	Homo sapiens	207-216	
31939617-0	2020	Inhibition of TPA-induced metastatic potential by morin hydrate in MCF-7 human breast cancer cells via the Akt/GSK-3beta/c-Fos signaling pathway.	Tetradecanoylphorbol Acetate	14-17	glycogen synthase kinase 3 alpha	Homo sapiens	111-120