PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 32640883-5 2020 Mechanistic studies showed that the combined effects of DTC and TPA were associated with a decrease in Bcl-2. Tetradecanoylphorbol Acetate 64-67 BCL2 apoptosis regulator Homo sapiens 103-108 21901143-4 2011 In this report, we showed that the replication and transcription activator (RTA) encoded by KSHV ORF 50, a key regulator for KSHV reactivation from latent to lytic infection, upregulates the mRNA and protein levels of Bcl-2 in 293 cells, and TPA-induced KSHV-infected cells. Tetradecanoylphorbol Acetate 242-245 BCL2 apoptosis regulator Homo sapiens 218-223 27520485-7 2016 At the molecular level, the expression of several key TPA-induced pro-survival and pro-proliferative genes (Bcl2, Cyclin D1, and c-Myc) decreased rapidly after BET inhibition. Tetradecanoylphorbol Acetate 54-57 BCL2 apoptosis regulator Homo sapiens 108-112 25310083-2 2014 TPA-treated macrophages were more resistant to arsenite-induced apoptosis than monocytes, which may be associated with the induction of Bcl-2 expression. Tetradecanoylphorbol Acetate 0-3 BCL2 apoptosis regulator Homo sapiens 136-141 10961874-3 2000 U937 cells constitutively express the antiapoptotic protein Bcl-2; but during differentiation, in response to the phorbol ester PMA (phorbol 12 beta-myristate 13 alpha-acetate), Mcl-1 is transiently induced. Tetradecanoylphorbol Acetate 128-131 BCL2 apoptosis regulator Homo sapiens 60-65 16761109-1 2006 The antiapoptotic BCL2 family member MCL1 is rapidly upregulated upon exposure of ML-1 myeloid leukemia cells to either differentiation-inducing phorbol 12"-myristate 13"-acetate (PMA) or chemotherapeutic microtubule disrupting agents (MTDAs). Tetradecanoylphorbol Acetate 145-178 BCL2 apoptosis regulator Homo sapiens 18-22 16761109-1 2006 The antiapoptotic BCL2 family member MCL1 is rapidly upregulated upon exposure of ML-1 myeloid leukemia cells to either differentiation-inducing phorbol 12"-myristate 13"-acetate (PMA) or chemotherapeutic microtubule disrupting agents (MTDAs). Tetradecanoylphorbol Acetate 180-183 BCL2 apoptosis regulator Homo sapiens 18-22 15748703-6 2005 A PKC activator, 12-O-tetradecaoylphorbol-13-acetate (TPA) significantly attenuated ME-induced apoptosis via preventing cytochrome c release to the cytosol and maintaining the mitochondrial membrane potential by inhibiting the decrease in the Bcl-2/Bax protein ratio; these effects were blocked by protein kinase C (PKC) inhibitors including GF-109203X, H7, and staurosporin. Tetradecanoylphorbol Acetate 54-57 BCL2 apoptosis regulator Homo sapiens 243-248 12684678-3 2003 In the present studies, we determined the effect of high intracellular levels of the anti-apoptosis Bcl-2 protein on caspase 3 activation and cyctochrome c release during phorbol ester 12-myristate 13-acetate (PMA)-induced apoptosis. Tetradecanoylphorbol Acetate 210-213 BCL2 apoptosis regulator Homo sapiens 100-105 12684678-7 2003 Treatment with 20 nM PMA for 24 h produced morphological features of apoptosis and DNA fragmentation in U937 and U937/Bcl-2 cells, but not in R-U937 cells. Tetradecanoylphorbol Acetate 21-24 BCL2 apoptosis regulator Homo sapiens 118-123 12046067-7 2002 RESULTS: Treatment of MGC80-3 cells with TPA and VP-16 resulted in apoptosis, accompanied by the repression of Bcl-2 protein in a time-dependent manner. Tetradecanoylphorbol Acetate 41-44 BCL2 apoptosis regulator Homo sapiens 111-116 11476900-4 2001 Here we report that DP cells that were treated with PMA and ionomycin up-regulated bcl-2 and down-regulated CD1 expression. Tetradecanoylphorbol Acetate 52-55 BCL2 apoptosis regulator Homo sapiens 83-88 11095401-0 2000 Survival mechanisms induced by 12-O-tetradecanoylphorbol-13-acetate in normal human melanocytes include inhibition of apoptosis and increased Bcl-2 expression. Tetradecanoylphorbol Acetate 31-67 BCL2 apoptosis regulator Homo sapiens 142-147 11095401-7 2000 Following withdrawal of TPA from melanocytes, the expression of Bcl-2 decreased steadily. Tetradecanoylphorbol Acetate 24-27 BCL2 apoptosis regulator Homo sapiens 64-69 11095401-9 2000 These results suggest that TPA plays an important role in stimulating the growth of melanocytes by promoting anti-apoptotic mechanisms associated with high levels of Bcl-2. Tetradecanoylphorbol Acetate 27-30 BCL2 apoptosis regulator Homo sapiens 166-171 16277846-6 2005 In ATRA and TPA group, the change of HSP70 had positive correlation with JWA, and negative correlation with Bcl-2. Tetradecanoylphorbol Acetate 12-15 BCL2 apoptosis regulator Homo sapiens 108-113 12890888-6 2003 Pretreatment with phorbol-12-myristate-13-acetate, which induces the expression of antiapoptotic Bcl-2, inhibited thapsigargin-induced degradation of caspases-9 and -3, but not caspase-12-like protein degradation. Tetradecanoylphorbol Acetate 18-49 BCL2 apoptosis regulator Homo sapiens 97-102 10627292-6 2000 This possibility is corroborated by the fact that the pathway leading to the modulating activity of bcl-2 ARE is influenced by PKC, since the addition of DAG and TPA markedly attenuated the bcl-2 ARE destabilizing potential. Tetradecanoylphorbol Acetate 162-165 BCL2 apoptosis regulator Homo sapiens 100-105 10627292-6 2000 This possibility is corroborated by the fact that the pathway leading to the modulating activity of bcl-2 ARE is influenced by PKC, since the addition of DAG and TPA markedly attenuated the bcl-2 ARE destabilizing potential. Tetradecanoylphorbol Acetate 162-165 BCL2 apoptosis regulator Homo sapiens 190-195 9295281-5 1997 We found that Bcl-2 levels were increased by treatment of HL-60 cells with exogenous DAG or 12-O-tetradecanoylphorbol-13-acetate (TPA). Tetradecanoylphorbol Acetate 92-128 BCL2 apoptosis regulator Homo sapiens 14-19 9880563-2 1999 The MCL1 member of the BCL2 family is up-regulated during the induction of monocytic differentiation (approximately 10-fold with 12-O-tetradecanoylphorbol 13-acetate (TPA)). Tetradecanoylphorbol Acetate 129-165 BCL2 apoptosis regulator Homo sapiens 23-27 9880563-2 1999 The MCL1 member of the BCL2 family is up-regulated during the induction of monocytic differentiation (approximately 10-fold with 12-O-tetradecanoylphorbol 13-acetate (TPA)). Tetradecanoylphorbol Acetate 167-170 BCL2 apoptosis regulator Homo sapiens 23-27 9879997-4 1998 We found up-regulation of p21WAF1 and Bax expressions, however, the expressions of p53 and Bcl-2 genes remained unchanged in TPA-treated cells. Tetradecanoylphorbol Acetate 125-128 BCL2 apoptosis regulator Homo sapiens 91-96 9460707-3 1998 Protein level of Bcl-2 was decreased by pretreatment with diBu-cAMP or staurosporine, and, on the contrary, the level was increased by pretreatment with PMA. Tetradecanoylphorbol Acetate 153-156 BCL2 apoptosis regulator Homo sapiens 17-22 9364213-4 1997 bcl-2 overexpression in JB6 clone41 cells caused a TPA-induced soft-agar growth fivefold greater than the growth of nontransfected or vector-transfected (neo control) cells. Tetradecanoylphorbol Acetate 51-54 BCL2 apoptosis regulator Homo sapiens 0-5 9364213-7 1997 When compared with control cells, bcl-2-transfected cells expressed significantly more c-fos but not c-jun after TPA treatment. Tetradecanoylphorbol Acetate 113-116 BCL2 apoptosis regulator Homo sapiens 34-39 9364213-8 1997 Furthermore, the levels of AP-1 and AP-1-induced transactivation of TRE-CAT were greater in bcl-2-transfected cells than in control cells after TPA treatment. Tetradecanoylphorbol Acetate 144-147 BCL2 apoptosis regulator Homo sapiens 92-97 10400418-5 1999 In comparison, the stimulation of Raf-1 by phorbol ester (TPA) activates the MAPK pathway, causes MAPK-dependent p21WAF1/CIP1 induction, Rb dephosphorylation and growth arrest without Bcl-2 phosphorylation or apoptosis. Tetradecanoylphorbol Acetate 58-61 BCL2 apoptosis regulator Homo sapiens 184-189 10381626-5 1999 Exposure of TPA-differentiated U937 cells to 0.8 microg/ml cycloheximide for 24 h, that triggers apoptosis in 50% cells, activates procaspase-2L, -3 and -8, induces the mitochondrial release of cytochrome c and decreases Bcl-xL expression without modifying Bcl-2, Mcl-1 and Bax protein levels. Tetradecanoylphorbol Acetate 12-15 BCL2 apoptosis regulator Homo sapiens 257-262 9317114-8 1997 In this system, Fas ligation also triggers Bcl-2/Bcl-x down-regulation, an effect inhibited by sIgG cross-linking, the cysteine protease inhibitor acetyl-Tyr-Val-Ala-Asp-chloromethyl ketone, and PMA treatment. Tetradecanoylphorbol Acetate 195-198 BCL2 apoptosis regulator Homo sapiens 43-48 9295281-5 1997 We found that Bcl-2 levels were increased by treatment of HL-60 cells with exogenous DAG or 12-O-tetradecanoylphorbol-13-acetate (TPA). Tetradecanoylphorbol Acetate 130-133 BCL2 apoptosis regulator Homo sapiens 14-19 9295281-11 1997 ET-18-OCH3 also inhibited stimulation of Bcl-2 by TPA and enhanced the decrease in Bcl-2 observed in ara-C-treated cells. Tetradecanoylphorbol Acetate 50-53 BCL2 apoptosis regulator Homo sapiens 41-46 8816467-9 1996 Treatment of the mature B-cell line BAL-17 with either anti-immunoglobulin M or phorbol 12-myristate 13-acetate leads to an increase in bcl-2 expression that is mediated by the CRE site. Tetradecanoylphorbol Acetate 80-111 BCL2 apoptosis regulator Homo sapiens 136-141 8830674-3 1996 We show here that bax protein also declined with a time course similar to the downregulation of bcl-2 following treatment of HL60 with phorbol myristate acetate (PMA), dimethyl sulphoxide (DMSO) or retinoic acid (RA). Tetradecanoylphorbol Acetate 135-160 BCL2 apoptosis regulator Homo sapiens 96-101 8830674-3 1996 We show here that bax protein also declined with a time course similar to the downregulation of bcl-2 following treatment of HL60 with phorbol myristate acetate (PMA), dimethyl sulphoxide (DMSO) or retinoic acid (RA). Tetradecanoylphorbol Acetate 162-165 BCL2 apoptosis regulator Homo sapiens 96-101 8798441-6 1996 Treatment with phorbol 12-myristate 13-acetate (PMA) led to an increase in both the amount of phosphorylated CREB and the bcl-2 promoter activity. Tetradecanoylphorbol Acetate 15-46 BCL2 apoptosis regulator Homo sapiens 122-127 8666983-2 1996 WHen the cells were treated with 12-O-tetradecanoylphorbol 13-acetate (TPA) or retinoic acid, the level of Bcl-2 protein was increased compared with the control. Tetradecanoylphorbol Acetate 33-69 BCL2 apoptosis regulator Homo sapiens 107-112 8666983-2 1996 WHen the cells were treated with 12-O-tetradecanoylphorbol 13-acetate (TPA) or retinoic acid, the level of Bcl-2 protein was increased compared with the control. Tetradecanoylphorbol Acetate 71-74 BCL2 apoptosis regulator Homo sapiens 107-112 7747803-5 1995 Only faint Bcl-2 staining was detected in cultured keratinocytes exposed to IFN-gamma and TPA compared with the prominent expression of Bcl-x. Tetradecanoylphorbol Acetate 90-93 BCL2 apoptosis regulator Homo sapiens 11-16 8798441-6 1996 Treatment with phorbol 12-myristate 13-acetate (PMA) led to an increase in both the amount of phosphorylated CREB and the bcl-2 promoter activity. Tetradecanoylphorbol Acetate 48-51 BCL2 apoptosis regulator Homo sapiens 122-127 8635587-4 1996 We report here that apoptosis induced by PMA, sphingosine, and N,N-dimethylsphingosine (DMS) was accompanied by a concomitant decrease of bcl-2 expression in both RNA and protein levels in HL-60 cells, while expression of bcl-XL and bax mRNA did not change, and neither sphingosine nor DMS induced differentiation of HL-60 cells. Tetradecanoylphorbol Acetate 41-44 BCL2 apoptosis regulator Homo sapiens 138-143 7671257-11 1995 Additionally, in contrast to the parental or control-transfected cell lines, LNCaP/bcl-2 cells were highly resistant to a variety of apoptotic stimuli in vitro including serum starvation and 10 nM phorbol ester (phorbol 12-myristate 13-acetate) supplementation of the medium. Tetradecanoylphorbol Acetate 212-243 BCL2 apoptosis regulator Homo sapiens 83-88 8633098-4 1996 The Paju cell line displays moderate expression of BCL2, the level of which increases in parallel with further neural differentiation induced by treatment with phorbol 12-myristate 13-acetate. Tetradecanoylphorbol Acetate 160-191 BCL2 apoptosis regulator Homo sapiens 51-55 7795258-4 1995 Downregulation of protein kinase (PK) by a 24-hour incubation in 100 nmol/L 12-O-tetradecanoyl-phorbol-13-acetate (TPA) in the presence of IL-3 dramatically reduced bcl-2 mRNA levels, and induced apoptosis in the presence of IL-3. Tetradecanoylphorbol Acetate 76-113 BCL2 apoptosis regulator Homo sapiens 165-170 7795258-4 1995 Downregulation of protein kinase (PK) by a 24-hour incubation in 100 nmol/L 12-O-tetradecanoyl-phorbol-13-acetate (TPA) in the presence of IL-3 dramatically reduced bcl-2 mRNA levels, and induced apoptosis in the presence of IL-3. Tetradecanoylphorbol Acetate 115-118 BCL2 apoptosis regulator Homo sapiens 165-170 8402688-4 1993 Furthermore, stimulation of one of the N-type clones, SH-SY5Y, with the phorbol ester, 12-O-tetradecanoylphorbol-13-acetate, induced differentiation toward a more neuronal-like phenotype and resulted in a 5- to 10-fold elevation in the relative levels of Bcl-2 protein. Tetradecanoylphorbol Acetate 87-123 BCL2 apoptosis regulator Homo sapiens 255-260 7847852-7 1994 Flow immunocytometry revealed reduced levels of c-myc and bcl-2 oncoproteins in RA and PMA treated cells. Tetradecanoylphorbol Acetate 87-90 BCL2 apoptosis regulator Homo sapiens 58-63 8019487-4 1994 The reported bcl-2 up regulation in malignant lymphoid cells was confirmed in haemo- and lymphopoietic progenitor cells as well as in TPA/PHA activated peripheral blood lymphocytes. Tetradecanoylphorbol Acetate 134-137 BCL2 apoptosis regulator Homo sapiens 13-18 1375120-4 1992 Activation of 173 and 183 B-CLL cells by phorbol esters (12-O-tetradecanoylphorbol-13-acetate [TPA]) to IgM secretion without concomitant DNA synthesis resulted in a rapid but transient downregulation of bcl-2 expression. Tetradecanoylphorbol Acetate 57-93 BCL2 apoptosis regulator Homo sapiens 204-209 1375120-4 1992 Activation of 173 and 183 B-CLL cells by phorbol esters (12-O-tetradecanoylphorbol-13-acetate [TPA]) to IgM secretion without concomitant DNA synthesis resulted in a rapid but transient downregulation of bcl-2 expression. Tetradecanoylphorbol Acetate 95-98 BCL2 apoptosis regulator Homo sapiens 204-209 2011401-3 1991 In unstimulated proliferating JURKAT cells, high levels of C-MYC, N-RAS, and BCL2 mRNAs were found that diminished rapidly following TPA-induced cessation of growth. Tetradecanoylphorbol Acetate 133-136 BCL2 apoptosis regulator Homo sapiens 77-81 2011401-8 1991 Thus, although C-MYC and BCL2 proto-oncogene expression correlated with proliferation in TPA-treated JURKAT cells, continuous over-expression of even the combination of these oncogenes was insufficient for abrogating the effects of TPA in these leukemic T cells. Tetradecanoylphorbol Acetate 89-92 BCL2 apoptosis regulator Homo sapiens 25-29