PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
15748703-6	2005	A PKC activator, 12-O-tetradecaoylphorbol-13-acetate (TPA) significantly attenuated ME-induced apoptosis via preventing cytochrome c release to the cytosol and maintaining the mitochondrial membrane potential by inhibiting the decrease in the Bcl-2/Bax protein ratio; these effects were blocked by protein kinase C (PKC) inhibitors including GF-109203X, H7, and staurosporin.	Tetradecanoylphorbol Acetate	54-57	BCL2 associated X, apoptosis regulator	Homo sapiens	249-252	
9879997-8	1998	TPA-induced apoptosis appears to be mediated through a p53-independent pathway, and the up-regulation of p21WAF1 and Bax may be the molecular mechanisms by which TPA induces apoptosis.	Tetradecanoylphorbol Acetate	162-165	BCL2 associated X, apoptosis regulator	Homo sapiens	117-120	
10381626-5	1999	Exposure of TPA-differentiated U937 cells to 0.8 microg/ml cycloheximide for 24 h, that triggers apoptosis in 50% cells, activates procaspase-2L, -3 and -8, induces the mitochondrial release of cytochrome c and decreases Bcl-xL expression without modifying Bcl-2, Mcl-1 and Bax protein levels.	Tetradecanoylphorbol Acetate	12-15	BCL2 associated X, apoptosis regulator	Homo sapiens	274-277	
8830674-3	1996	We show here that bax protein also declined with a time course similar to the downregulation of bcl-2 following treatment of HL60 with phorbol myristate acetate (PMA), dimethyl sulphoxide (DMSO) or retinoic acid (RA).	Tetradecanoylphorbol Acetate	135-160	BCL2 associated X, apoptosis regulator	Homo sapiens	18-21	
9823934-9	1998	The expression of Bax was clearly induced only on IL-2-stimulated or PMA-plus-ionomycin-stimulated PBLs and that of other Bcl-2 family proteins such as Bcl-x and Bad could not be detected on human PBLs, including IL-2-stimulated or PMA-plus-ionomycin-stimulated PBLs.	Tetradecanoylphorbol Acetate	69-72	BCL2 associated X, apoptosis regulator	Homo sapiens	18-21	
9823934-9	1998	The expression of Bax was clearly induced only on IL-2-stimulated or PMA-plus-ionomycin-stimulated PBLs and that of other Bcl-2 family proteins such as Bcl-x and Bad could not be detected on human PBLs, including IL-2-stimulated or PMA-plus-ionomycin-stimulated PBLs.	Tetradecanoylphorbol Acetate	232-235	BCL2 associated X, apoptosis regulator	Homo sapiens	18-21	
9879997-4	1998	We found up-regulation of p21WAF1 and Bax expressions, however, the expressions of p53 and Bcl-2 genes remained unchanged in TPA-treated cells.	Tetradecanoylphorbol Acetate	125-128	BCL2 associated X, apoptosis regulator	Homo sapiens	38-41	
8830674-3	1996	We show here that bax protein also declined with a time course similar to the downregulation of bcl-2 following treatment of HL60 with phorbol myristate acetate (PMA), dimethyl sulphoxide (DMSO) or retinoic acid (RA).	Tetradecanoylphorbol Acetate	162-165	BCL2 associated X, apoptosis regulator	Homo sapiens	18-21	
24936444-4	2014	Treatments with hyperglycaemia (25 mM) or phorbol myristate acetate (PMA, a protein kinase C activator, 100 nM) significantly increased NADPH oxidase activity, O2 ( -) generation, proapoptotic protein Bax expression, TUNEL-positive staining and caspase-3/7 activities.	Tetradecanoylphorbol Acetate	42-67	BCL2 associated X, apoptosis regulator	Homo sapiens	201-204	
24936444-4	2014	Treatments with hyperglycaemia (25 mM) or phorbol myristate acetate (PMA, a protein kinase C activator, 100 nM) significantly increased NADPH oxidase activity, O2 ( -) generation, proapoptotic protein Bax expression, TUNEL-positive staining and caspase-3/7 activities.	Tetradecanoylphorbol Acetate	69-72	BCL2 associated X, apoptosis regulator	Homo sapiens	201-204	
8635587-4	1996	We report here that apoptosis induced by PMA, sphingosine, and N,N-dimethylsphingosine (DMS) was accompanied by a concomitant decrease of bcl-2 expression in both RNA and protein levels in HL-60 cells, while expression of bcl-XL and bax mRNA did not change, and neither sphingosine nor DMS induced differentiation of HL-60 cells.	Tetradecanoylphorbol Acetate	41-44	BCL2 associated X, apoptosis regulator	Homo sapiens	233-236