PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 12925217-6 2003 Two TPA-response elements on the nerve growth factor promoter were responsible for the activation by histamine. Tetradecanoylphorbol Acetate 4-7 nerve growth factor Homo sapiens 33-52 10848707-9 2000 The expression of c-Fos was increased by phorbol 12-myristate 13-acetate added before NGF, suggesting that c-Fos may be involved in regulating NGF production. Tetradecanoylphorbol Acetate 41-72 nerve growth factor Homo sapiens 143-146 1655978-2 1991 In previous studies we found that NGF production is up-regulated by 12-O-tetradecanoylphorbol 13-acetate (TPA) and serum, down-regulated by corticosterone, and unaffected by dibutyryl-cyclic AMP (db-cyclic AMP) in fibroblasts. Tetradecanoylphorbol Acetate 68-104 nerve growth factor Homo sapiens 34-37 8473901-3 1993 Here we show that activation of the cyclic AMP second messenger pathway antagonized the effect of phorbol 12-myristate 13-acetate (PMA) or serum on NGF synthesis, whereas it enhanced that of 1,25(OH)2D3. Tetradecanoylphorbol Acetate 98-129 nerve growth factor Homo sapiens 148-151 8473901-3 1993 Here we show that activation of the cyclic AMP second messenger pathway antagonized the effect of phorbol 12-myristate 13-acetate (PMA) or serum on NGF synthesis, whereas it enhanced that of 1,25(OH)2D3. Tetradecanoylphorbol Acetate 131-134 nerve growth factor Homo sapiens 148-151 1571784-2 1992 The molecular events leading to these responses are not fully understood, but one possible mediator of NGF"s actions is protein kinase C (PKC), which can be directly activated by phorbol esters, including phorbol myristate acetate (PMA). Tetradecanoylphorbol Acetate 205-230 nerve growth factor Homo sapiens 103-106 1571784-2 1992 The molecular events leading to these responses are not fully understood, but one possible mediator of NGF"s actions is protein kinase C (PKC), which can be directly activated by phorbol esters, including phorbol myristate acetate (PMA). Tetradecanoylphorbol Acetate 232-235 nerve growth factor Homo sapiens 103-106 1279947-1 1992 RNA synthesis in melanocytes and nevus cells, and the proliferation of those cells in the presence of nerve growth factor (NGF) and 12-0-tetradecanoyl-phorbol-13-acetate (TPA), were found to correlate with the amount of NGF bound to the chromatin versus the total internalized NGF (n/c NGF = nuclear/cellular ration). Tetradecanoylphorbol Acetate 171-174 nerve growth factor Homo sapiens 220-223 1279947-1 1992 RNA synthesis in melanocytes and nevus cells, and the proliferation of those cells in the presence of nerve growth factor (NGF) and 12-0-tetradecanoyl-phorbol-13-acetate (TPA), were found to correlate with the amount of NGF bound to the chromatin versus the total internalized NGF (n/c NGF = nuclear/cellular ration). Tetradecanoylphorbol Acetate 171-174 nerve growth factor Homo sapiens 220-223 1279947-1 1992 RNA synthesis in melanocytes and nevus cells, and the proliferation of those cells in the presence of nerve growth factor (NGF) and 12-0-tetradecanoyl-phorbol-13-acetate (TPA), were found to correlate with the amount of NGF bound to the chromatin versus the total internalized NGF (n/c NGF = nuclear/cellular ration). Tetradecanoylphorbol Acetate 171-174 nerve growth factor Homo sapiens 220-223 7921204-6 1994 On the other hand, NGF alone increased the CRH mRNA accumulation up to 10-fold, and further enhanced the stimulatory effect of dexamethasone on the CRH mRNA twofold, and TPA inhibited (30%) the dexamethasone-induced CRH mRNA accumulation. Tetradecanoylphorbol Acetate 170-173 nerve growth factor Homo sapiens 19-22 1279947-4 1992 Removal of TPA from the culture of nevus cells resulted in increased n/c NGF ratio and in a switch from activatory to inhibitory action of NGF. Tetradecanoylphorbol Acetate 11-14 nerve growth factor Homo sapiens 73-76 29872754-0 2018 Induction of nerve growth factor by phorbol 12-myristate 13-acetate is dependent upon the mitogen activated protein kinase pathway. Tetradecanoylphorbol Acetate 36-67 nerve growth factor Homo sapiens 13-32 1279947-4 1992 Removal of TPA from the culture of nevus cells resulted in increased n/c NGF ratio and in a switch from activatory to inhibitory action of NGF. Tetradecanoylphorbol Acetate 11-14 nerve growth factor Homo sapiens 139-142 2839841-3 1988 We have induced the expression of nerve growth factor (NGF) receptors on cultured human melanocytes with phorbol 12-tetradecanoate 13-acetate and have correlated this event with the appearance of a more differentiated, dendritic morphology. Tetradecanoylphorbol Acetate 105-141 nerve growth factor Homo sapiens 34-53 2839841-3 1988 We have induced the expression of nerve growth factor (NGF) receptors on cultured human melanocytes with phorbol 12-tetradecanoate 13-acetate and have correlated this event with the appearance of a more differentiated, dendritic morphology. Tetradecanoylphorbol Acetate 105-141 nerve growth factor Homo sapiens 55-58 7139611-4 1982 The potent promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) reversibly increased the proportion of SH-SY5Y cells with neurites and the average length of neurites; the effects of the combination of TPA and NGF were greater than that of either compound alone. Tetradecanoylphorbol Acetate 20-56 nerve growth factor Homo sapiens 208-211 7139611-4 1982 The potent promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) reversibly increased the proportion of SH-SY5Y cells with neurites and the average length of neurites; the effects of the combination of TPA and NGF were greater than that of either compound alone. Tetradecanoylphorbol Acetate 58-61 nerve growth factor Homo sapiens 208-211 7139611-11 1982 TPA also enhanced neurite outgrowth in another NGF responsive line, LA-N-5, but not in two unresponsive lines, CHP-100 and CHP-134. Tetradecanoylphorbol Acetate 0-3 nerve growth factor Homo sapiens 47-50 1655978-2 1991 In previous studies we found that NGF production is up-regulated by 12-O-tetradecanoylphorbol 13-acetate (TPA) and serum, down-regulated by corticosterone, and unaffected by dibutyryl-cyclic AMP (db-cyclic AMP) in fibroblasts. Tetradecanoylphorbol Acetate 106-109 nerve growth factor Homo sapiens 34-37 1655978-4 1991 TPA and serum together stimulated NGF production 10-fold more than either agent alone. Tetradecanoylphorbol Acetate 0-3 nerve growth factor Homo sapiens 34-37 1655978-7 1991 Forskolin and db-cyclic AMP prevented NGF mRNA induction by TPA and serum without changing basal levels. Tetradecanoylphorbol Acetate 60-63 nerve growth factor Homo sapiens 38-41 1655978-8 1991 TPA induced c-fos and junB mRNAs transiently and preceding NGF mRNA induction but c-jun mRNA remained undetectable. Tetradecanoylphorbol Acetate 0-3 nerve growth factor Homo sapiens 59-62 1655978-10 1991 Thus, TPA induction of NGF mRNA is modulated differentially by corticosterone and cyclic AMP. Tetradecanoylphorbol Acetate 6-9 nerve growth factor Homo sapiens 23-26 29872754-2 2018 To map the signal transduction cascade leading to NGF synthesis and secretion, cultured human glial cells were stimulated by phorbol 12-myristate 13-acetate (PMA), an agonist of Protein Kinase C. Changes in intracellular protein phosphorylation states were evaluated by reverse phase protein microarrays (RPPA), selectively screening over 130 protein endpoints. Tetradecanoylphorbol Acetate 158-161 nerve growth factor Homo sapiens 50-53