PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 9606549-0 1998 [Interleukin-2 and staurosporine abolish inhibition of splenocyte nonspecific cytotoxicity caused by high doses of phorbol myristate acetate in rats]. Tetradecanoylphorbol Acetate 115-140 interleukin 2 Rattus norvegicus 1-14 10737264-7 2000 Stimulation of IL-2 production by the extracts was higher in cultures with PMA/Ca ionophore than in cultures with R73 mAb. Tetradecanoylphorbol Acetate 75-78 interleukin 2 Rattus norvegicus 15-19 9081434-0 1996 [Modulation with phorbol myristate acetate and staurosporine of interleukin 2- induced proliferation and nonspecific cytotoxicity of rat lymphocytes]. Tetradecanoylphorbol Acetate 17-42 interleukin 2 Rattus norvegicus 65-78 8580531-3 1995 Furthermore, preincubation of the tissue with PMA prevents the IL-2 effect, suggesting that the kinases activated by the tumor promoter and IL-2 share a common substrate. Tetradecanoylphorbol Acetate 46-49 interleukin 2 Rattus norvegicus 63-67 8748696-4 1995 A 180 day exposure significantly suppressed the generation of IL-2 by either concanavalin A or phorbol myristate acetate/calcium ionophore stimulation, and reduced the lectin-induced proliferation of splenic T cells. Tetradecanoylphorbol Acetate 95-120 interleukin 2 Rattus norvegicus 62-66 8580531-3 1995 Furthermore, preincubation of the tissue with PMA prevents the IL-2 effect, suggesting that the kinases activated by the tumor promoter and IL-2 share a common substrate. Tetradecanoylphorbol Acetate 46-49 interleukin 2 Rattus norvegicus 140-144 3258574-4 1988 TPA to a variable degree also potentiates IL-2-stimulated growth of Nb2 cells when cultured in medium containing serum but has no effect on cells grown in serum-free medium. Tetradecanoylphorbol Acetate 0-3 interleukin 2 Rattus norvegicus 42-46 8104885-6 1993 However, when the stimulation signals were bypassed by ionomycin and phorbol 12-myristate 13-acetate (PMA), IL-2 was normally produced, suggesting that the IL-2 gene and nuclear factors for the IL-2 gene transcription are normal in LEC rats. Tetradecanoylphorbol Acetate 102-105 interleukin 2 Rattus norvegicus 108-112 8104885-6 1993 However, when the stimulation signals were bypassed by ionomycin and phorbol 12-myristate 13-acetate (PMA), IL-2 was normally produced, suggesting that the IL-2 gene and nuclear factors for the IL-2 gene transcription are normal in LEC rats. Tetradecanoylphorbol Acetate 102-105 interleukin 2 Rattus norvegicus 156-160 8104885-6 1993 However, when the stimulation signals were bypassed by ionomycin and phorbol 12-myristate 13-acetate (PMA), IL-2 was normally produced, suggesting that the IL-2 gene and nuclear factors for the IL-2 gene transcription are normal in LEC rats. Tetradecanoylphorbol Acetate 102-105 interleukin 2 Rattus norvegicus 156-160 8359866-1 1993 CD8 (Ly-2) expression was suppressed in purified murine CD4-CD8+ thymocytes at the mRNA level upon continuous stimulation with PMA and ionomycin in the presence of rIL-2. Tetradecanoylphorbol Acetate 127-130 interleukin 2 Rattus norvegicus 164-169 1588792-8 1992 In two cases tested high-affinity IL-2R on PMA-treated T-ALL cells could internalize 125I-rIL-2 at 37 degrees C. PMA alone enhanced the spontaneous proliferation of T-ALL cells in three cases, whereas a clear synergy between IL-2 and PMA could be detected in three patients" cells. Tetradecanoylphorbol Acetate 43-46 interleukin 2 Rattus norvegicus 90-95 7947460-4 1994 Activation with antigen or TPA/anti-CD3 mAb of Th2 T cell clones that had been preincubated with rIL-12 and rIL-2 for 5 days induced or enhanced the expression of IFN-gamma transcripts, as well as the production of IFN-gamma by these cells. Tetradecanoylphorbol Acetate 27-30 interleukin 2 Rattus norvegicus 108-113 1733630-7 1992 The accumulation of IL-2R-beta-specific mRNA is observed in freshly isolated thymocytes and it is increased in thymocytes cultured with rIL-2 alone, with Con A, and further enhanced by the addition of rIL-2 in combination with Con A or with TPA. Tetradecanoylphorbol Acetate 241-244 interleukin 2 Rattus norvegicus 136-141 1733630-7 1992 The accumulation of IL-2R-beta-specific mRNA is observed in freshly isolated thymocytes and it is increased in thymocytes cultured with rIL-2 alone, with Con A, and further enhanced by the addition of rIL-2 in combination with Con A or with TPA. Tetradecanoylphorbol Acetate 241-244 interleukin 2 Rattus norvegicus 201-206 1531763-2 1992 High in vitro growth ability was observed in response to recombinant human IL-2 (rIL-2) and human rIL-7, both in the absence of any co-mitogen and in combination with phorbol 12-myristate 13-acetate (PMA). Tetradecanoylphorbol Acetate 200-203 interleukin 2 Rattus norvegicus 81-86 2565932-4 1989 Recombinant interleukin 2 (rIL-2), albeit ineffective by itself, leads to vigorous proliferation of DETC when used with either ConA or PMA + ionomycin + IL-1. Tetradecanoylphorbol Acetate 135-138 interleukin 2 Rattus norvegicus 27-32 2523864-1 1989 Recombinant IL-2 (rIL-2) and IL-4 (rIL-4) promote proliferation of human CD4+ T cells activated in the presence of PHA, TPA or OKT-3 monoclonal antibody (MAb), whereas the production of interferon-gamma (IFN) can be induced only by rIL-2. Tetradecanoylphorbol Acetate 120-123 interleukin 2 Rattus norvegicus 18-23 3115340-7 1987 PMA-treated blast cells, however, generated B cell colonies in the presence of rIL2, thus suggesting that PMA could induce functional IL2-R on immature leukemic B cells. Tetradecanoylphorbol Acetate 0-3 interleukin 2 Rattus norvegicus 79-83 3115340-7 1987 PMA-treated blast cells, however, generated B cell colonies in the presence of rIL2, thus suggesting that PMA could induce functional IL2-R on immature leukemic B cells. Tetradecanoylphorbol Acetate 106-109 interleukin 2 Rattus norvegicus 79-83 3091685-3 1986 The expression of rat IL 2R on those hybrid cells could be up-regulated by IL 2 itself, ATL-derived factor, and TPA and CA++ ionophore. Tetradecanoylphorbol Acetate 112-115 interleukin 2 Rattus norvegicus 22-26 6600707-5 1983 The antibody, obtained from hybridomas derived from mice immunized with phorbol-myristate-acetate-pulsed rat T lymphoblasts, exhibited species specificity, indicating that IL-2 receptors of various species are not necessarily identical, even if they can respond to IL-2 from different species. Tetradecanoylphorbol Acetate 72-97 interleukin 2 Rattus norvegicus 172-176 6600707-5 1983 The antibody, obtained from hybridomas derived from mice immunized with phorbol-myristate-acetate-pulsed rat T lymphoblasts, exhibited species specificity, indicating that IL-2 receptors of various species are not necessarily identical, even if they can respond to IL-2 from different species. Tetradecanoylphorbol Acetate 72-97 interleukin 2 Rattus norvegicus 265-269