PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 30978354-4 2019 B19V infection increases the production of tumor necrosis factor-alpha and induces NLRP3-mediated caspase-1 activation in both THP-1 cells differentiated with phorbol 12-myristate 13-acetate and in monocytes from patients with SSc but not from healthy controls. Tetradecanoylphorbol Acetate 159-190 NLR family pyrin domain containing 3 Homo sapiens 83-88 27105502-8 2016 The in vitro study showed that MALT1 inhibitors decreased production of IL-1beta/IL-18 in phorbol myristate acetate-differentiated THP-1 cells and bone marrow derived macrophage via suppressing the activation of NF-kappaB and NLRP3 inflammasome. Tetradecanoylphorbol Acetate 90-115 NLR family pyrin domain containing 3 Homo sapiens 226-231 29207123-0 2018 NACHT, LRR and PYD domains-containing protein 3 inflammasome is activated and inhibited by berberine via toll-like receptor 4/myeloid differentiation primary response gene 88/nuclear factor-kappaB pathway, in phorbol 12-myristate 13-acetate-induced macrophages. Tetradecanoylphorbol Acetate 209-240 NLR family pyrin domain containing 3 Homo sapiens 0-47 29207123-2 2018 The present study investigated the expression of NLRP3 inflammasome in phorbol 12-myristate 13-acetate (PMA)-induced macrophages, and aimed to identify the effects of berberine on the inflammasome. Tetradecanoylphorbol Acetate 71-102 NLR family pyrin domain containing 3 Homo sapiens 49-54 29207123-2 2018 The present study investigated the expression of NLRP3 inflammasome in phorbol 12-myristate 13-acetate (PMA)-induced macrophages, and aimed to identify the effects of berberine on the inflammasome. Tetradecanoylphorbol Acetate 104-107 NLR family pyrin domain containing 3 Homo sapiens 49-54 29207123-5 2018 The present study demonstrated that NLRP3 inflammasome and IL-1beta were activated in PMA-induced macrophages in a time-dependent manner, whereas berberine significantly inhibited their expression in a dose-dependent manner in PMA-induced macrophages. Tetradecanoylphorbol Acetate 86-89 NLR family pyrin domain containing 3 Homo sapiens 36-41 27777559-2 2016 This study aimed to assess the effects of curcumin on NLRP3 inflammasome in phorbol 12-myristate 13-acetate (PMA)-induced macrophages and explore its underlying mechanism. Tetradecanoylphorbol Acetate 76-107 NLR family pyrin domain containing 3 Homo sapiens 54-59 27777559-2 2016 This study aimed to assess the effects of curcumin on NLRP3 inflammasome in phorbol 12-myristate 13-acetate (PMA)-induced macrophages and explore its underlying mechanism. Tetradecanoylphorbol Acetate 109-112 NLR family pyrin domain containing 3 Homo sapiens 54-59 27777559-9 2016 Furthermore, curcumin reversed PMA-stimulated P2X7R activation, which further reduced the expression of NLRP3 and cleavage of caspase-1 and IL-1beta secretion. Tetradecanoylphorbol Acetate 31-34 NLR family pyrin domain containing 3 Homo sapiens 104-109 27777559-11 2016 Conclusion: Curcumin inhibited NLRP3 inflammasome through suppressing TLR4/MyD88/NF-kappaB and P2X7R pathways in PMA-induced macrophages. Tetradecanoylphorbol Acetate 113-116 NLR family pyrin domain containing 3 Homo sapiens 31-36 29207123-7 2018 In conclusion, berberine reduced NLRP3 inflammasone expression by suppressing the activation of the TLR4/Myd88/NF-kappaB signaling pathway in PMA-induced macrophages. Tetradecanoylphorbol Acetate 142-145 NLR family pyrin domain containing 3 Homo sapiens 33-38 27777559-0 2016 Curcumin Represses NLRP3 Inflammasome Activation via TLR4/MyD88/NF-kappaB and P2X7R Signaling in PMA-Induced Macrophages. Tetradecanoylphorbol Acetate 97-100 NLR family pyrin domain containing 3 Homo sapiens 19-24 25677765-10 2015 Furthermore, wogonoside markedly decreased production of IL-1beta, TNF-alpha and IL-6 and suppressed mRNA expression of pro-IL-1beta and NLRP3 in phorbol myristate acetate (PMA)-differentiated monocytic THP-1 cells via inhibiting the activation of NF-kappaB and NLRP3 inflammasome. Tetradecanoylphorbol Acetate 146-171 NLR family pyrin domain containing 3 Homo sapiens 137-142 25677765-10 2015 Furthermore, wogonoside markedly decreased production of IL-1beta, TNF-alpha and IL-6 and suppressed mRNA expression of pro-IL-1beta and NLRP3 in phorbol myristate acetate (PMA)-differentiated monocytic THP-1 cells via inhibiting the activation of NF-kappaB and NLRP3 inflammasome. Tetradecanoylphorbol Acetate 173-176 NLR family pyrin domain containing 3 Homo sapiens 137-142 25677765-10 2015 Furthermore, wogonoside markedly decreased production of IL-1beta, TNF-alpha and IL-6 and suppressed mRNA expression of pro-IL-1beta and NLRP3 in phorbol myristate acetate (PMA)-differentiated monocytic THP-1 cells via inhibiting the activation of NF-kappaB and NLRP3 inflammasome. Tetradecanoylphorbol Acetate 173-176 NLR family pyrin domain containing 3 Homo sapiens 262-267 25022544-7 2014 To determine the role of PKC activation in the effects of DPP-4 inhibitors, cells were treated with PMA- which blocked the effect of DPP-4 inhibitors on NLRP3 and IL-1beta as well as TLR4 and GLP-1R. Tetradecanoylphorbol Acetate 100-103 NLR family pyrin domain containing 3 Homo sapiens 153-158 8194473-6 1994 The effect of AII on AT1-R mRNA levels was fully reproduced by the combination of calcium ionophore (A23187) and phorbol ester (12-O-tetradecanoylphorbol 13-acetate), suggesting that AII action was through protein kinase-C and possibly other Ca(2+)-sensitive protein kinases. Tetradecanoylphorbol Acetate 128-164 NLR family pyrin domain containing 3 Homo sapiens 14-17 8194473-6 1994 The effect of AII on AT1-R mRNA levels was fully reproduced by the combination of calcium ionophore (A23187) and phorbol ester (12-O-tetradecanoylphorbol 13-acetate), suggesting that AII action was through protein kinase-C and possibly other Ca(2+)-sensitive protein kinases. Tetradecanoylphorbol Acetate 128-164 NLR family pyrin domain containing 3 Homo sapiens 183-186