PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 11327693-2 2001 We found that PMA-induced phosphorylation of myristoylated alanine-rich C kinase substrate (MARCKS) increased its binding with Tob that exerts an anti-proliferative effect through the binding with ErbB-2. Tetradecanoylphorbol Acetate 14-17 erb-b2 receptor tyrosine kinase 2 Homo sapiens 197-203 11682064-7 2001 In addition, the tumor promoters 12-O-tetradecanoylphorbol-13-acetate and okadaic acid stimulated the association of phosphorylated histone H3 on serine 10 with the HER2 promoter and also stimulated HER2 expression. Tetradecanoylphorbol Acetate 33-69 erb-b2 receptor tyrosine kinase 2 Homo sapiens 165-169 11682064-7 2001 In addition, the tumor promoters 12-O-tetradecanoylphorbol-13-acetate and okadaic acid stimulated the association of phosphorylated histone H3 on serine 10 with the HER2 promoter and also stimulated HER2 expression. Tetradecanoylphorbol Acetate 33-69 erb-b2 receptor tyrosine kinase 2 Homo sapiens 199-203 20734918-11 2010 DLBS1425 also down-regulated c-fos and HER-2/neu mRNA expression in TPA- or fatty acid-induced MDA-MB-231 cells. Tetradecanoylphorbol Acetate 68-71 erb-b2 receptor tyrosine kinase 2 Homo sapiens 39-48 10674883-6 1999 Here, we demonstrate the effects of steroids/thyroids/retinoids and of activators of protein kinase A (forskolin, Forsk) and C (12-O-tetradecanoylphorbol-13-acetate, TPA), on growth and expression of c-erbB and RARs in MCF-7 breast cancer cells, which contain high levels of RAR-alpha and -gamma, and which express significant amounts of c-erbB-2 and -3. Tetradecanoylphorbol Acetate 128-164 erb-b2 receptor tyrosine kinase 2 Homo sapiens 338-353 28915606-10 2017 Matriptase silencing in the Her2, matriptase, and HAI-1 triple-positive SKBR3 human breast cancer cells enhanced Her2 protein down-regulation induced by a sustained exposure to phorbol 12-myristate 13-acetate (PMA), which down-regulated matriptase protein. Tetradecanoylphorbol Acetate 177-208 erb-b2 receptor tyrosine kinase 2 Homo sapiens 28-32 28915606-10 2017 Matriptase silencing in the Her2, matriptase, and HAI-1 triple-positive SKBR3 human breast cancer cells enhanced Her2 protein down-regulation induced by a sustained exposure to phorbol 12-myristate 13-acetate (PMA), which down-regulated matriptase protein. Tetradecanoylphorbol Acetate 177-208 erb-b2 receptor tyrosine kinase 2 Homo sapiens 113-117 2897079-1 1988 Treatment of human adenocarcinoma MKN-7 cells with epidermal growth factor (EGF) or phorbol tetradecanoate acetate (TPA) stimulated phosphorylation of the c-erbB-2 gene product. Tetradecanoylphorbol Acetate 116-119 erb-b2 receptor tyrosine kinase 2 Homo sapiens 155-163 2897079-4 1988 Tryptic phosphopeptide mapping analysis suggested that treatments with EGF and TPA induced phosphorylation of many common sites in the c-erbB-2 gene product. Tetradecanoylphorbol Acetate 79-82 erb-b2 receptor tyrosine kinase 2 Homo sapiens 135-143 2897079-5 1988 However, in contrast to TPA, EGF increased the phosphorylation of the c-erbB-2 protein in cells whose protein kinase C had been down-regulated by long-term pretreatment with TPA, suggesting that EGF and TPA induce phosphorylation by different mechanisms. Tetradecanoylphorbol Acetate 174-177 erb-b2 receptor tyrosine kinase 2 Homo sapiens 70-78 2897079-5 1988 However, in contrast to TPA, EGF increased the phosphorylation of the c-erbB-2 protein in cells whose protein kinase C had been down-regulated by long-term pretreatment with TPA, suggesting that EGF and TPA induce phosphorylation by different mechanisms. Tetradecanoylphorbol Acetate 174-177 erb-b2 receptor tyrosine kinase 2 Homo sapiens 70-78 3496852-5 1987 Phosphorylation of the c-erbB-2 protein was stimulated by TPA via protein kinase C in vivo. Tetradecanoylphorbol Acetate 58-61 erb-b2 receptor tyrosine kinase 2 Homo sapiens 23-31 25225290-10 2014 PMA-induced Erk phosphorylation was reduced by ErbB2 inhibitor lapatinib, as well as by knockdown of PKC-delta but not that of PKC-alpha. Tetradecanoylphorbol Acetate 0-3 erb-b2 receptor tyrosine kinase 2 Homo sapiens 47-52 20179161-7 2010 Furthermore, PD98059, a specific inhibitor of MEK1/2, and Juglone, a potent Pin1 inhibitor, markedly suppressed the expression of activator protein-2alpha and the HER-2 promoter activity induced by EGF or 12-O-tetradecanoylphorbol-13-acetate in MCF-7 cells. Tetradecanoylphorbol Acetate 205-241 erb-b2 receptor tyrosine kinase 2 Homo sapiens 163-168 8603385-3 1996 The effects in general were small, the greatest being increases of 46-67% in Her2/neu mRNA levels in response to treatments with TPA or sodium saccharin following NMU treatments. Tetradecanoylphorbol Acetate 129-132 erb-b2 receptor tyrosine kinase 2 Homo sapiens 77-85 7906679-7 1994 Of the agents which inhibit the growth of T47D and ZR75.1 cells--Pg, Prl, cAMP, RA and TPA--only Pg and cAMP caused an increase in the erbB-2 protein level. Tetradecanoylphorbol Acetate 87-90 erb-b2 receptor tyrosine kinase 2 Homo sapiens 135-141 1675782-0 1991 TPA inhibits the tyrosine kinase activity of the neu protein in vivo and in vitro. Tetradecanoylphorbol Acetate 0-3 erb-b2 receptor tyrosine kinase 2 Homo sapiens 49-52 1675782-3 1991 We report here that incubation of cells with 12-O-tetradecanoylphorbol-13-acetate (TPA) stimulates the phosphorylation of the normal neu protein (p185) and the oncogenic neu protein (p185*). Tetradecanoylphorbol Acetate 45-81 erb-b2 receptor tyrosine kinase 2 Homo sapiens 133-136 1675782-3 1991 We report here that incubation of cells with 12-O-tetradecanoylphorbol-13-acetate (TPA) stimulates the phosphorylation of the normal neu protein (p185) and the oncogenic neu protein (p185*). Tetradecanoylphorbol Acetate 45-81 erb-b2 receptor tyrosine kinase 2 Homo sapiens 170-173 1675782-3 1991 We report here that incubation of cells with 12-O-tetradecanoylphorbol-13-acetate (TPA) stimulates the phosphorylation of the normal neu protein (p185) and the oncogenic neu protein (p185*). Tetradecanoylphorbol Acetate 83-86 erb-b2 receptor tyrosine kinase 2 Homo sapiens 133-136 1675782-3 1991 We report here that incubation of cells with 12-O-tetradecanoylphorbol-13-acetate (TPA) stimulates the phosphorylation of the normal neu protein (p185) and the oncogenic neu protein (p185*). Tetradecanoylphorbol Acetate 83-86 erb-b2 receptor tyrosine kinase 2 Homo sapiens 170-173 30098331-6 2018 We confirm that PMA-induced PKC activation causes ErbB2 internalization, but while the Hsp90 inhibitor 17-AAG induced ErbB2 degradation, PMA had no such effect. Tetradecanoylphorbol Acetate 16-19 erb-b2 receptor tyrosine kinase 2 Homo sapiens 50-55 30098331-7 2018 When combined with 17-AAG, PMA had additive effect on ErbB2 internalization indicating that Hsp90 inhibition and PKC activation induce internalization by alternative mechanisms. Tetradecanoylphorbol Acetate 27-30 erb-b2 receptor tyrosine kinase 2 Homo sapiens 54-59 27531070-4 2016 In contrast to the decreased tyrosine phosphorylation, Phos-tag Western blot analysis revealed that TPA induced phosphorylation of ErbB2 in an ERK-dependent manner. Tetradecanoylphorbol Acetate 100-103 erb-b2 receptor tyrosine kinase 2 Homo sapiens 131-136 12869563-7 2003 When the m80 ErbB-4 fragment is generated by cell treatment with heregulin or 12-O-tetradecanoylphorbol-13-acetate, the fragment associates with intact ErbB-2. Tetradecanoylphorbol Acetate 78-114 erb-b2 receptor tyrosine kinase 2 Homo sapiens 152-158