PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 32979364-12 2020 We demonstrate that IS promotes the HASMCs phenotype switch by suppressing MGP expression via ROS/NF-kappaB/miR-155-5p signaling and provide a new insight for the pathogenesis of IS-induced VC. Indican 20-22 nuclear factor kappa B subunit 1 Homo sapiens 98-107 32979364-0 2020 Indoxyl sulfate promotes osteogenic differentiation of vascular smooth muscle cells by miR-155-5p-dependent downregulation of matrix Gla protein via ROS/NF-kappaB signaling. Indican 0-15 nuclear factor kappa B subunit 1 Homo sapiens 153-162 31284759-0 2019 Indoxyl sulfate-induced TNF-alpha is regulated by crosstalk between the aryl hydrocarbon receptor, NF-kappaB, and SOCS2 in human macrophages. Indican 0-15 nuclear factor kappa B subunit 1 Homo sapiens 99-108 31448474-0 2019 Indoxyl sulfate-induced calcification of vascular smooth muscle cells via the PI3K/Akt/NF-kappaB signaling pathway. Indican 0-15 nuclear factor kappa B subunit 1 Homo sapiens 87-96 25556305-2 2015 The present study aimed to determine whether nuclear factor-kappaB (NF-kappaB) p65, signal transducer and activator of transcription 3 (Stat3), and reactive oxygen species are involved in indoxyl sulfate-induced prorenin expression in cultured human proximal tubular cells (HK-2 cells). Indican 188-203 nuclear factor kappa B subunit 1 Homo sapiens 45-66 26659566-0 2016 Indoxyl sulfate enhances IL-1beta-induced E-selectin expression in endothelial cells in acute kidney injury by the ROS/MAPKs/NFkappaB/AP-1 pathway. Indican 0-15 nuclear factor kappa B subunit 1 Homo sapiens 125-133 26567049-0 2016 Upregulation of nuclear factor-kappaB activity mediates CYP24 expression and reactive oxygen species production in indoxyl sulfate-induced chronic kidney disease. Indican 115-130 nuclear factor kappa B subunit 1 Homo sapiens 16-37 25556305-0 2015 Indoxyl sulfate upregulates prorenin expression via nuclear factor-kappaB p65, signal transducer and activator of transcription 3, and reactive oxygen species in proximal tubular cells. Indican 0-15 nuclear factor kappa B subunit 1 Homo sapiens 52-73 25482161-7 2015 Indoxyl sulphate also increased the abundance of NADPH oxidase 4 (NOX4) and nuclear factor (NF)-kappaB. Indican 0-16 nuclear factor kappa B subunit 1 Homo sapiens 76-102 25556305-2 2015 The present study aimed to determine whether nuclear factor-kappaB (NF-kappaB) p65, signal transducer and activator of transcription 3 (Stat3), and reactive oxygen species are involved in indoxyl sulfate-induced prorenin expression in cultured human proximal tubular cells (HK-2 cells). Indican 188-203 nuclear factor kappa B subunit 1 Homo sapiens 68-77 25556305-5 2015 siRNAs specific to NF-kappaB p65 and Stat3 inhibited indoxyl sulfate-induced prorenin expression. Indican 53-68 nuclear factor kappa B subunit 1 Homo sapiens 19-28 25556305-7 2015 Indoxyl sulfate upregulates the expression of prorenin via NF-kappaB p65, Stat3, and reactive oxygen species in proximal tubular cells. Indican 0-15 nuclear factor kappa B subunit 1 Homo sapiens 59-68 23407882-11 2013 Taken together, CREB, NF-kappaB, and NOX4 coordinately upregulate indoxyl sulfate-induced AGT expression in proximal tubular cells. Indican 66-81 nuclear factor kappa B subunit 1 Homo sapiens 22-31 23407882-7 2013 Both NAC and DPI suppressed indoxyl sulfate-induced expression of NF-kappaB p65 and CREB. Indican 28-43 nuclear factor kappa B subunit 1 Homo sapiens 66-75 21832251-9 2011 NF-kappaB inhibitors partially alleviated indoxyl sulfate-induced inhibition of cellular proliferation. Indican 42-57 nuclear factor kappa B subunit 1 Homo sapiens 0-9 23407882-8 2013 CREB siRNA suppressed indoxyl sulfate-induced NF-kappaB p65 expression, whereas both NF-kappaB inhibitors and NF-kappaB p65 siRNA prevented indoxyl sulfate-induced CREB expression. Indican 22-37 nuclear factor kappa B subunit 1 Homo sapiens 46-55 23407882-8 2013 CREB siRNA suppressed indoxyl sulfate-induced NF-kappaB p65 expression, whereas both NF-kappaB inhibitors and NF-kappaB p65 siRNA prevented indoxyl sulfate-induced CREB expression. Indican 140-155 nuclear factor kappa B subunit 1 Homo sapiens 85-94 23407882-8 2013 CREB siRNA suppressed indoxyl sulfate-induced NF-kappaB p65 expression, whereas both NF-kappaB inhibitors and NF-kappaB p65 siRNA prevented indoxyl sulfate-induced CREB expression. Indican 140-155 nuclear factor kappa B subunit 1 Homo sapiens 85-94 23407882-10 2013 Indoxyl sulfate induced the expression of NOX4 in proximal tubular cells, which was suppressed by NAC, DPI, NF-kappaB inhibitors, NF-kappaB p65 siRNA, and CREB siRNA. Indican 0-15 nuclear factor kappa B subunit 1 Homo sapiens 108-117 23407882-10 2013 Indoxyl sulfate induced the expression of NOX4 in proximal tubular cells, which was suppressed by NAC, DPI, NF-kappaB inhibitors, NF-kappaB p65 siRNA, and CREB siRNA. Indican 0-15 nuclear factor kappa B subunit 1 Homo sapiens 130-139 21832251-0 2011 NF-kappaB plays an important role in indoxyl sulfate-induced cellular senescence, fibrotic gene expression, and inhibition of proliferation in proximal tubular cells. Indican 37-52 nuclear factor kappa B subunit 1 Homo sapiens 0-9 21832251-3 2011 The present study examines whether activation (phosphorylation) of NF-kappaB by indoxyl sulfate promotes senescence and dysfunction in human proximal tubular cells (HK-2 cells). Indican 80-95 nuclear factor kappa B subunit 1 Homo sapiens 67-76 23407882-0 2013 CREB, NF-kappaB, and NADPH oxidase coordinately upregulate indoxyl sulfate-induced angiotensinogen expression in proximal tubular cells. Indican 59-74 nuclear factor kappa B subunit 1 Homo sapiens 6-15 23407882-5 2013 Our previous study demonstrated that indoxyl sulfate activated nuclear factor-kappaB (NF-kappaB) through reactive oxygen species (ROS) production. Indican 37-52 nuclear factor kappa B subunit 1 Homo sapiens 86-95 21832251-4 2011 Indoxyl sulfate induced phosphorylation of NF-kappaB p65 on Ser-276, which was suppressed by N-acetylcysteine, an antioxidant. Indican 0-15 nuclear factor kappa B subunit 1 Homo sapiens 43-52 21832251-10 2011 NF-kappaB p65 siRNA-transfected cells showed less proliferation in the presence of indoxyl sulfate than control cells. Indican 83-98 nuclear factor kappa B subunit 1 Homo sapiens 0-9 21832251-5 2011 Furthermore, indoxyl sulfate induced NF-kappaB p65 expression. Indican 13-28 nuclear factor kappa B subunit 1 Homo sapiens 37-46 21832251-13 2011 Taken together, NF-kappaB plays an important role in indoxyl sulfate-induced cellular senescence, fibrotic gene expression, and inhibition of proliferation in proximal tubular cells. Indican 53-68 nuclear factor kappa B subunit 1 Homo sapiens 16-25 21832251-6 2011 Inhibitors of NF-kappaB (pyrrolidine dithiocarbamate and isohelenin) and NF-kappaB p65 small interfering RNA (siRNA) suppressed indoxyl sulfate-induced senescence-associated beta-galactosidase activity and expression of p53, transforming growth factor (TGF)-beta1, and alpha-smoothe muscle actin (SMA). Indican 128-143 nuclear factor kappa B subunit 1 Homo sapiens 14-23 21832251-14 2011 More notably, indoxyl sulfate accelerates proximal tubular cell senescence with progression of CRF through reactive oxygen species-NF-kappaB-p53 pathway. Indican 14-29 nuclear factor kappa B subunit 1 Homo sapiens 131-140 21832251-6 2011 Inhibitors of NF-kappaB (pyrrolidine dithiocarbamate and isohelenin) and NF-kappaB p65 small interfering RNA (siRNA) suppressed indoxyl sulfate-induced senescence-associated beta-galactosidase activity and expression of p53, transforming growth factor (TGF)-beta1, and alpha-smoothe muscle actin (SMA). Indican 128-143 nuclear factor kappa B subunit 1 Homo sapiens 73-82 21832251-8 2011 NF-kappaB inhibitors suppressed indoxyl sulfate-induced p21 expression, whereas NF-kappaB p65 siRNA enhanced its expression. Indican 32-47 nuclear factor kappa B subunit 1 Homo sapiens 0-9 20389059-0 2010 Indoxyl sulfate upregulates expression of ICAM-1 and MCP-1 by oxidative stress-induced NF-kappaB activation. Indican 0-15 nuclear factor kappa B subunit 1 Homo sapiens 87-96 20389059-2 2010 The present study aimed to determine whether indoxyl sulfate increases the expression of intercellular adhesion molecule-1 (ICAM-1) and monocyte chemotactic protein-1 (MCP-1) by reactive oxygen species (ROS)-induced activation of nuclear factor-kappaB (NF-kappaB) in vascular endothelial cells. Indican 45-60 nuclear factor kappa B subunit 1 Homo sapiens 230-251 20389059-2 2010 The present study aimed to determine whether indoxyl sulfate increases the expression of intercellular adhesion molecule-1 (ICAM-1) and monocyte chemotactic protein-1 (MCP-1) by reactive oxygen species (ROS)-induced activation of nuclear factor-kappaB (NF-kappaB) in vascular endothelial cells. Indican 45-60 nuclear factor kappa B subunit 1 Homo sapiens 253-262 20389059-7 2010 Inhibitors of NF-kappaB (ammonium pyrrolidinedithiocarbamate and isohelenin) and an antioxidant (N-acetyl-L-cysteine) suppressed the indoxyl sulfate-induced expression of ICAM-1 and MCP-1 in HUVEC. Indican 133-148 nuclear factor kappa B subunit 1 Homo sapiens 14-23 20389059-8 2010 Indoxyl sulfate increased phospho- NF-kappaB p65 in HUVEC, and N-acetyl-L-cysteine suppressed it. Indican 0-15 nuclear factor kappa B subunit 1 Homo sapiens 35-44 20389059-9 2010 CONCLUSIONS: Indoxyl sulfate upregulates the expression of ICAM-1 and MCP-1 by ROS-induced activation of NF-kappaB in vascular endothelial cells. Indican 13-28 nuclear factor kappa B subunit 1 Homo sapiens 105-114 12675842-12 2003 The luciferase reporter gene assay revealed that indoxyl sulfate and indoleacetic acid dose dependently activated NF-kappaB and PAI-1 promoter. Indican 49-64 nuclear factor kappa B subunit 1 Homo sapiens 114-123 12675842-14 2003 Both antioxidant and NF-kappaB inhibitors dose dependently inhibited the activation of PAI-1 promoter by indoxyl sulfate. Indican 105-120 nuclear factor kappa B subunit 1 Homo sapiens 21-30