PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
27990791-2	2017	Indoxyl sulfate induces cellular dysfunction by producing reactive oxygen species (ROS) such as superoxide by activating nicotinamide adenine dinucleotide phosphate oxidase, and by activating aryl hydrocarbon receptor through its uptake via organic anion transporters (OAT1 and OAT3).	Indican	0-15	solute carrier family 22 member 8	Homo sapiens	278-282	
26208844-7	2015	The uric acid-, indoxyl sulfate-, and methylguanidine-depolarized RVLM neurons showed the presence of urate transporter 1 (URAT 1), organic anion transporter (OAT)1 or OAT3, and organic cation transporter (OCT)3, respectively.	Indican	16-31	solute carrier family 22 member 8	Homo sapiens	168-172	
21611756-3	2011	Our recent research provides novel molecular and functional evidence that indoxyl sulfate, an anionic uremic toxin, undergoes efflux transport at the BBB via OAT3 and creatinine, a uremic guanidino compound, undergoes efflux transport at the BCSFB via OCT3.	Indican	74-89	solute carrier family 22 member 8	Homo sapiens	158-162	
25376195-0	2014	Indoxyl sulfate induces IL-6 expression in vascular endothelial and smooth muscle cells through OAT3-mediated uptake and activation of AhR/NF-kappaB pathway.	Indican	0-15	solute carrier family 22 member 8	Homo sapiens	96-100	
19837111-9	2010	Indoxyl sulfate, a uremic toxin and substrate of OAT1 and OAT3, appears to mediate the progression of AKI evoked by renal ischemia and cisplatin treatment.	Indican	0-15	solute carrier family 22 member 8	Homo sapiens	58-62	
20797565-4	2010	Indoxyl sulfate is taken up by the cells through organic anion transporters (OAT1 and/or OAT3), and induces cellular production of free radicals such as superoxide by activating nicotinamide adenine dinucleotide phosphate oxidase, especially Nox4, thereby impairing the cellular antioxidative system.	Indican	0-15	solute carrier family 22 member 8	Homo sapiens	89-93	
17264878-8	2007	Furthermore, expression of organic anion transporter-3 (OAT-3) that is known to mediate cellular uptake of IS was identified in the primary osteoblast culture.	Indican	107-109	solute carrier family 22 member 8	Homo sapiens	27-54	
17264878-8	2007	Furthermore, expression of organic anion transporter-3 (OAT-3) that is known to mediate cellular uptake of IS was identified in the primary osteoblast culture.	Indican	107-109	solute carrier family 22 member 8	Homo sapiens	56-61	
16825019-6	2006	Indoxyl sulfate was localized in the hOAT1- and hOAT3-positive renal tubular cells in the kidneys of CRF patients.	Indican	0-15	solute carrier family 22 member 8	Homo sapiens	48-53	
16825019-9	2006	In conclusion, in CRF patients, indoxyl sulfate is accumulated in the tubular cells with hOAT1 and/or hOAT3 localized at the basolateral membrane.	Indican	32-47	solute carrier family 22 member 8	Homo sapiens	102-107	
12679137-3	2003	Indoxyl sulfate inhibited human-OAT1, human-OAT3 and human-OAT4, but not human-OAT2, human-OCT1 and human-OCT2.	Indican	0-15	solute carrier family 22 member 8	Homo sapiens	44-48	
12679137-6	2003	In conclusion, by comparing the K(i) values with the plasma concentration of unbound indoxyl sulfate, it was predicted that human-OAT1 and human-OAT3 mediate the transport of indoxyl sulfate in vivo.	Indican	175-190	solute carrier family 22 member 8	Homo sapiens	145-149	
12679137-7	2003	In addition, it was suggested that human-OAT1 and human-OAT3 are involved in the urinary excretion of indoxyl sulfate, the exacerbation of renal dysfunction and the induction of uremic encephalopathy by indoxyl sulfate.	Indican	102-117	solute carrier family 22 member 8	Homo sapiens	56-60	
12679137-7	2003	In addition, it was suggested that human-OAT1 and human-OAT3 are involved in the urinary excretion of indoxyl sulfate, the exacerbation of renal dysfunction and the induction of uremic encephalopathy by indoxyl sulfate.	Indican	203-218	solute carrier family 22 member 8	Homo sapiens	56-60	
12679137-5	2003	Human-OAT1 and human-OAT3 mediated the uptake of indoxyl sulfate and human-OAT4 mediated not only the uptake but also the efflux of indoxyl sulfate.	Indican	49-64	solute carrier family 22 member 8	Homo sapiens	21-25	
12679137-5	2003	Human-OAT1 and human-OAT3 mediated the uptake of indoxyl sulfate and human-OAT4 mediated not only the uptake but also the efflux of indoxyl sulfate.	Indican	132-147	solute carrier family 22 member 8	Homo sapiens	21-25	
12679137-6	2003	In conclusion, by comparing the K(i) values with the plasma concentration of unbound indoxyl sulfate, it was predicted that human-OAT1 and human-OAT3 mediate the transport of indoxyl sulfate in vivo.	Indican	85-100	solute carrier family 22 member 8	Homo sapiens	145-149	
11967025-0	2002	Major role of organic anion transporter 3 in the transport of indoxyl sulfate in the kidney.	Indican	62-77	solute carrier family 22 member 8	Homo sapiens	14-41