PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 32777075-0 2020 HLA DRB1*15:01-DQB1*06:02-restricted human CD4+ T-cells are selectively activated with amoxicillin-peptide adducts. Amoxicillin 87-98 major histocompatibility complex, class II, DR beta 1 Homo sapiens 0-8 32777075-6 2020 This study aimed to (1) investigate whether amoxicillin-modified HLA-DRB1*15:01-DQB1*06:02 binding peptides selectively activate DILI patient T-cells and (2) define the nature of the T-cell response with respective to antigen structure. Amoxicillin 44-55 major histocompatibility complex, class II, DR beta 1 Homo sapiens 65-73 32777075-11 2020 The T-cells response was HLA class II-restricted and the amoxicillin-modified peptides bound selectively to HLA-DRB1*15:01 and/or DQB1*06:02. Amoxicillin 57-68 major histocompatibility complex, class II, DR beta 1 Homo sapiens 108-116 32777075-12 2020 To conclude, we show that amoxicillin-modified peptides bind to both components of the risk haplotype to stimulate DILI patient T-cells and describe the importance of the position of nucleophilic lysine residue in the HLA binding peptide sequence. Amoxicillin 26-37 major histocompatibility complex, class II, DR beta 1 Homo sapiens 218-221 30664875-8 2019 Among amoxicillin- and clavulanate-associated cases of European ancestry, rs2476601 doubled the risk for DILI among those with the HLA risk alleles A*02:01 and DRB1*15:01. Amoxicillin 6-17 major histocompatibility complex, class II, DR beta 1 Homo sapiens 160-164