PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
12564931-0	2003	Hepatocyte apoB-containing lipoprotein secretion is decreased by the grapefruit flavonoid, naringenin, via inhibition of MTP-mediated microsomal triglyceride accumulation.	naringenin	91-101	metallothionein 1B	Homo sapiens	121-124	
12564931-1	2003	Naringenin, the principal flavonoid in grapefruit, reduces plasma lipids in vivo and inhibits apoB secretion, cholesterol esterification, and MTP activity in HepG2 human hepatoma cells.	naringenin	0-10	metallothionein 1B	Homo sapiens	142-145	
12564931-3	2003	We therefore hypothesized that inhibition of TG accumulation in the ER lumen, secondary to MTP inhibition, is the primary mechanism whereby naringenin blocks lipidation and subsequent secretion of apoB.	naringenin	140-150	metallothionein 1B	Homo sapiens	91-94	
12564931-7	2003	Newly synthesized CE accumulation in the lumen was reduced by 80% and 33% with naringenin and BMS-197636, respectively, demonstrating for the first time that MTP is involved in CE accumulation in the microsomal lumen.	naringenin	79-89	metallothionein 1B	Homo sapiens	158-161	
12564931-11	2003	Taken together, our results indicate that naringenin inhibits the lipidation and subsequent secretion of apoB-containing lipoproteins primarily by limiting the accumulation of TG in the ER lumen, secondary to MTP inhibition.	naringenin	42-52	metallothionein 1B	Homo sapiens	209-212