PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
31553923-4	2019	The results showed that Cu2+ supplemented directly into the culture medium or released from Cu-Hier-Ti surface could polarize macrophages to pro-inflammatory M1 phenotype by activating Cu-transport signaling (copper transporter 1 (CTR1) and ATP7A) in macrophages, while the material characteristics exhibited anti-inflammatory effect to some extent by regulating integrin (alpha5, alphaM, beta1 and beta2) and TLR (TLR-3, TLR-4, Myd88 and Ticam-1/2) signaling.	Titanium	100-102	integrin subunit alpha 5	Homo sapiens	363-379