PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 24975671-2 2014 The physiological function of ASGPR has not been completely clarified and is thought to be specific binding and internalization of galactose (Gal) or N-acetylgalactosamine (GalNAc)-terminating glycoproteins by hepatocytes. Galactose 131-140 asialoglycoprotein receptor 1 Homo sapiens 30-35 24975671-2 2014 The physiological function of ASGPR has not been completely clarified and is thought to be specific binding and internalization of galactose (Gal) or N-acetylgalactosamine (GalNAc)-terminating glycoproteins by hepatocytes. Galactose 142-145 asialoglycoprotein receptor 1 Homo sapiens 30-35 24180291-5 2013 This study, therefore, describes the surface functionalization of these materials with galactose, a carbohydrate known to specifically bind to hepatocytes via the asialoglycoprotein receptor (ASGPR), to further improve hepatocyte adhesion and function when growing on the scaffold. Galactose 87-96 asialoglycoprotein receptor 1 Homo sapiens 163-190 24180291-5 2013 This study, therefore, describes the surface functionalization of these materials with galactose, a carbohydrate known to specifically bind to hepatocytes via the asialoglycoprotein receptor (ASGPR), to further improve hepatocyte adhesion and function when growing on the scaffold. Galactose 87-96 asialoglycoprotein receptor 1 Homo sapiens 192-197 23711662-11 2013 It is suggested that the interaction of the galactose units of the polymer brush with the asialoglycoprotein receptor (ASGPR) of HepG2 cells has resulted in the protein enrichment along the cell periphery. Galactose 44-53 asialoglycoprotein receptor 1 Homo sapiens 90-117 23711662-11 2013 It is suggested that the interaction of the galactose units of the polymer brush with the asialoglycoprotein receptor (ASGPR) of HepG2 cells has resulted in the protein enrichment along the cell periphery. Galactose 44-53 asialoglycoprotein receptor 1 Homo sapiens 119-124 22613667-1 2012 Asialoglycoprotein receptor (ASGP-R) is an endocytic C-type lectin receptor in hepatocytes that clears plasma glycoconjugates containing a terminal galactose or N-acetylgalactosamine. Galactose 148-157 asialoglycoprotein receptor 1 Homo sapiens 0-27 23247039-6 2013 Through the recognition between galactose ligand and ASGP-R of HepG2 cells, the endocytosis of galactosylated nanomedicine was significantly promoted, which was demonstrated by confocal laser scanning microscopy and flow cytometry. Galactose 32-41 asialoglycoprotein receptor 1 Homo sapiens 53-59 22613667-1 2012 Asialoglycoprotein receptor (ASGP-R) is an endocytic C-type lectin receptor in hepatocytes that clears plasma glycoconjugates containing a terminal galactose or N-acetylgalactosamine. Galactose 148-157 asialoglycoprotein receptor 1 Homo sapiens 29-35 21351570-1 2010 The asialoglycoprotein receptor (ASGPR) was used to mediate drug carrier for hepatic targeted drug delivery, this article showed the enzyme-catalyzed esterification of galactose and vinyl stearate and a kind of ASGPR ligand-targeted which was used to insert the surface of liposome has been synthesized. Galactose 168-177 asialoglycoprotein receptor 1 Homo sapiens 4-31 21112624-4 2011 Using a blocking assay with free galactose, electron microscopy and co-cultures of HepG2 and non-ASGPR-1 expressing C17.2 cells, the specificity of the particles for the ASGPR-1 receptor was demonstrated. Galactose 33-42 asialoglycoprotein receptor 1 Homo sapiens 170-177 21351570-1 2010 The asialoglycoprotein receptor (ASGPR) was used to mediate drug carrier for hepatic targeted drug delivery, this article showed the enzyme-catalyzed esterification of galactose and vinyl stearate and a kind of ASGPR ligand-targeted which was used to insert the surface of liposome has been synthesized. Galactose 168-177 asialoglycoprotein receptor 1 Homo sapiens 33-38 21351570-1 2010 The asialoglycoprotein receptor (ASGPR) was used to mediate drug carrier for hepatic targeted drug delivery, this article showed the enzyme-catalyzed esterification of galactose and vinyl stearate and a kind of ASGPR ligand-targeted which was used to insert the surface of liposome has been synthesized. Galactose 168-177 asialoglycoprotein receptor 1 Homo sapiens 211-216 20480507-2 2010 A series of galactose-containing polymers has been produced to demonstrate the ease of modification of this polynucleotide delivery vehicle motif via the click reaction and to study how various structural modifications affect recognition by ASGPr on hepatocytes. Galactose 12-21 asialoglycoprotein receptor 1 Homo sapiens 241-246 20403430-2 2010 The conjugates selectively enter hepatocytes after interaction of the carrier galactose residues with the asialoglycoprotein receptor (ASGP-R) present only on these cells. Galactose 78-87 asialoglycoprotein receptor 1 Homo sapiens 106-133 20403430-2 2010 The conjugates selectively enter hepatocytes after interaction of the carrier galactose residues with the asialoglycoprotein receptor (ASGP-R) present only on these cells. Galactose 78-87 asialoglycoprotein receptor 1 Homo sapiens 135-141 20067439-2 2010 In agreement with the "clustering effect" known to occur with more complex oligomeric structures, the addition of galactose residues under optimized spatial arrangement condition invariably increased the transfect efficiency into hepatoma cells, which can be owed to the sufficient binding of galactose ligands to the ASGPR on hepatocytes. Galactose 114-123 asialoglycoprotein receptor 1 Homo sapiens 318-323 20067439-2 2010 In agreement with the "clustering effect" known to occur with more complex oligomeric structures, the addition of galactose residues under optimized spatial arrangement condition invariably increased the transfect efficiency into hepatoma cells, which can be owed to the sufficient binding of galactose ligands to the ASGPR on hepatocytes. Galactose 293-302 asialoglycoprotein receptor 1 Homo sapiens 318-323 19576873-3 2009 METHODS: Rabbit ASGPR was purified by affinity chromatography on galactose-Sepharose and used for standardised detection of anti-ASGPR by ELISA. Galactose 65-74 asialoglycoprotein receptor 1 Homo sapiens 16-21 20641996-23 2004 Because ASGP-R recognizes galactose, (99m)Tc-diethylenetriamine pentaacetic acid-galactosyl-human serum albumin ((99m)Tc-GSA) (3, 4) and (99m)Tc-galactosyl-neoglycoalbumin ((99m)Tc-NGA) (5) are ASGP-R probes that accumulate specifically in the liver and are used for liver scintigraphy to determine liver mass and function. Galactose 26-35 asialoglycoprotein receptor 1 Homo sapiens 8-14 20641386-6 2004 Because ASGP-R recognizes galactose, (99m)Tc-diethylenetriamine pentaacetic acid-galactosyl-human serum albumin ((99m)Tc-GSA) (2, 3) and (99m)Tc-galactosyl-neoglycoalbumin ((99m)Tc-NGA) (4) are ASGP-R probes that accumulate specifically in the liver and are used for liver scintigraphy to determine liver mass and function. Galactose 26-35 asialoglycoprotein receptor 1 Homo sapiens 8-14 20641386-9 2004 (5) conjugated hydrazinonicotinamide (HYNIC) and galactose (via lactobionic acid) to deacetylate chitosan for radiolabeling with (99m)Tc to form (99m)Tc-HYNIC-galactosyl-chitosan ((99m)Tc-HGC) for imaging ASGP-R expression in the liver. Galactose 49-58 asialoglycoprotein receptor 1 Homo sapiens 205-211 20641848-6 2004 Because ASGP-R recognizes galactose, (99m)Tc-diethylenetriamine pentaacetic acid-galactosyl-human serum albumin ((99m)Tc-GSA) (2, 3) and (99m)Tc-galactosyl-neoglycoalbumin ((99m)Tc-NGA) (4) are ASGP-R probes that accumulate specifically in the liver and are used for liver scintigraphy to determine liver mass and function. Galactose 26-35 asialoglycoprotein receptor 1 Homo sapiens 8-14 20641848-9 2004 (5) conjugated galactose (via lactobionic acid) to methylated chitosan for radiolabeling with (99m)Tc to form (99m)Tc-galactosyl-methylated chitosan ((99m)Tc-GMC) for imaging ASGP-R expression in the liver. Galactose 15-24 asialoglycoprotein receptor 1 Homo sapiens 175-181 15648108-3 2004 Through the confocal laser scanning microscopy, it is shown that the endocytosis by interaction between galactose ligands of GCPVP and ASGPR of the hepatocytes was the major route of transfection of GCPVP/F-plasmid complexes. Galactose 104-113 asialoglycoprotein receptor 1 Homo sapiens 135-140 18855599-1 2008 The asialoglycoprotein receptor (ASGPR), an endocytotic cell surface receptor expressed by hepatocytes, is triggered by triantennary binding to galactose residues of macromolecules such as asialoorosomucoid (ASOR). Galactose 144-153 asialoglycoprotein receptor 1 Homo sapiens 4-31 18855599-1 2008 The asialoglycoprotein receptor (ASGPR), an endocytotic cell surface receptor expressed by hepatocytes, is triggered by triantennary binding to galactose residues of macromolecules such as asialoorosomucoid (ASOR). Galactose 144-153 asialoglycoprotein receptor 1 Homo sapiens 33-38 18855599-9 2008 (125)I-ASOR binding to ASGPR on HepG2 cells was confirmed through galactose- and EDTA- challenge studies. Galactose 66-75 asialoglycoprotein receptor 1 Homo sapiens 23-28 16683522-10 2006 The transfection of SG-liposomes were reduced significantly by the 20/30 mmol galactose as a competitor of ASGP-R. Galactose 78-87 asialoglycoprotein receptor 1 Homo sapiens 107-113 18539417-9 2008 The association of Gal-ASPIO-278 to HepG2 cells was reduced by free galactose, supporting the model of ASGPR-mediated binding. Galactose 68-77 asialoglycoprotein receptor 1 Homo sapiens 103-108 15885467-5 2005 By galactose-specific aggregation test of particles using beta-galactose specific lectin, and flow cytometry measurement, specific interaction between asialoglycoprotein receptors (ASGPR) of HepG2, human hepatoma cell line, and galactose moieties of the GEG nanoparticles was confirmed. Galactose 3-12 asialoglycoprotein receptor 1 Homo sapiens 151-179 15885467-6 2005 From cell cytotoxicity test, HepG2 cells with ASGPR are more sensitive to paclitaxel (TX)-loaded nanoparticles than free TX whereas, P388 cells, murine leukemia cell line, and SK-Hep 01, human hepatoma cell line, without ASGPR is less sensitive to TX-loaded nanoparticles than free TX, suggesting that specific interaction between HepG2 cells and galactose moiety of the nanoparticles occurred. Galactose 347-356 asialoglycoprotein receptor 1 Homo sapiens 46-51 12711166-2 2003 The complexes were transfected into hepatocyte through specific interaction of galactose moiety of the GCP and asialoglycoprotein receptors (ASGPR) of the hepatocytes. Galactose 79-88 asialoglycoprotein receptor 1 Homo sapiens 141-146 8005623-7 1993 A direct comparison of the fusion activity of F,HN-virosomes and F-virosomes was made by using desialylated HepG2 cells as target containing the asialoglycoprotein receptor (ASGP-R) that binds to a terminal beta-galactose moiety of F protein. Galactose 212-221 asialoglycoprotein receptor 1 Homo sapiens 145-172 11149519-1 2000 The human hepatic Asialoglycoprotein Receptor (ASGP-R) consists of two different types of liver specific membrane glycoproteins that bind to terminal galactose and N-acetylgalactosamine residues of serum glycoproteins. Galactose 150-159 asialoglycoprotein receptor 1 Homo sapiens 47-53 10844691-6 2000 Binding of wild-type gonococcal LOS to sperm was higher than that of mutant LOS lacking the galactose ligand for ASGP-R. Galactose 92-101 asialoglycoprotein receptor 1 Homo sapiens 113-119 10607305-1 1999 Immunoglobulin A (IgA), which is heavily glycosylated, interacts with a variety of receptors, e.g. the asialoglycoprotein receptor (ASGP-R), which binds terminal galactose residues, and the Fcalpha receptor (FcalphaRI). Galactose 162-171 asialoglycoprotein receptor 1 Homo sapiens 103-130 10607305-1 1999 Immunoglobulin A (IgA), which is heavily glycosylated, interacts with a variety of receptors, e.g. the asialoglycoprotein receptor (ASGP-R), which binds terminal galactose residues, and the Fcalpha receptor (FcalphaRI). Galactose 162-171 asialoglycoprotein receptor 1 Homo sapiens 132-138 9895415-1 1999 Galactose-targeted delivery of macromolecules and drug conjugates to asialoglycoprotein receptor (ASGPR) positive cells has been widely documented in animals, although targeting in humans has never been demonstrated. Galactose 0-9 asialoglycoprotein receptor 1 Homo sapiens 69-96 9895415-1 1999 Galactose-targeted delivery of macromolecules and drug conjugates to asialoglycoprotein receptor (ASGPR) positive cells has been widely documented in animals, although targeting in humans has never been demonstrated. Galactose 0-9 asialoglycoprotein receptor 1 Homo sapiens 98-103 7964611-8 1994 HBV binding to purified ASGPR was saturable and inhibitable by an excess of D-galactose-bearing ligands, by EDTA and anti-receptor immunoglobulin. Galactose 76-87 asialoglycoprotein receptor 1 Homo sapiens 24-29 9555658-11 1998 It is concluded that MC possess ASGP-R specific for galactose residues of several glycoproteins, including IgA1. Galactose 52-61 asialoglycoprotein receptor 1 Homo sapiens 32-38 8005623-7 1993 A direct comparison of the fusion activity of F,HN-virosomes and F-virosomes was made by using desialylated HepG2 cells as target containing the asialoglycoprotein receptor (ASGP-R) that binds to a terminal beta-galactose moiety of F protein. Galactose 212-221 asialoglycoprotein receptor 1 Homo sapiens 174-180 33892061-3 2021 Because galactose group can recognize ASGPR overexpressed on hepatoma cells and morpholine group can target to the lysosome, they are integrated into a dual-targeted lipid material with low toxicity. Galactose 8-17 asialoglycoprotein receptor 1 Homo sapiens 38-43 2005089-1 1991 One proposed function of the asialoglycoprotein receptor in hepatocytes is to mediate the endocytosis of galactose and N-acetylgalactosamine-exposing glycoproteins. Galactose 105-114 asialoglycoprotein receptor 1 Homo sapiens 29-56 33815292-3 2021 It is generally agreed that high sialylation, 2,3 sialic acid capping of terminal N-acetyl galactosamine or galactose leads to longer circulating half-life, by blocking binding of asialoglycoprotein receptor (ASGPR) in the liver. Galactose 108-117 asialoglycoprotein receptor 1 Homo sapiens 180-207 33815292-3 2021 It is generally agreed that high sialylation, 2,3 sialic acid capping of terminal N-acetyl galactosamine or galactose leads to longer circulating half-life, by blocking binding of asialoglycoprotein receptor (ASGPR) in the liver. Galactose 108-117 asialoglycoprotein receptor 1 Homo sapiens 209-214 34508778-1 2021 The hepatic carbohydrate-recognizing asialoglycoprotein receptor (ASGR1) mediates the endocytosis/lysosomal degradation of desialylated glycoproteins following binding to terminal galactose/N-acetylgalactosamine. Galactose 180-189 asialoglycoprotein receptor 1 Homo sapiens 66-71 34595917-3 2021 The hepatocyte-targeting capacities of the aimed compounds followed the W-105 (parent compound) < W-1-5 (monodentate-galactose) < W-2-9 (bidentate-galactose) < W-3-8 (tridentate-galactose) order, which is attributed to the excellent affinity of the galactose ligand to ASGPR and the galactose-cluster recognition effect. Galactose 117-126 asialoglycoprotein receptor 1 Homo sapiens 269-274 34595917-3 2021 The hepatocyte-targeting capacities of the aimed compounds followed the W-105 (parent compound) < W-1-5 (monodentate-galactose) < W-2-9 (bidentate-galactose) < W-3-8 (tridentate-galactose) order, which is attributed to the excellent affinity of the galactose ligand to ASGPR and the galactose-cluster recognition effect. Galactose 147-156 asialoglycoprotein receptor 1 Homo sapiens 269-274 34595917-3 2021 The hepatocyte-targeting capacities of the aimed compounds followed the W-105 (parent compound) < W-1-5 (monodentate-galactose) < W-2-9 (bidentate-galactose) < W-3-8 (tridentate-galactose) order, which is attributed to the excellent affinity of the galactose ligand to ASGPR and the galactose-cluster recognition effect. Galactose 178-187 asialoglycoprotein receptor 1 Homo sapiens 269-274 34595917-3 2021 The hepatocyte-targeting capacities of the aimed compounds followed the W-105 (parent compound) < W-1-5 (monodentate-galactose) < W-2-9 (bidentate-galactose) < W-3-8 (tridentate-galactose) order, which is attributed to the excellent affinity of the galactose ligand to ASGPR and the galactose-cluster recognition effect. Galactose 249-258 asialoglycoprotein receptor 1 Homo sapiens 269-274 35149352-3 2022 The glycol-targeting NO nanogenerator demonstrated specific targeting ability to HepG2 cells owing to the recognition between galactose residues and asialoglycoprotein receptors (ASGPR). Galactose 126-135 asialoglycoprotein receptor 1 Homo sapiens 149-177 35149352-3 2022 The glycol-targeting NO nanogenerator demonstrated specific targeting ability to HepG2 cells owing to the recognition between galactose residues and asialoglycoprotein receptors (ASGPR). Galactose 126-135 asialoglycoprotein receptor 1 Homo sapiens 179-184 35276499-4 2022 Low toxic MP-Gal-1, MP-Gal-2 and MP-Gal-3 exhibited favorable hepatic targeting effect in both cell and tissue levels, which was because the galactose group of probe could be recognized by ASGPR overexpressed on the hepatocytes. Galactose 141-150 asialoglycoprotein receptor 1 Homo sapiens 189-194 35176648-4 2022 These low-toxic probes exhibited excellent hepatic targeting capacity, which is attributed to the specific recognition of asialoglycoprotein receptor (ASGPR) overexpressed on hepatocytes by the galactose group of probes. Galactose 194-203 asialoglycoprotein receptor 1 Homo sapiens 122-149 35176648-4 2022 These low-toxic probes exhibited excellent hepatic targeting capacity, which is attributed to the specific recognition of asialoglycoprotein receptor (ASGPR) overexpressed on hepatocytes by the galactose group of probes. Galactose 194-203 asialoglycoprotein receptor 1 Homo sapiens 151-156 2983337-8 1985 F, the only glycoprotein on the HN- virus, was shown to compete with the galactose-terminated protein asialoorosomucoid for the ASGP-R. Galactose 73-82 asialoglycoprotein receptor 1 Homo sapiens 128-134 33892061-6 2021 The endocytosis of Gal-Mor-LPs was competitively inhibited by galactose, which confirmed the galactose modified liposomes entered hepatoma cells via ASGPR-mediated pathway. Galactose 62-71 asialoglycoprotein receptor 1 Homo sapiens 149-154 33892061-6 2021 The endocytosis of Gal-Mor-LPs was competitively inhibited by galactose, which confirmed the galactose modified liposomes entered hepatoma cells via ASGPR-mediated pathway. Galactose 93-102 asialoglycoprotein receptor 1 Homo sapiens 149-154 32353494-4 2020 Galactose ligands could bind to the asialoglycoprotein receptor (ASGPR) on the surface of hepatocytes. Galactose 0-9 asialoglycoprotein receptor 1 Homo sapiens 36-63 33860988-5 2021 A novel triantennary galactose conjugated quinoline derivative 4 has been synthesized that demonstrates a 17 fold higher binding affinity to isolated ASGPR-H1-CRD protein receptor (K d ~ 54 microM) in comparison to D-Galactose (Kd ~ 900 microM). Galactose 21-30 asialoglycoprotein receptor 1 Homo sapiens 150-155 33212117-3 2021 The GAL residue allows the targeting to the asialo-glycoprotein receptor (ASGPR), overexpressed in HCC cells compared to normal hepatocytes. Galactose 4-7 asialoglycoprotein receptor 1 Homo sapiens 44-72 33212117-3 2021 The GAL residue allows the targeting to the asialo-glycoprotein receptor (ASGPR), overexpressed in HCC cells compared to normal hepatocytes. Galactose 4-7 asialoglycoprotein receptor 1 Homo sapiens 74-79 32936032-3 2021 Asialoglycoprotein receptor (ASGPR) is a C-type lectin expressed in the hepatocyte plasma membrane that efficiently endocytoses glycoproteins exposing galactose (Gal) or N-acetylgalactosamine (GalNAc). Galactose 151-160 asialoglycoprotein receptor 1 Homo sapiens 0-27 32936032-3 2021 Asialoglycoprotein receptor (ASGPR) is a C-type lectin expressed in the hepatocyte plasma membrane that efficiently endocytoses glycoproteins exposing galactose (Gal) or N-acetylgalactosamine (GalNAc). Galactose 151-160 asialoglycoprotein receptor 1 Homo sapiens 29-34 32936032-3 2021 Asialoglycoprotein receptor (ASGPR) is a C-type lectin expressed in the hepatocyte plasma membrane that efficiently endocytoses glycoproteins exposing galactose (Gal) or N-acetylgalactosamine (GalNAc). Galactose 162-165 asialoglycoprotein receptor 1 Homo sapiens 0-27 32936032-3 2021 Asialoglycoprotein receptor (ASGPR) is a C-type lectin expressed in the hepatocyte plasma membrane that efficiently endocytoses glycoproteins exposing galactose (Gal) or N-acetylgalactosamine (GalNAc). Galactose 162-165 asialoglycoprotein receptor 1 Homo sapiens 29-34 32353494-4 2020 Galactose ligands could bind to the asialoglycoprotein receptor (ASGPR) on the surface of hepatocytes. Galactose 0-9 asialoglycoprotein receptor 1 Homo sapiens 65-70 31357127-12 2019 Thus, the carborane-containing PEGylated galactose micelles with ASGP-R targeting can be used as a promising therapeutic vector for effective boron neutron capture therapy of hepatocellular carcinoma. Galactose 41-50 asialoglycoprotein receptor 1 Homo sapiens 65-71 32449085-4 2020 Galactose (GAL) can target the asialoglycoprotein receptor (ASGPR) that is highly expressed on liver cancer cells. Galactose 0-9 asialoglycoprotein receptor 1 Homo sapiens 31-58 32449085-4 2020 Galactose (GAL) can target the asialoglycoprotein receptor (ASGPR) that is highly expressed on liver cancer cells. Galactose 0-9 asialoglycoprotein receptor 1 Homo sapiens 60-65 32449085-4 2020 Galactose (GAL) can target the asialoglycoprotein receptor (ASGPR) that is highly expressed on liver cancer cells. Galactose 11-14 asialoglycoprotein receptor 1 Homo sapiens 31-58 32449085-4 2020 Galactose (GAL) can target the asialoglycoprotein receptor (ASGPR) that is highly expressed on liver cancer cells. Galactose 11-14 asialoglycoprotein receptor 1 Homo sapiens 60-65 31740124-5 2020 The results indicated that the specific recognition of ASGPR over-expressed in hepatocytes by galactose group was an important reason for the good targeting ability of probe QL-Gal-N3. Galactose 94-103 asialoglycoprotein receptor 1 Homo sapiens 55-60 31714050-5 2019 Anti-EpCAM antibodies and galactose-rhodamine-polyacrylamide nanoparticles (Gal-Rh-PAA NPs) specifically recognizing ASGPR are modified on the surface of a graphene film that quenches the rhodamine fluorescence. Galactose 26-35 asialoglycoprotein receptor 1 Homo sapiens 117-122 31756283-2 2019 Galactose specifically binds to the hepatocytes via the asialoglycoprotein receptor (ASGPR) and an increase in galactose density further improves the hepatocyte proliferation and functions. Galactose 0-9 asialoglycoprotein receptor 1 Homo sapiens 56-83 31756283-2 2019 Galactose specifically binds to the hepatocytes via the asialoglycoprotein receptor (ASGPR) and an increase in galactose density further improves the hepatocyte proliferation and functions. Galactose 0-9 asialoglycoprotein receptor 1 Homo sapiens 85-90 27998813-6 2017 The success of the complementary gradient relies on the specific interaction between galactose and asialoglycoprotein receptor (ASGPR) expressed on HepG2 cells. Galactose 85-94 asialoglycoprotein receptor 1 Homo sapiens 128-133 29808997-2 2018 Galactose (Gal) residues recognized by the asialoglycoprotein receptor (ASGPR) can serve as potent targeting moieties for hepatocellular carcinoma (HCC) cells. Galactose 0-9 asialoglycoprotein receptor 1 Homo sapiens 43-70 29808997-2 2018 Galactose (Gal) residues recognized by the asialoglycoprotein receptor (ASGPR) can serve as potent targeting moieties for hepatocellular carcinoma (HCC) cells. Galactose 0-9 asialoglycoprotein receptor 1 Homo sapiens 72-77 29808997-2 2018 Galactose (Gal) residues recognized by the asialoglycoprotein receptor (ASGPR) can serve as potent targeting moieties for hepatocellular carcinoma (HCC) cells. Galactose 0-3 asialoglycoprotein receptor 1 Homo sapiens 43-70 29808997-2 2018 Galactose (Gal) residues recognized by the asialoglycoprotein receptor (ASGPR) can serve as potent targeting moieties for hepatocellular carcinoma (HCC) cells. Galactose 0-3 asialoglycoprotein receptor 1 Homo sapiens 72-77 28155331-6 2017 Galactose-mediated competitive inhibition confirmed ASGPR-mediated uptake of ligand-anchored NPs in HepG2 cell lines. Galactose 0-9 asialoglycoprotein receptor 1 Homo sapiens 52-57 26345600-6 2015 Observation by fluorescence microscopy as well as flow cytometry showed that galactose-containing Curdlan derivatives delivered fluorescently labeled short nucleic acid to HepG2 cells expressing ASGPR receptor but not in other cells lacking surface ASGPR protein. Galactose 77-86 asialoglycoprotein receptor 1 Homo sapiens 195-200 28119125-5 2017 The presence of GAL residues in the polyplexes allows the targeting of HCC cells that express the asialo-glycoprotein receptor (ASGP-R). Galactose 16-19 asialoglycoprotein receptor 1 Homo sapiens 98-126 28119125-5 2017 The presence of GAL residues in the polyplexes allows the targeting of HCC cells that express the asialo-glycoprotein receptor (ASGP-R). Galactose 16-19 asialoglycoprotein receptor 1 Homo sapiens 128-134 26057877-4 2015 We determined the binding of the glycopeptides to the hepatocytes, and we established the optimal distance and orientation of the galactose moieties for interaction with the ASGPR using flow cytometry. Galactose 130-139 asialoglycoprotein receptor 1 Homo sapiens 174-179 26258607-2 2015 Hepatocytes exclusively express asialoglycoprotein receptor (ASGPR), which can recognize and bind to galactose or N-acetylgalactosamine. Galactose 101-110 asialoglycoprotein receptor 1 Homo sapiens 32-59 26258607-2 2015 Hepatocytes exclusively express asialoglycoprotein receptor (ASGPR), which can recognize and bind to galactose or N-acetylgalactosamine. Galactose 101-110 asialoglycoprotein receptor 1 Homo sapiens 61-66 27643636-5 2017 We built a 3D culture platform for hepatocytes-attachment and formation of cell monolayer by interacting the galactose chain of galactosylated alginate gel (GA-gel) with asialoglycoprotein receptor (ASGPR) of hepatocytes. Galactose 109-118 asialoglycoprotein receptor 1 Homo sapiens 170-197 27643636-5 2017 We built a 3D culture platform for hepatocytes-attachment and formation of cell monolayer by interacting the galactose chain of galactosylated alginate gel (GA-gel) with asialoglycoprotein receptor (ASGPR) of hepatocytes. Galactose 109-118 asialoglycoprotein receptor 1 Homo sapiens 199-204 26347169-5 2015 HepG2 cells and rat primary hepatocytes cultured in Polyvinyl alcohol (PVA)/Gelatin hydrogel scaffolds with and without galactose (a ligand for ASGPR) modification are studied using SECM. Galactose 120-129 asialoglycoprotein receptor 1 Homo sapiens 144-149 26347169-6 2015 Systematic investigation of live cells cultured for different durations in scaffolds of different compositions (9:1 and 8:2 PVA:Gelatin with and without galactose) reveals significant improvement in cell-cell communication and proliferation on galactose incorporated scaffolds, thereby demonstrating the positive influence of ASGPR-mediated adhesion. Galactose 153-162 asialoglycoprotein receptor 1 Homo sapiens 326-331 26347169-6 2015 Systematic investigation of live cells cultured for different durations in scaffolds of different compositions (9:1 and 8:2 PVA:Gelatin with and without galactose) reveals significant improvement in cell-cell communication and proliferation on galactose incorporated scaffolds, thereby demonstrating the positive influence of ASGPR-mediated adhesion. Galactose 244-253 asialoglycoprotein receptor 1 Homo sapiens 326-331 26345600-6 2015 Observation by fluorescence microscopy as well as flow cytometry showed that galactose-containing Curdlan derivatives delivered fluorescently labeled short nucleic acid to HepG2 cells expressing ASGPR receptor but not in other cells lacking surface ASGPR protein. Galactose 77-86 asialoglycoprotein receptor 1 Homo sapiens 249-254 26345600-7 2015 Moreover, highly galactose-substituted Curdlan derivatives delivered siRNA specifically to ASGPR-expressing cells and induced RNAi activities, silencing endogenous GAPDH gene expression. Galactose 17-26 asialoglycoprotein receptor 1 Homo sapiens 91-96 25841057-1 2015 Asialoglycoprotein receptors (ASGPR) are hepatocyte bound receptors, which exhibit receptor mediated endocytosis (RME) for galactose specific moieties. Galactose 123-132 asialoglycoprotein receptor 1 Homo sapiens 0-28 26369013-4 2015 Flow cytometry and laser confocal scanning microscopy analyses showed that the galactose-modified liposomes facilitated the intracellular uptake of liposomes into HepG2 via asialoglycoprotein receptor (ASGP-R) mediated endocytosis. Galactose 79-88 asialoglycoprotein receptor 1 Homo sapiens 202-208 25841057-1 2015 Asialoglycoprotein receptors (ASGPR) are hepatocyte bound receptors, which exhibit receptor mediated endocytosis (RME) for galactose specific moieties. Galactose 123-132 asialoglycoprotein receptor 1 Homo sapiens 30-35 25701309-4 2015 ASGPR facilitates internalization by clathrin-mediated endocytosis and exhibits high affinity for carbohydrates specifically galactose, N-acetylgalactosamine and glucose. Galactose 125-134 asialoglycoprotein receptor 1 Homo sapiens 0-5 24515582-5 2014 Mannose- or galactose-displaying HFPCNs recognize and tightly bind to DC-SIGN or ASGP-R lectins on the surface of the mammalian cells, DCEK or HepG2 cells. Galactose 12-21 asialoglycoprotein receptor 1 Homo sapiens 81-87 25368518-7 2014 In the presence of galactose, which competes with lactosyl-PE for the binding to the asialoglycoprotein receptor (ASGP-R), a significant reduction in biological activity was observed, showing that the potentiation of transfection induced by the presence of lactosyl-PE could be due to its specific interaction with ASGP-R, which is overexpressed in HCC. Galactose 19-28 asialoglycoprotein receptor 1 Homo sapiens 85-112 25368518-7 2014 In the presence of galactose, which competes with lactosyl-PE for the binding to the asialoglycoprotein receptor (ASGP-R), a significant reduction in biological activity was observed, showing that the potentiation of transfection induced by the presence of lactosyl-PE could be due to its specific interaction with ASGP-R, which is overexpressed in HCC. Galactose 19-28 asialoglycoprotein receptor 1 Homo sapiens 114-120 25368518-7 2014 In the presence of galactose, which competes with lactosyl-PE for the binding to the asialoglycoprotein receptor (ASGP-R), a significant reduction in biological activity was observed, showing that the potentiation of transfection induced by the presence of lactosyl-PE could be due to its specific interaction with ASGP-R, which is overexpressed in HCC. Galactose 19-28 asialoglycoprotein receptor 1 Homo sapiens 315-321 25155912-2 2014 Galactose or N-acetylgalactosamine is known to be recognized and incorporated into the cells through asialoglycoprotein receptor (ASGPR) that is exclusively expressed on hepatocyte and hepatoma. Galactose 0-9 asialoglycoprotein receptor 1 Homo sapiens 101-128 25155912-2 2014 Galactose or N-acetylgalactosamine is known to be recognized and incorporated into the cells through asialoglycoprotein receptor (ASGPR) that is exclusively expressed on hepatocyte and hepatoma. Galactose 0-9 asialoglycoprotein receptor 1 Homo sapiens 130-135