PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 35284456-0 2022 Green Tea Polyphenols Upregulate the Nrf2 Signaling Pathway and Suppress Oxidative Stress and Inflammation Markers in D-Galactose-Induced Liver Aging in Mice. Galactose 118-129 nuclear factor, erythroid derived 2, like 2 Mus musculus 37-41 34788354-0 2021 Taxifolin retards the D-galactose-induced aging process through inhibiting Nrf2-mediated oxidative stress and regulating the gut microbiota in mice. Galactose 22-33 nuclear factor, erythroid derived 2, like 2 Mus musculus 75-79 34788354-9 2021 Furthermore, TAX decreased the apoptosis of the aging brain by regulating the phosphorylation levels of phosphatidylinositol 3-kinase (PI3K), protein kinase B (AKT), and activating nuclear factor-erythroid 2-related factor 2 (Nrf2), nuclear heme oxygenase-1 (HO-1), and NADH dehydrogenase quinone 1 (NQO1) to maximally moderate the oxidative stress injury that occurred after D-Gal induction. Galactose 376-381 nuclear factor, erythroid derived 2, like 2 Mus musculus 181-224 34788354-9 2021 Furthermore, TAX decreased the apoptosis of the aging brain by regulating the phosphorylation levels of phosphatidylinositol 3-kinase (PI3K), protein kinase B (AKT), and activating nuclear factor-erythroid 2-related factor 2 (Nrf2), nuclear heme oxygenase-1 (HO-1), and NADH dehydrogenase quinone 1 (NQO1) to maximally moderate the oxidative stress injury that occurred after D-Gal induction. Galactose 376-381 nuclear factor, erythroid derived 2, like 2 Mus musculus 226-230 34471563-0 2021 Anwulignan alleviates d-galactose induced renal damage by regulating Nrf2/ARE signaling pathway in mice. Galactose 22-33 nuclear factor, erythroid derived 2, like 2 Mus musculus 69-73 34471563-7 2021 These results suggest that anwulignan significantly alleviates the renal damage by its antioxidant effect through regulating the production of Nrf2/ARE pathway-related proteins in the renal tissue in the d-galactose induced aging mice. Galactose 204-215 nuclear factor, erythroid derived 2, like 2 Mus musculus 143-147 35244654-1 2022 shoots attenuate D-galactose-induced brain injury and cognitive disorders of mice through the PI3K/Akt/Nrf2 pathway. Galactose 17-28 nuclear factor, erythroid derived 2, like 2 Mus musculus 103-107 34896111-1 2022 On D-galactose/AlCl3-induced Alzheimer"s disease-like mice via Nrf2/HO-1 signaling pathways. Galactose 3-14 nuclear factor, erythroid derived 2, like 2 Mus musculus 63-67 34874096-2 2022 Here, we report that natural and D-galactose (D-gal)-induced aging kidneys display marked suppression of antiaging factor NRF2 (nuclear factor erythroid-derived 2-like 2) and KLOTHO, accompanied by upregulations of DNA methyltransferase (DNMT) 1/3a/3b and NRF2/KLOTHO gene promoter hypermethylations. Galactose 33-44 nuclear factor, erythroid derived 2, like 2 Mus musculus 122-126 34874096-2 2022 Here, we report that natural and D-galactose (D-gal)-induced aging kidneys display marked suppression of antiaging factor NRF2 (nuclear factor erythroid-derived 2-like 2) and KLOTHO, accompanied by upregulations of DNA methyltransferase (DNMT) 1/3a/3b and NRF2/KLOTHO gene promoter hypermethylations. Galactose 33-44 nuclear factor, erythroid derived 2, like 2 Mus musculus 128-169 34874096-2 2022 Here, we report that natural and D-galactose (D-gal)-induced aging kidneys display marked suppression of antiaging factor NRF2 (nuclear factor erythroid-derived 2-like 2) and KLOTHO, accompanied by upregulations of DNA methyltransferase (DNMT) 1/3a/3b and NRF2/KLOTHO gene promoter hypermethylations. Galactose 33-44 nuclear factor, erythroid derived 2, like 2 Mus musculus 256-260 34874096-2 2022 Here, we report that natural and D-galactose (D-gal)-induced aging kidneys display marked suppression of antiaging factor NRF2 (nuclear factor erythroid-derived 2-like 2) and KLOTHO, accompanied by upregulations of DNA methyltransferase (DNMT) 1/3a/3b and NRF2/KLOTHO gene promoter hypermethylations. Galactose 46-51 nuclear factor, erythroid derived 2, like 2 Mus musculus 122-126 34874096-2 2022 Here, we report that natural and D-galactose (D-gal)-induced aging kidneys display marked suppression of antiaging factor NRF2 (nuclear factor erythroid-derived 2-like 2) and KLOTHO, accompanied by upregulations of DNA methyltransferase (DNMT) 1/3a/3b and NRF2/KLOTHO gene promoter hypermethylations. Galactose 46-51 nuclear factor, erythroid derived 2, like 2 Mus musculus 128-169 34874096-2 2022 Here, we report that natural and D-galactose (D-gal)-induced aging kidneys display marked suppression of antiaging factor NRF2 (nuclear factor erythroid-derived 2-like 2) and KLOTHO, accompanied by upregulations of DNA methyltransferase (DNMT) 1/3a/3b and NRF2/KLOTHO gene promoter hypermethylations. Galactose 46-51 nuclear factor, erythroid derived 2, like 2 Mus musculus 256-260 34257818-3 2021 We treated D-galactose- (D-gal-) induced aging mice with PTX and measured the changes in behavior, degree of oxidative damage, and mitochondrial ultrastructure and content as well as the expression of nuclear factor erythroid 2-related factor 2- (Nrf2-) mediated antioxidant genes and peroxisome proliferator-activated receptor-gamma coactivator 1-alpha- (PGC-1alpha-) dependent mitochondrial biogenesis genes. Galactose 11-22 nuclear factor, erythroid derived 2, like 2 Mus musculus 201-244 34257818-3 2021 We treated D-galactose- (D-gal-) induced aging mice with PTX and measured the changes in behavior, degree of oxidative damage, and mitochondrial ultrastructure and content as well as the expression of nuclear factor erythroid 2-related factor 2- (Nrf2-) mediated antioxidant genes and peroxisome proliferator-activated receptor-gamma coactivator 1-alpha- (PGC-1alpha-) dependent mitochondrial biogenesis genes. Galactose 11-22 nuclear factor, erythroid derived 2, like 2 Mus musculus 247-251 34257818-5 2021 However, the above antiaging effects of PTX were obviously decreased in the brains of Nrf2-deficient D-gal-induced aging mice. Galactose 101-106 nuclear factor, erythroid derived 2, like 2 Mus musculus 86-90 35153783-0 2022 Nrf2 Signaling Pathway Mediates the Protective Effects of Daphnetin Against D-Galactose Induced-Premature Ovarian Failure. Galactose 76-87 nuclear factor, erythroid derived 2, like 2 Mus musculus 0-4 35153783-11 2022 Moreover, daphnetin, an Nrf2 activator, rescued d-gal-induced POF in a dose-dependent manner, while the protective effect was weakened or even lost in Nrf2 knockout mice. Galactose 48-53 nuclear factor, erythroid derived 2, like 2 Mus musculus 151-155 33506023-0 2021 Alginate Oligosaccharide Ameliorates D-Galactose-Induced Kidney Aging in Mice through Activation of the Nrf2 Signaling Pathway. Galactose 37-48 nuclear factor, erythroid derived 2, like 2 Mus musculus 104-108 33997037-5 2021 Moreover, the immunohistochemistry results of NRF-2 and HO-1 were also detected in the livers of mice in the D-gal/CEp group. Galactose 109-114 nuclear factor, erythroid derived 2, like 2 Mus musculus 46-51 33153341-15 2021 RT-qPCR results showed that AOS suppressed the down-regulation of Nrf2 and HO-1 mRNA expressions induced by D-gal. Galactose 108-113 nuclear factor, erythroid derived 2, like 2 Mus musculus 66-70 33536915-11 2020 In addition, HO-1 inhibitor ZnPP blocked the therapeutic effects of OEA on LPS/D-Gal-induced liver damage and oxidative stress, suggesting crucial role of Nrf-2/HO-1 pathway in the protective effects of OEA in acute liver injury. Galactose 79-84 nuclear factor, erythroid derived 2, like 2 Mus musculus 155-160 33536915-12 2020 Together, these findings demonstrated that OEA protect against the LPS/D-Gal-induced acute liver injury in mice through the inhibition of apoptosis, oxidative stress and inflammation, and its mechanisms might be associated with the Nrf-2/HO-1 and NLRP3 inflammasome signaling pathways. Galactose 71-76 nuclear factor, erythroid derived 2, like 2 Mus musculus 232-237 33200472-0 2021 Agaricus blazei polypeptide exerts a protective effect on D-galactose-induced aging mice via the Keap1/Nrf2/ARE and P53/Trim32 signaling pathways. Galactose 58-69 nuclear factor, erythroid derived 2, like 2 Mus musculus 103-107 33271531-0 2021 The Role of Nrf2 in D-Galactose-Induced Cardiac Aging in Mice: Involvement of Oxidative Stress. Galactose 20-31 nuclear factor, erythroid derived 2, like 2 Mus musculus 12-16 33271531-4 2021 RESULTS AND CONCLUSIONS: D-galactose injection significantly induced cardiac aging, cell apoptosis, and oxidative stress in Nrf2+/+ mice, all of which were further exacerbated in Nrf2-/- mice. Galactose 25-36 nuclear factor, erythroid derived 2, like 2 Mus musculus 124-128 33271531-4 2021 RESULTS AND CONCLUSIONS: D-galactose injection significantly induced cardiac aging, cell apoptosis, and oxidative stress in Nrf2+/+ mice, all of which were further exacerbated in Nrf2-/- mice. Galactose 25-36 nuclear factor, erythroid derived 2, like 2 Mus musculus 179-183 33271531-6 2021 Nrf2 activator CDDO-Im could therefore effectively protect against D-galactose-induced cardiac aging by inhibiting oxidative stress, suggesting that CDDO-Im might be a potential and promising therapeutic candidate drug to treat cardiac aging. Galactose 67-78 nuclear factor, erythroid derived 2, like 2 Mus musculus 0-4 33148324-0 2020 hPMSCs protects against D-galactose-induced oxidative damage of CD4+ T cells through activating Akt-mediated Nrf2 antioxidant signaling. Galactose 24-35 nuclear factor, erythroid derived 2, like 2 Mus musculus 109-113 33159979-0 2021 Vitamin D Exerts Neuroprotection via SIRT1/Nrf-2/ NF-kB Signaling Pathways against D-Galactose-induced Memory Impairment in Adult Mice. Galactose 83-94 nuclear factor, erythroid derived 2, like 2 Mus musculus 43-48 31461273-9 2019 The above results clearly indicate that supplementation of maltol diminishes d-Gal-induced behavioral dysfunction and neurological deficits via activation of the PI3K/Akt-mediated Nrf2/HO-1 signaling pathway in brain. Galactose 77-82 nuclear factor, erythroid derived 2, like 2 Mus musculus 180-184 32099340-12 2020 Conclusion: Anwulignan can restore the immune function that is declined in D-gal-induced aging mice partly related to its antioxidant capacity by activating the Nrf2/ARE pathway and downstream enzymes, as well as its anti-apoptotic effect by regulating Caspase-3 and the ratio of Bcl2 to Bax in the spleen. Galactose 75-80 nuclear factor, erythroid derived 2, like 2 Mus musculus 161-165 32476418-0 2020 Torularhodin from Sporidiobolus pararoseus Attenuates d-galactose/AlCl3-Induced Cognitive Impairment, Oxidative Stress, and Neuroinflammation via the Nrf2/NF-kappaB Pathway. Galactose 54-65 nuclear factor, erythroid derived 2, like 2 Mus musculus 150-154 32158388-0 2020 Bungeanum Improves Cognitive Dysfunction and Neurological Deficits in D-Galactose-Induced Aging Mice via Activating PI3K/Akt/Nrf2 Signaling Pathway. Galactose 70-81 nuclear factor, erythroid derived 2, like 2 Mus musculus 125-129 31630800-0 2020 Trehalose targets Nrf2 signal to alleviate d-galactose induced aging and improve behavioral ability. Galactose 43-54 nuclear factor, erythroid derived 2, like 2 Mus musculus 18-22 31527304-0 2019 Leonurine ameliorates D-galactose-induced aging in mice through activation of the Nrf2 signalling pathway. Galactose 22-33 nuclear factor, erythroid derived 2, like 2 Mus musculus 82-86 30639021-4 2019 The antioxidant-related proteins nuclear factor erythroid 2-related factor 2 (Nrf2) and heme oxygenase-1 (HO-1) were upregulated in liver after treatment of d-galactose-treated aging mice with probiotics. Galactose 157-168 nuclear factor, erythroid derived 2, like 2 Mus musculus 33-76 31431007-5 2019 The inhibition of d-galactose-induced oxidative damage in the liver was correlated with the torularhodin-mediated effects on improving the activity of Nrf2/HO-1, reducing the expression of Bax and NF-kappaB p65 by western blot analysis. Galactose 18-29 nuclear factor, erythroid derived 2, like 2 Mus musculus 151-155 30639021-4 2019 The antioxidant-related proteins nuclear factor erythroid 2-related factor 2 (Nrf2) and heme oxygenase-1 (HO-1) were upregulated in liver after treatment of d-galactose-treated aging mice with probiotics. Galactose 157-168 nuclear factor, erythroid derived 2, like 2 Mus musculus 78-82 30488048-0 2018 Lactobacillus helveticus KLDS1.8701 alleviates d-galactose-induced aging by regulating Nrf-2 and gut microbiota in mice. Galactose 47-58 nuclear factor, erythroid derived 2, like 2 Mus musculus 87-92 30323572-0 2018 Protective effect of Anwulignan against D-galactose-induced hepatic injury through activating p38 MAPK-Nrf2-HO-1 pathway in mice. Galactose 40-51 nuclear factor, erythroid derived 2, like 2 Mus musculus 103-107 28622086-0 2017 Naringenin Ameliorates Behavioral Dysfunction and Neurological Deficits in a d-Galactose-Induced Aging Mouse Model Through Activation of PI3K/Akt/Nrf2 Pathway. Galactose 77-88 nuclear factor, erythroid derived 2, like 2 Mus musculus 146-150 29905928-0 2018 Lactobacillus plantarum AR501 Alleviates the Oxidative Stress of D-Galactose-Induced Aging Mice Liver by Upregulation of Nrf2-Mediated Antioxidant Enzyme Expression. Galactose 65-76 nuclear factor, erythroid derived 2, like 2 Mus musculus 121-125 29437881-9 2018 In conclusion, curcumin effectively inhibited d-gal-induced oxidative stress, apoptosis and ovarian injury via a mechanism involving the Nrf2/HO-1 and PI3K/Akt signaling pathways, suggesting that curcumin is a potential protective agent against POF. Galactose 46-51 nuclear factor, erythroid derived 2, like 2 Mus musculus 137-141 28472605-0 2017 Total Flavonoid Extract from Abelmoschus manihot (L.) Medic Flowers Attenuates d-Galactose-Induced Oxidative Stress in Mouse Liver Through the Nrf2 Pathway. Galactose 79-90 nuclear factor, erythroid derived 2, like 2 Mus musculus 143-147 28757412-0 2017 Quercetin ameliorates learning and memory via the Nrf2-ARE signaling pathway in d-galactose-induced neurotoxicity in mice. Galactose 80-91 nuclear factor, erythroid derived 2, like 2 Mus musculus 50-54 28757412-6 2017 Quercetin also prevented changes in the neuronal cell morphology and apoptosis in the hippocampus as well as increased the expression of Nrf2, HO-1 and SOD in d-galactose-treated mice. Galactose 159-170 nuclear factor, erythroid derived 2, like 2 Mus musculus 137-141 28757412-8 2017 In conclusion, quercetin protected mice from d-galactose-induced cognitive functional impairment and neuronal cell apoptosis via activation of the Nrf2-ARE signaling pathway. Galactose 45-56 nuclear factor, erythroid derived 2, like 2 Mus musculus 147-151 28502776-0 2017 Dried plum and chokeberry ameliorate d-galactose-induced aging in mice by regulation of Pl3k/Akt-mediated Nrf2 and Nf-kB pathways. Galactose 37-48 nuclear factor, erythroid derived 2, like 2 Mus musculus 106-110 28598487-0 2017 Apigenin exhibits protective effects in a mouse model of d-galactose-induced aging via activating the Nrf2 pathway. Galactose 57-68 nuclear factor, erythroid derived 2, like 2 Mus musculus 102-106 27148819-10 2016 Moreover, it appeared that GAL conjugate induced LTB4DH expression via activating the Nrf2/HO-1 pathway. Galactose 27-30 nuclear factor, erythroid derived 2, like 2 Mus musculus 86-90 27148819-12 2016 Taken together, our results suggest that GAL enhances macrophage phagocytosis via sequentially activating Nrf2 and up-regulating LTB4DH expression. Galactose 41-44 nuclear factor, erythroid derived 2, like 2 Mus musculus 106-110 25196440-2 2014 This study was designed to investigate the neuroprotective effects of sulforaphane (an activator of NF-E2-related factor 2) on mice with AD-like lesions induced by combined administration of aluminum and D-galactose. Galactose 204-215 nuclear factor, erythroid derived 2, like 2 Mus musculus 100-122 25701356-0 2015 Fibroblast growth factor (FGF21) protects mouse liver against D-galactose-induced oxidative stress and apoptosis via activating Nrf2 and PI3K/Akt pathways. Galactose 62-73 nuclear factor, erythroid derived 2, like 2 Mus musculus 128-132