PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
31420820-0	2019	Activation of the miR-34a-Mediated SIRT1/mTOR Signaling Pathway by Urolithin A Attenuates D-Galactose-Induced Brain Aging in Mice.	Galactose	90-101	sirtuin 1	Mus musculus	35-40	
31435952-6	2020	The mRNA expression levels of stress-related genes (SOD2, SIRT1 and FOXO3a) were remarkably up-regulated after d-galactose induction, but the up-regulation was weakened or disappeared by the gavage of oyster polypeptides.	Galactose	111-122	sirtuin 1	Mus musculus	58-63	
34938181-1	2021	Skeels on d-Galactose-Induced Aging Model in Mice via Activating the SIRT1/p53 Pathway.	Galactose	10-21	sirtuin 1	Mus musculus	69-74	
29325995-8	2018	These results suggest that AS can execute the prevention and treatment of d-gal-induced brain aging by SIRT1/P53/P21 pathway.	Galactose	74-79	sirtuin 1	Mus musculus	103-108	
31430865-5	2019	In this study, we evaluated the estrogen receptor alpha (ERalpha)/silent mating type information regulation 2 homolog 1 (SIRT1)-dependent antioxidant efficacy of 17beta-estradiol against d-gal-induced oxidative damage-mediated cognitive dysfunction in a male mouse model.	Galactose	187-192	sirtuin 1	Mus musculus	121-126	
31430865-8	2019	Interestingly, inhibition of SIRT1 with Ex527 (a potent and selective SIRT1 inhibitor) further enhanced d-gal-induced toxicity and abolished the beneficial effect of 17beta-estradiol.	Galactose	104-109	sirtuin 1	Mus musculus	29-34	
31430865-8	2019	Interestingly, inhibition of SIRT1 with Ex527 (a potent and selective SIRT1 inhibitor) further enhanced d-gal-induced toxicity and abolished the beneficial effect of 17beta-estradiol.	Galactose	104-109	sirtuin 1	Mus musculus	70-75	
31430865-10	2019	In summary, we can conclude that 17beta-estradiol, in an ERalpha/SIRT1-dependent manner, abrogates d-gal-induced oxidative stress-mediated memory impairment, neuroinflammation, and neurodegeneration in adult mice.	Galactose	99-104	sirtuin 1	Mus musculus	65-70	
30650605-7	2019	Furthermore, ascorbic acid ameliorated D-gal-induced downregulation of superoxide dismutase 1 and 2, sirtuin1, caveolin-1, and brain-derived neurotrophic factor and upregulation of interleukin 1 beta and tumor necrosis factor alpha in the hippocampus.	Galactose	39-44	sirtuin 1	Mus musculus	101-109	
34630111-0	2021	Qiangji Decoction Alleviates Neurodegenerative Changes and Hippocampal Neuron Apoptosis Induced by D-Galactose via Regulating AMPK/SIRT1/NF-kappaB Signaling Pathway.	Galactose	99-110	sirtuin 1	Mus musculus	131-136	
34880753-0	2021	beta-hydroxybutyrate Alleviates Learning and Memory Impairment Through the SIRT1 Pathway in D-Galactose-Injured Mice.	Galactose	92-103	sirtuin 1	Mus musculus	75-80	
34880753-10	2021	Collectively, BHBA inhibited hippocampal OS and the inflammation process to alleviate learning and memory impairment through activating the SIRT1 pathway in D-gal-injured mice, suggesting that BHBA could be a potential option for drug development of learning and memory impairment induced by nervous system injuries.	Galactose	157-162	sirtuin 1	Mus musculus	140-145	
33872003-0	2021	Ameliorative Effect of Dietary Tryptophan on Neurodegeneration and Inflammation in d-Galactose-Induced Aging Mice with the Potential Mechanism Relying on AMPK/SIRT1/PGC-1alpha Pathway and Gut Microbiota.	Galactose	83-94	sirtuin 1	Mus musculus	159-164	
35053883-0	2022	2"-Fucosyllactose Ameliorates Oxidative Stress Damage in d-Galactose-Induced Aging Mice by Regulating Gut Microbiota and AMPK/SIRT1/FOXO1 Pathway.	Galactose	57-68	sirtuin 1	Mus musculus	126-131	
33678756-4	2021	These data indicated that treatment with the SIRT1 activator SRT1720 alleviated LPS/D-Gal-induced fulminant hepatitis, which might be attributed to the suppressive effects of SRT1720 on TNF-alpha production and the subsequent activation of the apoptosis cascade.	Galactose	84-89	sirtuin 1	Mus musculus	45-50	
33159979-0	2021	Vitamin D Exerts Neuroprotection via SIRT1/Nrf-2/ NF-kB Signaling Pathways against D-Galactose-induced Memory Impairment in Adult Mice.	Galactose	83-94	sirtuin 1	Mus musculus	37-42