PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
30610105-4	2019	The mechanism of CF3DODA-Me-induced Sp-downregulation involved ROS-dependent repression of c-Myc and cMyc-regulated miR-27a and miR-17/20a, and this resulted in induction of the miRNA-regulated Sp repressors ZBTB4, ZBTB10, and ZBTB34.	sp	36-38	zinc finger and BTB domain containing 10	Homo sapiens	215-221	
26673922-8	2015	Sulindac sulfide also induced reactive oxygen species (ROS) and decreased the level of microRNA-27a in colon cancer cells, which resulted in the upregulation of the Sp-repressor ZBTB10 and this resulted in downregulation of Sp proteins.	sp	165-167	zinc finger and BTB domain containing 10	Homo sapiens	178-184	
26673922-8	2015	Sulindac sulfide also induced reactive oxygen species (ROS) and decreased the level of microRNA-27a in colon cancer cells, which resulted in the upregulation of the Sp-repressor ZBTB10 and this resulted in downregulation of Sp proteins.	sp	224-226	zinc finger and BTB domain containing 10	Homo sapiens	178-184	
23530649-8	2013	RQ decreased microRNA-27a (miR-27a) and induced zinc finger protein ZBTB10, an Sp-repressor, suggesting that interactions of RQ with the miR-27a-ZBTB10-axis play a role in Sp downregulation.	sp	79-81	zinc finger and BTB domain containing 10	Homo sapiens	68-74	
23471840-5	2013	Additionally, Sp1, Sp3, and Sp4 and Sp-regulated genes were downregulated by curcuminoids in SW-480 and this was accompanied by suppression of microRNA-27a (miR-27a) and induction of ZBTB10, an mRNA target of miR-27a and a transcriptional repressor of Sp expression.	sp	14-16	zinc finger and BTB domain containing 10	Homo sapiens	183-189	
24173369-8	2014	QH decreased microRNA-27a (miR-27a) and induced the zinc finger protein ZBTB10, an Sp-repressor, suggesting that interactions between QH and the miR-27a-ZBTB10 axis play a role in Sp downregulation.	sp	83-85	zinc finger and BTB domain containing 10	Homo sapiens	72-78	
24173369-8	2014	QH decreased microRNA-27a (miR-27a) and induced the zinc finger protein ZBTB10, an Sp-repressor, suggesting that interactions between QH and the miR-27a-ZBTB10 axis play a role in Sp downregulation.	sp	83-85	zinc finger and BTB domain containing 10	Homo sapiens	153-159	
24173369-8	2014	QH decreased microRNA-27a (miR-27a) and induced the zinc finger protein ZBTB10, an Sp-repressor, suggesting that interactions between QH and the miR-27a-ZBTB10 axis play a role in Sp downregulation.	sp	180-182	zinc finger and BTB domain containing 10	Homo sapiens	72-78	
24173369-8	2014	QH decreased microRNA-27a (miR-27a) and induced the zinc finger protein ZBTB10, an Sp-repressor, suggesting that interactions between QH and the miR-27a-ZBTB10 axis play a role in Sp downregulation.	sp	180-182	zinc finger and BTB domain containing 10	Homo sapiens	153-159	
23530649-8	2013	RQ decreased microRNA-27a (miR-27a) and induced zinc finger protein ZBTB10, an Sp-repressor, suggesting that interactions of RQ with the miR-27a-ZBTB10-axis play a role in Sp downregulation.	sp	79-81	zinc finger and BTB domain containing 10	Homo sapiens	145-151	
23530649-8	2013	RQ decreased microRNA-27a (miR-27a) and induced zinc finger protein ZBTB10, an Sp-repressor, suggesting that interactions of RQ with the miR-27a-ZBTB10-axis play a role in Sp downregulation.	sp	172-174	zinc finger and BTB domain containing 10	Homo sapiens	68-74	
23530649-8	2013	RQ decreased microRNA-27a (miR-27a) and induced zinc finger protein ZBTB10, an Sp-repressor, suggesting that interactions of RQ with the miR-27a-ZBTB10-axis play a role in Sp downregulation.	sp	172-174	zinc finger and BTB domain containing 10	Homo sapiens	145-151	
22583404-6	2012	ROS decreases expression of microRNA-27a (miR-27a) and miR-20a/miR-17-5p and this results in the induction of the transcriptional "Sp-repressors" ZBTB10 and ZBTB4, respectively, which in turn downregulate Sp and Sp-regulated genes.	sp	131-133	zinc finger and BTB domain containing 10	Homo sapiens	146-152	
22583404-6	2012	ROS decreases expression of microRNA-27a (miR-27a) and miR-20a/miR-17-5p and this results in the induction of the transcriptional "Sp-repressors" ZBTB10 and ZBTB4, respectively, which in turn downregulate Sp and Sp-regulated genes.	sp	205-207	zinc finger and BTB domain containing 10	Homo sapiens	146-152	
22583404-6	2012	ROS decreases expression of microRNA-27a (miR-27a) and miR-20a/miR-17-5p and this results in the induction of the transcriptional "Sp-repressors" ZBTB10 and ZBTB4, respectively, which in turn downregulate Sp and Sp-regulated genes.	sp	205-207	zinc finger and BTB domain containing 10	Homo sapiens	146-152	
21156786-6	2011	GT-094-mediated repression of Sp and Sp-regulated gene products was due to downregulation of microRNA-27a (miR-27a) and induction of ZBTB10, an Sp repressor that is regulated by miR-27a in colon cancer cells.	sp	37-39	zinc finger and BTB domain containing 10	Homo sapiens	133-139	
22334592-5	2012	This response was due to induction of the Sp repressors ZBTB10 and ZBTB4 and downregulation of miR-27a and miR-20a/17-5p, respectively, which regulate expression of these transcriptional repressors.	sp	42-44	zinc finger and BTB domain containing 10	Homo sapiens	56-62	
22334592-6	2012	Thus, the anticancer activity of CSL in 253JB-V cells is due to induction of ROS and ROS-mediated induction of Sp repressors (ZBTB4/ZBTB10) through downregulation of miR-27a and miR-20a/17-5p.	sp	111-113	zinc finger and BTB domain containing 10	Homo sapiens	132-138	
23194063-8	2012	The mechanism of curcumin-/RL197-induced repression of Sp transcription factors was ROS-dependent and due to induction of the Sp repressors ZBTB10 and ZBTB4 and downregulation of microRNAs (miR)-27a, miR-20a and miR-17-5p that regulate these repressors.	sp	55-57	zinc finger and BTB domain containing 10	Homo sapiens	140-146	
21156786-6	2011	GT-094-mediated repression of Sp and Sp-regulated gene products was due to downregulation of microRNA-27a (miR-27a) and induction of ZBTB10, an Sp repressor that is regulated by miR-27a in colon cancer cells.	sp	37-39	zinc finger and BTB domain containing 10	Homo sapiens	133-139	
20488920-6	2010	Repression of Sp and Sp-dependent genes by CDDO-Me was due to the down-regulation of microRNA-27a and induction of zinc finger and BTB domain containing 10 (ZBTB10), an Sp repressor, and these responses were also reversed by antioxidants.	sp	14-16	zinc finger and BTB domain containing 10	Homo sapiens	157-163	
20488920-6	2010	Repression of Sp and Sp-dependent genes by CDDO-Me was due to the down-regulation of microRNA-27a and induction of zinc finger and BTB domain containing 10 (ZBTB10), an Sp repressor, and these responses were also reversed by antioxidants.	sp	21-23	zinc finger and BTB domain containing 10	Homo sapiens	157-163	
20382698-4	2010	as-miR-27a and overexpression of ZBTB10 inhibited 17beta-estradiol (E2)-induced transactivation in MCF-7 cells, and this was accompanied by decreased binding of Sp and ER proteins in cell lysates to oligonucleotides containing GC-rich motifs or estrogen-responsive elements, respectively.	sp	161-163	zinc finger and BTB domain containing 10	Homo sapiens	33-39