PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
14991602-7	2004	The CD4+ SP/CD8+ SP T cell ratio was decreased in Trp53(-/-) splenocytes and thymocytes.	sp	9-11	CD4 antigen	Mus musculus	4-7	
14991602-7	2004	The CD4+ SP/CD8+ SP T cell ratio was decreased in Trp53(-/-) splenocytes and thymocytes.	sp	17-19	CD4 antigen	Mus musculus	4-7	
11120804-4	2000	One phenotypic change seen in the AML1-diminished mice was the reduction in the numbers of both CD4 SP and CD8 SP thymocytes, reflecting the partial impairment of the transition from the double-positive to SP stage.	sp	100-102	CD4 antigen	Mus musculus	96-99	
14971027-1	2004	In normal mice, more than 10% of thymocytes in the CD4+CD8- and CD4-CD8+ single-positive (SP) subsets express a medium level of CD3 on the cell surface.	sp	90-92	CD4 antigen	Mus musculus	64-67	
12121437-3	2002	There was a lower ratio of CD4 single-positive (SP) to CD8 SP cells and decreased apoptosis of CD4+CD8+ (DP) thymocytes from Apaf-1-/- mice compared with wild-type.	sp	48-50	CD4 antigen	Mus musculus	27-30	
10499914-9	1999	They also indicate that the TCR-MHC class II interaction(s) required for the intrathymic development of long-lived CD4(+) SP cells occurs before the CD4(hi) SP stage of development.	sp	122-124	CD4 antigen	Mus musculus	115-118	
9782318-3	1998	Single positive (SP) CD4+ or CD8+ cells strongly increased in the liver.	sp	17-19	CD4 antigen	Mus musculus	21-24	
9295041-1	1997	Thymocytes with a CD4(hi)CD8(lo) coreceptor-skewed (CRS) phenotype have been shown to contain precursors for CD8 single-positive (SP) thymocytes, in addition to precursors for CD4 SP cells.	sp	130-132	CD4 antigen	Mus musculus	18-21	
8671615-7	1996	We found that pretreatment of DP thymocytes with ionomycin and PMA followed by 1 day culture of the cells without the reagents resulted in the differentiation of the cells into CD4 SP and CD4+ CD8lo T cells that have mostly committed to the CD4 lineage.	sp	181-183	CD4 antigen	Mus musculus	177-180	
9166429-6	1997	Correlation with CD4 and CD8 levels suggests that 9-O-acetylation appears as an early differentiation marker as cells mature from the DP to the CD4 SP phenotype.	sp	148-150	CD4 antigen	Mus musculus	144-147	
24100390-8	2013	These results suggest that ROS may be involved in promoting the functional maturation of CD4(+) SPs and thymic medullary microenvironment contributes to the pro-oxidant shift of SP thymocytes.	sp	96-98	CD4 antigen	Mus musculus	89-92	
7803485-5	1994	The CD4+ and CD8+ single positive (SP) and CD4-CD8- double negative (DN) subsets, in the low-density subpopulation in particular, were most resistant to the Dex-mediated depletion, thus giving rise to an enrichment of SP (2-fold) and particularly DN subset in the medium- and low-density populations (5-fold) recovered.	sp	35-37	CD4 antigen	Mus musculus	4-7	
7803485-5	1994	The CD4+ and CD8+ single positive (SP) and CD4-CD8- double negative (DN) subsets, in the low-density subpopulation in particular, were most resistant to the Dex-mediated depletion, thus giving rise to an enrichment of SP (2-fold) and particularly DN subset in the medium- and low-density populations (5-fold) recovered.	sp	218-220	CD4 antigen	Mus musculus	4-7	
1535784-3	1992	Intravenous transfer of CD3low CD4 SP cells into nude mice resulted in significant peripheral expansion of these cells with apparent upregulation of CD3.	sp	35-37	CD4 antigen	Mus musculus	31-34	
24592261-12	2014	Approximately 46.3% of CD4 SP and 27% of CD8 SP thymocytes divide before dying or exiting the thymus.	sp	27-29	CD4 antigen	Mus musculus	23-26	
7511929-8	1994	Both single-positive (SP) subsets were largely Fas+ (CD8 SP < CD4 SP) but expressed lower levels of Fas than DP cells.	sp	22-24	CD4 antigen	Mus musculus	65-68	
2140562-6	1990	The proportion of J11d+ cells in the CD4+ SP thymocytes transiently increased from day 12 to 14 and decreased thereafter, even though almost half of CD4+ SP cells were still dull J11d+ at day 35 after BMT.	sp	42-44	CD4 antigen	Mus musculus	37-40	
24820417-2	2014	Conditional inactivation of F-box protein Fbw7 in mouse T-cell development resulted in reduced thymic CD4 single-positive (SP) and splenic CD4(+) and CD8(+) cell proportions.	sp	123-125	CD4 antigen	Mus musculus	102-105	
21950267-10	2012	There was significant increase in the percentage of CD4+FOXP3+ and CD4+CD25+ cells in the SP group, indicating the significant role of Tregs in immune regulation.	sp	90-92	CD4 antigen	Mus musculus	52-55	
23093039-16	2012	Our lab has developed the HY(cd4) model, in which the transgenic HY TCRalpha is conditionally expressed at the DP stage, allowing negative selection to occur during the DP to SP transition as occurs in wildtype mice(10).	sp	175-177	CD4 antigen	Mus musculus	29-32	
21950267-10	2012	There was significant increase in the percentage of CD4+FOXP3+ and CD4+CD25+ cells in the SP group, indicating the significant role of Tregs in immune regulation.	sp	90-92	CD4 antigen	Mus musculus	67-70	
20599940-4	2010	This occurs at the transition from a double positive (DP) to a single positive (SP) phenotype, resulting in higher numbers of CD4 and CD8 SP cells, and to a lesser extent at the transition from double negative (DN) to DP cells.	sp	80-82	CD4 antigen	Mus musculus	126-129	
17604837-8	2008	Triggering the CD3/TCR complex together with co-stimulation applied by rVCAM-1 or rICAM-1 induced the generation of CD4+ single positive (SP) thymocytes from CD4+CD8+ DP thymocytes whereas either signal alone did not result in generation of CD4+ SP thymocytes.	sp	138-140	CD4 antigen	Mus musculus	116-119	
17604837-8	2008	Triggering the CD3/TCR complex together with co-stimulation applied by rVCAM-1 or rICAM-1 induced the generation of CD4+ single positive (SP) thymocytes from CD4+CD8+ DP thymocytes whereas either signal alone did not result in generation of CD4+ SP thymocytes.	sp	138-140	CD4 antigen	Mus musculus	158-161	
17604837-8	2008	Triggering the CD3/TCR complex together with co-stimulation applied by rVCAM-1 or rICAM-1 induced the generation of CD4+ single positive (SP) thymocytes from CD4+CD8+ DP thymocytes whereas either signal alone did not result in generation of CD4+ SP thymocytes.	sp	138-140	CD4 antigen	Mus musculus	158-161	
17604837-8	2008	Triggering the CD3/TCR complex together with co-stimulation applied by rVCAM-1 or rICAM-1 induced the generation of CD4+ single positive (SP) thymocytes from CD4+CD8+ DP thymocytes whereas either signal alone did not result in generation of CD4+ SP thymocytes.	sp	246-248	CD4 antigen	Mus musculus	116-119	
17493961-2	2007	Here, we show that in the perivascular spaces (PVS) of mice surrounding large blood vessels, CD117-positive hematopoietic progenitor cells, CD4 single-positive (SP) and CD8SP T cells are located.	sp	161-163	CD4 antigen	Mus musculus	140-143	
23300712-4	2012	We demonstrate here that conventional SP CD4+ thymocytes bearing autoreactive TCRs drive a homeostatic process that fine-tunes medullary plasticity in adult mice by governing the expansion and patterning of the medulla.	sp	38-40	CD4 antigen	Mus musculus	41-44