PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
14711880-4	2004	By depleting Wee1 protein levels using antisense morpholino oligonucleotides, we show that Wee1 regulates M-phase entry and Cdc2 tyrosine phosphorylation in early gastrula embryos.	Tyrosine	129-137	WEE2 oocyte meiosis inhibiting kinase S homeolog	Xenopus laevis	13-17	
17961226-6	2007	Overexpression of Wee1 caused cell cycle delay and tyrosine phosphorylation of Cdks prior to the MBT.	Tyrosine	51-59	WEE2 oocyte meiosis inhibiting kinase S homeolog	Xenopus laevis	18-22	
17961226-8	2007	Overexpression of Wee1 also resulted in post-MBT apoptosis, tyrosine phosphorylation of Cdks and persistence of cyclin E/Cdk2 activity.	Tyrosine	60-68	WEE2 oocyte meiosis inhibiting kinase S homeolog	Xenopus laevis	18-22	
14711880-4	2004	By depleting Wee1 protein levels using antisense morpholino oligonucleotides, we show that Wee1 regulates M-phase entry and Cdc2 tyrosine phosphorylation in early gastrula embryos.	Tyrosine	129-137	WEE2 oocyte meiosis inhibiting kinase S homeolog	Xenopus laevis	91-95	
14711880-6	2004	In addition, Wee1 is positively regulated by tyrosine autophosphorylation in early gastrula embryos and this upregulation of Wee1 activity is required for normal gastrulation.	Tyrosine	45-53	WEE2 oocyte meiosis inhibiting kinase S homeolog	Xenopus laevis	13-17	
14711880-6	2004	In addition, Wee1 is positively regulated by tyrosine autophosphorylation in early gastrula embryos and this upregulation of Wee1 activity is required for normal gastrulation.	Tyrosine	45-53	WEE2 oocyte meiosis inhibiting kinase S homeolog	Xenopus laevis	125-129	
10601234-2	1999	In Xenopus egg extracts, the inhibitory phosphorylations of Cdc2 on Tyr-15 and Thr-14 are controlled by the phosphatase Cdc25 and the kinases Myt1 and Wee1.	Tyrosine	68-71	WEE2 oocyte meiosis inhibiting kinase S homeolog	Xenopus laevis	151-155	
11134069-15	2000	We have demonstrated a specific interaction between tyrosine-phosphorylated Wee1 and the Crk SH2 domain and have shown that recombinant Wee1 can restore apoptosis to an extract depleted of SH2 interactors.	Tyrosine	52-60	WEE2 oocyte meiosis inhibiting kinase S homeolog	Xenopus laevis	76-80	
11134069-15	2000	We have demonstrated a specific interaction between tyrosine-phosphorylated Wee1 and the Crk SH2 domain and have shown that recombinant Wee1 can restore apoptosis to an extract depleted of SH2 interactors.	Tyrosine	52-60	WEE2 oocyte meiosis inhibiting kinase S homeolog	Xenopus laevis	136-140	
11251070-1	2001	Wee1 inactivates the Cdc2-cyclin B complex during interphase by phosphorylating Cdc2 on Tyr-15.	Tyrosine	88-91	WEE2 oocyte meiosis inhibiting kinase S homeolog	Xenopus laevis	0-4	
10072389-7	1999	We find that Xe-Wee1 tyrosine autophosphorylation positively regulates Xe-Wee1 and is only detected in the first 30 min of the first cell cycle.	Tyrosine	21-29	WEE2 oocyte meiosis inhibiting kinase S homeolog	Xenopus laevis	13-20	
10072389-7	1999	We find that Xe-Wee1 tyrosine autophosphorylation positively regulates Xe-Wee1 and is only detected in the first 30 min of the first cell cycle.	Tyrosine	21-29	WEE2 oocyte meiosis inhibiting kinase S homeolog	Xenopus laevis	71-78	
10072389-8	1999	The level and duration of Xe-Wee1 tyrosine phosphorylation is elevated significantly when the first cell cycle is elongated with nondegradable Mos.	Tyrosine	34-42	WEE2 oocyte meiosis inhibiting kinase S homeolog	Xenopus laevis	26-33	
10072389-9	1999	Importantly, we show that the tyrosine phosphorylation of Xe-Wee1 is required for the Mos-mediated M-phase delay.	Tyrosine	30-38	WEE2 oocyte meiosis inhibiting kinase S homeolog	Xenopus laevis	58-65	
9486797-4	1998	A dominant negative form of Xe-wee1 (KM wee1) reduced the level cdc2 tyrosine phosphorylation and length of the first cycle.	Tyrosine	69-77	WEE2 oocyte meiosis inhibiting kinase S homeolog	Xenopus laevis	28-35	
9486797-4	1998	A dominant negative form of Xe-wee1 (KM wee1) reduced the level cdc2 tyrosine phosphorylation and length of the first cycle.	Tyrosine	69-77	WEE2 oocyte meiosis inhibiting kinase S homeolog	Xenopus laevis	31-35	
7749193-2	1995	The recombinant Xenopus Wee1 protein efficiently phosphorylates Cdc2 exclusively on Tyr-15 in a cyclin-dependent manner.	Tyrosine	84-87	WEE2 oocyte meiosis inhibiting kinase S homeolog	Xenopus laevis	24-28	
7749193-3	1995	The addition of exogenous Wee1 protein to Xenopus cell cycle extracts results in a dose-dependent delay of mitotic initiation that is accompanied by enhanced tyrosine phosphorylation of Cdc2.	Tyrosine	158-166	WEE2 oocyte meiosis inhibiting kinase S homeolog	Xenopus laevis	26-30	
7569953-3	1995	Although Wee1 has been identified as the kinase that phosphorylates tyrosine-15 in various organisms, the threonine-14-specific kinase has not been isolated.	Tyrosine	68-76	WEE2 oocyte meiosis inhibiting kinase S homeolog	Xenopus laevis	9-13	
7569953-4	1995	A complementary DNA was cloned from Xenopus that encodes Myt1, a member of the Wee1 family that was discovered to phosphorylate Cdc2 efficiently on both threonine-14 and tyrosine-15.	Tyrosine	170-178	WEE2 oocyte meiosis inhibiting kinase S homeolog	Xenopus laevis	79-83	
8573790-6	1995	Dwee1 kinase is closely related to human and Xenopus Wee1 homologues, and can inhibit Cdc2 activity by phosphorylating a critical tyrosine residue.	Tyrosine	130-138	WEE2 oocyte meiosis inhibiting kinase S homeolog	Xenopus laevis	53-57