PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
21056997-9	2010	Leptin receptor-free tumor cells display reduced STAT3 tyrosine phosphorylation on residue Y705 but have increased serine phosphorylation on residue S727, consistent with preserved mitochondrial function in the absence of the leptin receptor.	Tyrosine	55-63	leptin	Mus musculus	0-6	
20360640-5	2010	RESULTS: SH2B1 dramatically enhanced the leptin-stimulated tyrosine phosphorylation of JAK2 and IRS2 in HEK293 cells stably expressing LRb (HEK239(LRb)).	Tyrosine	59-67	leptin	Mus musculus	41-47	
20068132-2	2010	Leptin binding to LepRb initiates signaling by activating the associated Janus kinase 2 (Jak2) tyrosine kinase, which promotes the phosphorylation of tyrosine residues on the intracellular tail of LepRb.	Tyrosine	95-103	leptin	Mus musculus	0-6	
22685316-2	2012	Leptin"s actions are mediated by signaling events initiated by phosphorylation of tyrosine residues on the long form of the leptin receptor.	Tyrosine	82-90	leptin	Mus musculus	0-6	
19524014-3	2009	We found that leptin increased Sam68 tyrosine-phosphorylation so decreasing its poly(U)-binding capacity.	Tyrosine	37-45	leptin	Mus musculus	14-20	
10080923-0	1999	Tyrosine phosphorylation of STAT3 by leptin through leptin receptor in mouse metaphase 2 stage oocyte.	Tyrosine	0-8	leptin	Mus musculus	37-43	
10080923-6	1999	Leptin at 15 ng/ml, the concentration observed in follicular fluid, caused tyrosine phosphorylation of STAT3 in mouse M2 stage oocytes.	Tyrosine	75-83	leptin	Mus musculus	0-6	
9434783-1	1997	Leptin at 1-5 nM, the concentrations observed in obese subjects, caused an increase in the active form of mitogen-activated protein kinase (MAPK) that was accompanied by increased tyrosine phosphorylation of STAT-1 and STAT-3 in a mouse pancreatic beta cell line, MIN6.	Tyrosine	180-188	leptin	Mus musculus	0-6	
33045434-12	2020	Compared to HSD2OB/OCY mice, leptin-resistant wild-type mice displayed attenuated sympathetic outflow, with reduced tyrosine hydroxylase expression in both the hypothalamus and thermogenic adipose tissues.	Tyrosine	116-124	leptin	Mus musculus	29-35	
30269370-6	2019	In contrast, mutation of LepRb Tyr 985 , which blocks SHP2/SOCS3 recruitment to LepRb and contributes to leptin hypersensitivity, promoted increased femur bone density only in male mice, while marrow adiposity and bone growth were not affected.	Tyrosine	31-34	leptin	Mus musculus	105-111	
19015522-0	2008	Tyrosine-dependent and -independent actions of leptin receptor in control of energy balance and glucose homeostasis.	Tyrosine	0-8	leptin	Mus musculus	47-53	
19015522-3	2008	Here, we generated 2 knockin lines of mice expressing mutant leptin receptors with phenylalanine substitution for all 3 tyrosines (Y123F) or for Tyr(1138) alone (Y3F).	Tyrosine	120-129	leptin	Mus musculus	61-67	
14698207-4	2003	Native murine leptin (1-147) enhanced aldosterone and corticosterone secretion from dispersed ZG and ZF/R cells, and similar effects were elicited by murine leptin fragment 116-130, and human leptin fragments 138-167, 150-167 and [Tyr] 26-39.	Tyrosine	231-234	leptin	Mus musculus	14-20	
24024119-2	2012	Leptin binding to its receptor (LepR-b) promotes the tyrosine phosphorylation of three sites on LepR-b, each of which mediates distinct downstream signals.	Tyrosine	53-61	leptin	Mus musculus	0-6	
22685316-2	2012	Leptin"s actions are mediated by signaling events initiated by phosphorylation of tyrosine residues on the long form of the leptin receptor.	Tyrosine	82-90	leptin	Mus musculus	124-130	
22685316-4	2012	In this report, we assessed leptin receptor-mediated ERK activation, a pathway that was ablated in the l/l mouse through a mutation of the tyrosine 985 residue in the leptin receptor, to determine its role in host defense against bacterial pneumonia in vivo and in alveolar macrophage (AM) antibacterial functions in vitro.	Tyrosine	139-147	leptin	Mus musculus	28-34	
22685316-4	2012	In this report, we assessed leptin receptor-mediated ERK activation, a pathway that was ablated in the l/l mouse through a mutation of the tyrosine 985 residue in the leptin receptor, to determine its role in host defense against bacterial pneumonia in vivo and in alveolar macrophage (AM) antibacterial functions in vitro.	Tyrosine	139-147	leptin	Mus musculus	167-173	
21521753-3	2011	Leptin action is mediated by phosphorylation of several tyrosine residues on LepRb.	Tyrosine	56-64	leptin	Mus musculus	0-6	
21124310-7	2011	Mutation of tyrosine 985 or 1138 in the intracellular domain of the leptin receptor, which mediates signaling through the SH2-containing tyrosine phosphatase/extracellular signal-regulated kinase (SHP2/ERK) and signal transducer and activator of transcription 3 (STAT3) pathways, respectively, demonstrated that both were important for mucosal protection.	Tyrosine	12-20	leptin	Mus musculus	68-74