PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 18809728-5 2008 Moreover, we demonstrate that although Abl does not regulate the recruitment of CrkL-C3G into the membrane, it does affect the tyrosine phosphorylation of C3G, which is required for its guanine nucleotide exchange factor activity toward Rap1. Tyrosine 127-135 Rap guanine nucleotide exchange factor 1 Homo sapiens 155-158 24396067-6 2014 We also showed that CTLA-4 receptor signaling mediates tyrosine phosphorylation in the C3G protein, and that this is required for augmented activation of Rap1 and increased adhesion mediated by leukocyte function-associated antigen type 1 (LFA-1). Tyrosine 55-63 Rap guanine nucleotide exchange factor 1 Homo sapiens 87-90 18981215-7 2009 The other two tyrosines are required to stimulate a Crk/CrkL-C3G pathway. Tyrosine 14-23 Rap guanine nucleotide exchange factor 1 Homo sapiens 61-64 21876762-2 2011 C3G is regulated by tyrosine phosphorylation on Y504, known to be mediated by c-Abl and Src family kinases. Tyrosine 20-28 Rap guanine nucleotide exchange factor 1 Homo sapiens 0-3 21876762-10 2011 TC48 expression inhibited forskolin induced tyrosine phosphorylation of C3G and neurite outgrowth in IMR-32 cells. Tyrosine 44-52 Rap guanine nucleotide exchange factor 1 Homo sapiens 72-75 10808124-10 2000 Cas-L is transiently phosphorylated following CD3 cross-linking, and tyrosine-phosphorylated Cas-L binds to Crk and C3G. Tyrosine 69-77 Rap guanine nucleotide exchange factor 1 Homo sapiens 116-119 16472699-3 2006 TC10 activation by insulin is catalyzed by the exchange factor C3G, which is translocated to lipid rafts along with its binding partner CrkII as a consequence of Cbl tyrosine phosphorylation by the insulin receptor. Tyrosine 166-174 Rap guanine nucleotide exchange factor 1 Homo sapiens 63-66 15982636-5 2005 These complexes contain highly elevated levels of tyrosine-phosphorylated C3G and P130Cas, a scaffolding protein. Tyrosine 50-58 Rap guanine nucleotide exchange factor 1 Homo sapiens 74-77 15982636-6 2005 Moreover, the presence of Rap1 further promoted tyrosine phosphorylation of C3G and Cas. Tyrosine 48-56 Rap guanine nucleotide exchange factor 1 Homo sapiens 76-79 15062102-9 2004 CrkL also binds C3G, an exchange factor (GEF) for the small GTPase Rap1 that is activated in other systems by tyrosine phosphorylation. Tyrosine 110-118 Rap guanine nucleotide exchange factor 1 Homo sapiens 16-19 15062102-10 2004 We report that Reelin stimulates tyrosine phosphorylation of C3G and activates Rap1. Tyrosine 33-41 Rap guanine nucleotide exchange factor 1 Homo sapiens 61-64 14551197-5 2003 C3G was phosphorylated on tyrosine 504 in cells when coexpressed with Hck but not with a catalytically inactive mutant of Hck. Tyrosine 26-34 Rap guanine nucleotide exchange factor 1 Homo sapiens 0-3 14551197-6 2003 Phosphorylation of endogenous C3G at Tyr-504 was increased by treatment of human myelomonocytic THP-1 cells with mercuric chloride, which is known to activate Hck tyrosine kinase specifically. Tyrosine 37-40 Rap guanine nucleotide exchange factor 1 Homo sapiens 30-33 15320955-3 2004 C3G is activated upon phosphorylation at tyrosine 504 and therefore, determining the localization of phosphorylated C3G would provide an insight into its site of action in the cellular context. Tyrosine 41-49 Rap guanine nucleotide exchange factor 1 Homo sapiens 0-3 15320955-3 2004 C3G is activated upon phosphorylation at tyrosine 504 and therefore, determining the localization of phosphorylated C3G would provide an insight into its site of action in the cellular context. Tyrosine 41-49 Rap guanine nucleotide exchange factor 1 Homo sapiens 116-119 15320955-5 2004 Here we have determined the subcellular localization of this protein using antibodies specific to C3G and Tyr 504 phosphorylated C3G (pY504 C3G). Tyrosine 106-109 Rap guanine nucleotide exchange factor 1 Homo sapiens 129-132 15320955-5 2004 Here we have determined the subcellular localization of this protein using antibodies specific to C3G and Tyr 504 phosphorylated C3G (pY504 C3G). Tyrosine 106-109 Rap guanine nucleotide exchange factor 1 Homo sapiens 129-132 15320955-7 2004 Tyrosine 504-phosphorylated C3G showed colocalization with Hck and Src. Tyrosine 0-8 Rap guanine nucleotide exchange factor 1 Homo sapiens 28-31 15320955-13 2004 We have demonstrated the localization of endogenous C3G modified by tyrosine phosphorylation to defined subcellular domains where it may be responsible for restricted activation of signaling pathways. Tyrosine 68-76 Rap guanine nucleotide exchange factor 1 Homo sapiens 52-55 10464310-5 1999 Tyrosine phosphorylation of C3G and Cas increased as a consequence of growth factor treatment. Tyrosine 0-8 Rap guanine nucleotide exchange factor 1 Homo sapiens 28-31 24383527-10 2000 Cas-L is transiently phosphorylated following CD3 crosslinking and tyrosine-phosphorylated Cas-L binds to Crk and C3G. Tyrosine 67-75 Rap guanine nucleotide exchange factor 1 Homo sapiens 114-117 10318861-10 1999 Thus, CrkI activates C3G by the phosphorylation of tyrosine 504, which represses the cis-acting negative regulatory domain outside the catalytic region. Tyrosine 51-59 Rap guanine nucleotide exchange factor 1 Homo sapiens 21-24 10438950-8 1999 One of these tyrosine phosphorylated proteins is identified as p130Cas (Crk-associated substrate), a signaling molecule previously known to bind to a GDP-exchange factor (C3G) and inducibly associate with the focal adhesion complex. Tyrosine 13-21 Rap guanine nucleotide exchange factor 1 Homo sapiens 171-174 9820557-3 1998 Tyrosine-phosphorylated Cas associates with the adaptor protein Crk and the GTP exchange factor C3G. Tyrosine 0-8 Rap guanine nucleotide exchange factor 1 Homo sapiens 96-99 10318861-0 1999 Activation of C3G guanine nucleotide exchange factor for Rap1 by phosphorylation of tyrosine 504. Tyrosine 84-92 Rap guanine nucleotide exchange factor 1 Homo sapiens 14-17 10318861-2 1999 We found that expression of CrkI in COS cells induced significant tyrosine phosphorylation of C3G. Tyrosine 66-74 Rap guanine nucleotide exchange factor 1 Homo sapiens 94-97 10318861-5 1999 When C3G was truncated to amino acid 390, C3G was still phosphorylated on tyrosine but was not effectively activated by CrkI. Tyrosine 74-82 Rap guanine nucleotide exchange factor 1 Homo sapiens 5-8 10318861-5 1999 When C3G was truncated to amino acid 390, C3G was still phosphorylated on tyrosine but was not effectively activated by CrkI. Tyrosine 74-82 Rap guanine nucleotide exchange factor 1 Homo sapiens 42-45 10318861-6 1999 Deletion of the amino terminus of C3G to amino acid 579 significantly reduced the Crk-dependent tyrosine phosphorylation of C3G and increased GTP-bound Rap1 irrespective of the presence of CrkI. Tyrosine 96-104 Rap guanine nucleotide exchange factor 1 Homo sapiens 34-37 10318861-6 1999 Deletion of the amino terminus of C3G to amino acid 579 significantly reduced the Crk-dependent tyrosine phosphorylation of C3G and increased GTP-bound Rap1 irrespective of the presence of CrkI. Tyrosine 96-104 Rap guanine nucleotide exchange factor 1 Homo sapiens 124-127 9497377-5 1998 Cas-L is transiently phosphorylated following CD3 cross-linking, and tyrosine-phosphorylated Cas-L binds to Crk and C3G. Tyrosine 69-77 Rap guanine nucleotide exchange factor 1 Homo sapiens 116-119 9497377-0 1998 T cell receptor-mediated tyrosine phosphorylation of Cas-L, a 105-kDa Crk-associated substrate-related protein, and its association of Crk and C3G. Tyrosine 25-33 Rap guanine nucleotide exchange factor 1 Homo sapiens 143-146 9353263-5 1997 Furthermore, pretreatment of the cells with the tyrosine kinase inhibitor, genistein, decreased both the basal and insulin-stimulated tyrosine phosphorylation of CrkII that directly correlated with the amount of CrkII that was immunoprecipitated with C3G. Tyrosine 48-56 Rap guanine nucleotide exchange factor 1 Homo sapiens 251-254 9478939-3 1998 Recent observations that C3G, a guanine nucleotide exchange factor specific for the Ras-related GTPase Rap1, is recruited into tyrosine-phosphorylated protein signaling complexes in activated T cells have suggested that Rap1 may also play a role in T cell activation. Tyrosine 127-135 Rap guanine nucleotide exchange factor 1 Homo sapiens 25-28 9374471-5 1997 Thus, tyrosine phosphorylation of CrkL links the functional Type I IFNR complex to the C3G-Rap-1 signaling cascade that mediates growth inhibitory responses. Tyrosine 6-14 Rap guanine nucleotide exchange factor 1 Homo sapiens 87-90 33799258-3 2021 When interacted with C3G, the fluorescence of SFP contributed by tyrosine and phenylalanine amino acids was quenched, which was proved a static quenching with the beta-sheet structure of SFP unchanged. Tyrosine 65-73 Rap guanine nucleotide exchange factor 1 Homo sapiens 21-24