PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 11862385-4 2002 Four of these family members (CD150, CD244, CD84, CD229) contain conserved tyrosine motifs in their cytoplasmic tails that enable them to bind intracellular signaling molecules SAP and EAT-2. Tyrosine 75-83 signaling lymphocytic activation molecule family member 1 Homo sapiens 30-35 12670406-4 2003 By way of its SH2 domain, SAP interacts with tyrosine-based motifs located in the cytoplasmic region of members of the SLAM (signaling lymphocyte activation molecule) family of receptors. Tyrosine 45-53 signaling lymphocytic activation molecule family member 1 Homo sapiens 119-123 12670406-4 2003 By way of its SH2 domain, SAP interacts with tyrosine-based motifs located in the cytoplasmic region of members of the SLAM (signaling lymphocyte activation molecule) family of receptors. Tyrosine 45-53 signaling lymphocytic activation molecule family member 1 Homo sapiens 125-165 12670406-5 2003 Recent findings indicate that SAP is required for the function of SLAM-related receptors, as a consequence of its capacity to promote the recruitment and activation of the Src-related protein tyrosine kinase FynT, thereby allowing SLAM receptor-mediated protein tyrosine phosphorylation signals in immune cells. Tyrosine 192-200 signaling lymphocytic activation molecule family member 1 Homo sapiens 66-70 12670406-5 2003 Recent findings indicate that SAP is required for the function of SLAM-related receptors, as a consequence of its capacity to promote the recruitment and activation of the Src-related protein tyrosine kinase FynT, thereby allowing SLAM receptor-mediated protein tyrosine phosphorylation signals in immune cells. Tyrosine 192-200 signaling lymphocytic activation molecule family member 1 Homo sapiens 231-235 15169881-13 2004 Furthermore, they provide firm evidence that the signals transduced by the various SLAM-related receptors are unique and that the specificity of these signals is defined by the distinctive arrays of intracytoplasmic tyrosines in the receptors. Tyrosine 216-225 signaling lymphocytic activation molecule family member 1 Homo sapiens 83-87 12787752-2 2003 Recent studies show that the SLAM-related receptors mediate intracellular protein tyrosine phosphorylation signals. Tyrosine 82-90 signaling lymphocytic activation molecule family member 1 Homo sapiens 29-33 12213321-2 2002 The cytoplasmic domain of CS1 contains immunoreceptor tyrosine-based switch motif (ITSM) which is present in 2B4, SLAM and CD84. Tyrosine 54-62 signaling lymphocytic activation molecule family member 1 Homo sapiens 114-118 11806999-3 2002 This report shows that CD150 colocalizes with the T-cell receptor (TCR) following CD3 triggering in human peripheral blood T cells and is rapidly and reversibly tyrosine phosphorylated on TCR cross-linking. Tyrosine 161-169 signaling lymphocytic activation molecule family member 1 Homo sapiens 23-28 11806999-4 2002 The Src-like kinases Lck and Fyn phosphorylate tyrosine residues in the cytoplasmic tail of CD150. Tyrosine 47-55 signaling lymphocytic activation molecule family member 1 Homo sapiens 92-97 11477068-3 2001 Characteristically, the SH2D1A three-pronged interaction with Tyr(281) of CD150 can occur in absence of phosphorylation. Tyrosine 62-65 signaling lymphocytic activation molecule family member 1 Homo sapiens 74-79 11689425-1 2001 The T and natural killer (NK) cell-specific gene SAP (SH2D1A) encodes a "free SH2 domain" that binds a specific tyrosine motif in the cytoplasmic tail of SLAM (CD150) and related cell surface proteins. Tyrosine 112-120 signaling lymphocytic activation molecule family member 1 Homo sapiens 154-158 11689425-1 2001 The T and natural killer (NK) cell-specific gene SAP (SH2D1A) encodes a "free SH2 domain" that binds a specific tyrosine motif in the cytoplasmic tail of SLAM (CD150) and related cell surface proteins. Tyrosine 112-120 signaling lymphocytic activation molecule family member 1 Homo sapiens 160-165 11477403-4 2001 We report here that the SLAM receptor is capable of triggering a protein tyrosine phosphorylation signal in T cells via a mechanism that is strictly dependent on SAP expression. Tyrosine 73-81 signaling lymphocytic activation molecule family member 1 Homo sapiens 24-28 10549287-2 1999 Here we describe structures that show that SAP binds phosphorylated and nonphosphorylated SLAM peptides in a similar mode, with the tyrosine or phosphotyrosine residue inserted into the phosphotyrosine-binding pocket. Tyrosine 132-140 signaling lymphocytic activation molecule family member 1 Homo sapiens 90-94 11513145-7 2001 CS1 is a novel member of the CD2 subset that contains two of the unique tyrosine motifs present in 2B4 and SLAM. Tyrosine 72-80 signaling lymphocytic activation molecule family member 1 Homo sapiens 107-111 33451089-2 2021 In immune cells, most SLAM family molecules bind to themselves to transmit co-stimulatory signals through the recruiting adaptor proteins SLAM-associated protein (SAP) or Ewing"s sarcoma-associated transcript 2 (EAT-2), which target immunoreceptor tyrosine-based switch motifs in the cytoplasmic regions of the receptors. Tyrosine 248-256 signaling lymphocytic activation molecule family member 1 Homo sapiens 22-26 10229804-3 1999 Here we show that CDw150 on B cells associates with two tyrosine-phosphorylated proteins, 59 kDa and 145 kDa in size. Tyrosine 56-64 signaling lymphocytic activation molecule family member 1 Homo sapiens 18-24 10229804-6 1999 Both Fgr and SHIP interact with phosphorylated tyrosines in CDw150"s cytoplasmic tail. Tyrosine 47-56 signaling lymphocytic activation molecule family member 1 Homo sapiens 60-66 10229804-9 1999 The ability of CDw150 to regulate cell death does not correlate with serine phosphorylation of the Akt kinase, but does correlate with SHIP tyrosine dephosphorylation. Tyrosine 140-148 signaling lymphocytic activation molecule family member 1 Homo sapiens 15-21 29729453-5 2018 These adaptors associate with the cytoplasmic domain of the SLAM family receptors through phosphorylated tyrosines. Tyrosine 105-114 signaling lymphocytic activation molecule family member 1 Homo sapiens 60-64 18501771-3 2008 Upon phosphorylation of one or more copies of a unique tyrosine-based signaling motif in their cytoplasmic tails, six of the SLAM receptors recruit the highly specific single SH2-domain adapters SLAM-associated protein (SAP), EAT-2A, and/or EAT-2B. Tyrosine 55-63 signaling lymphocytic activation molecule family member 1 Homo sapiens 125-129 16847311-4 2006 By way of its SH2 domain, SAP interacts with tyrosine-based motifs in the cytoplasmic domain of SLAM family receptors. Tyrosine 45-53 signaling lymphocytic activation molecule family member 1 Homo sapiens 96-100 16847311-5 2006 SAP promotes SLAM family receptor-induced protein tyrosine phosphorylation, due to its capacity to recruit the Src-related kinase FynT. Tyrosine 50-58 signaling lymphocytic activation molecule family member 1 Homo sapiens 13-17