PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 25404734-7 2015 Coexpression of nephrin-CD16 and SHP-1 reduced nephrin tyrosine phosphorylation in transfected human embryonic kidney 293 cells. Tyrosine 55-63 nuclear receptor subfamily 0 group B member 2 Homo sapiens 33-38 26942442-5 2016 The findings that Fas tyrosine phosphorylation is regulated by Src family kinases (SFKs) and the phosphatase SHP-1 and that Y291 phosphorylation primes clathrin-dependent Fas endocytosis, which contributes to Fas pro-survival signaling, reveals for the first time the mechanistic link between SFK/SHP-1-dependent Fas tyrosine phosphorylation, internalization route, and signaling choice. Tyrosine 22-30 nuclear receptor subfamily 0 group B member 2 Homo sapiens 109-114 25535246-3 2015 This complex requires the adapter GRB2, which bridges SHP to THEMIS in a Tyr-phosphorylation-independent fashion. Tyrosine 73-76 nuclear receptor subfamily 0 group B member 2 Homo sapiens 54-57 25404734-4 2015 SHP-1 possesses two Src homology 2 domains that serve as docking elements to dephosphorylate tyrosine residues of target proteins. Tyrosine 93-101 nuclear receptor subfamily 0 group B member 2 Homo sapiens 0-5 24073274-2 2013 This "don"t eat me" signal is mediated through tyrosine phosphorylation of SIRPalpha at the cytoplasmic ITIM motifs and the recruitment of the phosphatase, SHP-1. Tyrosine 47-55 nuclear receptor subfamily 0 group B member 2 Homo sapiens 156-161 22624709-3 2012 show that CD37 is tyrosine phosphorylated following engagement by a bivalent engineered antibody fragment that binds CD37 and activates both SHP-1-dependent apoptotic signaling and PI3K-AKT-mediated survival signaling. Tyrosine 18-26 nuclear receptor subfamily 0 group B member 2 Homo sapiens 141-146 22624718-3 2012 Moreover, we have identified two tyrosine residues with opposing regulatory functions: one lies in the N-terminal domain of CD37 in a predicted "ITIM-like" motif and mediates SHP1-dependent death, whereas the second lies in a predicted "ITAM motif" in the C-terminal domain of CD37 and counteracts death signals by mediating phosphatidylinositol 3-kinase-dependent survival. Tyrosine 33-41 nuclear receptor subfamily 0 group B member 2 Homo sapiens 175-179 19843936-6 2009 Mutational analysis showed the tyrosine residues in two potential ITIMs at 662 and 692 offer the main contributions to this inhibition, which is further supported by strong associations of SH-2 domain-containing phosphatases with the following phosphotyrosine motifs: SHIP with the ITIM-like motif at 662; and SHP-1 and -2 with the canonical ITIM at 692. Tyrosine 31-39 nuclear receptor subfamily 0 group B member 2 Homo sapiens 310-322 19749791-2 2009 SHP-1 is a trkA phosphatase that dephosphorylates trkA at tyrosines (Y) 674 and 675. Tyrosine 58-67 nuclear receptor subfamily 0 group B member 2 Homo sapiens 0-5 15769739-4 2005 Tyrosine phosphorylation of Siglec-5 led to recruitment of the tyrosine phosphatases SHP-1 and SHP-2, as seen in both pull-down assays and microscopy. Tyrosine 0-8 nuclear receptor subfamily 0 group B member 2 Homo sapiens 85-90 19749791-0 2009 Repression of SHP-1 expression by p53 leads to trkA tyrosine phosphorylation and suppression of breast cancer cell proliferation. Tyrosine 52-60 nuclear receptor subfamily 0 group B member 2 Homo sapiens 14-19 17311996-1 2007 The G6B cell-surface receptor, which contains a single Ig-like domain, has been shown to bind to SHP-1 and SHP-2 after phosphorylation of 2 immunoreceptor tyrosine-based inhibitory motifs (ITIMs) in its cytoplasmic tail, classifying this protein as a new member of the family of inhibitory receptors. Tyrosine 155-163 nuclear receptor subfamily 0 group B member 2 Homo sapiens 97-102 17008544-2 2007 CD33 contains a cytoplasmic immunoreceptor tyrosine-based inhibitory motif (ITIM), which can recruit SHP-1 and SHP-2. Tyrosine 43-51 nuclear receptor subfamily 0 group B member 2 Homo sapiens 101-106 16725108-2 2006 We previously identified two tyrosine-containing signaling motifs in the cytoplasmic domain of BTLA that interact with the SHP-1 and SHP-2 phosphatases. Tyrosine 29-37 nuclear receptor subfamily 0 group B member 2 Homo sapiens 123-128 17678728-1 2007 The G6b-B gene encodes a novel cell surface receptor of the immunoglobulin superfamily that activates inhibitory signaling pathways by triggering SHP-1/SHP-2 via immunoreceptor tyrosine-based inhibitory motifs (ITIM) in its cytoplasmic domain. Tyrosine 177-185 nuclear receptor subfamily 0 group B member 2 Homo sapiens 146-151 17138568-1 2007 CD33-related Siglecs (sialic acid-binding immunoglobulin-like lectins) 5-11 are inhibitory receptors that contain a membrane proximal ITIM (immunoreceptor tyrosine-based inhibitory motif) (I/V/L/)XYXX(L/V), which can recruit SHP-1/2. Tyrosine 155-163 nuclear receptor subfamily 0 group B member 2 Homo sapiens 225-232 11551923-3 2001 Although CD22 contains three immunoreceptor tyrosine-based inhibitory motifs (ITIMs), only the two carboxyl-terminal ITIM tyrosines are required for efficient recruitment of the SHP-1 phosphatase after BCR ligation. Tyrosine 122-131 nuclear receptor subfamily 0 group B member 2 Homo sapiens 178-183 15557178-6 2004 We then show by site-directed mutagenesis that the membrane-proximal tyrosine motif is essential for the inhibitory function of both Siglec-7 and -9, and is also required for tyrosine phosphorylation and recruitment of SHP-1 and SHP-2 phosphatases. Tyrosine 69-77 nuclear receptor subfamily 0 group B member 2 Homo sapiens 219-224 14652006-10 2003 Thus, similar to the bisphosphoryl tyrosine-based activation motif (BTAM) by which the Grb-2 associated binder (Gab1), PDGF receptor, and PECAM-1 recruit SHP-2, BTLA also relies on dual ITIMs for its association with the phosphatases SHP-1 and SHP-2. Tyrosine 35-43 nuclear receptor subfamily 0 group B member 2 Homo sapiens 234-239 12832410-0 2003 The protein-tyrosine phosphatase SHP-1 associates with the phosphorylated immunoreceptor tyrosine-based activation motif of Fc gamma RIIa to modulate signaling events in myeloid cells. Tyrosine 12-20 nuclear receptor subfamily 0 group B member 2 Homo sapiens 33-38 12832410-5 2003 Using synthetic phosphopeptides, and stable transfectants expressing immunoreceptor tyrosine-based activation motif (ITAM) tyrosine mutants of Fc gamma RIIa, we demonstrate that SHP-1 associates with the phosphorylated amino-terminal ITAM tyrosine of Fc gamma RIIa, whereas the tyrosine kinase Syk associates with the carboxyl-terminal ITAM tyrosine. Tyrosine 84-92 nuclear receptor subfamily 0 group B member 2 Homo sapiens 178-183 12832410-5 2003 Using synthetic phosphopeptides, and stable transfectants expressing immunoreceptor tyrosine-based activation motif (ITAM) tyrosine mutants of Fc gamma RIIa, we demonstrate that SHP-1 associates with the phosphorylated amino-terminal ITAM tyrosine of Fc gamma RIIa, whereas the tyrosine kinase Syk associates with the carboxyl-terminal ITAM tyrosine. Tyrosine 123-131 nuclear receptor subfamily 0 group B member 2 Homo sapiens 178-183 12832410-5 2003 Using synthetic phosphopeptides, and stable transfectants expressing immunoreceptor tyrosine-based activation motif (ITAM) tyrosine mutants of Fc gamma RIIa, we demonstrate that SHP-1 associates with the phosphorylated amino-terminal ITAM tyrosine of Fc gamma RIIa, whereas the tyrosine kinase Syk associates with the carboxyl-terminal ITAM tyrosine. Tyrosine 123-131 nuclear receptor subfamily 0 group B member 2 Homo sapiens 178-183 12832410-5 2003 Using synthetic phosphopeptides, and stable transfectants expressing immunoreceptor tyrosine-based activation motif (ITAM) tyrosine mutants of Fc gamma RIIa, we demonstrate that SHP-1 associates with the phosphorylated amino-terminal ITAM tyrosine of Fc gamma RIIa, whereas the tyrosine kinase Syk associates with the carboxyl-terminal ITAM tyrosine. Tyrosine 123-131 nuclear receptor subfamily 0 group B member 2 Homo sapiens 178-183 12832410-6 2003 Association of SHP-1 with Fc gamma RIIa ITAM appears to suppress total cellular tyrosine phosphorylation. Tyrosine 80-88 nuclear receptor subfamily 0 group B member 2 Homo sapiens 15-20 12882840-6 2003 As observed previously in the mouse, hCD100-Fc induces the tyrosine dephosphorylation of human CD72, leading to the dissociation of SHP-1 from the CD72 cytoplasmic tail. Tyrosine 59-67 nuclear receptor subfamily 0 group B member 2 Homo sapiens 132-137 10542280-6 1999 Furthermore, the tyrosine phosphorylation and activities of the SHP-1 and SHP-2 tyrosine phosphatases, enzymes that regulate Ang II-induced JAK2 tyrosine phosphorylation, are altered by HG. Tyrosine 17-25 nuclear receptor subfamily 0 group B member 2 Homo sapiens 64-69 11178971-6 2001 The ITIM in LLIR was demonstrated to bind SHP-1 in HL-60 cell after the tyrosine had been phosphorylated. Tyrosine 72-80 nuclear receptor subfamily 0 group B member 2 Homo sapiens 42-47 10542280-6 1999 Furthermore, the tyrosine phosphorylation and activities of the SHP-1 and SHP-2 tyrosine phosphatases, enzymes that regulate Ang II-induced JAK2 tyrosine phosphorylation, are altered by HG. Tyrosine 80-88 nuclear receptor subfamily 0 group B member 2 Homo sapiens 64-69 10542280-7 1999 SHP-1, which is responsible for JAK2 tyrosine dephosphorylation in VSMC, is completely deactivated in HG, resulting in a prolonged duration of JAK2 phosphorylation under HG conditions. Tyrosine 37-45 nuclear receptor subfamily 0 group B member 2 Homo sapiens 0-5 33589816-2 2021 Here, we describe unexpected involvement of the tyrosine phosphatase Shp1 and the B cell lectin CD22 (Siglec-2) in the regulation of alpha4beta7 surface expression and gut immunity. Tyrosine 48-56 nuclear receptor subfamily 0 group B member 2 Homo sapiens 69-73 10327049-4 1999 Overexpression of a catalytically inactive form of SHP-1 prevents the PIR-B-mediated inhibition of tyrosine phosphorylation of Syk, Btk, and PLC-gamma2. Tyrosine 99-107 nuclear receptor subfamily 0 group B member 2 Homo sapiens 51-56 10327049-5 1999 Dephosphorylation of Syk and Btk mediated by SHP-1 leads to a decrease of their kinase activity, which in turn inhibits tyrosine phosphorylation of PLC-gamma2. Tyrosine 120-128 nuclear receptor subfamily 0 group B member 2 Homo sapiens 45-50 9730901-2 1998 PIR-B bears immunoreceptor tyrosine-based inhibitory motif (ITIM) sequences in its cytoplasmic domain that recruit Src homology (SH)2 domain-containing tyrosine phosphatases SHP-1 and SHP-2, leading to inhibition of B and mast cell activation. Tyrosine 27-35 nuclear receptor subfamily 0 group B member 2 Homo sapiens 174-179 21528234-6 1997 We found that SHP-1 was highly and constitutively tyrosine phosphorylated in 32DCl3 and TF-1 cells transfected with BCR-ABL expression vector. Tyrosine 50-58 nuclear receptor subfamily 0 group B member 2 Homo sapiens 14-17 9059884-7 1997 By studying the inhibitory receptor Ly-49A, we have demonstrated that inhibition utilizes the cytoplasmic phosphatase, SHP-1, which binds to a motif in the receptor cytoplasmic domain, termed an immunoreceptor tyrosine-based inhibitory motif (ITIM). Tyrosine 210-218 nuclear receptor subfamily 0 group B member 2 Homo sapiens 119-124 9597134-5 1998 Upon ligand binding and activation, the inhibitory NK cell receptors become tyrosine phosphorylated and recruit tyrosine phosphatases, SHP-1 and possibly SHP-2, resulting in inhibition of NK cell-mediated cytotoxicity and cytokine expression. Tyrosine 76-84 nuclear receptor subfamily 0 group B member 2 Homo sapiens 135-140 7618087-3 1995 Tyrosine-phosphorylated CD22 binds and activates SHP, a protein tyrosine phosphatase known to negatively regulate signaling through mIg. Tyrosine 0-8 nuclear receptor subfamily 0 group B member 2 Homo sapiens 49-52 29997173-6 2018 Thus, soluble CD52 exerts a concerted immunosuppressive effect by first sequestering HMGB1 to nullify its proinflammatory Box B, followed by binding to the inhibitory Siglec-10 receptor, triggering recruitment of SHP1 to the intracellular immunoreceptor tyrosine-based inhibitory motif of Siglec-10 and its interaction with the TCR. Tyrosine 254-262 nuclear receptor subfamily 0 group B member 2 Homo sapiens 213-217 31882261-3 2021 Some of the Siglecs (Siglec-2-12, -17, -E, -F and -G) with three domains including immunoreceptor tyrosine-based inhibitory motif associated with Src homology 2 (SH2) tyrosine phosphatases (SHP1/2) usually deliver an inhibitory signal. Tyrosine 98-106 nuclear receptor subfamily 0 group B member 2 Homo sapiens 190-196 33123602-7 2020 Focusing on the mechanism responsible for reduced phosphorylation levels of ERK and STAT3, we reveal that the activation of protein tyrosine phosphatase SHP-1 (Src homology region 2 domain-containing phosphatase-1) following hypoxia might play an essential role in this process. Tyrosine 132-140 nuclear receptor subfamily 0 group B member 2 Homo sapiens 153-158 34319780-8 2021 Mechanistically, BGLF2 promoted the recruitment of SHP1 phosphatase to STAT1 to inhibit its tyrosine phosphorylation. Tyrosine 92-100 nuclear receptor subfamily 0 group B member 2 Homo sapiens 51-55 35219918-1 2022 SHP1 is a non-receptor protein tyrosine phosphatase that is widely expressed in hematopoietic cells such as white blood cells, neutrophils, and immune cells. Tyrosine 31-39 nuclear receptor subfamily 0 group B member 2 Homo sapiens 0-4 35085834-4 2022 Interestingly, IDO1 protein contains two immunoreceptor tyrosine-based inhibitory motifs (ITIM) which trigger suppressive signaling through the binding of PI3K p110 and SHP-1 proteins. Tyrosine 56-64 nuclear receptor subfamily 0 group B member 2 Homo sapiens 169-174 29669741-5 2018 Mechanistically, SHP-1 interacts with the immunoreceptor tyrosine-based inhibition motif on TGF-beta receptor 1 and is critical for TGF-beta signaling activation in HSCs. Tyrosine 57-65 nuclear receptor subfamily 0 group B member 2 Homo sapiens 17-22 28811476-3 2017 SHP-1 tyrosine 536 phosphorylation by Lyn activates the phosphatase promoting inhibitory signaling through the immunoreceptor. Tyrosine 6-14 nuclear receptor subfamily 0 group B member 2 Homo sapiens 0-5 27696702-3 2017 However, IDO1 also harbours immunoreceptor tyrosine-based inhibitory motifs, (ITIM1 and ITIM2), that, once phosphorylated, bind protein tyrosine phosphatases, (SHP-1 and SHP-2), and thus trigger an immunoregulatory signalling in DCs. Tyrosine 43-51 nuclear receptor subfamily 0 group B member 2 Homo sapiens 160-165