PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31984217-4 2019 More recently, we demonstrated that the SRC family of non-receptor tyrosine kinases (SFK) can phosphorylate SOCS1 leading to its homodimerization and inhibiting its interaction with p53. Tyrosine 67-75 suppressor of cytokine signaling 1 Homo sapiens 108-113 34023736-4 2021 Notably, when assayed for their biological cell responses mimicking SOCS1 activity, the internal cyclic PS5 analogues demonstrated able to inhibit JAK-mediated tyrosine phosphorylation of STAT1 and to reduce cytokine-induced proinflammatory gene expression, oxidative stress generation and cell migration. Tyrosine 160-168 suppressor of cytokine signaling 1 Homo sapiens 68-73 30048621-1 2018 We describe an immunosuppressive peptide corresponding to the kinase inhibitory region (KIR) of the intracellular checkpoint protein suppressor of cytokine signaling 1 (SOCS-1) that binds to the phospho-tyrosine containing regions of the tyrosine kinases JAK2 and TYK2 and the adaptor protein MAL, and thereby inhibits signaling downstream from these signaling mediators. Tyrosine 203-211 suppressor of cytokine signaling 1 Homo sapiens 169-175 31101761-3 2019 We report here that the ability of SOCS1 to interact with p53 and regulate cellular senescence depends on a structural motif that includes tyrosine (Y)80 in the SH2 domain of SOCS1. Tyrosine 139-147 suppressor of cytokine signaling 1 Homo sapiens 35-40 31101761-3 2019 We report here that the ability of SOCS1 to interact with p53 and regulate cellular senescence depends on a structural motif that includes tyrosine (Y)80 in the SH2 domain of SOCS1. Tyrosine 139-147 suppressor of cytokine signaling 1 Homo sapiens 175-180 25954276-5 2015 A peptide corresponding to KIR (SOCS1-KIR) bound to the activation loop of JAK2 and inhibited tyrosine phosphorylation of STAT1alpha transcription factor by JAK2. Tyrosine 94-102 suppressor of cytokine signaling 1 Homo sapiens 32-37 27507812-0 2016 Suppressor of Cytokine Signaling (SOCS)1 Regulates Interleukin-4 (IL-4)-activated Insulin Receptor Substrate (IRS)-2 Tyrosine Phosphorylation in Monocytes and Macrophages via the Proteasome. Tyrosine 117-125 suppressor of cytokine signaling 1 Homo sapiens 0-40 27507812-5 2016 We found that siRNA knockdown of SOCS1 prolonged IRS-2 tyrosine phosphorylation and enhanced M2 differentiation, although siRNA knockdown of SOCS3 did not affect either. Tyrosine 55-63 suppressor of cytokine signaling 1 Homo sapiens 33-38 18725457-9 2008 SOCS1 mutants with loss of nuclear localization were still effective in suppressing IFN-alpha-mediated STAT1 tyrosine phosphorylation. Tyrosine 109-117 suppressor of cytokine signaling 1 Homo sapiens 0-5 22787435-9 2012 Strikingly, disrupting the tyrosine phosphorylation of SOCS-1 or SOCS-3 impaired the expression of Bcl-X(L) protein and sensitized K562 leukemic cells to undergo apoptosis. Tyrosine 27-35 suppressor of cytokine signaling 1 Homo sapiens 55-61 21386060-6 2011 In addition, adenovirus-mediated overexpression of either SOCS1 or SOCS3 inhibited insulin-induced tyrosine phosphorylation of IRS-1, whereas the reduction of IRS-1 protein was observed only in SOCS3-expressed cells. Tyrosine 99-107 suppressor of cytokine signaling 1 Homo sapiens 58-63 20059770-10 2010 The inhibitory effects of SOCS1 and SOCS3 differ in the dependence on the tyrosine residues in the intracellular domain of LEPRb. Tyrosine 74-82 suppressor of cytokine signaling 1 Homo sapiens 26-31 20934424-3 2010 Focal adhesion kinase (FAK) and the GTPase RhoA, control cell adhesion and migration and we show the presence of SOCS1 or 3 regulates expression and tyrosine phosphorylation of FAK, while also enhancing activation of RhoA. Tyrosine 149-157 suppressor of cytokine signaling 1 Homo sapiens 113-118 15491991-10 2004 However, STAT-1 tyrosine phosphorylation following TLR triggering was severely impaired by SOCS-1 overexpression. Tyrosine 16-24 suppressor of cytokine signaling 1 Homo sapiens 91-97 16033816-0 2005 Tyrosine 729 of the G-CSF receptor controls the duration of receptor signaling: involvement of SOCS3 and SOCS1. Tyrosine 0-8 suppressor of cytokine signaling 1 Homo sapiens 105-110 16033816-7 2005 Expression of SOCS3 or SOCS1, but not SOCS2 and cytokine-inducible SH2 domain-containing protein, completely suppressed G-CSF-induced Stat5 activation but had only a weak effect on Stat5 activation mediated by the receptor mutant lacking Tyr 729. Tyrosine 238-241 suppressor of cytokine signaling 1 Homo sapiens 23-28 16033816-8 2005 SOCS1 and SOCS3 also inhibited G-CSF-dependent cell proliferation, but the inhibitory effect of the two SOCS proteins on cell proliferation was diminished when Tyr 729 of the G-CSF-R was mutated. Tyrosine 160-163 suppressor of cytokine signaling 1 Homo sapiens 0-5 16033816-9 2005 These data indicate that Tyr 729 of the G-CSF-R is required for SOCS1- and SOCS3-mediated negative regulation of G-CSF-R signaling and that the duration and intensity of G-CSF-induced Stat5 activation are regulated by two distinct mechanisms. Tyrosine 25-28 suppressor of cytokine signaling 1 Homo sapiens 64-69 15169905-0 2004 Suppressor of cytokine signaling 1 (SOCS-1) and SOCS-3 cause insulin resistance through inhibition of tyrosine phosphorylation of insulin receptor substrate proteins by discrete mechanisms. Tyrosine 102-110 suppressor of cytokine signaling 1 Homo sapiens 0-34 15169905-8 2004 By contrast, a reduction of SOCS-1 or SOCS-3 by antisense treatment partially restores tumor necrosis factor alpha-induced downregulation of tyrosine phosphorylation of IRS proteins in 3T3L1 adipocytes. Tyrosine 141-149 suppressor of cytokine signaling 1 Homo sapiens 28-34 15169905-0 2004 Suppressor of cytokine signaling 1 (SOCS-1) and SOCS-3 cause insulin resistance through inhibition of tyrosine phosphorylation of insulin receptor substrate proteins by discrete mechanisms. Tyrosine 102-110 suppressor of cytokine signaling 1 Homo sapiens 36-42 12051728-5 2002 In contrast, IL-10 inhibited IFN-alpha-mediated tyrosine phosphorylation of STAT1 by induction of a Janus kinase inhibitor, JAB. Tyrosine 48-56 suppressor of cytokine signaling 1 Homo sapiens 124-127 12734778-6 2003 With overexpression of GHR, Jak2 and IRS-1 along with each of these SOCS proteins in human A293 cells, we could demonstrate that both SOCS-1 and SOCS-3 completely inhibited the GH-stimulated tyrosine phosphorylation of IRS-1, whereas SOCS-2 and CIS did not. Tyrosine 191-199 suppressor of cytokine signaling 1 Homo sapiens 134-140 12223098-5 2003 These responses to IFN-gamma were blocked by overexpression of the JAK inhibitor, JAK-binding protein (JAB), or reversed by dominant-negative Stat1 alpha Y701F containing a mutation at Tyr-701, the JAK phosphorylation site. Tyrosine 185-188 suppressor of cytokine signaling 1 Homo sapiens 103-106 14522994-2 2003 We report that SHP-2 dephosphorylates tyrosine (Tyr-1007) of Jak2 kinase, a critical recruitment site for the ubiquitin ligase-associated inhibitory protein suppressor of cytokine signaling-1 (SOCS-1), thereby contributing to Jak2 stability. Tyrosine 38-46 suppressor of cytokine signaling 1 Homo sapiens 193-199 14522994-2 2003 We report that SHP-2 dephosphorylates tyrosine (Tyr-1007) of Jak2 kinase, a critical recruitment site for the ubiquitin ligase-associated inhibitory protein suppressor of cytokine signaling-1 (SOCS-1), thereby contributing to Jak2 stability. Tyrosine 48-51 suppressor of cytokine signaling 1 Homo sapiens 193-199 14517242-4 2003 SOCS-1 and SOCS-3 were found to inhibit FAK-associated kinase activity in vitro and tyrosine phosphorylation of FAK in cells. Tyrosine 84-92 suppressor of cytokine signaling 1 Homo sapiens 0-6 11133764-4 2001 In cotransfection experiments, JAB/SOCS1/SSI-1 associates with both Jak1 and Jak3; however, JAB/SOCS1/SSI-1 had a greater effect on Jak1 tyrosine phosphorylation and kinase activity. Tyrosine 137-145 suppressor of cytokine signaling 1 Homo sapiens 31-34 11133764-4 2001 In cotransfection experiments, JAB/SOCS1/SSI-1 associates with both Jak1 and Jak3; however, JAB/SOCS1/SSI-1 had a greater effect on Jak1 tyrosine phosphorylation and kinase activity. Tyrosine 137-145 suppressor of cytokine signaling 1 Homo sapiens 35-40 11133764-4 2001 In cotransfection experiments, JAB/SOCS1/SSI-1 associates with both Jak1 and Jak3; however, JAB/SOCS1/SSI-1 had a greater effect on Jak1 tyrosine phosphorylation and kinase activity. Tyrosine 137-145 suppressor of cytokine signaling 1 Homo sapiens 41-46 11133764-4 2001 In cotransfection experiments, JAB/SOCS1/SSI-1 associates with both Jak1 and Jak3; however, JAB/SOCS1/SSI-1 had a greater effect on Jak1 tyrosine phosphorylation and kinase activity. Tyrosine 137-145 suppressor of cytokine signaling 1 Homo sapiens 92-95 11133764-4 2001 In cotransfection experiments, JAB/SOCS1/SSI-1 associates with both Jak1 and Jak3; however, JAB/SOCS1/SSI-1 had a greater effect on Jak1 tyrosine phosphorylation and kinase activity. Tyrosine 137-145 suppressor of cytokine signaling 1 Homo sapiens 96-101 11133764-4 2001 In cotransfection experiments, JAB/SOCS1/SSI-1 associates with both Jak1 and Jak3; however, JAB/SOCS1/SSI-1 had a greater effect on Jak1 tyrosine phosphorylation and kinase activity. Tyrosine 137-145 suppressor of cytokine signaling 1 Homo sapiens 102-107 10585430-3 1999 SOCS-1, SOCS-2, SOCS-3, and CIS each strongly inhibited the GH receptor (GHR)-dependent tyrosine phosphorylation of JAK2 seen at low levels of transfected JAK2; however, only SOCS-1 strongly inhibited the GHR-independent tyrosine phosphorylation of JAK2 seen at higher JAK2 levels. Tyrosine 88-96 suppressor of cytokine signaling 1 Homo sapiens 0-6 10975987-7 2000 Since JAB has already been shown to bind JAK2 via a phosphorylated tyrosine, the current data suggest that JAB binds to phosphorylated JAK2, enhances JAK2 dephosphorylation and remains associated in a complex, with dephosphorylated JAK2, that may be a precursor leading to irreversible JAK2 degradation. Tyrosine 67-75 suppressor of cytokine signaling 1 Homo sapiens 6-9 10975987-7 2000 Since JAB has already been shown to bind JAK2 via a phosphorylated tyrosine, the current data suggest that JAB binds to phosphorylated JAK2, enhances JAK2 dephosphorylation and remains associated in a complex, with dephosphorylated JAK2, that may be a precursor leading to irreversible JAK2 degradation. Tyrosine 67-75 suppressor of cytokine signaling 1 Homo sapiens 107-110 10585430-3 1999 SOCS-1, SOCS-2, SOCS-3, and CIS each strongly inhibited the GH receptor (GHR)-dependent tyrosine phosphorylation of JAK2 seen at low levels of transfected JAK2; however, only SOCS-1 strongly inhibited the GHR-independent tyrosine phosphorylation of JAK2 seen at higher JAK2 levels. Tyrosine 221-229 suppressor of cytokine signaling 1 Homo sapiens 0-6 10585430-6 1999 By contrast, SOCS-3 binding required tyrosine-phosphorylated GHR membrane-proximal sequences, SOCS-1 binding was tyrosine phosphorylation-independent, and SOCS-6 did not bind the GHR fusion proteins at all. Tyrosine 113-121 suppressor of cytokine signaling 1 Homo sapiens 94-100 10551777-7 1999 These data suggest that SOCS-1 and -3 can suppress GH-induced transcriptional activity, presumably by inhibiting the kinase activity of JAK2 either directly in the case of SOCS-1 or via binding to the tyrosine-phosphorylated GH receptor in the case of SOCS-3. Tyrosine 201-209 suppressor of cytokine signaling 1 Homo sapiens 24-37 10551777-7 1999 These data suggest that SOCS-1 and -3 can suppress GH-induced transcriptional activity, presumably by inhibiting the kinase activity of JAK2 either directly in the case of SOCS-1 or via binding to the tyrosine-phosphorylated GH receptor in the case of SOCS-3. Tyrosine 201-209 suppressor of cytokine signaling 1 Homo sapiens 24-30 10064597-4 1999 In the studies presented here we demonstrate that JAB specifically binds to the tyrosine residue (Y1007) in the activation loop of JAK2, whose phosphorylation is required for activation of kinase activity. Tyrosine 80-88 suppressor of cytokine signaling 1 Homo sapiens 50-53 9202126-6 1997 Interaction of JAB with Jak1, Jak2 or Jak3 markedly reduces their tyrosine-kinase activity and suppresses the tyrosine-phosphorylation and activation of STATs. Tyrosine 66-74 suppressor of cytokine signaling 1 Homo sapiens 15-18 10585430-8 1999 SOCS/CIS proteins can thus inhibit GH signaling to STAT5b by three distinct mechanisms, distinguished by their molecular targets within the GHR-JAK2 signaling complex, as exemplified by SOCS-1 (direct JAK2 kinase inhibition), SOCS-3 (inhibition of JAK2 signaling via membrane-proximal GHR tyrosines 333 and 338), and CIS and SOCS-2 (inhibition via membrane-distal tyrosine(s)). Tyrosine 289-298 suppressor of cytokine signaling 1 Homo sapiens 186-192 10585430-8 1999 SOCS/CIS proteins can thus inhibit GH signaling to STAT5b by three distinct mechanisms, distinguished by their molecular targets within the GHR-JAK2 signaling complex, as exemplified by SOCS-1 (direct JAK2 kinase inhibition), SOCS-3 (inhibition of JAK2 signaling via membrane-proximal GHR tyrosines 333 and 338), and CIS and SOCS-2 (inhibition via membrane-distal tyrosine(s)). Tyrosine 289-297 suppressor of cytokine signaling 1 Homo sapiens 186-192 9857039-4 1998 SOCS1 and SOCS3 but not SOCS2 inhibited the tyrosine phosphorylation and nuclear translocation of STAT1 in response to IFN stimulation. Tyrosine 44-52 suppressor of cytokine signaling 1 Homo sapiens 0-5