PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 22307148-7 2012 Tyr-397 of FAK mediates interactions with Src homology 2 (SH2) domains in a number of other signaling proteins, including PI3K, PLC-gamma, Shc, Grb7, Src and Nck2. Tyrosine 0-3 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 42-45 22307148-7 2012 Tyr-397 of FAK mediates interactions with Src homology 2 (SH2) domains in a number of other signaling proteins, including PI3K, PLC-gamma, Shc, Grb7, Src and Nck2. Tyrosine 0-3 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 174-177 22349424-8 2012 Src PTK inhibitor pretreatment decreased phosphorylation of Src PTKs, total protein tyrosine phosphorylation, and STAT3 phosphorylation. Tyrosine 84-92 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 0-3 22006118-7 2012 Phosphorylation of FAK on Tyr 576 by Src activates FAK. Tyrosine 26-29 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 37-40 21397667-6 2011 The stimulatory effect of these compounds on the tyrosine phosphorylation of CDCP1 and its Src-dependent association with PKCdelta was blocked by knockdown of CDCP1, which also blocked Src and PKCdelta phosphorylation. Tyrosine 49-57 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 91-94 22120166-8 2012 Following stimulation with Ang II, AT(2) receptors recruit c-Src, which was responsible for SHP-1 tyr-phosphorylation and activation. Tyrosine 98-101 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 59-64 22030427-11 2011 CONCLUSIONS: The results indicated that depolarization-induced neuronal death might be due to extracellular Ca2+ influx through L-VGCCs and subsequently Src activationmediated NR2A tyrosine phosphorylation. Tyrosine 181-189 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 153-156 21063895-3 2011 They also indicated a direct action of PTP1B on phosphorylated tyrosine 527 residue of Src, thus implicating a role for PTP1B in the modulation of Src activity in mitochondria. Tyrosine 63-71 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 87-90 21063895-3 2011 They also indicated a direct action of PTP1B on phosphorylated tyrosine 527 residue of Src, thus implicating a role for PTP1B in the modulation of Src activity in mitochondria. Tyrosine 63-71 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 147-150 21397667-6 2011 The stimulatory effect of these compounds on the tyrosine phosphorylation of CDCP1 and its Src-dependent association with PKCdelta was blocked by knockdown of CDCP1, which also blocked Src and PKCdelta phosphorylation. Tyrosine 49-57 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 185-188 19164509-5 2009 Among the signaling molecules investigated, phosphorylation of the Src protein at tyrosine 416 was the most striking in OV-treated HSCs. Tyrosine 82-90 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 67-70 20441772-4 2010 PP2, a specific inhibitor of Src family protein tyrosine kinases (SrcPTKs), not only attenuated the Abeta25-35-induced increases in the tyrosine phosphorylation of NR2A and in the associations among Src, NR2A, and PSD-95, but also protected against neuronal loss in the CA1 region. Tyrosine 48-56 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 29-32 20441772-4 2010 PP2, a specific inhibitor of Src family protein tyrosine kinases (SrcPTKs), not only attenuated the Abeta25-35-induced increases in the tyrosine phosphorylation of NR2A and in the associations among Src, NR2A, and PSD-95, but also protected against neuronal loss in the CA1 region. Tyrosine 48-56 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 66-69 20107068-5 2010 This effect was blocked by inhibitors of the VEGF receptor flk-1 and Src kinase, but not by inhibitors of phosphatidylinositol-3-kinase or protein kinase C. VEGF also increased Tyr-14 phosphorylation of caveolin-1, and this was blocked by the Src inhibitor PP2. Tyrosine 177-180 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 69-72 20107068-5 2010 This effect was blocked by inhibitors of the VEGF receptor flk-1 and Src kinase, but not by inhibitors of phosphatidylinositol-3-kinase or protein kinase C. VEGF also increased Tyr-14 phosphorylation of caveolin-1, and this was blocked by the Src inhibitor PP2. Tyrosine 177-180 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 243-246 20107068-6 2010 Pharmacological activation of Src kinase activity mimicked the effects of VEGF on P-glycoprotein activity and Tyr-14 phosphorylation of caveolin-1. Tyrosine 110-113 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 30-33 19737347-0 2009 Peroxynitrite induces tyrosine residue modifications in synaptophysin C-terminal domain, affecting its interaction with src. Tyrosine 22-30 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 120-123 19737347-4 2009 We found that tyrosine-phosphorylated, but not tyrosine-nitrated, SYP bound to the src tyrosine kinase and enhanced its catalytic activity. Tyrosine 14-22 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 83-86 20828828-4 2010 The phosphorylation of Syk tyrosine 346 was completely blocked by the novel Src family kinase inhibitor BIRA766, suggesting this tyrosine is a pure substrate for Src family kinases. Tyrosine 27-35 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 76-79 20828828-4 2010 The phosphorylation of Syk tyrosine 346 was completely blocked by the novel Src family kinase inhibitor BIRA766, suggesting this tyrosine is a pure substrate for Src family kinases. Tyrosine 27-35 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 162-165 20828828-4 2010 The phosphorylation of Syk tyrosine 346 was completely blocked by the novel Src family kinase inhibitor BIRA766, suggesting this tyrosine is a pure substrate for Src family kinases. Tyrosine 129-137 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 76-79 20828828-4 2010 The phosphorylation of Syk tyrosine 346 was completely blocked by the novel Src family kinase inhibitor BIRA766, suggesting this tyrosine is a pure substrate for Src family kinases. Tyrosine 129-137 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 162-165 20828828-6 2010 The phosphorylation of other Syk tyrosines 317, 342, 519 and 520 was reduced by Syk and Src family inhibitors, suggesting a role for auto- and trans-phosphorylation. Tyrosine 33-42 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 88-91 20537760-5 2010 Area expansion, migration and phosphorylation of PLCgamma1-Tyr(783) and ERK1/2-Thr(202)/Tyr(204) are inhibited (p<0.05) after pretreatment with Src inhibitor (PP2). Tyrosine 59-62 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 147-150 20537760-6 2010 We further demonstrate that area expansion, migration and phosphorylation of ERK1/2-Thr(202)/Tyr(204) are significantly inhibited (p<0.05) after pretreatment with PLCgamma1 inhibitor (U73122); the phosphorylation site of Src-Tyr(418) is not affected. Tyrosine 93-96 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 224-227 20537760-7 2010 After pretreatment with an ERK1/2 inhibitor (PD98059), area expansion and migration are inhibited (p<0.05), while the phosphorylation sites of Src-Tyr(418) and PLCgamma1-Tyr(783) are not affected. Tyrosine 150-153 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 146-149 20537760-7 2010 After pretreatment with an ERK1/2 inhibitor (PD98059), area expansion and migration are inhibited (p<0.05), while the phosphorylation sites of Src-Tyr(418) and PLCgamma1-Tyr(783) are not affected. Tyrosine 173-176 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 146-149 20441772-6 2010 These results suggest that the activation of NMDA receptors after Abeta treatment promotes the formation of NR2A-PSD-95-Src complex and thus increases the tyrosine phosphorylation of NR2A by Src kinases, which up-regulates the function of NMDA receptors. Tyrosine 155-163 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 120-123 20441772-6 2010 These results suggest that the activation of NMDA receptors after Abeta treatment promotes the formation of NR2A-PSD-95-Src complex and thus increases the tyrosine phosphorylation of NR2A by Src kinases, which up-regulates the function of NMDA receptors. Tyrosine 155-163 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 191-194 19254952-9 2009 beta-Arrestin2 facilitates ANG and SII stimulation of Src-mediated phosphorylation of Tyr-845 on the EGFR, a known site for Src phosphorylation. Tyrosine 86-89 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 54-57 19254952-9 2009 beta-Arrestin2 facilitates ANG and SII stimulation of Src-mediated phosphorylation of Tyr-845 on the EGFR, a known site for Src phosphorylation. Tyrosine 86-89 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 124-127 18583343-4 2008 Importantly, we found that in brain mitochondria, ATP addition induced Src autophosphorylation at Tyr-416 in its catalytic site, leading to its activation, whereas the regulatory Tyr-527 site remained unphosphorylated. Tyrosine 98-101 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 71-74 19046409-4 2009 Cocaine induced an increase in the activity of both Fyn and Src kinases, and the Src-protein tyrosine kinase (Src-PTKs) inhibitor, 4-amino-5-(4-chlorophenyl)-7-(t-butyl)pyrazolo[3,4-d]pyrimidine (PP2), abolished both cocaine-induced increase in tyrosine phosphorylation of the NR2A subunit and the increase in the expression of NR1, NR2A, and NR2B in the VTA. Tyrosine 93-101 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 81-84 19046409-4 2009 Cocaine induced an increase in the activity of both Fyn and Src kinases, and the Src-protein tyrosine kinase (Src-PTKs) inhibitor, 4-amino-5-(4-chlorophenyl)-7-(t-butyl)pyrazolo[3,4-d]pyrimidine (PP2), abolished both cocaine-induced increase in tyrosine phosphorylation of the NR2A subunit and the increase in the expression of NR1, NR2A, and NR2B in the VTA. Tyrosine 93-101 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 81-84 19046409-6 2009 Taken together, these results suggest that acute cocaine induced an increase in the expression of NMDAR subunits and enhanced tyrosine phosphorylation of NR2A-containing NMDAR through members of the Src-PTKs. Tyrosine 126-134 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 199-202 18721130-0 2009 Increased tyrosine phosphorylation of PSD-95 by Src family kinases after brain ischaemia. Tyrosine 10-18 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 48-51 18721130-3 2009 PP2, a specific inhibitor of SrcPTKs (Src family protein tyrosine kinases), prevents the ischaemia-induced increases not only in the tyrosine phosphorylation of PSD-95, but also in the interaction between PSD-95 and Src kinases. Tyrosine 57-65 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 29-32 18721130-3 2009 PP2, a specific inhibitor of SrcPTKs (Src family protein tyrosine kinases), prevents the ischaemia-induced increases not only in the tyrosine phosphorylation of PSD-95, but also in the interaction between PSD-95 and Src kinases. Tyrosine 57-65 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 38-41 18682436-8 2008 Hypoxia enhanced phosphorylation of three srcFK proteins at Tyr-416 (60, 59, and 54 kDa, corresponding to src, fyn, and yes, respectively) and enhanced srcFK-dependent tyrosine phosphorylation of multiple target proteins. Tyrosine 60-63 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 42-45 18583343-3 2008 In contrast, ATP induced an enhancement in the tyrosine-phosphorylated protein profile of brain mitochondria, which was further greatly enhanced with orthovanadate and which disappeared when Src was inhibited with two inhibitors: PP2 and PP1. Tyrosine 47-55 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 191-194 19208792-8 2009 In conclusion, the Lck and c-Src kinases appear to play an important role in regulating tyrosine phosphorylation of phospholipase C1 and contractile activity in the rat uterus. Tyrosine 88-96 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 27-32 18583343-8 2008 Therefore, the present data suggest a possible control point in the regulation of respiration by tyrosine phosphorylation of the complexes mediated by Src auto-activation. Tyrosine 97-105 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 151-154 17175272-7 2006 Tyrosine phosphorylation of the VEGF receptor Flk-1 and the platelet-derived growth factor receptor (PDGF-R) was increased only at 1 hour after reperfusion, while c-Src tyrosine phosphorylation remained increased at 3 hours and remained up to 6 hours after reperfusion. Tyrosine 169-177 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 163-168 18539271-7 2008 Treatment with HU210 caused tyrosine phosphorylation of Src and Fyn, and increased their kinase activities. Tyrosine 28-36 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 56-59 18498770-0 2008 Tyrosine phosphorylation of HPK1 by activated Src promotes ischemic brain injury in rat hippocampal CA1 region. Tyrosine 0-8 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 46-49 18498770-6 2008 We speculate that this unique signaling pathway through the tyrosine phosphorylation of HPK1 promotes ischemic brain injury by activated Src via N-methyl-d-aspartate receptor and, ultimately, the activation of the MLK3-MKK7-JNK3 pathway after cerebral ischemia. Tyrosine 60-68 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 137-140 18295415-9 2008 HCB induced the association of the EGFR with c-Src and increased the phosphorylation of EGFR at tyrosine 845 (Tyr845), a known c-Src phosphorylation site. Tyrosine 96-104 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 127-132 18032393-6 2008 Nine srcFK were expressed at the mRNA level, including src, fyn, and yes, and PGF(2 alpha) enhanced phosphorylation of three srcFK proteins at tyr-416. Tyrosine 143-146 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 5-8 18022328-0 2007 Activation of GABA receptors attenuates neuronal apoptosis through inhibiting the tyrosine phosphorylation of NR2A by Src after cerebral ischemia and reperfusion. Tyrosine 82-90 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 118-121 17855367-6 2007 Site-directed mutagenesis of putative tyrosine phosphorylation sites in CUGBP2 identified tyrosine 39 as a c-Src target, and a CUGBP2 with a mutated tyrosine 39 displayed an attenuated ability to bind COX-2 mRNA. Tyrosine 38-46 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 107-112 17855367-6 2007 Site-directed mutagenesis of putative tyrosine phosphorylation sites in CUGBP2 identified tyrosine 39 as a c-Src target, and a CUGBP2 with a mutated tyrosine 39 displayed an attenuated ability to bind COX-2 mRNA. Tyrosine 90-98 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 107-112 17855367-6 2007 Site-directed mutagenesis of putative tyrosine phosphorylation sites in CUGBP2 identified tyrosine 39 as a c-Src target, and a CUGBP2 with a mutated tyrosine 39 displayed an attenuated ability to bind COX-2 mRNA. Tyrosine 90-98 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 107-112 17855367-10 2007 Therefore, our data suggest that tyrosine phosphorylation of CUGBP2 is an important underlying mechanism for the ability of PDGFR/c-Src signaling to control the stability of COX-2 mRNA. Tyrosine 33-41 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 130-135 16888778-6 2007 Screening by anti-phosphotyrosine immunoblotting for focal adhesion signaling in response to stretch reveals a significant increase in the tyrosine phosphorylated bands identified as focal adhesion kinase (FAK), A-Raf, paxillin, and Src. Tyrosine 25-33 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 233-236 16973240-6 2006 Leptin and H(2)O(2) increased Src phosphorylation at Tyr(418). Tyrosine 53-56 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 30-33 18449527-7 2008 RESULTS: Ouabain caused a rapid Tyr(418) phosphorylation, indicating activation of Src in the presence of high glucose. Tyrosine 32-35 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 83-86 18644992-3 2008 In the azoxymethane-treated rat model of experimental colon carcinogenesis, sulindac treatment markedly induced Csk with a corresponding increase in inhibitory phosphorylation of Src (Tyr(527)). Tyrosine 184-187 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 179-182 18353971-4 2008 Furthermore, Src-mediated cortactin tyrosine phosphorylation was markedly increased after suprastimulation. Tyrosine 36-44 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 13-16 16983688-7 2007 We conclude that the inhibitory effect of 18beta-glycyrrhetinic acid on GJIC in cardiomyocytes involves Src-mediated tyrosine phosphorylation of Cx43. Tyrosine 117-125 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 104-107 16337085-9 2006 The inhibition of tyrosine phosphorylation and down-regulation of src protein observed may also contribute to Connexin 43 dephosphorylation and GJIC restoration by TSA and NaBu partly through depletion of src protein pool. Tyrosine 18-26 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 205-208 16597920-0 2006 Involvement of JAK2 and Src kinase tyrosine phosphorylation in human growth hormone-stimulated increases in cytosolic free Ca2+ and insulin secretion. Tyrosine 35-43 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 24-27 16500731-9 2006 Phosphorylation of src at tyrosine-416 was reduced by PP1 but changes in its phosphorylation did not correlate with the effects of PP1 on release. Tyrosine 26-34 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 19-22 16597920-5 2006 hGH caused tyrosine phosphorylation of Janus kinase (JAK)2 and c-Src, events inhibited by the JAK2 inhibitor AG490 or the Src kinase inhibitor PP2. Tyrosine 11-19 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 63-68 16597920-5 2006 hGH caused tyrosine phosphorylation of Janus kinase (JAK)2 and c-Src, events inhibited by the JAK2 inhibitor AG490 or the Src kinase inhibitor PP2. Tyrosine 11-19 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 65-68 16877402-9 2006 Carbachol increased the phosphorylation of Pyk2 on tyrosine 402 and c-src on tyrosine 416 in a time-dependent manner. Tyrosine 77-85 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 68-73 16394176-5 2006 The hormone activates c-Src in intestinal cells through fast changes in tyrosine phosphorylation of the enzyme. Tyrosine 72-80 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 22-27 16394176-10 2006 The results of this work indicate that PTH activates c-Src in intestinal cells through conformational changes via G proteins and calcium-dependent modulation of tyrosine phosphorylation of the enzyme, and that PTH receptor activation leads via Gbetagamma-c-Src to the phosphorylation of the MAP kinases, ERK1 and ERK2. Tyrosine 161-169 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 53-58 16151024-4 2005 The nonreceptor tyrosine kinase, proto-oncogene cAbl is a substrate of Src and is a major mediator for ROS-dependent tyrosine phosphorylation of Cav1. Tyrosine 16-24 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 71-74 16079134-6 2005 We have mapped the major tyrosine phosphorylation site to position 192 of beta1, where it forms part of a highly acidic phospho-acceptor site for Src-like kinases. Tyrosine 25-33 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 146-149 16079134-7 2005 In the phosphorylated state Tyr(P)-192 exposes a docking site for SH2 domains and efficiently recruits Src and Fyn to sGCbeta1, thereby promoting multiple phosphorylation of the enzyme. Tyrosine 28-31 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 103-106 16083718-7 2005 The broad-spectrum protein kinase C inhibitor and the Src kinase inhibitor both inhibited tumor necrosis factor-alpha-induced proline-rich tyrosine kinase 2 phosphorylation, but at different tyrosine residues. Tyrosine 139-147 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 54-57 15901799-7 2005 Preglomerular microvascular smooth muscle cells expressed phospholipase (PLC)-beta(2), PLC-beta(3), c-src, phospho(tyrosine 416)-c-src, and PI3K. Tyrosine 115-123 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 129-134 15735685-3 2005 Here, we report that the r-PTPeta protein binds to c-Src in living cells and dephosphorylates the c-Src inhibitory tyrosine phosphorylation site (Tyr 529), thereby increasing c-Src tyrosine kinase activity in malignant rat thyroid cells stably transfected with r-PTPeta. Tyrosine 115-123 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 51-56 15705590-7 2005 This study is the first demonstration that PLD2 activation is implicated in Src-dependent phosphorylation of Pyk2 (Tyr(580) and Tyr(881)) by promoting the complex formation between Pyk2 and activated Src in PC12 cells exposed to H(2)O(2), thereby resulting in activation of the survival signaling pathway PI3K/Akt/p70S6K. Tyrosine 115-118 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 76-79 15705590-7 2005 This study is the first demonstration that PLD2 activation is implicated in Src-dependent phosphorylation of Pyk2 (Tyr(580) and Tyr(881)) by promoting the complex formation between Pyk2 and activated Src in PC12 cells exposed to H(2)O(2), thereby resulting in activation of the survival signaling pathway PI3K/Akt/p70S6K. Tyrosine 115-118 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 200-203 15705590-7 2005 This study is the first demonstration that PLD2 activation is implicated in Src-dependent phosphorylation of Pyk2 (Tyr(580) and Tyr(881)) by promoting the complex formation between Pyk2 and activated Src in PC12 cells exposed to H(2)O(2), thereby resulting in activation of the survival signaling pathway PI3K/Akt/p70S6K. Tyrosine 128-131 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 76-79 15817454-2 2005 Following autophosphorylation at tyrosine 397, FAK binds the Src homology 2 domains of Src and phosphoinositide 3-kinase, among several other possible binding partners. Tyrosine 33-41 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 61-64 15817454-2 2005 Following autophosphorylation at tyrosine 397, FAK binds the Src homology 2 domains of Src and phosphoinositide 3-kinase, among several other possible binding partners. Tyrosine 33-41 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 87-90 15735685-3 2005 Here, we report that the r-PTPeta protein binds to c-Src in living cells and dephosphorylates the c-Src inhibitory tyrosine phosphorylation site (Tyr 529), thereby increasing c-Src tyrosine kinase activity in malignant rat thyroid cells stably transfected with r-PTPeta. Tyrosine 115-123 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 98-103 15735685-3 2005 Here, we report that the r-PTPeta protein binds to c-Src in living cells and dephosphorylates the c-Src inhibitory tyrosine phosphorylation site (Tyr 529), thereby increasing c-Src tyrosine kinase activity in malignant rat thyroid cells stably transfected with r-PTPeta. Tyrosine 146-149 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 51-56 15735685-3 2005 Here, we report that the r-PTPeta protein binds to c-Src in living cells and dephosphorylates the c-Src inhibitory tyrosine phosphorylation site (Tyr 529), thereby increasing c-Src tyrosine kinase activity in malignant rat thyroid cells stably transfected with r-PTPeta. Tyrosine 146-149 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 98-103 15735685-7 2005 Interestingly, the extent of both c-Src dephosphorylation at Tyr 529, FAK and paxillin phosphorylation, and the increased cell adhesion were associated with the degree of r-PTPeta expression. Tyrosine 61-64 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 34-39 15576648-5 2005 This was paralleled by increases of Fak/Src association and Src activity (Tyr-418 phosphorylation). Tyrosine 74-77 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 60-63 15748156-6 2005 Tyrosine phosphorylation of the NR2A and NR2B subunits of the NMDAR increased 3-4-fold over control values during SE, continued to increase during the first hour following SE and then declined to control levels by 24 h. SE resulted in the activation of Src and Pyk2 associated with the postsynaptic apparatus, suggesting a role for these enzymes in the SE-induced increase in tyrosine phosphorylation. Tyrosine 0-8 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 253-256 15451029-4 2005 However, treatment of intact cells with the selective Src family kinase inhibitor PP2, at concentrations which abolished Src-mediated phosphorylation of focal adhesion kinase (FAK) at Tyr-577, unexpectedly led to increased phosphorylation at Src Tyr-418 and diminished phosphorylation at Tyr-529. Tyrosine 246-249 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 121-124 15322113-4 2004 DNA laddering was decreased by mutation of the Tyr(402) Src-binding site in RAFTK, suggesting a central role for Src activity in apoptotic cell death that was confirmed by adenoviral-mediated Src expression. Tyrosine 47-50 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 56-59 15451029-4 2005 However, treatment of intact cells with the selective Src family kinase inhibitor PP2, at concentrations which abolished Src-mediated phosphorylation of focal adhesion kinase (FAK) at Tyr-577, unexpectedly led to increased phosphorylation at Src Tyr-418 and diminished phosphorylation at Tyr-529. Tyrosine 246-249 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 54-57 15451029-4 2005 However, treatment of intact cells with the selective Src family kinase inhibitor PP2, at concentrations which abolished Src-mediated phosphorylation of focal adhesion kinase (FAK) at Tyr-577, unexpectedly led to increased phosphorylation at Src Tyr-418 and diminished phosphorylation at Tyr-529. Tyrosine 246-249 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 121-124 15451029-4 2005 However, treatment of intact cells with the selective Src family kinase inhibitor PP2, at concentrations which abolished Src-mediated phosphorylation of focal adhesion kinase (FAK) at Tyr-577, unexpectedly led to increased phosphorylation at Src Tyr-418 and diminished phosphorylation at Tyr-529. Tyrosine 246-249 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 121-124 15451029-6 2005 These results imply that a distinct, non-Src family kinase may be responsible for phosphorylating Src at Tyr-418 in intact fibroblasts and epithelial cells stimulated by GPCR agonists. Tyrosine 105-108 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 41-44 15451029-6 2005 These results imply that a distinct, non-Src family kinase may be responsible for phosphorylating Src at Tyr-418 in intact fibroblasts and epithelial cells stimulated by GPCR agonists. Tyrosine 105-108 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 98-101 15451029-0 2005 Bombesin and angiotensin II rapidly stimulate Src phosphorylation at Tyr-418 in fibroblasts and intestinal epithelial cells through a PP2-insensitive pathway. Tyrosine 69-72 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 46-49 15451029-1 2005 Src is activated in response to a variety of growth factors and hormones that bind G protein-coupled receptors (GPCRs), and its activity is regulated by phosphorylation at key sites, including the autophosphorylation site Tyr-418 and the inhibitory site Tyr-529. Tyrosine 222-225 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 0-3 15451029-1 2005 Src is activated in response to a variety of growth factors and hormones that bind G protein-coupled receptors (GPCRs), and its activity is regulated by phosphorylation at key sites, including the autophosphorylation site Tyr-418 and the inhibitory site Tyr-529. Tyrosine 254-257 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 0-3 15451029-3 2005 Phosphorylation at Src Tyr-418, the activation loop site, was rapidly and markedly increased after GPCR agonist addition in both cell types. Tyrosine 23-26 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 19-22 15451029-4 2005 However, treatment of intact cells with the selective Src family kinase inhibitor PP2, at concentrations which abolished Src-mediated phosphorylation of focal adhesion kinase (FAK) at Tyr-577, unexpectedly led to increased phosphorylation at Src Tyr-418 and diminished phosphorylation at Tyr-529. Tyrosine 184-187 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 54-57 15451029-4 2005 However, treatment of intact cells with the selective Src family kinase inhibitor PP2, at concentrations which abolished Src-mediated phosphorylation of focal adhesion kinase (FAK) at Tyr-577, unexpectedly led to increased phosphorylation at Src Tyr-418 and diminished phosphorylation at Tyr-529. Tyrosine 184-187 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 121-124 15451029-4 2005 However, treatment of intact cells with the selective Src family kinase inhibitor PP2, at concentrations which abolished Src-mediated phosphorylation of focal adhesion kinase (FAK) at Tyr-577, unexpectedly led to increased phosphorylation at Src Tyr-418 and diminished phosphorylation at Tyr-529. Tyrosine 184-187 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 121-124 15451029-4 2005 However, treatment of intact cells with the selective Src family kinase inhibitor PP2, at concentrations which abolished Src-mediated phosphorylation of focal adhesion kinase (FAK) at Tyr-577, unexpectedly led to increased phosphorylation at Src Tyr-418 and diminished phosphorylation at Tyr-529. Tyrosine 246-249 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 54-57 15451029-4 2005 However, treatment of intact cells with the selective Src family kinase inhibitor PP2, at concentrations which abolished Src-mediated phosphorylation of focal adhesion kinase (FAK) at Tyr-577, unexpectedly led to increased phosphorylation at Src Tyr-418 and diminished phosphorylation at Tyr-529. Tyrosine 246-249 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 121-124 15322113-4 2004 DNA laddering was decreased by mutation of the Tyr(402) Src-binding site in RAFTK, suggesting a central role for Src activity in apoptotic cell death that was confirmed by adenoviral-mediated Src expression. Tyrosine 47-50 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 113-116 15322113-4 2004 DNA laddering was decreased by mutation of the Tyr(402) Src-binding site in RAFTK, suggesting a central role for Src activity in apoptotic cell death that was confirmed by adenoviral-mediated Src expression. Tyrosine 47-50 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 113-116 15345719-6 2004 Expression of ct-betaARK also prevented Src-mediated tyrosine phosphorylation of caveolin-1 and dynamin-2 and the resultant phosphorylation-dependent association of dynamin-2 and caveolin-1. Tyrosine 53-61 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 40-43 15464232-10 2004 The effects of forskolin on cholangiocyte proliferation were associated with increased activity of PKA, Src Tyrosine 139 (Tyr 139) and ERK1/2. Tyrosine 108-116 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 104-107 15337529-6 2004 Inhibition of Src by treatment with the Src family inhibitor PP2 reduced insulin-stimulated Src-PKCdelta association, PKCdelta tyrosine phosphorylation and PKCdelta activation. Tyrosine 127-135 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 14-17 15337529-6 2004 Inhibition of Src by treatment with the Src family inhibitor PP2 reduced insulin-stimulated Src-PKCdelta association, PKCdelta tyrosine phosphorylation and PKCdelta activation. Tyrosine 127-135 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 40-43 15337529-6 2004 Inhibition of Src by treatment with the Src family inhibitor PP2 reduced insulin-stimulated Src-PKCdelta association, PKCdelta tyrosine phosphorylation and PKCdelta activation. Tyrosine 127-135 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 40-43 15337529-7 2004 PP2 inhibition of Src also decreased insulin-induced IR tyrosine phosphorylation, IR-PKCdelta association and association of Src with both PKCdelta and IR. Tyrosine 56-64 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 18-21 15337529-10 2004 Thus, Src tyrosine kinase may play an important role in insulin-induced tyrosine phosphorylation of both IR and PKCdelta. Tyrosine 10-18 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 6-9 15464232-10 2004 The effects of forskolin on cholangiocyte proliferation were associated with increased activity of PKA, Src Tyrosine 139 (Tyr 139) and ERK1/2. Tyrosine 108-111 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 104-107 15161929-8 2004 The high affinity site for ouabain is associated with Src-dependent tyrosine phosphorylation of rat alpha1 Na-K ATPase. Tyrosine 68-76 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 54-57 14985335-10 2004 Thus, the ability of the Tyr(T)-independent mechanism to suppress the activity of both non-phosphorylated and autophosphorylated SFKs represents a fail-safe measure employed by CHK to down-regulate SFK signaling under all circumstances. Tyrosine 25-28 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 129-132 15173175-5 2004 Mutation analysis of tyrosine with phenylalanine in COS-7 cells revealed that paired tyrosines at the ITAM sequence of tamalin are phosphorylated preferentially by c-Src and Fyn, and this phosphorylation can recruit Syk kinase and enables it to be phosphorylated by the Src family kinases. Tyrosine 85-94 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 164-169 15096502-8 2004 CS also induced both Src-Tyr-418 phosphorylation and Src to FAK association. Tyrosine 25-28 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 21-24 14630916-6 2004 Bradykinin caused activation of p60Src and Src-dependent phosphorylation of the EGFR on Tyr-845 in lipid rafts, as well as recruitment of phospholipase C (PLC) gamma1 to the rafts. Tyrosine 88-91 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 32-38 14985335-1 2004 Although C-terminal Src kinase (CSK)-homologous kinase (CHK) is generally believed to inactivate Src-family tyrosine kinases (SFKs) by phosphorylating their consensus C-terminal regulatory tyrosine (Tyr(T)), exactly how CHK inactivates SFKs is not fully understood. Tyrosine 108-116 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 20-23 14985335-1 2004 Although C-terminal Src kinase (CSK)-homologous kinase (CHK) is generally believed to inactivate Src-family tyrosine kinases (SFKs) by phosphorylating their consensus C-terminal regulatory tyrosine (Tyr(T)), exactly how CHK inactivates SFKs is not fully understood. Tyrosine 108-116 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 97-100 14985335-1 2004 Although C-terminal Src kinase (CSK)-homologous kinase (CHK) is generally believed to inactivate Src-family tyrosine kinases (SFKs) by phosphorylating their consensus C-terminal regulatory tyrosine (Tyr(T)), exactly how CHK inactivates SFKs is not fully understood. Tyrosine 199-202 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 20-23 14985335-1 2004 Although C-terminal Src kinase (CSK)-homologous kinase (CHK) is generally believed to inactivate Src-family tyrosine kinases (SFKs) by phosphorylating their consensus C-terminal regulatory tyrosine (Tyr(T)), exactly how CHK inactivates SFKs is not fully understood. Tyrosine 199-202 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 97-100 15044612-6 2004 Here we demonstrated that Ang II rapidly and significantly stimulated tyrosine phosphorylation of Src and Cas and their association in rat aortic smooth muscle cells (RASMC). Tyrosine 70-78 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 98-101 15044612-7 2004 Ang II-stimulated tyrosine phosphorylation of Src and Cas and activation of ERK1/2 and JNK, but not p38, were potently inhibited by Src family tyrosine kinase inhibitors, herbimycin A (HA) and PP2. Tyrosine 18-26 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 46-49 15044612-7 2004 Ang II-stimulated tyrosine phosphorylation of Src and Cas and activation of ERK1/2 and JNK, but not p38, were potently inhibited by Src family tyrosine kinase inhibitors, herbimycin A (HA) and PP2. Tyrosine 18-26 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 132-135 15044612-8 2004 Ang II-stimulated Src and Cas association, tyrosine phosphorylation of Cas, and activation of ERK1/2 and JNK were suppressed in kinase-inactive Src (KI Src)-overexpressed RASMC. Tyrosine 43-51 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 144-147 15044612-8 2004 Ang II-stimulated Src and Cas association, tyrosine phosphorylation of Cas, and activation of ERK1/2 and JNK were suppressed in kinase-inactive Src (KI Src)-overexpressed RASMC. Tyrosine 43-51 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 144-147 14630916-6 2004 Bradykinin caused activation of p60Src and Src-dependent phosphorylation of the EGFR on Tyr-845 in lipid rafts, as well as recruitment of phospholipase C (PLC) gamma1 to the rafts. Tyrosine 88-91 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 35-38 12950452-7 2003 The results are consistent with a role for PKC in the ischemia-induced increase in tyrosine phosphorylation of the NMDAR, via a pathway involving Pyk2 and Src-family kinases. Tyrosine 83-91 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 155-158 12932824-5 2003 These results suggest that the inhibition of NR2A tyrosine phosphorylation and its interactions with Src and Fyn mediated by PSD-95 may contribute to the lithium-induced downregulation of NMDA receptor function and provide neuroprotection against excitotoxicity. Tyrosine 50-58 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 101-104 14741724-6 2004 Intensities of the Src band and amounts of tyrosine phosphorylated Src were enhanced by CCK stimulation. Tyrosine 43-51 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 67-70 14556939-5 2003 Tyrosine phosphorylation of the NMDA receptor subunit NR2A by Src or Fyn has been implicated in the up-regulation of NMDA receptor activity. Tyrosine 0-8 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 62-65 14499346-2 2003 By probing total cell extracts and anti-P-Tyr immunoprecipitates with a phosphorylation site-specific antibody targeting a conserved site of positive regulation of the overall family of Src kinases, a sustained and a transient downregulation of the immunoprecipitable subpopulation of nominally active Src kinases is detected in response to NGF and EGF, respectively. Tyrosine 42-45 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 186-189 14499346-2 2003 By probing total cell extracts and anti-P-Tyr immunoprecipitates with a phosphorylation site-specific antibody targeting a conserved site of positive regulation of the overall family of Src kinases, a sustained and a transient downregulation of the immunoprecipitable subpopulation of nominally active Src kinases is detected in response to NGF and EGF, respectively. Tyrosine 42-45 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 302-305 12819032-4 2003 In vitro kinase assay confirmed increased Src activity that concurred with PDGFR-beta activation as detected by the increment of receptor-phosphorylated tyrosine. Tyrosine 153-161 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 42-45 12850569-1 2003 It has been reported that the Src family kinases-mediated tyrosine phosphorylation of alpha(1C) subunits of L-type voltage-gated calcium channels (L-VGCCs) potentiates the channel currents. Tyrosine 58-66 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 30-33 12850569-9 2003 These results suggest a novel mechanism involving the ischemia/reperfusion-induced recruitment of L-VGCCs, Src and Fyn to the PSD-95 signaling complex that facilitates the tyrosine phosphorylation of alpha(1C) subunits by Src family kinases and may contribute to the up-regulation of L-VGCCs activity in postischemic hippocampus. Tyrosine 172-180 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 107-110 12850569-9 2003 These results suggest a novel mechanism involving the ischemia/reperfusion-induced recruitment of L-VGCCs, Src and Fyn to the PSD-95 signaling complex that facilitates the tyrosine phosphorylation of alpha(1C) subunits by Src family kinases and may contribute to the up-regulation of L-VGCCs activity in postischemic hippocampus. Tyrosine 172-180 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 222-225 12695509-1 2003 Tyrosine phosphorylation of the NR2A and NR2B subunits of the N-methyl-d-aspartate (NMDA) receptor by Src protein-tyrosine kinases modulates receptor channel activity and is necessary for the induction of long term potentiation (LTP). Tyrosine 0-8 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 102-105 12695509-6 2003 Cotransfection of H-Ras and Src inhibited Src activity and decreased NR2A tyrosine phosphorylation. Tyrosine 74-82 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 28-31 12711087-7 2003 Src and Pyk2 interacting with NR2A might also be involved in this regulation of the tyrosine phosphorylation of NR2A induced by I/R. Tyrosine 84-92 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 0-3 12759180-5 2003 These data suggested that PSD-95 is critical for facilitating NR2A tyrosine phosphorylation by Src family kinases in postischemic brain. Tyrosine 67-75 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 95-98 12697723-4 2003 Furthermore, p-FAK-Tyr(397) was shown to coimmunoprecipitate with beta 1-integrin, vinculin, and c-Src both in vitro and in vivo using Sertoli-germ cell cocultures and seminiferous tubules, respectively. Tyrosine 19-22 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 97-102 12244095-1 2002 STAT3 is a member of a family of transcription factors with Src homology 2 (SH2) domains that are activated by tyrosine phosphorylation in response to a wide variety of cytokines and growth factors. Tyrosine 111-119 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 60-63 12618293-4 2003 These results demonstrated that PTK and PTP were involved in regulating tyrosine phosphorylation of NR2A through changing the interaction among NR2A, PSD-95, Fyn/Src. Tyrosine 72-80 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 162-165 12526090-5 2002 Interestingly, CPTP1-like rat PTP1 was coimmunoprecipitated with a 70-kDa protein which has a possibility to be tyrosine- phosphorylated by p60(v-src) in v-src-transformed Rat-1 fibroblasts. Tyrosine 112-120 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 146-149 12526090-5 2002 Interestingly, CPTP1-like rat PTP1 was coimmunoprecipitated with a 70-kDa protein which has a possibility to be tyrosine- phosphorylated by p60(v-src) in v-src-transformed Rat-1 fibroblasts. Tyrosine 112-120 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 156-159 12447877-10 2002 EGF stimulated the tyrosine phosphorylation of Src, and induced its association with the IGF-IR. Tyrosine 19-27 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 47-50 12633868-2 2003 Since this receptor tyrosine phosphorylation is mediated by the Src-family tyrosine kinases, we investigated the effects of lithium on the Src kinase activity. Tyrosine 20-28 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 64-67 12488346-3 2003 In previous studies, we reported an increase in Tyr phosphorylation of pp60(c-Src) in intestinal epithelial cells (IEC) in response to the fully processed form of gastrin [gastrin(1-17) (G17)]. Tyrosine 48-51 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 76-81 12244095-3 2002 Using Sf-9 insect cells, we demonstrate direct STAT3 tyrosine phosphorylation and stimulation of DNA binding activity by five members of the Src kinase family (Src, Hck, Lyn, Fyn, and Fgr). Tyrosine 53-61 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 141-144 12244095-3 2002 Using Sf-9 insect cells, we demonstrate direct STAT3 tyrosine phosphorylation and stimulation of DNA binding activity by five members of the Src kinase family (Src, Hck, Lyn, Fyn, and Fgr). Tyrosine 53-61 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 160-163 12419528-1 2002 Recent studies have indicated that tyrosine phosphorylation of NMDA receptor subunit 2A (NR2A) by Src family kinases (Src, Fyn, etc.) Tyrosine 35-43 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 98-101 12419528-1 2002 Recent studies have indicated that tyrosine phosphorylation of NMDA receptor subunit 2A (NR2A) by Src family kinases (Src, Fyn, etc.) Tyrosine 35-43 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 118-121 11907028-4 2002 Immunoprecipitation experiments showed that ouabain stimulated Src binding to Na(+)/K(+)-ATPase in a dose- and time-dependent manner and increased phosphorylation of Src at Tyr(418) but had no effect on Tyr(529) phosphorylation. Tyrosine 203-206 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 63-66 12219031-0 2002 Complement regulatory protein CD59 involves c-SRC related tyrosine phosphorylation of the creatine transporter in skeletal muscle during sepsis. Tyrosine 58-66 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 44-49 12219031-4 2002 The purpose of this study was to determine the association between myocellular free Cr, c-Src related tyrosine phosphorylation of the CreaT, and CD59 during sepsis. Tyrosine 102-110 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 88-93 12219031-11 2002 Tyrosine phosphorylated c-Src (Tyr-416) in the CreaT-c-Src immune complex was 24% higher after CLP. Tyrosine 0-8 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 24-29 12219031-11 2002 Tyrosine phosphorylated c-Src (Tyr-416) in the CreaT-c-Src immune complex was 24% higher after CLP. Tyrosine 0-8 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 53-58 12219031-11 2002 Tyrosine phosphorylated c-Src (Tyr-416) in the CreaT-c-Src immune complex was 24% higher after CLP. Tyrosine 0-3 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 24-29 12219031-11 2002 Tyrosine phosphorylated c-Src (Tyr-416) in the CreaT-c-Src immune complex was 24% higher after CLP. Tyrosine 0-3 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 53-58 12219031-12 2002 Sepsis also increased protein expression of tyrosine phosphorylated c-Src (Tyr-416) or CreaT in the CD59-c-Src or CD59-CreaT complex by 20% or 30%, respectively. Tyrosine 44-52 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 68-73 12219031-12 2002 Sepsis also increased protein expression of tyrosine phosphorylated c-Src (Tyr-416) or CreaT in the CD59-c-Src or CD59-CreaT complex by 20% or 30%, respectively. Tyrosine 44-52 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 105-110 12219031-12 2002 Sepsis also increased protein expression of tyrosine phosphorylated c-Src (Tyr-416) or CreaT in the CD59-c-Src or CD59-CreaT complex by 20% or 30%, respectively. Tyrosine 75-78 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 68-73 12219031-12 2002 Sepsis also increased protein expression of tyrosine phosphorylated c-Src (Tyr-416) or CreaT in the CD59-c-Src or CD59-CreaT complex by 20% or 30%, respectively. Tyrosine 75-78 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 105-110 12219031-13 2002 CONCLUSIONS: During sepsis, an increase in myocellular free Cr levels is associated with enhanced tyrosine phosphorylation of the CreaT, which is likely induced by active c-Src. Tyrosine 98-106 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 171-176 11925438-7 2002 In addition, we show that tyrosine phosphorylation of p190RhoGAP is increased upon 12-O-tetradecanoylphorbol-13-acetate stimulation, directly linking Src activation to a decrease in RhoA activity. Tyrosine 26-34 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 150-153 12114187-6 2002 Mechanical stretch increased tyrosine phosphorylation of rat AFAP and its binding to c-Src within the initial several minutes. Tyrosine 29-37 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 85-90 11907028-4 2002 Immunoprecipitation experiments showed that ouabain stimulated Src binding to Na(+)/K(+)-ATPase in a dose- and time-dependent manner and increased phosphorylation of Src at Tyr(418) but had no effect on Tyr(529) phosphorylation. Tyrosine 173-176 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 166-169 11907028-4 2002 Immunoprecipitation experiments showed that ouabain stimulated Src binding to Na(+)/K(+)-ATPase in a dose- and time-dependent manner and increased phosphorylation of Src at Tyr(418) but had no effect on Tyr(529) phosphorylation. Tyrosine 203-206 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 166-169 11867627-5 2002 The latter is a scaffolding protein structurally similar to the SRC substrate Cas, tyrosine phosphorylation of which is critical for migration in fibroblasts and epithelial cells. Tyrosine 83-91 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 64-67 12007793-0 2002 Characterization and location of Src-dependent tyrosine phosphorylation in rat brain mitochondria. Tyrosine 47-55 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 33-36 11934669-3 2002 The association between myocellular Cr and c-Src-related tyrosine phosphorylation of the CreaT and the influence of oral Cr supplementation on this association were investigated during sepsis. Tyrosine 57-65 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 43-48 11934669-7 2002 Western blotting of the immunoprecipitated CreaT with an anti-phosphotyrosine or anti-phospho-c-Src (Y-416) antibody revealed that tyrosine phosphorylation of the CreaT and tyrosine-phosphorylated c-Src (Tyr(416)) expression in the CreaT-c-Src complex were significantly increased after CLP compared with sham operation. Tyrosine 131-139 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 94-99 11934669-7 2002 Western blotting of the immunoprecipitated CreaT with an anti-phosphotyrosine or anti-phospho-c-Src (Y-416) antibody revealed that tyrosine phosphorylation of the CreaT and tyrosine-phosphorylated c-Src (Tyr(416)) expression in the CreaT-c-Src complex were significantly increased after CLP compared with sham operation. Tyrosine 131-139 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 197-202 11934669-7 2002 Western blotting of the immunoprecipitated CreaT with an anti-phosphotyrosine or anti-phospho-c-Src (Y-416) antibody revealed that tyrosine phosphorylation of the CreaT and tyrosine-phosphorylated c-Src (Tyr(416)) expression in the CreaT-c-Src complex were significantly increased after CLP compared with sham operation. Tyrosine 131-139 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 197-202 11934669-9 2002 Although oral Cr supplementation increased myocellular free Cr levels equivalently in CLP and sham-operated animals, c-Src-related tyrosine phosphorylation of the CreaT in homogenates and plasma membrane fractions of gastrocnemius muscles was, however, downregulated in Cr-supplemented CLP animals compared with Cr-supplemented sham-operated rats. Tyrosine 131-139 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 117-122 11934669-10 2002 During sepsis, increased myocellular free Cr levels are associated with enhanced tyrosine phosphorylation of the CreaT, which is likely induced by active c-Src. Tyrosine 81-89 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 154-159 11934669-11 2002 Oral Cr supplementation downregulates c-Src-related tyrosine phosphorylation of the CreaT. Tyrosine 52-60 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 38-43 12007793-3 2002 Tyrosine phosphorylation disappears when mitochondria are treated with PP2, an inhibitor of the Src kinase family, suggesting the presence of members of this family in rat brain mitochondria. Tyrosine 0-8 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 96-99 11640929-8 2001 Together our results suggests that tyrosine phosphorylation of the gamma2 subunit, possibly by closely associated Src, may be a dynamic mechanism for regulating GABA(A) receptor function in the brain. Tyrosine 35-43 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 114-117 11583916-9 2001 DETA/NO was also able to induce autophosphorylation and activation c-Src protein both in vivo and in vitro and active c-Src was able to induce tyrosine phosphorylation of Bcl-2 in vitro. Tyrosine 143-151 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 118-123 11713277-0 2001 Nerve growth factor stimulates multisite tyrosine phosphorylation and activation of the atypical protein kinase C"s via a src kinase pathway. Tyrosine 41-49 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 122-125 11713277-3 2001 Tyrosine phosphorylation and activation of PKC-iota were inhibited in a dose-dependent manner by both PP2 and K252a, src and TrkA kinase inhibitors. Tyrosine 0-8 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 117-120 11713277-5 2001 In PC12 cells deficient in src kinase activity, both NGF-induced tyrosine phosphorylation and activation of PKC-iota were also diminished. Tyrosine 65-73 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 27-30 11713277-10 2001 Tyrosine 256, 271, and 325 were identified as major sites phosphorylated by src in the catalytic domain. Tyrosine 0-8 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 76-79 11713277-14 2001 In summary, we have identified a novel mechanism for NGF-induced activation of atypical PKC involving tyrosine phosphorylation by c-Src. Tyrosine 102-110 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 130-135 11487731-7 2001 SynGAP bound to the SH2 domains of Src and Fyn in a tyrosine phosphorylation-dependent fashion, and this interaction increased after ischemia. Tyrosine 52-60 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 35-38 11257458-8 2001 The hormone-induced Src tyrosine dephosphorylation, a major mechanism of Src activation, an effect that was blunted in old animals. Tyrosine 24-32 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 20-23 11331247-7 2001 Tamoxifen also induced an association between c-Src and PKCdelta that resulted in the tyrosine phosphorylation and down-regulation of PKCdelta. Tyrosine 86-94 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 46-51 11124251-6 2001 Mutation of residue Cx43 Tyr(265) (Cx43-Y265F mutant) abolishes both tyrosine phosphorylation of Cx43 and its coprecipitation with c-Src. Tyrosine 25-28 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 131-136 11124251-6 2001 Mutation of residue Cx43 Tyr(265) (Cx43-Y265F mutant) abolishes both tyrosine phosphorylation of Cx43 and its coprecipitation with c-Src. Tyrosine 69-77 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 131-136 11124251-9 2001 Our results support a model in which activated c-Src phosphorylates the COOH-terminal tail of Cx43 on residue Tyr(265), resulting in a stable interaction between both proteins leading to inhibition of gap junctional communication. Tyrosine 110-113 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 47-52 11257458-8 2001 The hormone-induced Src tyrosine dephosphorylation, a major mechanism of Src activation, an effect that was blunted in old animals. Tyrosine 24-32 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 73-76 10884433-0 2000 Nonreceptor tyrosine protein kinase pp60c-src in spatial learning: synapse-specific changes in its gene expression, tyrosine phosphorylation, and protein-protein interactions. Tyrosine 12-20 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 36-45 10975856-3 2000 Our results suggest that PLC are responsible, via a calcium- and protein kinase C (PKC)-dependent pathway, for p60Src activation and tyrosine phosphorylation of the p60Src substrate, cortactin. Tyrosine 133-141 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 165-171 10884433-4 2000 Training also triggered an increase in c-src protein tyrosine kinase activity that was correlated with its tyrosine dephosphorylation in the synaptic membrane fraction. Tyrosine 53-61 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 39-44 10807658-3 2000 Total tyrosine phosphorylation level and phosphorylation of tyrosine 419 on pp60(src) required for its full catalytic activity were immunocytochemically detected in situ. Tyrosine 60-68 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 81-84 10585878-6 1999 NE, UTP, EGF and NGF all increased tyrosine phosphorylation of Src, and this was inhibited by the Src inhibitor PP2. Tyrosine 35-43 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 63-66 10585878-6 1999 NE, UTP, EGF and NGF all increased tyrosine phosphorylation of Src, and this was inhibited by the Src inhibitor PP2. Tyrosine 35-43 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 98-101 10545487-11 1999 Pretreatment of the cells with Src family-selective tyrosine kinase inhibitor, PP1, decreased the amount of tyrosine phosphorylated proteins in gamma-tubulin complexes, as well as the amount of gamma-tubulin in Lyn kinase immunocomplexes. Tyrosine 52-60 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 31-34 10487518-2 1999 CAS has been shown to be heavily tyrosine-phosphorylated in src-transformed cells, and genetic variants of src that are deficient in CAS binding are also unable to mediate cellular transformation. Tyrosine 33-41 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 60-63 10487518-4 1999 Expression of the carboxy-terminal src binding domain of CAS in Rat 1 fibroblasts expressing a temperature-sensitive allele of v-src inhibited the formation of src-CAS complexes and also inhibited tyrosine phosphorylation of CAS. Tyrosine 197-205 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 35-38 10487518-4 1999 Expression of the carboxy-terminal src binding domain of CAS in Rat 1 fibroblasts expressing a temperature-sensitive allele of v-src inhibited the formation of src-CAS complexes and also inhibited tyrosine phosphorylation of CAS. Tyrosine 197-205 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 129-132 10487518-4 1999 Expression of the carboxy-terminal src binding domain of CAS in Rat 1 fibroblasts expressing a temperature-sensitive allele of v-src inhibited the formation of src-CAS complexes and also inhibited tyrosine phosphorylation of CAS. Tyrosine 197-205 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 129-132 9446595-5 1998 Transfection studies in COS cells demonstrated that both cellugyrin and synaptogyrin are tyrosine phosphorylated in vivo by pp60c-src, and experiments with recombinant proteins showed that pp60c-src phosphorylates the cytoplasmic tails of these proteins in vitro. Tyrosine 89-97 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 124-133 10527887-8 1999 At the permissive temperature where src was active, PKC-zeta was tyrosine phosphorylated and coassociated with src in vivo; by comparison, at the nonpermissive temperature (40 degrees C) PKC-zeta was not tyrosine phosphorylated. Tyrosine 65-73 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 36-39 10527887-8 1999 At the permissive temperature where src was active, PKC-zeta was tyrosine phosphorylated and coassociated with src in vivo; by comparison, at the nonpermissive temperature (40 degrees C) PKC-zeta was not tyrosine phosphorylated. Tyrosine 204-212 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 36-39 10527887-9 1999 Taken together, these findings support a novel role for the interaction of src and atypical PKC in vivo, which is dependent upon the activity of src and the tyrosine phosphorylation state of PKC-zeta. Tyrosine 157-165 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 75-78 10321903-8 1999 The phosphorylation of Src in IC8.1 cells reflected phosphorylation of the negative regulatory tyrosine 527 (Y527); thus, the inhibitor was selective against the Y527 C-terminal Src kinase Csk. Tyrosine 95-103 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 23-26 10321903-8 1999 The phosphorylation of Src in IC8.1 cells reflected phosphorylation of the negative regulatory tyrosine 527 (Y527); thus, the inhibitor was selective against the Y527 C-terminal Src kinase Csk. Tyrosine 95-103 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 178-181 12935502-3 1999 Specific inhibition of Src-family tyrosine kinases attenuated the AII-induced p130(cas) tyrosine phosphorylation. Tyrosine 34-42 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 23-26 12935502-7 1999 These findings strongly suggest that the AII-induced p130(cas) tyrosine phosphorylation might be associated with the signaling pathways of Src-family tyrosine kinases, protein kinase C and calcineurin in rat cardiac muscle. Tyrosine 63-71 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 139-142 9759894-6 1998 Coexpression of c-Src lacking the C-terminal tyrosine reconstructed podosomes, but could not restore the cell migration regardless of its expression level. Tyrosine 45-53 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 16-21 9753611-0 1998 c-Src and phosphatidylinositol 3-kinase are involved in NGF-dependent tyrosine phosphorylation of Shc in PC12 cells. Tyrosine 70-78 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 0-5 9753611-8 1998 Upon NGF stimulation, c-Src also becomes tyrosine-phosphorylated and accumulates in the Triton-insoluble fraction. Tyrosine 41-49 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 22-27 9753611-10 1998 These results suggest that coordinate action of PtdIns 3-kinase and/or PtdIns 3,4,5-trisphosphate and c-Src can function as positive regulator in tyrosine phosphorylation of Shc in vitro and in vivo. Tyrosine 146-154 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 102-107 10435591-7 1999 The binding of GST-p58gag to c-Src was almost completely abolished by a 50-fold excess of the GST-SH3 domain of Src, and a parallel decrease in tyrosine phosphorylation of p58gag was observed. Tyrosine 144-152 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 29-34 10435591-7 1999 The binding of GST-p58gag to c-Src was almost completely abolished by a 50-fold excess of the GST-SH3 domain of Src, and a parallel decrease in tyrosine phosphorylation of p58gag was observed. Tyrosine 144-152 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 31-34 10435591-8 1999 These results demonstrate that p58gag is tyrosine-phosphorylated as a consequence of its specific association with c-Src via its SH3 domain. Tyrosine 41-49 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 115-120 10321903-6 1999 To measure the inhibition of cellular Src activity, we identified the major tyrosine-phosphorylated proteins in an Src-overexpressing cell line IC8.1 as Src, Fak, and paxillin. Tyrosine 76-84 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 38-41 10321903-6 1999 To measure the inhibition of cellular Src activity, we identified the major tyrosine-phosphorylated proteins in an Src-overexpressing cell line IC8.1 as Src, Fak, and paxillin. Tyrosine 76-84 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 115-118 10321903-6 1999 To measure the inhibition of cellular Src activity, we identified the major tyrosine-phosphorylated proteins in an Src-overexpressing cell line IC8.1 as Src, Fak, and paxillin. Tyrosine 76-84 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 115-118 10321903-7 1999 CGP77675 potently inhibited tyrosine phosphorylation of the Src substrates Fak and paxillin, but had much less effect on Src (IC50 values 0.3, 0.5, and 5.7 micromol/L). Tyrosine 28-36 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 60-63 9692543-0 1998 Tyrosine phosphorylation-dependent and -independent associations of protein kinase C-delta with Src family kinases in the RBL-2H3 mast cell line: regulation of Src family kinase activity by protein kinase C-delta. Tyrosine 0-8 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 96-99 9446595-9 1998 The conserved tyrosine phosphorylation of cellugyrin and synaptogyrins suggests a link between tyrosine phosphorylation via pp60c-src and membrane traffic. Tyrosine 14-22 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 124-133 9446595-9 1998 The conserved tyrosine phosphorylation of cellugyrin and synaptogyrins suggests a link between tyrosine phosphorylation via pp60c-src and membrane traffic. Tyrosine 95-103 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 124-133 9422762-11 1998 Hic-5 was tyrosine-phosphorylated in Src-transformed 3Y1 cells and in cells treated with pervanadate. Tyrosine 10-18 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 37-40 9314836-3 1997 We have previously shown that in rat aortic smooth muscle (RASM) cells Ang II stimulates tyrosine phosphorylation of PLC-gamma via activation of c-Src. Tyrosine 89-97 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 145-150 9314836-9 1997 An important role for Src in tyrosine phosphorylation of p97 was suggested by findings that p97 phosphorylation was inhibited by the selective Src-family kinase inhibitor CP-118,556, diminished in mouse aortic smooth muscle (MASM) cells from c-Src knockout mice compared with wild-type MASM cells, and increased in v-Src-transformed NIH-3T3 cells compared with wild-type NIH-3T3 cells. Tyrosine 29-37 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 242-247 9109427-7 1997 This secosteroid also induced a twofold increase in the activity of Src, a proximate activator of PLC-gamma in other cells, with peaks at 1 and 9 min in association with Src tyrosine dephosphorylation. Tyrosine 174-182 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 68-71 9278444-0 1997 Tyrosine phosphorylation of connexin 43 by v-Src is mediated by SH2 and SH3 domain interactions. Tyrosine 0-8 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 45-48 9278444-1 1997 Reduction of gap junctional communication in v-src transformed cells is accompanied by tyrosine phosphorylation of the gap junction protein, connexin 43 (Cx43). Tyrosine 87-95 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 47-50 9278444-2 1997 Cx43 is phosphorylated on tyrosine by v-Src. Tyrosine 26-34 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 40-43 9278444-6 1997 We present evidence that the SH3 and SH2 domains of v-Src bind to proline-rich motifs and a phosphorylated tyrosine residue in the C-terminal tail of Cx43. Tyrosine 107-115 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 54-57 9278444-8 1997 Tyrosine-phosphorylated Cx43 bound to the SH2 domain of v-Src in vitro. Tyrosine 0-8 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 58-61 9278444-10 1997 Mutations in the SH3 and SH2 domains of v-Src, and in the proline-rich region or tyrosine 265 of Cx43, reduced interactions between v-Src and Cx43 in vivo. Tyrosine 81-89 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 134-137 9278444-11 1997 Tyrosine phosphorylation of Cx43 was dependent on the association of v-Src and Cx43. Tyrosine 0-8 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 71-74 9278444-12 1997 These results provide further evidence for the direct involvement of v-Src in tyrosine phosphorylation of Cx43 and inhibition of gap junctional communication in v-src-transformed cells. Tyrosine 78-86 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 71-74 9278444-12 1997 These results provide further evidence for the direct involvement of v-Src in tyrosine phosphorylation of Cx43 and inhibition of gap junctional communication in v-src-transformed cells. Tyrosine 78-86 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 163-166 9234708-10 1997 These data demonstrate that Raf-1 residues 338 to 341 constitute a unique phosphoregulatory site in which the phosphorylation of serine and tyrosine residues contributes to the regulation of Raf by Ras, Src, and Ras-independent membrane localization. Tyrosine 140-148 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 203-206 9109427-7 1997 This secosteroid also induced a twofold increase in the activity of Src, a proximate activator of PLC-gamma in other cells, with peaks at 1 and 9 min in association with Src tyrosine dephosphorylation. Tyrosine 174-182 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 170-173 9109427-10 1997 Inhibition of 1,25(OH)2D3-induced Src activation by PP1, a specific Src family protein tyrosine kinase inhibitor, blocked the ability of this secosteroid to stimulate the translocation and tyrosine phosphorylation of PLC-gamma in the basolateral membrane (BLM). Tyrosine 87-95 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 34-37 9109427-10 1997 Inhibition of 1,25(OH)2D3-induced Src activation by PP1, a specific Src family protein tyrosine kinase inhibitor, blocked the ability of this secosteroid to stimulate the translocation and tyrosine phosphorylation of PLC-gamma in the basolateral membrane (BLM). Tyrosine 87-95 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 68-71 8777137-5 1996 The cellular tyrosine kinase c-src appears to play a critical role in the angiotensin II-stimulated tyrosine phosphorylation of PLC-gamma 1 and the generation of 1,4,5-IP3. Tyrosine 13-21 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 29-34 9079817-1 1997 The catalytic activity of src-family protein tyrosine kinases (src-PTK) is suppressed when a C-terminal tyrosine is phosphorylated by an intracellular PTK, C-terminal Src kinase (Csk). Tyrosine 45-53 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 26-29 9079817-1 1997 The catalytic activity of src-family protein tyrosine kinases (src-PTK) is suppressed when a C-terminal tyrosine is phosphorylated by an intracellular PTK, C-terminal Src kinase (Csk). Tyrosine 45-53 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 63-66 8849729-3 1996 Here we show that lysophosphatidic acid (LPA) and bradykinin induce tyrosine phosphorylation of Pyk2 and complex formation between Pyk2 and activated Src. Tyrosine 68-76 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 150-153 8849729-4 1996 Moreover, tyrosine phosphorylation of Pyk2 leads to binding of the SH2 domain of Src to tyrosine 402 of Pyk2 and activation of Src. Tyrosine 10-18 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 81-84 8849729-4 1996 Moreover, tyrosine phosphorylation of Pyk2 leads to binding of the SH2 domain of Src to tyrosine 402 of Pyk2 and activation of Src. Tyrosine 10-18 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 127-130 8849729-4 1996 Moreover, tyrosine phosphorylation of Pyk2 leads to binding of the SH2 domain of Src to tyrosine 402 of Pyk2 and activation of Src. Tyrosine 88-96 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 81-84 8626602-3 1996 Electroporation of anti-pp60c-src antibody into cultured, adherent smooth muscle cells blocked the angiotensin II stimulation of Ras-GAP and Rho-GAP tyrosine phosphorylation. Tyrosine 149-157 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 24-33 8981371-3 1997 It has been reported previously that c-Src becomes tyrosine phosphorylated following CSF-1 treatment of fibroblasts overexpressing c-Fms. Tyrosine 51-59 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 37-42 8814263-9 1996 Interestingly, CINC-1 induction appeared to be related to protein tyrosine phosphorylation reactions on the basis of both the appearance of several tyrosine-phosphorylated protein bands in lysates from adherent peritoneal cells treated with immune complexes and the complete blockade of CINC-1 induction by treatment with 1 microM herbimycin A, an inhibitor of src protein tyrosine kinases. Tyrosine 66-74 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 361-364 8649794-0 1996 Tyrosine phosphorylation at the membrane-microfilament interface: a p185neu-associated signal transduction particle containing Src, Abl and phosphorylated p58, a membrane- and microfilament-associated retroviral gag-like protein. Tyrosine 0-8 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 127-130 8603605-1 1996 Bone remodeling requires regulated tyrosine phosphorylation mediated by specific protein tyrosine kinases, such as c-src and c-fms, and to date, unknown protein tyrosine phosphatases (PTPs). Tyrosine 35-43 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 115-120 8845164-4 1995 Protein tyrosine phosphorylation, gene induction, and neurite outgrowth are inhibited by the expression of dominant negative forms of both Src and Ras, indicating a requirement for both proto-oncoproteins in calcium signaling. Tyrosine 8-16 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 139-142 7478608-10 1995 Although both c-Src and c-Yes kinase associate with Neu in vivo, a tyrosine phosphorylated protein of 89 kd (p89) was found associated with c-Src but not with c-Yes in cell lysates derived from mammary epithelial cells transformed by either Neu or PyV middle T antigen. Tyrosine 67-75 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 140-145 7478513-6 1995 Others have shown that overexpression of the receptor tyrosine phosphatase alpha in rat embryo fibroblasts results in Src activation by dephosphorylation of Tyr 527, cell transformation and tumorigenesis. Tyrosine 157-160 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 118-121 7478608-8 1995 Studies with Rat.2 fibroblasts overexpressing activated Neu revealed that c-Src requires the presence of tyrosine phosphorylated Neu for its ability to interact with Neu in vivo. Tyrosine 105-113 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 74-79 7478608-11 1995 Furthermore, this tyrosine phosphorylated protein was not detected in c-Src complexes derived from fibroblasts transformed by either Neu or PyV middle T. These observations suggest that p89 associates with c-Src only in mammary epithelial cells and not in fibroblasts. Tyrosine 18-26 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 206-211 7758136-8 1995 Under these conditions tyrosine phosphorylation was increased selectively in released c-src and primarily on tyrosine 527. Tyrosine 23-31 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 86-91 8593245-3 1995 However, pp60c-src was strongly phosphorylated on tyrosine, weakly phosphorylated on serine with no observed threonine phosphorylation. Tyrosine 50-58 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 9-18 7796910-4 1995 These sites include multiple acidic residues flanking tyrosine on both sides and they also display the consensus sequences (YEDL and YEEV) preferred by the SH2 domains of the Src family. Tyrosine 54-62 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 175-178 7535926-1 1995 We have previously reported that a serine(threonine) protein kinase that phosphorylates histone H1 in vitro is activated by tyrosine phosphorylation in v-Src-transformed rat 3Y1 fibroblasts. Tyrosine 124-132 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 154-157 7758136-11 1995 This regulation is explained by a model in which c-src binds to the cytoskeleton via its SH2 domain and is released when phosphorylated tyrosine-527 binds to this domain intramolecularly, inhibiting kinase activity. Tyrosine 136-144 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 49-54 7513329-4 1994 A similar phenomenon was also observed for Tyr-k activity of pp60c-src in that the aged rats revealed a 69% (p < .025) higher enzyme activity and a 5-fold rise in the extent of autophosphorylation of this protein when compared with the corresponding values from young animals. Tyrosine 43-46 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 61-70 7513329-5 1994 Increased Tyr-k activity of pp60c-src in the gastric mucosa of aged rats could in part be due to higher levels of this protein because the relative concentration of pp60c-src, as assessed by Western blot analysis, showed a 2-5-fold increase over the young animals. Tyrosine 10-13 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 28-37 7513329-5 1994 Increased Tyr-k activity of pp60c-src in the gastric mucosa of aged rats could in part be due to higher levels of this protein because the relative concentration of pp60c-src, as assessed by Western blot analysis, showed a 2-5-fold increase over the young animals. Tyrosine 10-13 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 165-174 7678701-0 1993 Phosphorylation of Src mutants at Tyr 527 in fibroblasts does not correlate with in vitro phosphorylation by CSK. Tyrosine 34-37 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 19-22 8190127-7 1994 The 72, 78 and 110 kDa tyrosine phosphorylated proteins were precipitated by a fusion protein containing the Lyn Src Homology 2 (SH2) domain. Tyrosine 23-31 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 113-116 7909803-4 1994 Here we describe, using a well differentiated rat brain endothelial cell line (RBE4 cells), that ICAM-1 activation by a specific monoclonal antibody, or by syngeneic encephalitogenic T cells, induces tyrosine phosphorylation of several proteins together with stimulation of the tyrosine kinase p60src activity. Tyrosine 200-208 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 294-300 7909803-5 1994 One of the major tyrosine-phosphorylated proteins, of 85 kDa, has been identified by immunoprecipitation and immunoblotting, as the recently described actin-binding protein, p60src substrate, cortactin. Tyrosine 17-25 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 174-180 8388373-7 1993 In addition, it was confirmed that PLC-gamma 1 purified from rat liver was phosphorylated at a tyrosine residue and associated with viral src kinase and that src kinases associated with the recombinant SH2 region of PLC-gamma 1, expressed in Escherichia coli, depending upon phosphorylation of tyrosine residues. Tyrosine 294-302 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 158-161 7513159-6 1994 In summary, this study shows that the AT1 receptor is serine and tyrosine phosphorylated in vivo and suggests that a soluble kinase related to the src family may be responsible for the tyrosine phosphorylation. Tyrosine 65-73 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 147-150 7513159-6 1994 In summary, this study shows that the AT1 receptor is serine and tyrosine phosphorylated in vivo and suggests that a soluble kinase related to the src family may be responsible for the tyrosine phosphorylation. Tyrosine 185-193 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 147-150 7503985-0 1993 Tyrosine phosphorylation of Ras GTPase-activating protein stabilizes its association with p62 at membranes of v-Src transformed cells. Tyrosine 0-8 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 112-115 7503985-2 1993 Previous studies indicated that Tyr-457 of bovine GAP (Tyr-460 of human GAP) is the major site of phosphorylation by viral Src (v-Src) kinase and epidermal growth factor receptor. Tyrosine 32-35 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 130-133 7503985-2 1993 Previous studies indicated that Tyr-457 of bovine GAP (Tyr-460 of human GAP) is the major site of phosphorylation by viral Src (v-Src) kinase and epidermal growth factor receptor. Tyrosine 55-58 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 130-133 7503985-3 1993 The finding that Tyr-457 in GAP is located immediately adjacent to Src homology 2 (SH2) and 3 (SH3) domains led us to investigate the possibility that this specific phosphorylation regulates protein-protein interactions involving GAP. Tyrosine 17-20 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 67-70 7678701-1 1993 In normal fibroblasts, the product of the cellular src gene, p60c-src or Src, is repressed by phosphorylation at its C-terminal tyrosine residue, Tyr 527. Tyrosine 128-136 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 51-54 7678701-1 1993 In normal fibroblasts, the product of the cellular src gene, p60c-src or Src, is repressed by phosphorylation at its C-terminal tyrosine residue, Tyr 527. Tyrosine 128-136 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 66-69 7678701-1 1993 In normal fibroblasts, the product of the cellular src gene, p60c-src or Src, is repressed by phosphorylation at its C-terminal tyrosine residue, Tyr 527. Tyrosine 128-136 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 73-76 7678701-1 1993 In normal fibroblasts, the product of the cellular src gene, p60c-src or Src, is repressed by phosphorylation at its C-terminal tyrosine residue, Tyr 527. Tyrosine 146-149 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 51-54 7678701-1 1993 In normal fibroblasts, the product of the cellular src gene, p60c-src or Src, is repressed by phosphorylation at its C-terminal tyrosine residue, Tyr 527. Tyrosine 146-149 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 66-69 7678701-1 1993 In normal fibroblasts, the product of the cellular src gene, p60c-src or Src, is repressed by phosphorylation at its C-terminal tyrosine residue, Tyr 527. Tyrosine 146-149 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 73-76 7678701-3 1993 The tyrosine kinases that phosphorylate Src at Tyr 527 in vivo have not been identified, but a tyrosine kinase known as CSK is an excellent candidate. Tyrosine 47-50 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 40-43 7678701-4 1993 CSK has the unusual ability to phosphorylate Src in vitro only at Tyr 527. Tyrosine 66-69 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 45-48 7678701-5 1993 To examine whether CSK has the appropriate sequence specificy to explain the phosphorylation of Src at Tyr 527 in fibroblasts, we have made use of a set of C-terminal substitution mutants of Src. Tyrosine 103-106 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 96-99 7678701-10 1993 The other mutant Src molecules tested were not phophorylated by CSK, even though some of these mutants are highly phosphorylated at Tyr 527 in Rat 2 cells. Tyrosine 132-135 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 17-20 1379555-0 1992 Zinc-induced tyrosine phosphorylation of hippocampal p60c-src is catalyzed by another protein tyrosine kinase. Tyrosine 13-21 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 58-61 1334249-3 1992 Nuclear pp60v-src was active as a tyrosine kinase and phosphorylated nuclear proteins at tyrosine. Tyrosine 34-42 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 14-17 1280164-2 1992 For example, the inhibitors dinitrophenol-tyrosine and tyrphostins act at the enzyme level to inhibit phosphorylation of all substrates by c-Src and v-Src kinases. Tyrosine 42-50 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 139-144 1280164-2 1992 For example, the inhibitors dinitrophenol-tyrosine and tyrphostins act at the enzyme level to inhibit phosphorylation of all substrates by c-Src and v-Src kinases. Tyrosine 42-50 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 141-144 1383688-2 1992 A candidate tyrosine kinase, Csk (C-terminal Src kinase), has been implicated in c-Src Tyr-527 phosphorylation, which negatively regulates the protein tyrosine kinase of pp60c-src (c-Src). Tyrosine 87-90 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 81-86 1383688-2 1992 A candidate tyrosine kinase, Csk (C-terminal Src kinase), has been implicated in c-Src Tyr-527 phosphorylation, which negatively regulates the protein tyrosine kinase of pp60c-src (c-Src). Tyrosine 87-90 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 170-179 1383688-2 1992 A candidate tyrosine kinase, Csk (C-terminal Src kinase), has been implicated in c-Src Tyr-527 phosphorylation, which negatively regulates the protein tyrosine kinase of pp60c-src (c-Src). Tyrosine 87-90 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 181-186 1383688-4 1992 We found that cooverexpression of v-Crk and c-Src caused elevation of c-Src kinase activity, resulting in an increase of tyrosine phosphorylation of cellular proteins and morphological transformation of rat 3Y1 fibroblasts. Tyrosine 121-129 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 44-49 1383688-8 1992 These results strongly suggest that Csk acts on Tyr-527 of c-Src and suppresses c-Src kinase activity in vivo. Tyrosine 48-51 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 59-64 1383688-9 1992 Because Csk can suppress transformation by cooverexpression of v-Crk and c-Src, we suggest that v-Crk causes activation of c-Src in vivo by altering the phosphorylation state of Tyr-527. Tyrosine 178-181 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 73-78 1383688-9 1992 Because Csk can suppress transformation by cooverexpression of v-Crk and c-Src, we suggest that v-Crk causes activation of c-Src in vivo by altering the phosphorylation state of Tyr-527. Tyrosine 178-181 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 123-128 1379555-4 1992 Cyanogen bromide cleavage of p60c-src phosphorylated in the presence of Zn2+ yields a 4-kDa phosphopeptide corresponding to phosphorylation of a carboxy-terminal tyrosine residue of Src kinase. Tyrosine 162-170 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 34-37 1379555-4 1992 Cyanogen bromide cleavage of p60c-src phosphorylated in the presence of Zn2+ yields a 4-kDa phosphopeptide corresponding to phosphorylation of a carboxy-terminal tyrosine residue of Src kinase. Tyrosine 162-170 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 182-185 1279117-3 1992 Furthermore, only GCGP-associated src that was also tyrosine phosphorylated was active. Tyrosine 52-60 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 34-37 1512257-2 1992 Previous studies demonstrated that v-Src induces tyrosine phosphorylation of GAP, suggesting that GAP may provide a biochemical link between v-Src and Ras signaling pathways. Tyrosine 49-57 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 37-40 1512257-2 1992 Previous studies demonstrated that v-Src induces tyrosine phosphorylation of GAP, suggesting that GAP may provide a biochemical link between v-Src and Ras signaling pathways. Tyrosine 49-57 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 143-146 1512257-4 1992 Phosphopeptide mapping analysis revealed that v-Src and normal cellular Src (c-Src) phosphorylate tyrosine residues in bovine GAP at one major site and one minor site in vitro. Tyrosine 98-106 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 48-51 1512257-4 1992 Phosphopeptide mapping analysis revealed that v-Src and normal cellular Src (c-Src) phosphorylate tyrosine residues in bovine GAP at one major site and one minor site in vitro. Tyrosine 98-106 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 72-75 1512257-5 1992 Significantly, the major site of GAP phosphorylation in vitro is also the major site of in vivo tyrosine phosphorylation of GAP in rat fibroblasts transformed by v-Src. Tyrosine 96-104 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 164-167 1512257-7 1992 Our results demonstrate that the v-Src kinase induces phosphorylation of the same tyrosine residue of GAP in vitro and in vivo, suggesting that GAP is a direct substrate of activated Src kinases in vivo. Tyrosine 82-90 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 35-38 1379555-1 1992 Tyrosine phosphorylation of p60c-src induced by Zn2+ in rat hippocampal membranes is shown to inhibit Src tyrosine kinase activity. Tyrosine 0-8 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 33-36 1379555-1 1992 Tyrosine phosphorylation of p60c-src induced by Zn2+ in rat hippocampal membranes is shown to inhibit Src tyrosine kinase activity. Tyrosine 0-8 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 102-105 1437718-5 1992 The bombesin-induced stimulation of pp60c-src Tyr-k activity was also associated with a 25% increase in phosphorylation of this protein. Tyrosine 46-49 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 36-45 1527803-7 1992 Additional experiments revealed that the 60K tyrosine-phosphorylated polypeptide present in the PY20 precipitates was indeed pp60c-src. Tyrosine 45-53 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 125-134 1709258-1 1991 The protein-tyrosine kinase activity of the proto-oncogene product p60c-src is negatively regulated by the phosphorylation of a tyrosine residue close to the C terminus, tyrosine 527. Tyrosine 12-20 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 72-75 1534851-17 1992 Thus, host cell factors can affect the tyrosine phosphorylation and activity of the v-src kinase in the absence of the SH2 and SH3 regions. Tyrosine 39-47 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 86-89 1875950-8 1991 A comparison of phosphotyrosine containing-protein profiles showed that v-src and NGF each increase tyrosine phosphorylation of multiple cellular proteins. Tyrosine 23-31 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 74-77 1875950-9 1991 There was overlap in substrates; however, both NGF-specific and v-src-specific tyrosine phosphorylations were observed. Tyrosine 79-87 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 66-69 1372000-4 1992 The mT-pp60c-src complex phosphorylated both subunits of PtdIns 3-kinase on tyrosine residues. Tyrosine 76-84 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 7-16 1709258-1 1991 The protein-tyrosine kinase activity of the proto-oncogene product p60c-src is negatively regulated by the phosphorylation of a tyrosine residue close to the C terminus, tyrosine 527. Tyrosine 128-136 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 72-75 1709258-3 1991 Recently we purified a protein-tyrosine kinase that specifically phosphorylates tyrosine 527 of p60c-src from neonatal rat brain. Tyrosine 31-39 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 101-104 30350722-0 2019 S-nitrosylation of Src by NR2B-nNOS signal causes Src activation and NR2B tyrosine phosphorylation in levodopa-induced dyskinetic rat model. Tyrosine 74-82 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 19-22 1710464-1 1991 The analysis of phosphotyrosine-containing proteins in Rat 1 cells overexpressing either the tyrosine kinase pp60c-src or genetic variants containing alterations in functional and structural domains has led to the identification of three proteins whose tyrosine phosphorylation correlated with pp60src-induced cellular transformation. Tyrosine 23-31 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 109-118 1699949-0 1990 Tubulin is phosphorylated at tyrosine by pp60c-src in nerve growth cone membranes. Tyrosine 29-37 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 41-50 26283020-6 2015 In cultured RPE-J cells, and in transfected heterologous cells, MERTK stimulated SRC-mediated tyrosine phosphorylation of GDI1. Tyrosine 94-102 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 81-84 2456763-3 1988 The enzyme was found to phosphorylate purified pp60c-src at a tyrosine residue(s). Tyrosine 62-70 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 47-56 6433659-4 1984 The kinase could phosphorylate src-related as well as unrelated peptides and casein at tyrosine residues. Tyrosine 87-95 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 31-34 32014448-11 2020 In addition, phosphorylation levels of protein kinase B(PKB) and tyrosine protein kinase-Src family(Src) were increased in the Sal A treatment group. Tyrosine 65-73 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 89-92 32014448-11 2020 In addition, phosphorylation levels of protein kinase B(PKB) and tyrosine protein kinase-Src family(Src) were increased in the Sal A treatment group. Tyrosine 65-73 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 100-103 31676368-2 2020 Our previous study suggested that the muscarinic signal is transmitted to the non-receptor tyrosine kinase Src through PKC and Pyk2. Tyrosine 91-99 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 107-110 31690042-0 2019 RON Receptor Tyrosine Kinase Regulates Epithelial Mesenchymal Transition and the Expression of Pro-Fibrotic Markers via Src/Smad Signaling in HK-2 and NRK49F Cells. Tyrosine 13-21 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 120-123 30926678-5 2019 Src phosphorylates EGFR at tyrosine 845 and then transactive EGFR. Tyrosine 27-35 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 0-3 1709169-0 1991 Specific proto-oncogenic tyrosine kinases of src family are enriched in cell-to-cell adherens junctions where the level of tyrosine phosphorylation is elevated. Tyrosine 25-33 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 45-48 1709169-13 1991 Based on these findings, it is concluded that, in various types of cells, specific proto-oncogenic tyrosine kinases of src-family (c-yes and c-src) are enriched to work as signal mediators in the cell-to-cell AJ where the level of tyrosine phosphorylation is elevated. Tyrosine 99-107 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 119-122 1709169-13 1991 Based on these findings, it is concluded that, in various types of cells, specific proto-oncogenic tyrosine kinases of src-family (c-yes and c-src) are enriched to work as signal mediators in the cell-to-cell AJ where the level of tyrosine phosphorylation is elevated. Tyrosine 99-107 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 141-146 34992524-9 2021 Along with the increased p-Src levels observed at 2 h after injury, the phosphorylation of NMDAR subunit NR2B at tyrosine 1472 was increased. Tyrosine 113-121 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 27-30 2481817-4 1989 In these mutants, the tyrosines at positions 416, 527, or 519, or various combinations of these, have been replaced by phenylalanine by site directed mutagenesis, resulting in mutated c-src proteins that possess varying tyrosine kinase activity and transforming potential. Tyrosine 22-31 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 184-189 2481817-6 1989 However, when Tyr 527 in the COOH terminus of the c-src protein is replaced with Phe, the tyrosine kinase activity and transforming potential of the protein are increased and the protein acquires a potent ability to increase levels of glucose transporter mRNA and protein, as well as the rate of 2-deoxy-D-glucose uptake. Tyrosine 14-17 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 50-55 31606204-7 2019 The Aldo-induced upregulation of Kv1.5 was also reversed by the Src protein tyrosine kinase family inhibitor PP2, the Nox2 inhibitor gp91ds-tat and the Nox1/Nox4 inhibitor GKT137831 but not by the Rac GTPase inhibitor NSC23766. Tyrosine 76-84 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 64-67 30350722-2 2019 N-methyl-D-aspartate receptor (NMDAR) subunit NR2B tyrosine phosphorylation mediated by Src family protein tyrosine kinases is closely associated with dyskinesia. Tyrosine 51-59 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 88-91 30350722-8 2019 Coinstantaneously, the S-nitrosylation (SNO-Src) and autophosphorylation (p-Src) of Src and NR2B tyrosine phosphorylation were upregulated in dyskinetic rat model. Tyrosine 97-105 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 76-79 30350722-8 2019 Coinstantaneously, the S-nitrosylation (SNO-Src) and autophosphorylation (p-Src) of Src and NR2B tyrosine phosphorylation were upregulated in dyskinetic rat model. Tyrosine 97-105 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 76-79 30350722-11 2019 Taken together, the S-nitrosylation of Src is caused by nNOS/NO signal, which is overactivated via Ca2+ influx dependent on NR2B/NMDAR, and subsequently facilitates Src auto-tyrosine phosphorylation and further phosphorylates NR2B. Tyrosine 174-182 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 39-42 30350722-11 2019 Taken together, the S-nitrosylation of Src is caused by nNOS/NO signal, which is overactivated via Ca2+ influx dependent on NR2B/NMDAR, and subsequently facilitates Src auto-tyrosine phosphorylation and further phosphorylates NR2B. Tyrosine 174-182 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 165-168 30350722-12 2019 The "NR2B/NMDAR-nNOS/NO-SNO-Src-p-Src-NR2B/NMDAR" signaling cycle may be the molecular basis of NR2B tyrosine phosphorylation upward positive feedback, which demonstrates the possibility as one latent target for dyskinesia therapy. Tyrosine 101-109 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 28-31 30350722-12 2019 The "NR2B/NMDAR-nNOS/NO-SNO-Src-p-Src-NR2B/NMDAR" signaling cycle may be the molecular basis of NR2B tyrosine phosphorylation upward positive feedback, which demonstrates the possibility as one latent target for dyskinesia therapy. Tyrosine 101-109 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 34-37 30359790-9 2018 Additionally, western blotting analysis showed that TNF-alpha significantly reduced (Tyr 416)-c-Src and (Tyr773)-beta3 subunit of alphaIIbbeta3 integrin phosphorylation. Tyrosine 85-88 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 94-99 30130562-0 2019 Tat-Src reduced NR2B tyrosine phosphorylation and its interaction with NR2B in levodopa-induced dyskinetic rats model. Tyrosine 21-29 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 4-7 30130562-5 2019 The data showed that in dyskinetic rats model intraperitoneal microinjection of Tat-Src improved dyskinetic behaviors and decreased NR2B tyrosine phosphorylation and the interactions of Src with NR2B induced by chronic levodopa treatment. Tyrosine 137-145 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 84-87 28943431-5 2017 This sustained EGFR transactivation is mainly due to Src kinase-mediated persistent EGFR tyrosine phosphorylation at Y845 rather than Y1173. Tyrosine 89-97 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 53-56 28122732-13 2017 Ouabain increased cSrc autophosphorylation of tyrosine 418 (Y418) required for full catalytic activity whereas pNaKtide antagonized it. Tyrosine 46-54 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 18-22 28944482-4 2017 This muscarinic signal for the endocytosis was mediated in sequence by phospholipase C (PLC), protein kinase C (PKC), and then the non-receptor tyrosine kinase Src with the consequent tyrosine phosphorylation of TASK1. Tyrosine 144-152 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 160-163 28944482-15 2017 We conclude that M1 R stimulation results in internalization of TASK1 channels through the PLC-PKC-Src pathway with the consequent phosphorylation of tyrosine and that this M1 R-mediated internalization is at least in part responsible for muscarinic inhibition of TASK1 channels in rat AM cells. Tyrosine 150-158 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 99-102 28561330-6 2017 Src tyrosine kinase activity and tyrosine phosphorylation of VE-cadherin were increased in old arteries. Tyrosine 4-12 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 0-3 28122732-14 2017 This cSrc activation was associated with Cx43 phosphorylation of tyrosine 265 (Y265). Tyrosine 65-73 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 5-9 28122732-15 2017 Our findings demonstrate that Na-K-ATPase regulates intercellular communication in the vascular wall via cSrc-dependent Cx43 tyrosine phosphorylation. Tyrosine 125-133 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 105-109 26865271-0 2016 Multisite tyrosine phosphorylation of the N-terminus of Mint1/X11alpha by Src kinase regulates the trafficking of amyloid precursor protein. Tyrosine 10-18 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 74-77 27385592-0 2016 Protease activated receptor 1 (PAR1) enhances Src-mediated tyrosine phosphorylation of NMDA receptor in intracerebral hemorrhage (ICH). Tyrosine 59-67 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 46-49 27385592-5 2016 Both in vivo and in vitro results showed the elevated phosphorylation of tyrosine in Src and GluN2A and enhanced interaction of the Src-PSD95-GluN2A under model conditions. Tyrosine 73-81 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 85-88 26865271-4 2016 A canonical SH2-binding motif ((202) YEEI) was identified in the N-terminus of Mint1 that is phosphorylated on tyrosine by C-Src and recruits the active kinase for sequential phosphorylation of further tyrosines (Y191 and Y187). Tyrosine 111-119 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 123-128 26865271-4 2016 A canonical SH2-binding motif ((202) YEEI) was identified in the N-terminus of Mint1 that is phosphorylated on tyrosine by C-Src and recruits the active kinase for sequential phosphorylation of further tyrosines (Y191 and Y187). Tyrosine 202-211 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 123-128 24370594-6 2014 Western blotting demonstrated that ANG II increased the phosphorylation of c-Src at tyrosine residue 416, an indication of c-Src activation. Tyrosine 84-92 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 75-80 24728870-6 2015 Y-P30 increased for 90 min in axonal growth cones the level of Tyr418-phosphorylated Src kinase and the amount of F-actin, and transiently the level of Tyr-phosphorylated ERK. Tyrosine 63-66 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 85-88 25748795-6 2015 Tyr(14)-caveolin-1/Tyr(416) cSrc phosphorylation and FITC-insulin uptake were quantified by immunostaining and/or western blots. Tyrosine 0-3 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 28-32 25371038-5 2015 We found that the non-receptor tyrosine kinase Src mediates TACE activation in mechanically stretched rat cardiomyocytes by phosphorylating the Tyr-702 residue within the intracellular tail of TACE. Tyrosine 144-147 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 47-50 25371038-6 2015 The rapid activation of Src in mechanically stretched cardiomyocytes is followed by TACE phosphorylation on Tyr-702, leading to activation of p38 MAPK, a kinase that is an effector of TNFalpha receptor activation. Tyrosine 108-111 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 24-27 25371038-7 2015 Pharmacological inhibition or silencing of Src attenuated stretch-induced TACE phosphorylation on Tyr-702 and p38 activation. Tyrosine 98-101 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 43-46 25201974-5 2014 GluK2 binds to Src, and the tyrosine residue at position 590 (Y590) on GluK2 is a major site of phosphorylation by Src kinases. Tyrosine 28-36 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 115-118 24578126-4 2014 Here, we show that PC1-p30 interacts with the nonreceptor tyrosine kinase Src, resulting in Src-dependent activation of STAT3 by tyrosine phosphorylation. Tyrosine 58-66 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 74-77 24578126-4 2014 Here, we show that PC1-p30 interacts with the nonreceptor tyrosine kinase Src, resulting in Src-dependent activation of STAT3 by tyrosine phosphorylation. Tyrosine 58-66 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 92-95 24611720-13 2014 Tyrosine 284 within a concensus Src phosphorylation site was the key point for ClC-3 channel activation. Tyrosine 0-8 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 32-35 25968938-4 2015 Mitochondrial Src phosphorylation (Tyr(416)) was dramatically decreased during I/R, implying inactivation of Src tyrosine kinase by I/R. Tyrosine 35-38 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 14-17 25998537-11 2015 These results suggest that brain mitochondrial dysfunction following LPS-induced sepsis in rats is partly attributed to PTP1B and Src mediated decrease in mitochondrial protein tyrosine phosphorylation. Tyrosine 177-185 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 130-133 25505586-9 2014 OVA also induced EGFR phosphorylation at Tyr-845, one of residues phosphorylated by Src. Tyrosine 41-44 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 84-87 24370594-6 2014 Western blotting demonstrated that ANG II increased the phosphorylation of c-Src at tyrosine residue 416, an indication of c-Src activation. Tyrosine 84-92 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 123-128 24370594-7 2014 This effect was mimicked by PKC stimulator but abolished by calphostin C. Moreover, inhibition of NADPH oxidase (NOX) also blocked the effect of ANG II on c-Src tyrosine phosphorylation. Tyrosine 161-169 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 155-160 23868980-5 2013 We observed that mechanical stretch of C2C12 or primary rat myoblasts rapidly activates Src, which in turn interacts and colocalizes with TACE, resulting in tyrosine phosphorylation and activation of TACE. Tyrosine 157-165 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 88-91 23673471-7 2013 The results from the present study suggest that the dephosphorylation of Src tyrosine kinase 529, the phosphorylation of tyrosine 418 and their subnuclear redistribution are involved in endonuclear signal transduction in cardiac myocytes, which regulates the development and progression of LV eccentric hypertrophy induced by hypertension. Tyrosine 77-85 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 73-76 23447623-7 2013 We further demonstrate that the tyrosine residue is phosphorylated by Src family kinases, and that Src-activation limits surface GluN3A expression in neurons. Tyrosine 32-40 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 70-73 23376245-1 2013 Tyrosine phosphorylation of N-methyl-d-aspartate (NMDA) subtype glutamate receptors by Src-family protein tyrosine kinases (SFKs) plays a critical role in spinal sensitization. Tyrosine 0-8 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 87-90 23447623-7 2013 We further demonstrate that the tyrosine residue is phosphorylated by Src family kinases, and that Src-activation limits surface GluN3A expression in neurons. Tyrosine 32-40 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 99-102 24217647-7 2013 Furthermore, pretreatment with the Src-selective inhibitor, PP2, and shRNA targeted to Src or suppression of Rac1 with its selective inhibitor, NSC23766, blocked FAK phosphorylation at Tyr,(576/577) but not Tyr,(397) under periodic mechanical stress. Tyrosine 185-188 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 35-38 24217647-10 2013 CONCLUSION: Our findings collectively suggest that periodic mechanical stress promotes chondrocyte proliferation and matrix synthesis through at least two pathways, integrin beta1-Src-Rac1-FAK(Tyr(576/577))-ERK1/2 and integrin beta1-FAK (Tyr(397))-ERK1/2. Tyrosine 238-241 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 180-183 24217647-7 2013 Furthermore, pretreatment with the Src-selective inhibitor, PP2, and shRNA targeted to Src or suppression of Rac1 with its selective inhibitor, NSC23766, blocked FAK phosphorylation at Tyr,(576/577) but not Tyr,(397) under periodic mechanical stress. Tyrosine 185-188 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 87-90 24217647-7 2013 Furthermore, pretreatment with the Src-selective inhibitor, PP2, and shRNA targeted to Src or suppression of Rac1 with its selective inhibitor, NSC23766, blocked FAK phosphorylation at Tyr,(576/577) but not Tyr,(397) under periodic mechanical stress. Tyrosine 207-210 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 35-38 24217647-7 2013 Furthermore, pretreatment with the Src-selective inhibitor, PP2, and shRNA targeted to Src or suppression of Rac1 with its selective inhibitor, NSC23766, blocked FAK phosphorylation at Tyr,(576/577) but not Tyr,(397) under periodic mechanical stress. Tyrosine 207-210 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 87-90 24217647-10 2013 CONCLUSION: Our findings collectively suggest that periodic mechanical stress promotes chondrocyte proliferation and matrix synthesis through at least two pathways, integrin beta1-Src-Rac1-FAK(Tyr(576/577))-ERK1/2 and integrin beta1-FAK (Tyr(397))-ERK1/2. Tyrosine 193-196 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 180-183 22496359-8 2012 Addition of Src family kinase inhibitors, PP1 or PP2, during cAMP treatment abolished tyrosine phosphorylation of PI3KAP/XB130 and its interaction with p85 PI3K. Tyrosine 86-94 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 12-15 23103755-3 2013 Here, we have characterized the association between SYP and c-src tyrosine kinase demonstrating that phosphorylation of Tyr(273) in the C-terminal domain of SYP is crucial in mediating SYP binding to and activation of c-src. Tyrosine 120-123 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 60-65 23103755-9 2013 In addition, we tested DynI self-assembly and GTPase activity, which are enhanced by c-src-dependent tyrosine phosphorylation of DynI, and found that both were inhibited by PN. Tyrosine 101-109 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 85-90 23390493-2 2013 A fundamental aspect of signal transduction by receptor tyrosine kinases involves autophosphorylation of tyrosine residues that recruit Src-homology 2 (SH2)-domain proteins to the receptor intracellular domain. Tyrosine 56-64 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 136-139 22993256-12 2012 Taken together, our present results suggest that the arcuate Src activation-induced tyrosine phosphorylation of NR2B NMDA subunit may contribute to inflammatory pain. Tyrosine 84-92 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 61-64 23022504-4 2012 Transient ischemia increased the tyrosine phosphorylation of NMDA receptor subunits, which are a major target of Src family tyrosine kinases. Tyrosine 33-41 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 113-116 23022504-8 2012 We further demonstrated that the administration of a Src-family kinase inhibitor prevented cell death in the hippocampal CA1 region and attenuated the increase in the tyrosine phosphorylation of the NMDA receptor subunits after the reperfusion. Tyrosine 167-175 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 53-56 22422045-6 2012 Taken together, the S-nitrosylation of c-Src is provoked by NO derived from endogenous nNOS, which is activated by Ca(2+) influx from NMDA receptors, and promotes the auto-phosphorylation at tyrosines and further phosphorylates NR2A. Tyrosine 191-200 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 39-44 22422045-1 2012 Previous studies suggested that activated c-Src promote the tyrosine phosphorylation of NMDA receptor subunit NR2A, and thus aggravate the injury induced by transient cerebral ischemia/reperfusion (I/R) in rat hippocampus CA1 region. Tyrosine 60-68 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 42-47