PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 24216507-5 2013 These 2 proteins formed a functional ligand/receptor pair that recruited components to CD33"s immunoreceptor tyrosine-based inhibition motif (ITIM), inducing secretion of the suppressive cytokines IL-10 and TGF-beta by immature myeloid cells. Tyrosine 109-117 CD33 molecule Homo sapiens 87-91 24308974-2 2014 CD33-related Siglecs (CD33rSiglecs) on innate immune cells recognize endogenous sialoglycans as "self-associated molecular patterns" (SAMPs), dampening immune responses via cytosolic immunoreceptor tyrosine-based inhibition motifs that recruit tyrosine phosphatases. Tyrosine 198-206 CD33 molecule Homo sapiens 0-4 24216507-7 2013 Importantly, early forced maturation of MDSC by either all-trans-retinoic acid treatment or active immunoreceptor tyrosine-based activation motif-bearing (ITAM-bearing) adapter protein (DAP12) interruption of CD33 signaling rescued the hematologic phenotype. Tyrosine 114-122 CD33 molecule Homo sapiens 209-213 17947393-0 2008 ITIM-dependent endocytosis of CD33-related Siglecs: role of intracellular domain, tyrosine phosphorylation, and the tyrosine phosphatases, Shp1 and Shp2. Tyrosine 82-90 CD33 molecule Homo sapiens 30-34 22500980-1 2012 BACKGROUND: CD33 is a membrane receptor containing a lectin domain and a cytoplasmic immunoreceptor tyrosine-based inhibitory motif (ITIM) that is able to inhibit cytokine production. Tyrosine 100-108 CD33 molecule Homo sapiens 12-16 21070233-5 2011 Most CD33rSiglecs have immune receptor tyrosine-based inhibitory motifs and signal negatively. Tyrosine 39-47 CD33 molecule Homo sapiens 5-9 18062779-4 2008 Here, we show, using CD33/sialic acid-binding immunoglobulin-like lectin (Siglec)-3 as a paradigm, that ITIMs can bind to the ubiquitin ligase Cbl and that ITIMs are ubiquitylated following Src family kinase-mediated tyrosine phosphorylation. Tyrosine 217-225 CD33 molecule Homo sapiens 21-83 17947393-5 2008 Tyrosine phosphorylation, most likely through Src family kinases, increases uptake of CD33 depending on the integrity of the two cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). Tyrosine 0-8 CD33 molecule Homo sapiens 86-90 17947393-5 2008 Tyrosine phosphorylation, most likely through Src family kinases, increases uptake of CD33 depending on the integrity of the two cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). Tyrosine 156-164 CD33 molecule Homo sapiens 86-90 15454492-3 2005 The CD33 cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs) control internalization of antibody bound to CD33. Tyrosine 36-44 CD33 molecule Homo sapiens 4-8 17138568-1 2007 CD33-related Siglecs (sialic acid-binding immunoglobulin-like lectins) 5-11 are inhibitory receptors that contain a membrane proximal ITIM (immunoreceptor tyrosine-based inhibitory motif) (I/V/L/)XYXX(L/V), which can recruit SHP-1/2. Tyrosine 155-163 CD33 molecule Homo sapiens 0-4 16682635-3 2006 CD33-related Siglecs are inhibitory signaling molecules expressed on most immune cells and are thought to down-regulate cellular activation pathways via cytosolic immunoreceptor tyrosine-based inhibitory motifs. Tyrosine 178-186 CD33 molecule Homo sapiens 0-4 15769739-2 2005 Similar to other CD33-related siglecs, Siglec-5 contains two tyrosine-based motifs in its cytoplasmic tail implicated in signaling functions. Tyrosine 61-69 CD33 molecule Homo sapiens 17-21 17580316-1 2007 CD33-related-Siglecs are lectins on immune cells that recognize sialic acids via extracellular domains, and deliver negative signals via cytosolic tyrosine-based regulatory motifs. Tyrosine 147-155 CD33 molecule Homo sapiens 0-4 17008544-2 2007 CD33 contains a cytoplasmic immunoreceptor tyrosine-based inhibitory motif (ITIM), which can recruit SHP-1 and SHP-2. Tyrosine 43-51 CD33 molecule Homo sapiens 0-4 17008544-7 2007 Our data suggest that the tyrosine motifs in CD33 are not important for internalization, while they are required for degradation. Tyrosine 26-34 CD33 molecule Homo sapiens 45-49 15454492-3 2005 The CD33 cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs) control internalization of antibody bound to CD33. Tyrosine 36-44 CD33 molecule Homo sapiens 122-126 15313016-0 2004 Sustained stimulation of platelet thrombin receptor is associated with tyrosine dephosphorylation of a novel p67 peptide in a manner regulated by extracellular calcium. Tyrosine 71-79 CD33 molecule Homo sapiens 109-112 15557178-0 2004 The membrane-proximal immunoreceptor tyrosine-based inhibitory motif is critical for the inhibitory signaling mediated by Siglecs-7 and -9, CD33-related Siglecs expressed on human monocytes and NK cells. Tyrosine 37-45 CD33 molecule Homo sapiens 140-144 15051513-7 2004 Alteration of the native CD33(65-73) peptide at the first amino acid residue from alanine (A) to tyrosine (Y) enhanced the HLA-A2.1 affinity/stability of the modified CD33 peptide (YIISGDSPV) and induced CTLs with increased cytotoxicity against AML cells. Tyrosine 97-105 CD33 molecule Homo sapiens 25-29 15331780-2 2004 CD33-related Siglecs (CD33rSiglecs) are a subgroup with as-yet-unknown functions, characterized by sequence homology, expression on innate immune cells, conserved cytosolic tyrosine-based signaling motifs, and a clustered localization of their genes. Tyrosine 173-181 CD33 molecule Homo sapiens 0-4 15051513-7 2004 Alteration of the native CD33(65-73) peptide at the first amino acid residue from alanine (A) to tyrosine (Y) enhanced the HLA-A2.1 affinity/stability of the modified CD33 peptide (YIISGDSPV) and induced CTLs with increased cytotoxicity against AML cells. Tyrosine 97-105 CD33 molecule Homo sapiens 167-171 15481154-2 2004 Amongst the 11 human siglecs, there are eight proteins highly related to CD33 which have biochemical features of inhibitory receptors, containing two conserved tyrosine-based inhibitory motifs. Tyrosine 160-168 CD33 molecule Homo sapiens 73-77 11970770-1 2002 The CD33 antigen is a 67-kd glycosylated transmembrane protein of the sialic acid-binding immunoglobulinlike lectin (siglec) family with immunoreceptor tyrosine-based inhibitory motifs. Tyrosine 152-160 CD33 molecule Homo sapiens 4-8 14617000-1 2003 Sialic acid-binding immunoglobulin-like lectin (Siglec)-5 or CD170 is a CD33-related receptor, containing cytoplasmic immune receptor-based tyrosine signalling motifs, that has previously been reported to be myeloid-specific like CD33 and thus may be useful in the characterization of both normal and malignant haemopoiesis. Tyrosine 140-148 CD33 molecule Homo sapiens 72-76 14617000-1 2003 Sialic acid-binding immunoglobulin-like lectin (Siglec)-5 or CD170 is a CD33-related receptor, containing cytoplasmic immune receptor-based tyrosine signalling motifs, that has previously been reported to be myeloid-specific like CD33 and thus may be useful in the characterization of both normal and malignant haemopoiesis. Tyrosine 140-148 CD33 molecule Homo sapiens 230-234 10206955-3 1999 Since CD33 contains two potential immunoreceptor tyrosine-based inhibition motifs in its cytoplasmic tail, we investigated whether it might act as a signaling receptor in myeloid cells. Tyrosine 49-57 CD33 molecule Homo sapiens 6-10 11095983-7 2000 Like the other members of the CD33-like subgroup of Siglecs, except for the previously published Siglec8, Siglec8-L also contains the two tyrosine-based motifs that have been found to recruit both SH2 domain-containing tyrosine and inositol phosphatases. Tyrosine 138-146 CD33 molecule Homo sapiens 30-34 11095983-7 2000 Like the other members of the CD33-like subgroup of Siglecs, except for the previously published Siglec8, Siglec8-L also contains the two tyrosine-based motifs that have been found to recruit both SH2 domain-containing tyrosine and inositol phosphatases. Tyrosine 219-227 CD33 molecule Homo sapiens 30-34 10887109-2 2000 Human CD33 has two tyrosine residues in its cytoplasmic domain (Y340 and Y358). Tyrosine 19-27 CD33 molecule Homo sapiens 6-10 10887109-3 2000 When phosphorylated, these tyrosines could function as docking sites for the phosphatases, SHP-1 and/or SHP-2, enabling CD33 to function as an inhibitory receptor. Tyrosine 27-36 CD33 molecule Homo sapiens 120-124 10887109-4 2000 Here we demonstrate that CD33 is tyrosine phosphorylated in the presence of the phosphatase inhibitor, pervanadate, and recruits SHP-1 and SHP-2. Tyrosine 33-41 CD33 molecule Homo sapiens 25-29 10556798-10 1999 CD33 exerts an inhibitory effect on tyrosine phosphorylation and Ca(2+) mobilization when co-engaged with the activating FcgammaRI receptor. Tyrosine 36-44 CD33 molecule Homo sapiens 0-4 10338137-3 1999 Phosphoamino acid analysis showed that isolated membranes can tyrosine-phosphorylate p67phox in vitro. Tyrosine 62-70 CD33 molecule Homo sapiens 85-88 10206955-4 1999 Tyrosine phosphorylation of CD33 in myeloid cell lines was stimulated by cell surface cross-linking or by pervanadate, and inhibited by PP2, a specific inhibitor of Src family tyrosine kinases. Tyrosine 0-8 CD33 molecule Homo sapiens 28-32 10206955-7 1999 The first CD33 phosphotyrosine motif is dominant in CD33-SHP-1/SHP-2 interactions, since mutating tyrosine 340 in a CD33-cytoplasmic tail fusion protein significantly reduced binding to SHP-1 and SHP-2 in THP-1 lysates, while mutation of tyrosine 358 had no effect. Tyrosine 22-30 CD33 molecule Homo sapiens 10-14 10206955-7 1999 The first CD33 phosphotyrosine motif is dominant in CD33-SHP-1/SHP-2 interactions, since mutating tyrosine 340 in a CD33-cytoplasmic tail fusion protein significantly reduced binding to SHP-1 and SHP-2 in THP-1 lysates, while mutation of tyrosine 358 had no effect. Tyrosine 22-30 CD33 molecule Homo sapiens 52-56 10206955-7 1999 The first CD33 phosphotyrosine motif is dominant in CD33-SHP-1/SHP-2 interactions, since mutating tyrosine 340 in a CD33-cytoplasmic tail fusion protein significantly reduced binding to SHP-1 and SHP-2 in THP-1 lysates, while mutation of tyrosine 358 had no effect. Tyrosine 22-30 CD33 molecule Homo sapiens 52-56 10206955-7 1999 The first CD33 phosphotyrosine motif is dominant in CD33-SHP-1/SHP-2 interactions, since mutating tyrosine 340 in a CD33-cytoplasmic tail fusion protein significantly reduced binding to SHP-1 and SHP-2 in THP-1 lysates, while mutation of tyrosine 358 had no effect. Tyrosine 98-106 CD33 molecule Homo sapiens 10-14 10206955-7 1999 The first CD33 phosphotyrosine motif is dominant in CD33-SHP-1/SHP-2 interactions, since mutating tyrosine 340 in a CD33-cytoplasmic tail fusion protein significantly reduced binding to SHP-1 and SHP-2 in THP-1 lysates, while mutation of tyrosine 358 had no effect. Tyrosine 98-106 CD33 molecule Homo sapiens 52-56 10206955-7 1999 The first CD33 phosphotyrosine motif is dominant in CD33-SHP-1/SHP-2 interactions, since mutating tyrosine 340 in a CD33-cytoplasmic tail fusion protein significantly reduced binding to SHP-1 and SHP-2 in THP-1 lysates, while mutation of tyrosine 358 had no effect. Tyrosine 98-106 CD33 molecule Homo sapiens 52-56 10206955-8 1999 Furthermore, the NH2-terminal Src homology 2 domain of SHP-1 and SHP-2, believed to be essential for phosphatase activation, selectively bound a CD33 phosphopeptide containing tyrosine 340 but not one containing tyrosine 358. Tyrosine 176-184 CD33 molecule Homo sapiens 145-149 10206955-9 1999 Finally, mutation of tyrosine 340 increased red blood cell binding by CD33 expressed in COS cells. Tyrosine 21-29 CD33 molecule Homo sapiens 70-74 31815204-2 2019 Divergent features between human CD33 (hCD33) and murine CD33 (mCD33) include a unique transmembrane lysine in mCD33 and cytoplasmic tyrosine in hCD33. Tyrosine 133-141 CD33 molecule Homo sapiens 33-37 9731071-4 1998 The cytoplasmic tail is also related to that of CD33, containing two tyrosine residues embodied in immunoreceptor tyrosine-based inhibitory motif-like motifs. Tyrosine 69-77 CD33 molecule Homo sapiens 48-52 9731071-4 1998 The cytoplasmic tail is also related to that of CD33, containing two tyrosine residues embodied in immunoreceptor tyrosine-based inhibitory motif-like motifs. Tyrosine 114-122 CD33 molecule Homo sapiens 48-52 34060491-3 2021 Moreover, HBV activated SIGLEC-3 on myeloid cells and induced immunosuppression by stimulating immunoreceptor tyrosine-based inhibitory motif phosphorylation and SHP-1/-2 recruitment via alpha2,6-biantennary sialoglycans on HBsAg. Tyrosine 110-118 CD33 molecule Homo sapiens 24-32 32845322-1 2021 CD33-related Siglecs are often found on innate immune cells and modulate their reactivity by recognition of sialic acid-based "self-associated molecular patterns" (SAMPs) and signaling via intracellular tyrosine-based cytosolic motifs. Tyrosine 203-211 CD33 molecule Homo sapiens 0-4 31815204-2 2019 Divergent features between human CD33 (hCD33) and murine CD33 (mCD33) include a unique transmembrane lysine in mCD33 and cytoplasmic tyrosine in hCD33. Tyrosine 133-141 CD33 molecule Homo sapiens 39-44 31815204-2 2019 Divergent features between human CD33 (hCD33) and murine CD33 (mCD33) include a unique transmembrane lysine in mCD33 and cytoplasmic tyrosine in hCD33. Tyrosine 133-141 CD33 molecule Homo sapiens 145-150