PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 11489940-6 2001 However, GH-induced tyrosine phosphorylation of JAK2, STAT5, and STAT3 was 75% lower in the CRF animals. Tyrosine 20-28 gonadotropin releasing hormone receptor Rattus norvegicus 9-11 11604224-1 2001 In vitro growth hormone (GH) stimulation of Janus kinase 2 (Jak2) tyrosine phosphorylation and activation has been detected in rat adipocytes where GH exerts both chronic diabetogenic and acute insulin-like effects but not in adipocytes where only chronic diabetogenic effects are exerted. Tyrosine 66-74 gonadotropin releasing hormone receptor Rattus norvegicus 9-23 11604224-1 2001 In vitro growth hormone (GH) stimulation of Janus kinase 2 (Jak2) tyrosine phosphorylation and activation has been detected in rat adipocytes where GH exerts both chronic diabetogenic and acute insulin-like effects but not in adipocytes where only chronic diabetogenic effects are exerted. Tyrosine 66-74 gonadotropin releasing hormone receptor Rattus norvegicus 25-27 11604224-1 2001 In vitro growth hormone (GH) stimulation of Janus kinase 2 (Jak2) tyrosine phosphorylation and activation has been detected in rat adipocytes where GH exerts both chronic diabetogenic and acute insulin-like effects but not in adipocytes where only chronic diabetogenic effects are exerted. Tyrosine 66-74 gonadotropin releasing hormone receptor Rattus norvegicus 148-150 11604224-2 2001 The 95 kDa transcription factor Stat5, which is tyrosine phosphorylated in response to GH in both cases, is here identified as the 5A-isoform. Tyrosine 48-56 gonadotropin releasing hormone receptor Rattus norvegicus 87-89 11604224-5 2001 However, in adipocytes where GH exerts both diabetogenic and insulin-like effects, and both Jak2 and Stat5A were activated, their phosphorylation kinetics and downregulation of tyrosine phosphorylation were almost identical. Tyrosine 177-185 gonadotropin releasing hormone receptor Rattus norvegicus 29-31 11601336-7 1999 In addition, GH induced tyrosine phosphorylation of JAK2, a cytoplasmic protein tyrosine kinase, in cardiac myocytes. Tyrosine 24-32 gonadotropin releasing hormone receptor Rattus norvegicus 13-15 11681720-8 2001 GH induced tyrosine phosphorylation of EGF receptor and JAK2 in cardiac myocytes, and an EGF receptor inhibitor tyrphostin AG1478 and a JAK2 inhibitor tyrphostin B42 completely inhibited GH-induced ERK activation. Tyrosine 11-19 gonadotropin releasing hormone receptor Rattus norvegicus 0-2 10752065-2 2000 Comparisons of liver nuclear protein tyrosine phosphorylation in male and female rats have led to the discovery that the liver transcription factor STAT5b is tyrosine phosphorylated in male but not female rats in response to GH pulses. Tyrosine 158-166 gonadotropin releasing hormone receptor Rattus norvegicus 225-227 10752065-3 2000 Intermittent plasma GH pulses trigger a rapid and repeated tyrosine phosphorylation and nuclear translocation of liver STAT5b in intact male rats, while the more continuous pattern of GH exposure down-regulates the STAT5b signalling pathway in female rat liver. Tyrosine 59-67 gonadotropin releasing hormone receptor Rattus norvegicus 20-22 10752065-7 2000 STAT5b is thus a liver-expressed, latent cytoplasmic transcription factor that undergoes repeated tyrosine phosphorylation and nuclear translocation in response to intermittent plasma GH stimulation, and is a key intracellular mediator of the stimulatory effects of GH pulses on male-specific liver gene transcription. Tyrosine 98-106 gonadotropin releasing hormone receptor Rattus norvegicus 184-186 10491284-3 1999 GHRH stimulated GH release from pituitary cells in a dose-dependent manner, and this secretion was inhibited by Tyr(11)-SST-14, a nonselective SST analog. Tyrosine 112-115 gonadotropin releasing hormone receptor Rattus norvegicus 0-2 9886807-0 1999 Growth hormone stimulates the tyrosine kinase activity of JAK2 and induces tyrosine phosphorylation of insulin receptor substrates and Shc in rat tissues. Tyrosine 30-38 gonadotropin releasing hormone receptor Rattus norvegicus 0-14 9528967-0 1998 Desensitization of the growth hormone-induced Janus kinase 2 (Jak 2)/signal transducer and activator of transcription 5 (Stat5)-signaling pathway requires protein synthesis and phospholipase C. Signal transducers and activators of transcription (Stat) proteins are latent cytoplasmic transcription factors that are tyrosine phosphorylated by Janus kinases (Jak) in response to GH and other cytokines. Tyrosine 315-323 gonadotropin releasing hormone receptor Rattus norvegicus 23-37 7768925-0 1995 Intermittent plasma growth hormone triggers tyrosine phosphorylation and nuclear translocation of a liver-expressed, Stat 5-related DNA binding protein. Tyrosine 44-52 gonadotropin releasing hormone receptor Rattus norvegicus 20-34 8892312-2 1996 Recent studies have demonstrated that ligand-induced activation of both GH and PRL receptors leads to the tyrosine phosphorylation of multiple intracellular proteins by the identical non-receptor tyrosine kinase, JAK2. Tyrosine 106-114 gonadotropin releasing hormone receptor Rattus norvegicus 72-74 8892312-7 1996 GH treatment induced tyrosine phosphorylation of several hepatic nuclear proteins, activated Stats1, 3, and 5, stimulated Spi 2.1 gene expression, and inhibited albumin gene transcription. Tyrosine 21-29 gonadotropin releasing hormone receptor Rattus norvegicus 0-2 8770909-0 1996 Growth hormone stimulates tyrosine phosphorylation of JAK2 and STAT5, but not insulin receptor substrate-1 or SHC proteins in liver and skeletal muscle of normal rats in vivo. Tyrosine 26-34 gonadotropin releasing hormone receptor Rattus norvegicus 0-14 8621467-1 1996 Differential kinetics of hormone desensitization and growth hormone stimulation of both tyrosine phosphorylation and serine/threonine phosphorylation. Tyrosine 88-96 gonadotropin releasing hormone receptor Rattus norvegicus 53-67 8621467-2 1996 Intermittent plasma growth hormone (GH) pulses, which occur in male but not female rats, activate liver Stat 5 by a mechanism that involves tyrosine phosphorylation and nuclear translocation of this latent cytoplasmic transcription factor (Waxman, D. J., Ram, P. A., Park, S. H., and Choi, H. K. (1995) J. Biol. Tyrosine 140-148 gonadotropin releasing hormone receptor Rattus norvegicus 20-34 8621467-2 1996 Intermittent plasma growth hormone (GH) pulses, which occur in male but not female rats, activate liver Stat 5 by a mechanism that involves tyrosine phosphorylation and nuclear translocation of this latent cytoplasmic transcription factor (Waxman, D. J., Ram, P. A., Park, S. H., and Choi, H. K. (1995) J. Biol. Tyrosine 140-148 gonadotropin releasing hormone receptor Rattus norvegicus 36-38 7545168-0 1995 Growth hormone-dependent phosphorylation of tyrosine 333 and/or 338 of the growth hormone receptor. Tyrosine 44-52 gonadotropin releasing hormone receptor Rattus norvegicus 0-14 7545168-3 1995 In this work, we examined whether tyrosines 333 and/or 338 in GHR are phosphorylated by JAK2 in response to GH. Tyrosine 34-43 gonadotropin releasing hormone receptor Rattus norvegicus 62-64 9211920-1 1997 Growth hormone (GH) rapidly stimulates tyrosine phosphorylation followed by serine/threonine phosphorylation of multiple cytoplasmic STAT transcription factors, including one, STAT5b, that is uniquely responsive to the temporal pattern of plasma GH stimulation in rat liver and is proposed to play a central role in the activation of male-expressed liver genes by GH pulses in vivo (Waxman, D. J., Ram, P. A., Park, S. H., and Choi, H. K. (1995) J. Biol. Tyrosine 39-47 gonadotropin releasing hormone receptor Rattus norvegicus 0-14 9211920-1 1997 Growth hormone (GH) rapidly stimulates tyrosine phosphorylation followed by serine/threonine phosphorylation of multiple cytoplasmic STAT transcription factors, including one, STAT5b, that is uniquely responsive to the temporal pattern of plasma GH stimulation in rat liver and is proposed to play a central role in the activation of male-expressed liver genes by GH pulses in vivo (Waxman, D. J., Ram, P. A., Park, S. H., and Choi, H. K. (1995) J. Biol. Tyrosine 39-47 gonadotropin releasing hormone receptor Rattus norvegicus 16-18 9211920-6 1997 GH also induces nuclear translocation and binding of SHP-1 to tyrosine-phosphorylated STAT5b, suggesting that this GH-activated phosphatase may play a role in dephosphorylation leading to deactivation of nuclear STAT5b following the termination of a plasma GH pulse in male rat liver in vivo. Tyrosine 62-70 gonadotropin releasing hormone receptor Rattus norvegicus 0-2 9211920-6 1997 GH also induces nuclear translocation and binding of SHP-1 to tyrosine-phosphorylated STAT5b, suggesting that this GH-activated phosphatase may play a role in dephosphorylation leading to deactivation of nuclear STAT5b following the termination of a plasma GH pulse in male rat liver in vivo. Tyrosine 62-70 gonadotropin releasing hormone receptor Rattus norvegicus 115-117 9211920-6 1997 GH also induces nuclear translocation and binding of SHP-1 to tyrosine-phosphorylated STAT5b, suggesting that this GH-activated phosphatase may play a role in dephosphorylation leading to deactivation of nuclear STAT5b following the termination of a plasma GH pulse in male rat liver in vivo. Tyrosine 62-70 gonadotropin releasing hormone receptor Rattus norvegicus 115-117 8828496-0 1996 Growth hormone induces tyrosine phosphorylation of annexin I in rat osteosarcoma cells. Tyrosine 23-31 gonadotropin releasing hormone receptor Rattus norvegicus 0-14 7768925-5 1995 GH, but not prolactin, rapidly stimulated p93 tyrosine phosphorylation in hypophysectomized rats. Tyrosine 46-54 gonadotropin releasing hormone receptor Rattus norvegicus 0-2 7768925-9 1995 p93 is thus a liver-expressed, Stat 5-related DNA binding protein that undergoes tyrosine phosphorylation and nuclear translocation in response to intermittent plasma GH stimulation and is proposed to be an intracellular mediator of the stimulatory effects of GH pulses on male-specific liver gene expression. Tyrosine 81-89 gonadotropin releasing hormone receptor Rattus norvegicus 167-169 7876077-0 1995 Growth hormone stimulates the tyrosine phosphorylation of the insulin receptor substrate-1 and its association with phosphatidylinositol 3-kinase in primary adipocytes. Tyrosine 30-38 gonadotropin releasing hormone receptor Rattus norvegicus 0-14 7876077-7 1995 Here we show that IRS-1 is tyrosine-phosphorylated in a time- and dose-dependent manner in response to GH in primary rat adipocytes. Tyrosine 27-35 gonadotropin releasing hormone receptor Rattus norvegicus 103-105 7876077-10 1995 Our data suggest that GH-induced tyrosine phosphorylation of IRS-1 and the subsequent docking of PI 3-kinase are important postreceptor events in GH action. Tyrosine 33-41 gonadotropin releasing hormone receptor Rattus norvegicus 22-24 7876077-10 1995 Our data suggest that GH-induced tyrosine phosphorylation of IRS-1 and the subsequent docking of PI 3-kinase are important postreceptor events in GH action. Tyrosine 33-41 gonadotropin releasing hormone receptor Rattus norvegicus 146-148 15698425-8 2005 Growth hormone-induced JAK2, growth hormone receptor (GHR), and STAT5 tyrosine phosphorylation was significantly depressed in CRF as was nuclear translocation of phosphorylated STAT5. Tyrosine 70-78 gonadotropin releasing hormone receptor Rattus norvegicus 0-14 7510676-0 1994 Rapid changes in nuclear protein tyrosine phosphorylation after growth hormone treatment in vivo. Tyrosine 33-41 gonadotropin releasing hormone receptor Rattus norvegicus 64-78 7510676-4 1994 However, addition of GH to cells in vitro has been shown to stimulate tyrosine phosphorylation of various intracellular proteins including mitogen-activated protein kinases (MAP kinases) and the newly described Janus kinase, JAK2. Tyrosine 70-78 gonadotropin releasing hormone receptor Rattus norvegicus 21-23 7510676-9 1994 GH rapidly stimulated the tyrosine phosphorylation of at least 8 nuclear proteins of 205, 91, 83, 80, 65, 53, 44, and 42 kDa, and caused the dephosphorylation of a single approximately 149-kDa protein. Tyrosine 26-34 gonadotropin releasing hormone receptor Rattus norvegicus 0-2 7510676-12 1994 These results show that nuclear protein tyrosine phosphorylation is a prominent early event in GH action in vivo and demonstrate a link between GH-stimulated signal transduction and target gene expression. Tyrosine 40-48 gonadotropin releasing hormone receptor Rattus norvegicus 95-97 7510676-12 1994 These results show that nuclear protein tyrosine phosphorylation is a prominent early event in GH action in vivo and demonstrate a link between GH-stimulated signal transduction and target gene expression. Tyrosine 40-48 gonadotropin releasing hormone receptor Rattus norvegicus 144-146 2882520-7 1987 The octapeptides containing D- or L-tryptophan at the N-terminus, phenylalanine at position 3, and threonine at position 6 exhibited a greater inhibitory effect on growth hormone release than that of the analogs with tyrosine and valine at positions 3 and 6, respectively. Tyrosine 217-225 gonadotropin releasing hormone receptor Rattus norvegicus 164-178 1385420-0 1992 Growth hormone (GH) induction of tyrosine phosphorylation and activation of mitogen-activated protein kinases in cells transfected with rat GH receptor cDNA. Tyrosine 33-41 gonadotropin releasing hormone receptor Rattus norvegicus 0-14 1385420-0 1992 Growth hormone (GH) induction of tyrosine phosphorylation and activation of mitogen-activated protein kinases in cells transfected with rat GH receptor cDNA. Tyrosine 33-41 gonadotropin releasing hormone receptor Rattus norvegicus 16-18 3178830-2 1988 Tyrosine peptide mapping showed partial resemblance of fingerprints for P16 and P17 (and possibly P18) to those for growth hormone, and of P13 and P14 to those for prolactin. Tyrosine 0-8 gonadotropin releasing hormone receptor Rattus norvegicus 116-130 16717097-12 2006 Further investigation suggested that insulin increased the amount of MEK bound to KSR (kinase suppressor of Ras) and restored GH-induced tyrosine phosphorylation of KSR. Tyrosine 137-145 gonadotropin releasing hormone receptor Rattus norvegicus 126-128 15056730-0 2004 Growth hormone promotes Ca(2+)-induced Ca2+ release in insulin-secreting cells by ryanodine receptor tyrosine phosphorylation. Tyrosine 101-109 gonadotropin releasing hormone receptor Rattus norvegicus 0-14