PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
22140559-6	2011	Conversely, epidermal growth factor receptor (EGFR)-mediated phosphorylation of the MUC1-C cytoplasmic domain on Tyr-46 conferred binding to PKM2 Lys-433 and inhibited PKM2 activity.	Tyrosine	113-116	mucin 1, cell surface associated	Homo sapiens	84-88	
17545600-3	2007	We identified a novel tyrosine phosphorylation site (HGRYVPP) in the MUC1CT by mass spectrometric analysis of MUC1 from human pancreatic adenocarcinoma cell lines.	Tyrosine	22-30	mucin 1, cell surface associated	Homo sapiens	69-73	
17586693-4	2007	Our results showed 1) activation of MUC1 induced recruitment of the PI3K regulatory subunit p85 to the MUC1 cytoplasmic tail (CT) as well as Akt phosphorylation, 2) MUC1-induced Akt phosphorylation required the presence of Tyr(20) within the PI3K binding motif of the MUC1 CT, and 3) mutation of Tyr(20) or pharmacological inhibition of PI3K activation failed to block MUC1-induced suppression of TLR5 signaling.	Tyrosine	223-226	mucin 1, cell surface associated	Homo sapiens	36-40	
17586693-4	2007	Our results showed 1) activation of MUC1 induced recruitment of the PI3K regulatory subunit p85 to the MUC1 cytoplasmic tail (CT) as well as Akt phosphorylation, 2) MUC1-induced Akt phosphorylation required the presence of Tyr(20) within the PI3K binding motif of the MUC1 CT, and 3) mutation of Tyr(20) or pharmacological inhibition of PI3K activation failed to block MUC1-induced suppression of TLR5 signaling.	Tyrosine	223-226	mucin 1, cell surface associated	Homo sapiens	103-107	
17586693-4	2007	Our results showed 1) activation of MUC1 induced recruitment of the PI3K regulatory subunit p85 to the MUC1 cytoplasmic tail (CT) as well as Akt phosphorylation, 2) MUC1-induced Akt phosphorylation required the presence of Tyr(20) within the PI3K binding motif of the MUC1 CT, and 3) mutation of Tyr(20) or pharmacological inhibition of PI3K activation failed to block MUC1-induced suppression of TLR5 signaling.	Tyrosine	223-226	mucin 1, cell surface associated	Homo sapiens	103-107	
17586693-4	2007	Our results showed 1) activation of MUC1 induced recruitment of the PI3K regulatory subunit p85 to the MUC1 cytoplasmic tail (CT) as well as Akt phosphorylation, 2) MUC1-induced Akt phosphorylation required the presence of Tyr(20) within the PI3K binding motif of the MUC1 CT, and 3) mutation of Tyr(20) or pharmacological inhibition of PI3K activation failed to block MUC1-induced suppression of TLR5 signaling.	Tyrosine	223-226	mucin 1, cell surface associated	Homo sapiens	103-107	
17586693-4	2007	Our results showed 1) activation of MUC1 induced recruitment of the PI3K regulatory subunit p85 to the MUC1 cytoplasmic tail (CT) as well as Akt phosphorylation, 2) MUC1-induced Akt phosphorylation required the presence of Tyr(20) within the PI3K binding motif of the MUC1 CT, and 3) mutation of Tyr(20) or pharmacological inhibition of PI3K activation failed to block MUC1-induced suppression of TLR5 signaling.	Tyrosine	296-299	mucin 1, cell surface associated	Homo sapiens	36-40	
17586693-4	2007	Our results showed 1) activation of MUC1 induced recruitment of the PI3K regulatory subunit p85 to the MUC1 cytoplasmic tail (CT) as well as Akt phosphorylation, 2) MUC1-induced Akt phosphorylation required the presence of Tyr(20) within the PI3K binding motif of the MUC1 CT, and 3) mutation of Tyr(20) or pharmacological inhibition of PI3K activation failed to block MUC1-induced suppression of TLR5 signaling.	Tyrosine	296-299	mucin 1, cell surface associated	Homo sapiens	103-107	
17586693-4	2007	Our results showed 1) activation of MUC1 induced recruitment of the PI3K regulatory subunit p85 to the MUC1 cytoplasmic tail (CT) as well as Akt phosphorylation, 2) MUC1-induced Akt phosphorylation required the presence of Tyr(20) within the PI3K binding motif of the MUC1 CT, and 3) mutation of Tyr(20) or pharmacological inhibition of PI3K activation failed to block MUC1-induced suppression of TLR5 signaling.	Tyrosine	296-299	mucin 1, cell surface associated	Homo sapiens	103-107	
17586693-4	2007	Our results showed 1) activation of MUC1 induced recruitment of the PI3K regulatory subunit p85 to the MUC1 cytoplasmic tail (CT) as well as Akt phosphorylation, 2) MUC1-induced Akt phosphorylation required the presence of Tyr(20) within the PI3K binding motif of the MUC1 CT, and 3) mutation of Tyr(20) or pharmacological inhibition of PI3K activation failed to block MUC1-induced suppression of TLR5 signaling.	Tyrosine	296-299	mucin 1, cell surface associated	Homo sapiens	103-107	
20697347-8	2010	We demonstrate the requirement of phosphorylation at distinct tyrosine motifs within the MUC1.CT for MUC1-induced CTGF expression and demonstrate a phosphorylation-specific localization of MUC1.CT to the CTGF promoter.	Tyrosine	62-70	mucin 1, cell surface associated	Homo sapiens	89-93	
20697347-8	2010	We demonstrate the requirement of phosphorylation at distinct tyrosine motifs within the MUC1.CT for MUC1-induced CTGF expression and demonstrate a phosphorylation-specific localization of MUC1.CT to the CTGF promoter.	Tyrosine	62-70	mucin 1, cell surface associated	Homo sapiens	101-105	
20697347-8	2010	We demonstrate the requirement of phosphorylation at distinct tyrosine motifs within the MUC1.CT for MUC1-induced CTGF expression and demonstrate a phosphorylation-specific localization of MUC1.CT to the CTGF promoter.	Tyrosine	62-70	mucin 1, cell surface associated	Homo sapiens	101-105	
19245809-5	2009	The tyrosine-rich cytoplasmic domain and the heavily glycosylated extracellular domain both play a role in MUC1-mediated signal transduction.	Tyrosine	4-12	mucin 1, cell surface associated	Homo sapiens	107-111	
16888623-4	2006	The results demonstrate that c-Abl phosphorylates MUC1 on Tyr-60 and forms a complex with MUC1 by binding of the c-Abl SH2 domain to the pTyr-60 site.	Tyrosine	58-61	mucin 1, cell surface associated	Homo sapiens	50-54	
17114345-5	2006	FGF1 stimulation also induced c-Src-dependent tyrosine phosphorylation of the MUC1 cytoplasmic domain on a YEKV motif.	Tyrosine	46-54	mucin 1, cell surface associated	Homo sapiens	78-82	
17114345-6	2006	FGF1-induced tyrosine phosphorylation of MUC1 was associated with increased binding of MUC1 to beta-catenin and targeting of MUC1 and beta-catenin to the nucleus.	Tyrosine	13-21	mucin 1, cell surface associated	Homo sapiens	41-45	
17114345-6	2006	FGF1-induced tyrosine phosphorylation of MUC1 was associated with increased binding of MUC1 to beta-catenin and targeting of MUC1 and beta-catenin to the nucleus.	Tyrosine	13-21	mucin 1, cell surface associated	Homo sapiens	87-91	
17114345-6	2006	FGF1-induced tyrosine phosphorylation of MUC1 was associated with increased binding of MUC1 to beta-catenin and targeting of MUC1 and beta-catenin to the nucleus.	Tyrosine	13-21	mucin 1, cell surface associated	Homo sapiens	87-91	
16888623-6	2006	We also show that expression of MUC1 with a mutation at Tyr-60 (i) disrupts the interaction between MUC1 and c-Abl, (ii) relieves the MUC1-induced block of c-Abl phosphorylation on Thr-735 and binding to 14-3-3, and (iii) attenuates the MUC1 antiapoptotic function.	Tyrosine	56-59	mucin 1, cell surface associated	Homo sapiens	32-36	
16888623-6	2006	We also show that expression of MUC1 with a mutation at Tyr-60 (i) disrupts the interaction between MUC1 and c-Abl, (ii) relieves the MUC1-induced block of c-Abl phosphorylation on Thr-735 and binding to 14-3-3, and (iii) attenuates the MUC1 antiapoptotic function.	Tyrosine	56-59	mucin 1, cell surface associated	Homo sapiens	100-104	
16888623-4	2006	The results demonstrate that c-Abl phosphorylates MUC1 on Tyr-60 and forms a complex with MUC1 by binding of the c-Abl SH2 domain to the pTyr-60 site.	Tyrosine	58-61	mucin 1, cell surface associated	Homo sapiens	90-94	
16888623-6	2006	We also show that expression of MUC1 with a mutation at Tyr-60 (i) disrupts the interaction between MUC1 and c-Abl, (ii) relieves the MUC1-induced block of c-Abl phosphorylation on Thr-735 and binding to 14-3-3, and (iii) attenuates the MUC1 antiapoptotic function.	Tyrosine	56-59	mucin 1, cell surface associated	Homo sapiens	100-104	
16888623-6	2006	We also show that expression of MUC1 with a mutation at Tyr-60 (i) disrupts the interaction between MUC1 and c-Abl, (ii) relieves the MUC1-induced block of c-Abl phosphorylation on Thr-735 and binding to 14-3-3, and (iii) attenuates the MUC1 antiapoptotic function.	Tyrosine	56-59	mucin 1, cell surface associated	Homo sapiens	100-104	
12750561-6	2003	Activation of Lyn in response to IL-7 stimulation results in increased tyrosine phosphorylation of the MUC1 C-terminal subunit.	Tyrosine	71-79	mucin 1, cell surface associated	Homo sapiens	103-107	
15358196-0	2004	MUC1 tyrosine phosphorylation activates the extracellular signal-regulated kinase.	Tyrosine	5-13	mucin 1, cell surface associated	Homo sapiens	0-4	
15358196-6	2004	Extracellular treatment of HEK293-CD8/MUC1 cells with CD8 antibody induced intracellular Tyr phosphorylation of the MUC1 CT and activated ERK1/2, but not the p38, SAPK/JNK, or ERK5 MAP kinases.	Tyrosine	89-92	mucin 1, cell surface associated	Homo sapiens	38-42	
15358196-6	2004	Extracellular treatment of HEK293-CD8/MUC1 cells with CD8 antibody induced intracellular Tyr phosphorylation of the MUC1 CT and activated ERK1/2, but not the p38, SAPK/JNK, or ERK5 MAP kinases.	Tyrosine	89-92	mucin 1, cell surface associated	Homo sapiens	116-120	
15358196-8	2004	These results establish that Tyr phosphorylation of the MUC1 CT is required for activation of a downstream ERK1/2 pathway.	Tyrosine	29-32	mucin 1, cell surface associated	Homo sapiens	56-60	
14521915-0	2003	Identification of four sites of stimulated tyrosine phosphorylation in the MUC1 cytoplasmic tail.	Tyrosine	43-51	mucin 1, cell surface associated	Homo sapiens	75-79	
14521915-4	2003	In this report, we used our previously characterized CD8/MUC1 chimeric protein that is tyrosine phosphorylated on the MUC1 CT in response to extracellular treatment with CD8 antibody and performed site-directed mutagenesis of all seven tyrosines, both individually and in multiple combinations, to identify the particular sites of stimulated phosphorylation.	Tyrosine	87-95	mucin 1, cell surface associated	Homo sapiens	57-61	
14521915-4	2003	In this report, we used our previously characterized CD8/MUC1 chimeric protein that is tyrosine phosphorylated on the MUC1 CT in response to extracellular treatment with CD8 antibody and performed site-directed mutagenesis of all seven tyrosines, both individually and in multiple combinations, to identify the particular sites of stimulated phosphorylation.	Tyrosine	87-95	mucin 1, cell surface associated	Homo sapiens	118-122	
14521915-4	2003	In this report, we used our previously characterized CD8/MUC1 chimeric protein that is tyrosine phosphorylated on the MUC1 CT in response to extracellular treatment with CD8 antibody and performed site-directed mutagenesis of all seven tyrosines, both individually and in multiple combinations, to identify the particular sites of stimulated phosphorylation.	Tyrosine	236-245	mucin 1, cell surface associated	Homo sapiens	57-61	
12377938-5	2002	Additionally, we confirm CD227 expression by activated human T cells and show for the first time that the CD227 cytoplasmic domain is tyrosine-phosphorylated in activated T cells and DC and is associated with other phosphoproteins, indicating a role in signaling.	Tyrosine	134-142	mucin 1, cell surface associated	Homo sapiens	106-111	
11483589-5	2001	We also show that the activated EGF-R phosphorylates the MUC1 cytoplasmic tail on tyrosine at a YEKV motif that functions as a binding site for the c-Src SH2 domain.	Tyrosine	82-90	mucin 1, cell surface associated	Homo sapiens	57-61	
10918188-2	2000	Tyrosine phosphorylation of the highly conserved cytoplasmic tail of MUC1 (MUC1-CT) has been demonstrated in MUC1 transfected cells and in one breast cancer cell line.	Tyrosine	0-8	mucin 1, cell surface associated	Homo sapiens	69-73	
10918188-2	2000	Tyrosine phosphorylation of the highly conserved cytoplasmic tail of MUC1 (MUC1-CT) has been demonstrated in MUC1 transfected cells and in one breast cancer cell line.	Tyrosine	0-8	mucin 1, cell surface associated	Homo sapiens	75-82	
10918188-2	2000	Tyrosine phosphorylation of the highly conserved cytoplasmic tail of MUC1 (MUC1-CT) has been demonstrated in MUC1 transfected cells and in one breast cancer cell line.	Tyrosine	0-8	mucin 1, cell surface associated	Homo sapiens	75-79	
10918188-4	2000	MUC1 clearly plays a role in intracellular signalling, since we were able to demonstrate tyrosine phosphorylation of the MUC1-CT in breast and ovarian cancer cell lines and in primary cultures of serous ovarian cancers.	Tyrosine	89-97	mucin 1, cell surface associated	Homo sapiens	0-4	
10918188-4	2000	MUC1 clearly plays a role in intracellular signalling, since we were able to demonstrate tyrosine phosphorylation of the MUC1-CT in breast and ovarian cancer cell lines and in primary cultures of serous ovarian cancers.	Tyrosine	89-97	mucin 1, cell surface associated	Homo sapiens	121-128	
10918188-6	2000	However, in several breast and ovarian cancer cell lines, we clearly showed the highest levels of MUC1-CT tyrosine phosphorylation occurred during recolonisation of culture dishes or in low-density adherent cultures.	Tyrosine	106-114	mucin 1, cell surface associated	Homo sapiens	98-102	
29467938-9	2018	We show that mutating the tyrosines in MUC1-CT to phenylalanine reverses the TGF-beta induced invasiveness.	Tyrosine	26-35	mucin 1, cell surface associated	Homo sapiens	39-43	
7988707-0	1994	Tyrosine phosphorylation of the MUC1 breast cancer membrane proteins.	Tyrosine	0-8	mucin 1, cell surface associated	Homo sapiens	32-36	
7988707-4	1994	Here it is shown that these MUC1 proteins are extensively phosphorylated, that phosphorylation occurs primarily on tyrosine residues and that following phosphorylation the MUC1 proteins may potentially interact with SH2 domain-containing proteins and thereby initiate a signal transduction cascade.	Tyrosine	115-123	mucin 1, cell surface associated	Homo sapiens	28-32	
7988707-5	1994	As with cytokine receptors, the MUC1 proteins do not harbor intrinsic tyrosine kinase activity yet are tyrosine phosphorylated and the MUC1/Y protein participates in a cell surface heteromeric complex whose formation is mediated by two cytoplasmically located MUC1 cysteine residues.	Tyrosine	70-78	mucin 1, cell surface associated	Homo sapiens	32-36	
10197628-2	1999	The MUC1/Y isoform is devoid of the mucin domain and is a cell membrane protein that undergoes transphosphorylation on both serine and tyrosine residues.	Tyrosine	135-143	mucin 1, cell surface associated	Homo sapiens	4-8	
29467938-10	2018	This suggests that the tyrosine residues in MUC1-CT are required for TGF-beta induced invasion.	Tyrosine	23-31	mucin 1, cell surface associated	Homo sapiens	44-48	
24838315-8	2014	Smoke-induced MUC1-C glycosylation modulated MUC1-C tyrosine phosphorylation (TyrP) that was essential for MUC1-C/p120ctn interaction through dose-dependent bridging of Src/MUC1-C/galectin-3/EGFR signalosomes.	Tyrosine	52-60	mucin 1, cell surface associated	Homo sapiens	14-18	
26645913-10	2016	Stimulation of NHBE cells with recombinant TNF-alpha increased both MUC1 and EGFR protein levels, and stimulation of these cells with Pa enhanced MUC1-CT tyrosine phosphorylation and increased MUC1-CT/TLR5 and MUC1-CT/EGFR protein association, in an EGFR-dependent manner.	Tyrosine	154-162	mucin 1, cell surface associated	Homo sapiens	146-150	
26645913-10	2016	Stimulation of NHBE cells with recombinant TNF-alpha increased both MUC1 and EGFR protein levels, and stimulation of these cells with Pa enhanced MUC1-CT tyrosine phosphorylation and increased MUC1-CT/TLR5 and MUC1-CT/EGFR protein association, in an EGFR-dependent manner.	Tyrosine	154-162	mucin 1, cell surface associated	Homo sapiens	146-150	
26645913-10	2016	Stimulation of NHBE cells with recombinant TNF-alpha increased both MUC1 and EGFR protein levels, and stimulation of these cells with Pa enhanced MUC1-CT tyrosine phosphorylation and increased MUC1-CT/TLR5 and MUC1-CT/EGFR protein association, in an EGFR-dependent manner.	Tyrosine	154-162	mucin 1, cell surface associated	Homo sapiens	146-150	
26645913-11	2016	CONCLUSIONS: These results indicate that in response to Pa or flagellin, EGFR associates with and tyrosine phosphorylates MUC1-CT in primary NHBE cells, leading to increased MUC1-CT association with TLR5.	Tyrosine	98-106	mucin 1, cell surface associated	Homo sapiens	122-126	
26645913-11	2016	CONCLUSIONS: These results indicate that in response to Pa or flagellin, EGFR associates with and tyrosine phosphorylates MUC1-CT in primary NHBE cells, leading to increased MUC1-CT association with TLR5.	Tyrosine	98-106	mucin 1, cell surface associated	Homo sapiens	174-178	
24838315-8	2014	Smoke-induced MUC1-C glycosylation modulated MUC1-C tyrosine phosphorylation (TyrP) that was essential for MUC1-C/p120ctn interaction through dose-dependent bridging of Src/MUC1-C/galectin-3/EGFR signalosomes.	Tyrosine	52-60	mucin 1, cell surface associated	Homo sapiens	45-49	
24838315-8	2014	Smoke-induced MUC1-C glycosylation modulated MUC1-C tyrosine phosphorylation (TyrP) that was essential for MUC1-C/p120ctn interaction through dose-dependent bridging of Src/MUC1-C/galectin-3/EGFR signalosomes.	Tyrosine	52-60	mucin 1, cell surface associated	Homo sapiens	45-49	
23912457-4	2014	Moreover, treatment with the MUC1-C inhibitor, GO-203, was associated with disruption of MUC1-C/HER2 complexes and decreases in tyrosine-phosphorylated HER2 (p-HER2) levels.	Tyrosine	128-136	mucin 1, cell surface associated	Homo sapiens	29-33	
22425740-4	2012	The cytoplasmic tail of MUC1 contains both immune tyrosine-based activation and inhibitory motifs; therefore, we investigated whether MUC1 can also act as a costimulatory molecule on human T cells.	Tyrosine	50-58	mucin 1, cell surface associated	Homo sapiens	24-28	
22833523-8	2013	The MUC1-CT/p120ctn interaction was highly dependent on EGFR/Src/Jnk-mediated tyrosine phosphorylation (TyrP) of MUC1-CT.	Tyrosine	78-86	mucin 1, cell surface associated	Homo sapiens	4-8	
22833523-8	2013	The MUC1-CT/p120ctn interaction was highly dependent on EGFR/Src/Jnk-mediated tyrosine phosphorylation (TyrP) of MUC1-CT.	Tyrosine	78-86	mucin 1, cell surface associated	Homo sapiens	4-11	
22250084-10	2012	In conclusion, epidermal growth factor receptor tyrosine phosphorylates MUC1, leading to an increase in its association with TLR5, thereby competitively and reversibly inhibiting recruitment of MyD88 to TLR5 and downstream signaling events.	Tyrosine	48-56	mucin 1, cell surface associated	Homo sapiens	72-76	
21102519-9	2011	Thus, functional tyrosines are critical in stimulating the interactions between MUC1 and beta-catenin and their nuclear translocation to initiate the process of EMT.	Tyrosine	17-26	mucin 1, cell surface associated	Homo sapiens	80-84