PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 9182757-2 1997 In this report, we describe the purification, cloning, and characterization of a novel protein, designated FRS2, that is tyrosine phosphorylated and binds to Grb2/Sos in response to FGF or NGF stimulation. Tyrosine 121-129 xylosyltransferase 2 Homo sapiens 163-166 9096689-11 1997 Taken together with all these findings, it is suggested that c-Src directly phosphorylates Shc on tyrosine residues, which in turn binds to Grb2 constitutively associated with Sos to form a Shc-Grb2-Sos complex, and that the complex formation is coupled with MAP kinase activation mediated by Ras activation in U937 cells. Tyrosine 98-106 xylosyltransferase 2 Homo sapiens 176-179 9096689-11 1997 Taken together with all these findings, it is suggested that c-Src directly phosphorylates Shc on tyrosine residues, which in turn binds to Grb2 constitutively associated with Sos to form a Shc-Grb2-Sos complex, and that the complex formation is coupled with MAP kinase activation mediated by Ras activation in U937 cells. Tyrosine 98-106 xylosyltransferase 2 Homo sapiens 199-202 8986819-6 1996 In this study we show that L-selectin triggering of Jurkat cells using different antibodies or glycomimetics resulted in activation of the src-tyrosine kinase p56lck; tyrosine phosphorylation of intracellular proteins, in particular mitogen-activating protein kinase and L-selectin; and association of Grb2/Sos with L-selectin. Tyrosine 143-151 xylosyltransferase 2 Homo sapiens 307-310 7529874-0 1995 Tyrosine phosphorylation of BCR by FPS/FES protein-tyrosine kinases induces association of BCR with GRB-2/SOS. Tyrosine 0-8 xylosyltransferase 2 Homo sapiens 106-109 8955135-3 1996 Tyrosine phosphorylation led to the association of BCR with the RAS guanine nucleotide exchange complex GRB2-SOS in vivo via the GRB2 SH2 domain, linking BCR to RAS signaling (Maru, Y., Peters, K. L., Afar, D. E. H., Shibuya, M., Witte, O. N., and Smithgall, T. E. (1995) Mol. Tyrosine 0-8 xylosyltransferase 2 Homo sapiens 109-112 7539794-4 1995 Shc is tyrosine phosphorylated in antigen receptor-activated T cells and can potentially form a complex with the adapter molecule Grb2 and could thus recruit the Ras guanine nucleotide exchange protein Sos into the antigen receptor complex. Tyrosine 7-15 xylosyltransferase 2 Homo sapiens 202-205 8765045-3 1996 The results reported here indicate that the resting, nonphosphorylated BCR associates with the Grb-2/Sos-linker SHC via the Ig-alpha immunoreceptor-based tyrosine activation motif (ITAM). Tyrosine 154-162 xylosyltransferase 2 Homo sapiens 101-104 8765045-10 1996 In view of previous studies which demonstrated p21ras co-capping with ligated BCR, the data presented here suggest that Ig-alpha/beta- and SHC tyrosine phosphorylation-dependent recruitment of the Grb2/Sos complex to the receptor can occur and may provide a mechanism by which the nucleotide exchange activity of Sos could mediate activation of BCR-localized p21ras. Tyrosine 143-151 xylosyltransferase 2 Homo sapiens 202-205 8765045-10 1996 In view of previous studies which demonstrated p21ras co-capping with ligated BCR, the data presented here suggest that Ig-alpha/beta- and SHC tyrosine phosphorylation-dependent recruitment of the Grb2/Sos complex to the receptor can occur and may provide a mechanism by which the nucleotide exchange activity of Sos could mediate activation of BCR-localized p21ras. Tyrosine 143-151 xylosyltransferase 2 Homo sapiens 313-316 8663461-9 1996 Together, these data suggest the presence of distinct Grb2-SOS pools that are independently utilized by insulin and EGF in their recruitment to tyrosine-phosphorylated Shc. Tyrosine 144-152 xylosyltransferase 2 Homo sapiens 59-62 7529874-6 1995 Tyrosine phosphorylation of BCR in v-fps-transformed cells induced its association with GRB-2/SOS, the RAS guanine nucleotide exchange factor complex. Tyrosine 0-8 xylosyltransferase 2 Homo sapiens 94-97 7510700-2 1994 Immunoprecipitates of Sos from the lysates of T cells contain a 36-kDa protein which is phosphorylated on tyrosine residues in response to T cell receptor/CD3 cross-linking. Tyrosine 106-114 xylosyltransferase 2 Homo sapiens 22-25 9480847-6 1998 Thus, in cells transformed by v-Src, tyrosine phosphorylation of FGFR-1 results not in the expected association with PLC gamma and p90, but rather in the recruitment of the Ras activating Shc/Grb2/Sos complex. Tyrosine 37-45 xylosyltransferase 2 Homo sapiens 197-200 10681590-2 2000 Here we demonstrate that the T cell antigen receptor zeta-chain-associated ZAP-70 kinase and T cell antigen receptor zeta-chain immunoreceptor tyrosine-based activation motifs are essential for the membrane recruitment of SOS and Vav. Tyrosine 143-151 xylosyltransferase 2 Homo sapiens 222-225 10681590-4 2000 The subsequent tyrosine phosphorylation of LAT (linker for activation of T cell) by ZAP-70 leads to a shift in equilibrium from the ZAP-70.Grb-2.SOS(Vav) complex to the (Vav)SOS.Grb-2.LAT complex. Tyrosine 15-23 xylosyltransferase 2 Homo sapiens 145-148 8264620-11 1994 Furthermore, both GRB2 and Sos coimmunoprecipitate with Syp from lysates of PDGF-stimulated cells, and GRB2 binds directly to tyrosine-phosphorylated Syp in vitro. Tyrosine 126-134 xylosyltransferase 2 Homo sapiens 27-30 15272025-6 2004 The activated SHP-2 then dephosphorylated IRS-1 Tyr(P)-895, resulting in blockade of the pathways from IRS-1/Grb2/Sos to the ERK and p38 MAPK. Tyrosine 48-51 xylosyltransferase 2 Homo sapiens 114-117 10681590-4 2000 The subsequent tyrosine phosphorylation of LAT (linker for activation of T cell) by ZAP-70 leads to a shift in equilibrium from the ZAP-70.Grb-2.SOS(Vav) complex to the (Vav)SOS.Grb-2.LAT complex. Tyrosine 15-23 xylosyltransferase 2 Homo sapiens 174-177