PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 11479293-7 2001 Experiments performed to investigate potential signaling pathways revealed that inhibition of tyrosine phosphorylation with genistein reversed the anti-CD47-mediated PMN migration delay, whereas inhibition of phosphatidylinositol 3-kinase only partially reversed anti-CD47 effects that correlated with a rapid increase in PMN cell surface CD47. Tyrosine 94-102 CD47 molecule Homo sapiens 152-156 12464013-7 2002 In contrast, cells infected with an isogenic strain carrying a G1098A mutation at the FHA RGD site did not show any recruitment of PI3-K. We found that ligation of FHA by alphavbeta3/IAP induced RGD-dependent tyrosine phosphorylation of a 60 kDa protein, which associated with IAP and PI3-K in human monocytes. Tyrosine 209-217 CD47 molecule Homo sapiens 183-186 9169439-3 1997 TS1, the CBD, and an IAP agonist peptide (4N1K) from the CBD of TS1 activate the platelet integrin alphaIIbbeta3, resulting in platelet spreading on immobilized fibrinogen, stimulation of platelet aggregation, and enhanced tyrosine phosphorylation of focal adhesion kinase. Tyrosine 223-231 CD47 molecule Homo sapiens 21-24 11509594-3 2001 In this study, we first show that CD47/integrin-associated protein, a ubiquitous multispan transmembrane protein highly expressed on T cells, interacts with signal-regulator protein (SIRP)-alpha, an immunoreceptor tyrosine-based inhibition motif-containing molecule selectively expressed on myelomonocytic cells, and next demonstrate that this pair of molecules negatively regulates human T and dendritic cell (DC) function. Tyrosine 214-222 CD47 molecule Homo sapiens 34-38 11509594-3 2001 In this study, we first show that CD47/integrin-associated protein, a ubiquitous multispan transmembrane protein highly expressed on T cells, interacts with signal-regulator protein (SIRP)-alpha, an immunoreceptor tyrosine-based inhibition motif-containing molecule selectively expressed on myelomonocytic cells, and next demonstrate that this pair of molecules negatively regulates human T and dendritic cell (DC) function. Tyrosine 214-222 CD47 molecule Homo sapiens 39-66 11114301-6 2001 A mutant form of CD47 without its Ig domain that did not induce actin polymerization or localize to rafts still enhanced T cell receptor (TCR)-dependent tyrosine phosphorylation of PLCgamma and associated Ca(2+) signaling but did not augment IL-2 secretion. Tyrosine 153-161 CD47 molecule Homo sapiens 17-21 8992983-7 1997 In an attempt to explore further the activation signal delivered by IAP, we show here that IAP cross-linking with the comitogenic B6H12 mAb induces the phosphorylation on tyrosine of several proteins, one of which is identified as p56(lck) protein tyrosine kinase. Tyrosine 171-179 CD47 molecule Homo sapiens 68-71 8992983-7 1997 In an attempt to explore further the activation signal delivered by IAP, we show here that IAP cross-linking with the comitogenic B6H12 mAb induces the phosphorylation on tyrosine of several proteins, one of which is identified as p56(lck) protein tyrosine kinase. Tyrosine 171-179 CD47 molecule Homo sapiens 91-94 28393401-13 2017 The tyrosine phosphorylation level of SIRP-alpha in activated THP-1 cells was further increased in the case of co-expression of CD47/TFPI than in individual non-expression or expression of CD47 or TFPI alone. Tyrosine 4-12 CD47 molecule Homo sapiens 128-132 8996237-8 1997 Furthermore, anti-IAP, but not anti-CD28, synergizes with suboptimal anti-CD3 to enhance tyrosine phosphorylation of the CD3 zeta chain and the T cell-specific tyrosine kinase Zap70. Tyrosine 89-97 CD47 molecule Homo sapiens 18-21 28393401-13 2017 The tyrosine phosphorylation level of SIRP-alpha in activated THP-1 cells was further increased in the case of co-expression of CD47/TFPI than in individual non-expression or expression of CD47 or TFPI alone. Tyrosine 4-12 CD47 molecule Homo sapiens 189-193 28393401-14 2017 CONCLUSIONS: When hCD47 was expressed, the expression of hTFPI leaded to tyrosine phosphorylation of SIRP-alpha in activated THP-1 cells via hTSP-1 inhibition, and consequently, it might improve the effect of hCD47-SIRP-a signaling. Tyrosine 73-81 CD47 molecule Homo sapiens 18-23 26534964-2 2015 SIRPalpha ligation by a broadly expressed transmembrane protein, CD47, results in phosphorylation of the cytoplasmic immunoreceptor tyrosine-based inhibitory motifs, resulting in the inhibition of NF-kappaB signaling in macrophages. Tyrosine 132-140 CD47 molecule Homo sapiens 65-69 18186923-9 2008 The function-blocking anti-CD47/IAP antibody Bric 126 inhibited changes in membrane potential, tyrosine phosphorylation, and elevation of relative levels of aggrecan mRNA induced by mechanical stimulation, whereas in the presence of B6H12, an antibody that has partial agonist activity, a membrane depolarisation rather than a membrane hyperpolarisation response was induced by mechanical stimulation. Tyrosine 95-103 CD47 molecule Homo sapiens 27-31 18292237-4 2008 The association of integrin-associated protein (IAP) with SHPS-1 is required for SHPS-1 tyrosine phosphorylation. Tyrosine 88-96 CD47 molecule Homo sapiens 19-46 18292237-4 2008 The association of integrin-associated protein (IAP) with SHPS-1 is required for SHPS-1 tyrosine phosphorylation. Tyrosine 88-96 CD47 molecule Homo sapiens 48-51 18186923-9 2008 The function-blocking anti-CD47/IAP antibody Bric 126 inhibited changes in membrane potential, tyrosine phosphorylation, and elevation of relative levels of aggrecan mRNA induced by mechanical stimulation, whereas in the presence of B6H12, an antibody that has partial agonist activity, a membrane depolarisation rather than a membrane hyperpolarisation response was induced by mechanical stimulation. Tyrosine 95-103 CD47 molecule Homo sapiens 32-35 18207024-2 2008 We previously showed that tyrosine phosphorylation might serve as the downstream signaling for the modulation of PMN transmigration by CD47. Tyrosine 26-34 CD47 molecule Homo sapiens 135-139