PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 17178895-6 2006 Furthermore, we show that Ron overexpression leads to receptor phosphorylation and is associated with elevated levels of tyrosine phosphorylated beta-catenin and the up-regulation of genes, including cyclin D1 and c-myc, which are associated with poor prognosis in patients with human breast cancers. Tyrosine 121-129 macrophage stimulating 1 receptor Homo sapiens 26-29 10871856-5 2000 Phosphate groups are transferred to the tyrosine phosphorylation sites responsible both for kinase up-regulation (Met: Y1234/Y1235 and Ron: Y1238/Y1239) and for generation of signal transducer docking sites (Met: Y1349/Y1356 and Ron Y1353/Y1360). Tyrosine 40-48 macrophage stimulating 1 receptor Homo sapiens 135-138 16166096-6 2005 Mutational analysis indicated that the two tyrosines present in this region in human RON, one of which has been previously shown to be a c-Cbl binding site, are not responsible for this difference. Tyrosine 43-52 macrophage stimulating 1 receptor Homo sapiens 85-88 12527888-4 2003 Accumulated RON is also constitutively active with autophosphorylation in tyrosine residues. Tyrosine 74-82 macrophage stimulating 1 receptor Homo sapiens 12-15 11332718-3 2001 MSP binding to RON causes receptor tyrosine phosphorylation leading to up-regulation of RON catalytic activity and subsequent activation of downstream signaling molecules. Tyrosine 35-43 macrophage stimulating 1 receptor Homo sapiens 15-18 11332718-3 2001 MSP binding to RON causes receptor tyrosine phosphorylation leading to up-regulation of RON catalytic activity and subsequent activation of downstream signaling molecules. Tyrosine 35-43 macrophage stimulating 1 receptor Homo sapiens 88-91 10871856-5 2000 Phosphate groups are transferred to the tyrosine phosphorylation sites responsible both for kinase up-regulation (Met: Y1234/Y1235 and Ron: Y1238/Y1239) and for generation of signal transducer docking sites (Met: Y1349/Y1356 and Ron Y1353/Y1360). Tyrosine 40-48 macrophage stimulating 1 receptor Homo sapiens 229-232 10631120-0 2000 Requirement of both tyrosine residues 1330 and 1337 in the C-terminal tail of the RON receptor tyrosine kinase for epithelial cell scattering and migration. Tyrosine 20-28 macrophage stimulating 1 receptor Homo sapiens 82-85 10747844-6 2000 The data fit a pathway in which ECM-induced integrin aggregation causes both c-Src activation and RON oligomerization followed by RON kinase-dependent autophosphorylation; this results in RON becoming a target for activated c-Src, which phosphorylates additional tyrosines on RON. Tyrosine 263-272 macrophage stimulating 1 receptor Homo sapiens 130-133 10747844-6 2000 The data fit a pathway in which ECM-induced integrin aggregation causes both c-Src activation and RON oligomerization followed by RON kinase-dependent autophosphorylation; this results in RON becoming a target for activated c-Src, which phosphorylates additional tyrosines on RON. Tyrosine 263-272 macrophage stimulating 1 receptor Homo sapiens 130-133 10747844-6 2000 The data fit a pathway in which ECM-induced integrin aggregation causes both c-Src activation and RON oligomerization followed by RON kinase-dependent autophosphorylation; this results in RON becoming a target for activated c-Src, which phosphorylates additional tyrosines on RON. Tyrosine 263-272 macrophage stimulating 1 receptor Homo sapiens 130-133 10631120-2 2000 This study focused on the function of two tyrosines, Y1330 and Y1337, in the C-terminus of RON in regulating epithelial cell scattering and migration. Tyrosine 42-51 macrophage stimulating 1 receptor Homo sapiens 91-94 8062829-5 1994 In vivo, tyrosine phosphorylation of p185RON is induced by stimulation with macrophage stimulating protein (MSP), a protease-like factor containing four "kringle" domains, homologous to HGF. Tyrosine 9-17 macrophage stimulating 1 receptor Homo sapiens 37-44 9715276-8 1998 Expression of Ron mutants in 3T3 fibroblasts led to different patterns of tyrosine-phos-phorylated proteins. Tyrosine 74-82 macrophage stimulating 1 receptor Homo sapiens 14-17 8816464-6 1996 Oligomerization and constitutive tyrosine phosphorylation of the full-size Ron was obtained by site-directed mutagenesis of a single cysteine residue in the region encoded by the cassette exon, mimicking that occurring in the delta-Ron isoform. Tyrosine 33-41 macrophage stimulating 1 receptor Homo sapiens 75-78 8062829-6 1994 In epithelial cells, MSP-induced tyrosine phosphorylation of p185RON is followed by DNA synthesis. Tyrosine 33-41 macrophage stimulating 1 receptor Homo sapiens 61-68 24739671-3 2014 RESULTS: Unlike other RTKs described to date, tyrosines in the juxtamembrane domain of Ron are inconsequential for receptor activation. Tyrosine 46-55 macrophage stimulating 1 receptor Homo sapiens 87-90 23542172-0 2014 The Ron receptor tyrosine kinase activates c-Abl to promote cell proliferation through tyrosine phosphorylation of PCNA in breast cancer. Tyrosine 17-25 macrophage stimulating 1 receptor Homo sapiens 4-7 21423209-2 2011 Biochemical analysis of mammary tumor lysates showed that Ron overexpression was associated with increases in beta-catenin expression and tyrosine phosphorylation. Tyrosine 138-146 macrophage stimulating 1 receptor Homo sapiens 58-61 21423209-6 2011 Our data also demonstrate that activation of Ron, through ligand binding by hepatocyte growth factor-like protein (HGFL), induces the tyrosine phosphorylation of beta-catenin, primarily on tyrosine residues Tyr 654 and Tyr 670. Tyrosine 134-142 macrophage stimulating 1 receptor Homo sapiens 45-48 21423209-6 2011 Our data also demonstrate that activation of Ron, through ligand binding by hepatocyte growth factor-like protein (HGFL), induces the tyrosine phosphorylation of beta-catenin, primarily on tyrosine residues Tyr 654 and Tyr 670. Tyrosine 189-197 macrophage stimulating 1 receptor Homo sapiens 45-48 21423209-6 2011 Our data also demonstrate that activation of Ron, through ligand binding by hepatocyte growth factor-like protein (HGFL), induces the tyrosine phosphorylation of beta-catenin, primarily on tyrosine residues Tyr 654 and Tyr 670. Tyrosine 207-210 macrophage stimulating 1 receptor Homo sapiens 45-48 21423209-6 2011 Our data also demonstrate that activation of Ron, through ligand binding by hepatocyte growth factor-like protein (HGFL), induces the tyrosine phosphorylation of beta-catenin, primarily on tyrosine residues Tyr 654 and Tyr 670. Tyrosine 219-222 macrophage stimulating 1 receptor Homo sapiens 45-48 22975341-0 2012 A novel variant of the RON receptor tyrosine kinase derived from colorectal carcinoma cells which lacks tyrosine phosphorylation but induces cell migration. Tyrosine 36-44 macrophage stimulating 1 receptor Homo sapiens 23-26