PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 20375009-1 2010 Previously we showed that Cool-1 (Cloned out of library-1)/beta-Pix (Pak-interactive exchange factor) is phosphorylated at a specific tyrosine residue (Tyr-442) in a Src-dependent manner and serves as a dual function guanine nucleotide exchange factor (GEF)/signaling-effector for Cdc42 that is essential for transformation by Src. Tyrosine 134-142 Ras protein specific guanine nucleotide releasing factor 1 Homo sapiens 217-251 20457609-4 2010 We found that mutation of either Tyr-826 (Y826F) or Tyr-841 (Y841F) to phenylalanine led to loss of Vav1 GEF activity. Tyrosine 33-36 Ras protein specific guanine nucleotide releasing factor 1 Homo sapiens 105-108 20457609-4 2010 We found that mutation of either Tyr-826 (Y826F) or Tyr-841 (Y841F) to phenylalanine led to loss of Vav1 GEF activity. Tyrosine 52-55 Ras protein specific guanine nucleotide releasing factor 1 Homo sapiens 105-108 20375009-1 2010 Previously we showed that Cool-1 (Cloned out of library-1)/beta-Pix (Pak-interactive exchange factor) is phosphorylated at a specific tyrosine residue (Tyr-442) in a Src-dependent manner and serves as a dual function guanine nucleotide exchange factor (GEF)/signaling-effector for Cdc42 that is essential for transformation by Src. Tyrosine 134-142 Ras protein specific guanine nucleotide releasing factor 1 Homo sapiens 253-256 20375009-1 2010 Previously we showed that Cool-1 (Cloned out of library-1)/beta-Pix (Pak-interactive exchange factor) is phosphorylated at a specific tyrosine residue (Tyr-442) in a Src-dependent manner and serves as a dual function guanine nucleotide exchange factor (GEF)/signaling-effector for Cdc42 that is essential for transformation by Src. Tyrosine 152-155 Ras protein specific guanine nucleotide releasing factor 1 Homo sapiens 217-251 20375009-1 2010 Previously we showed that Cool-1 (Cloned out of library-1)/beta-Pix (Pak-interactive exchange factor) is phosphorylated at a specific tyrosine residue (Tyr-442) in a Src-dependent manner and serves as a dual function guanine nucleotide exchange factor (GEF)/signaling-effector for Cdc42 that is essential for transformation by Src. Tyrosine 152-155 Ras protein specific guanine nucleotide releasing factor 1 Homo sapiens 253-256 18211801-8 2008 These results suggest that tyrosine phosphorylation of GIT1 by Src kinases may regulate cytoskeletal reorganization downstream of alpha(IIb)beta(3) by bringing the Rac GEF betaPIX to the vicinity of the integrin. Tyrosine 27-35 Ras protein specific guanine nucleotide releasing factor 1 Homo sapiens 168-171 10681520-4 2000 Tyrosine phosphorylation of Ras-GRF1 is critical for the induction of Rac-GEF activity as evidenced by inhibition by tyrosine kinase inhibitors. Tyrosine 0-8 Ras protein specific guanine nucleotide releasing factor 1 Homo sapiens 28-36 17050525-2 2006 The catalytic guanine nucleotide exchange factor (GEF) activity of the Vav Dbl homology (DH) domain is thought to be controlled by an intramolecular autoinhibitory mechanism involving an N-terminal extension and phosphorylation of tyrosine residues in the acidic region (AC). Tyrosine 231-239 Ras protein specific guanine nucleotide releasing factor 1 Homo sapiens 14-48 17050525-2 2006 The catalytic guanine nucleotide exchange factor (GEF) activity of the Vav Dbl homology (DH) domain is thought to be controlled by an intramolecular autoinhibitory mechanism involving an N-terminal extension and phosphorylation of tyrosine residues in the acidic region (AC). Tyrosine 231-239 Ras protein specific guanine nucleotide releasing factor 1 Homo sapiens 50-53 10681520-9 2000 Taken together, tyrosine phosphorylation by Src is sufficient for the induction of Rac-GEF activity of Ras-GRF1, which may imply the involvement of Src downstream of Gbetagamma to regulate Ras-GRF1. Tyrosine 16-24 Ras protein specific guanine nucleotide releasing factor 1 Homo sapiens 103-111 10681520-9 2000 Taken together, tyrosine phosphorylation by Src is sufficient for the induction of Rac-GEF activity of Ras-GRF1, which may imply the involvement of Src downstream of Gbetagamma to regulate Ras-GRF1. Tyrosine 16-24 Ras protein specific guanine nucleotide releasing factor 1 Homo sapiens 189-197 10882715-0 2000 Stimulation of Ras guanine nucleotide exchange activity of Ras-GRF1/CDC25(Mm) upon tyrosine phosphorylation by the Cdc42-regulated kinase ACK1. Tyrosine 83-91 Ras protein specific guanine nucleotide releasing factor 1 Homo sapiens 59-67 10882715-2 2000 In addition, Ras-GRF1 acts as a GEF for Rac when tyrosine-phosphorylated following G protein-coupled receptor stimulation. Tyrosine 49-57 Ras protein specific guanine nucleotide releasing factor 1 Homo sapiens 13-21 10882715-2 2000 In addition, Ras-GRF1 acts as a GEF for Rac when tyrosine-phosphorylated following G protein-coupled receptor stimulation. Tyrosine 49-57 Ras protein specific guanine nucleotide releasing factor 1 Homo sapiens 32-35 10882715-4 2000 We show here that activated ACK1, a nonreceptor tyrosine kinase that belongs to the focal adhesion kinase family, causes tyrosine phosphorylation of Ras-GRF1. Tyrosine 48-56 Ras protein specific guanine nucleotide releasing factor 1 Homo sapiens 149-157 10882715-6 2000 GEF activity of Ras-GRF1 toward Ha-Ras, as defined by in vitro GDP binding and release assays, was augmented after tyrosine phosphorylation by ACK1. Tyrosine 115-123 Ras protein specific guanine nucleotide releasing factor 1 Homo sapiens 0-3 10882715-6 2000 GEF activity of Ras-GRF1 toward Ha-Ras, as defined by in vitro GDP binding and release assays, was augmented after tyrosine phosphorylation by ACK1. Tyrosine 115-123 Ras protein specific guanine nucleotide releasing factor 1 Homo sapiens 16-24 10681520-6 2000 Ras-GRF1 transiently expressed with v-Src was tyrosine-phosphorylated and showed significant GEF activity toward Rac, but not Rho and Cdc42, which was comparable with that induced by Gbetagamma. Tyrosine 46-54 Ras protein specific guanine nucleotide releasing factor 1 Homo sapiens 0-8 10636924-9 2000 Moreover, mutation of Tyr-174 augmented the ability of Vav1 to up-regulate NF-AT activation as well as the Vav1 GEF function leading to Rac activation. Tyrosine 22-25 Ras protein specific guanine nucleotide releasing factor 1 Homo sapiens 112-115