PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 17786281-7 2007 Translocation of Rac1 to the cell membrane is known to be dependent on phosphorylation of tyrosine-221 residue of Crk. Tyrosine 90-98 Rac family small GTPase 1 Homo sapiens 17-21 17088251-9 2007 Src or Rac1 inhibition also prevented strain-induced FAK phosphorylation at Tyr(576) and ERK phosphorylation but not FAK phosphorylation at Tyr(397). Tyrosine 76-79 Rac family small GTPase 1 Homo sapiens 7-11 17686471-11 2007 Moreover, Vav2 is tyrosine phosphorylated upon VEGF treatment, which temporally correlates with Rac1 activation and requires VEGFR-2 signaling and Src kinase activity. Tyrosine 18-26 Rac family small GTPase 1 Homo sapiens 96-100 17560670-0 2007 Tyrosine phosphorylation of beta2-chimaerin by Src-family kinase negatively regulates its Rac-specific GAP activity. Tyrosine 0-8 Rac family small GTPase 1 Homo sapiens 90-93 17093062-8 2007 We demonstrated that FAK tyrosine-phosphorylated betaPIX and thereby increased its binding to Rac1. Tyrosine 25-33 Rac family small GTPase 1 Homo sapiens 94-98 17093062-10 2007 These data indicate that FAK has a role in the activation and focal adhesion translocation of Rac1 through the tyrosine phosphorylation of betaPIX. Tyrosine 111-119 Rac family small GTPase 1 Homo sapiens 94-98 15976327-5 2005 Ang II stimulates tyrosine phosphorylation of Sos-1, a Rac-guanine nucleotide exchange factor, which is inhibited by Cav1 siRNA, demonstrating involvement of Cav1 in Rac1 activation. Tyrosine 18-26 Rac family small GTPase 1 Homo sapiens 166-170 15485841-9 2005 Cdc42 activated through c-Src then enhanced the GEF activity of tyrosine-phosphorylated Vav2 on Rac1. Tyrosine 64-72 Rac family small GTPase 1 Homo sapiens 96-100 15778498-8 2005 These results implicate Pyk2 in the reduced cell-cell adhesion induced by the Rac-mediated production of ROS through the tyrosine phosphorylation of beta-catenin. Tyrosine 121-129 Rac family small GTPase 1 Homo sapiens 78-81 15893190-8 2005 The effect of SHP-1 was mediated by inhibition of PI3K/Rac1-dependent NAD(P)H-oxidase activation (p < 0.01); SHP-1 AS-ODN augmented tyrosine phosphorylation of the p85 regulatory subunit of PI3K (p < 0.05) and Rac1 activation. Tyrosine 135-143 Rac family small GTPase 1 Homo sapiens 55-59 15673687-5 2005 Using a constitutively active form for Mer (CDMer) or Gas6 as a ligand to stimulate Mer, we found that Mer activation induced a post-receptor signaling cascade involving Src-mediated tyrosine phosphorylation of FAK on Tyr(861), the recruitment of FAK(Tyr861) to the alphavbeta5 integrin, and increased formation of p130(CAS)/CrkII/Dock180 complex to activate Rac1. Tyrosine 183-191 Rac family small GTPase 1 Homo sapiens 359-363 12925758-8 2003 These results indicate that cortactin tyrosine phosphorylation requires Rac1-induced cortactin targeting to cortical actin networks, where it is tyrosine phosphorylated in hierarchical manner that is closely coordinated with its ability to regulate actin dynamics. Tyrosine 38-46 Rac family small GTPase 1 Homo sapiens 72-76 12810717-5 2003 We further show that Vav2 and the ubiquitously expressed Rac1 guanine nucleotide exchange factor Tiam1 are phosphorylated in tyrosine residues in cells transfected with active and oncogenic Src. Tyrosine 125-133 Rac family small GTPase 1 Homo sapiens 57-61 12925758-8 2003 These results indicate that cortactin tyrosine phosphorylation requires Rac1-induced cortactin targeting to cortical actin networks, where it is tyrosine phosphorylated in hierarchical manner that is closely coordinated with its ability to regulate actin dynamics. Tyrosine 145-153 Rac family small GTPase 1 Homo sapiens 72-76 11595749-5 2001 The results reveal that Rac1 residues of both the switch I and switch II regions are involved in GEF docking and GEF-mediated nucleotide disruption, because mutation of Asp(38), Asn(39), Gln(61), Tyr(64), or Arg(66)/Leu(67) into Ala results in the loss of GEF binding, whereas mutation at Tyr(32), Asp(65), or Leu(70)/Ser(71) leads to the loss of GEF catalysis while retaining the binding capability. Tyrosine 196-199 Rac family small GTPase 1 Homo sapiens 24-28 12925758-0 2003 Cortactin tyrosine phosphorylation requires Rac1 activity and association with the cortical actin cytoskeleton. Tyrosine 10-18 Rac family small GTPase 1 Homo sapiens 44-48 12925758-4 2003 Herein, we report that phosphorylation of cortactin tyrosine residues in the carboxy terminus requires the aminoterminal domain and Rac1-mediated localization to the cell periphery. Tyrosine 52-60 Rac family small GTPase 1 Homo sapiens 132-136 12925758-6 2003 Phosphorylation of cortactin tyrosine 421 and 466 was elevated in response to Src, epidermal growth factor receptor and Rac1 activation, and tyrosine 421 phosphorylated cortactin localized with F-actin in lamellipodia and podosomes. Tyrosine 29-37 Rac family small GTPase 1 Homo sapiens 120-124 12556491-3 2003 Here we show that GPCR-stimulated Rac activity and the subsequent generation of reactive oxygen species are necessary for activating tyrosine phosphorylation of Jaks and STAT-dependent transcription. Tyrosine 133-141 Rac family small GTPase 1 Homo sapiens 34-37 12556491-6 2003 We further show that GPCR agonists stimulate tyrosine phosphorylation of STAT1 and STAT3 proteins in a Rac-dependent manner. Tyrosine 45-53 Rac family small GTPase 1 Homo sapiens 103-106 12215529-0 2002 Cdc42/Rac1-mediated activation primes PAK2 for superactivation by tyrosine phosphorylation. Tyrosine 66-74 Rac family small GTPase 1 Homo sapiens 6-10 11595749-5 2001 The results reveal that Rac1 residues of both the switch I and switch II regions are involved in GEF docking and GEF-mediated nucleotide disruption, because mutation of Asp(38), Asn(39), Gln(61), Tyr(64), or Arg(66)/Leu(67) into Ala results in the loss of GEF binding, whereas mutation at Tyr(32), Asp(65), or Leu(70)/Ser(71) leads to the loss of GEF catalysis while retaining the binding capability. Tyrosine 289-292 Rac family small GTPase 1 Homo sapiens 24-28 10900195-9 2000 These data indicate that Cdc42Hs and Rac1 GTPases control vimentin IF organization involving tyrosine phosphorylation events. Tyrosine 93-101 Rac family small GTPase 1 Homo sapiens 37-41 11781818-1 2001 Vav proteins are GDP/GTP exchange factors for Rho/Rac GTPases that are activated by tyrosine phosphorylation. Tyrosine 84-92 Rac family small GTPase 1 Homo sapiens 50-53 11021801-3 2000 Dominant negative Rac1 inhibited STAT3 activation by growth factors, whereas activated Rac1 stimulated STAT3 phosphorylation on both tyrosine and serine residues. Tyrosine 133-141 Rac family small GTPase 1 Homo sapiens 87-91 11034388-2 2000 Vav-1, an exchange factor for Rho GTPases thought to regulate, mainly through Rac-1, various signaling components leading to cytokine gene expression, is tyrosine phosphorylated upon CD28 engagement. Tyrosine 154-162 Rac family small GTPase 1 Homo sapiens 78-83 8990121-8 1997 Here we show that tyrosine-phosphorylated Vav, but not the non-phosphorylated protein, catalyses GDP/GTP exchange on Rac-1, a protein implicated in cell proliferation and cytoskeletal organization, causing this GTPase to switch from its inactive to its active state. Tyrosine 18-26 Rac family small GTPase 1 Homo sapiens 117-122 9488731-3 1998 It becomes rapidly and transiently tyrosine-phosphorylated upon triggering of a large number of surface receptors and catalyzes GDP/GTP exchange on Rac-1. Tyrosine 35-43 Rac family small GTPase 1 Homo sapiens 148-153 10882715-2 2000 In addition, Ras-GRF1 acts as a GEF for Rac when tyrosine-phosphorylated following G protein-coupled receptor stimulation. Tyrosine 49-57 Rac family small GTPase 1 Homo sapiens 40-43 9488489-7 1998 The Rac1-specific guanine nucleotide exchange factor Vav is heavily phosphorylated on tyrosine residues upon CD5 costimulation, which is a prerequisite for its activation. Tyrosine 86-94 Rac family small GTPase 1 Homo sapiens 4-8 9488489-11 1998 We propose a model for the CD5-induced signaling pathway in which the PI 3-kinase lipid products, together with tyrosine phosphorylation, activate Vav, resulting in the activation of Rac1 by the Vav-mediated exchange of GDP for GTP. Tyrosine 112-120 Rac family small GTPase 1 Homo sapiens 183-187 8990121-9 1997 Transfection experiments also show that phosphorylation of Vav on tyrosine residues leads to nucleotide exchange on Rac-1 in vivo and stimulates c-Jun kinase, a downstream element in the signalling pathway involving this GTPase. Tyrosine 66-74 Rac family small GTPase 1 Homo sapiens 116-121 9109498-4 1996 After activation of cells with extracellular stimuli, Vav becomes phosphorylated on tyrosine residues and catalyzes the exchange of guanosine nucleotides on the GTP-binding protein Rac-1, thereby allowing the transition of this GTPase from the inactive (GDP-loaded) to the active (GTP-loaded) state. Tyrosine 84-92 Rac family small GTPase 1 Homo sapiens 181-186 22080864-4 2011 Here, we report that PDGFRalpha signaling in glioblastomas leads to Src-dependent phosphorylation of the guanine nucleotide exchange factor Dock180 at tyrosine 1811 (Dock180(Y1811)) that results in activation of the GTPase Rac1 and subsequent cell growth and invasion. Tyrosine 151-159 Rac family small GTPase 1 Homo sapiens 223-227 32823607-6 2020 In conclusion, GA-induced c-Src activation is a key inductive event for the formation of inactive Rac1-p-CK2alpha (Tyr 255) complexes, which disturbed lipid raft compartment of PI3K and PTEN molecules by impairing Akt-regulated GLUT-1-mediated sphingolipid synthesis, and finally resulting in inhibition of TSC cell invasion. Tyrosine 115-118 Rac family small GTPase 1 Homo sapiens 98-102 31644919-5 2019 There, Src tyrosine phosphorylates CCR7, required for the recruitment of Vav1 to form an endomembrane-residing multi-protein signaling complex comprising CCR7, the RhoGEF Vav1, and its effector, Rac1. Tyrosine 11-19 Rac family small GTPase 1 Homo sapiens 195-199 27562306-0 2016 Tyrosine 397 phosphorylation is critical for FAK-promoted Rac1 activation and invasive properties in oral squamous cell carcinoma cells. Tyrosine 0-8 Rac family small GTPase 1 Homo sapiens 58-62 27562307-0 2016 Response to: Tyrosine 397 phosphorylation is critical for FAK-promoted Rac1 activation and invasive properties in oral squamous cell carcinoma cells. Tyrosine 13-21 Rac family small GTPase 1 Homo sapiens 71-75 26752742-0 2016 Tyrosine 397 phosphorylation is critical for FAK-promoted Rac1 activation and invasive properties in oral squamous cell carcinoma cells. Tyrosine 0-8 Rac family small GTPase 1 Homo sapiens 58-62 24025335-3 2013 Thrombin induced tyrosine phosphorylation of Pyk2, Gab1, and p115 RhoGEF, leading to Rac1- and RhoA-dependent Pak2 activation. Tyrosine 17-25 Rac family small GTPase 1 Homo sapiens 85-89 28073159-5 2017 Specifically, pIgR activates the Yes-DNAX-activating protein of 12 kDa-spleen tyrosine kinase-Rac1/CDC42-MEK (extracellular signal-regulated kinase kinase)/ERK (extracellular signal-regulated kinase) cascade in an immunoreceptor tyrosine-based activating motif (ITAM)-dependent manner to promote cell transformation and tumor growth, although pIgR itself does not contain an ITAM sequence. Tyrosine 78-86 Rac family small GTPase 1 Homo sapiens 94-98 27519475-4 2016 The PLCgamma tyrosine phosphorylation was required to activate first PKCtheta, and then alphaPIX and Rac1/PYGM. Tyrosine 13-21 Rac family small GTPase 1 Homo sapiens 101-105 22659453-4 2012 Stimulation of the receptor tyrosine kinase EphA2 by ephrinA1 resulted in recruitment and tyrosine phosphorylation of Vav3, leading to Rac1 activation as well as increased migration and invasion in vitro. Tyrosine 28-36 Rac family small GTPase 1 Homo sapiens 135-139 21619876-5 2011 Specifically, Rac1, acting in a complex with the MgcRacGAP (male germ cell RacGAP), promotes tyrosine phosphorylation of Stat3 by the IL6-receptor family/Jak kinase complex, as well as its translocation to the nucleus. Tyrosine 93-101 Rac family small GTPase 1 Homo sapiens 14-18 18459146-4 2008 Tyr/Phe deprivation reduces the amount of Rho-GTP and Rac1-GTP. Tyrosine 0-3 Rac family small GTPase 1 Homo sapiens 54-58 22163037-0 2011 Tyrosine phosphorylation of Rac1: a role in regulation of cell spreading. Tyrosine 0-8 Rac family small GTPase 1 Homo sapiens 28-32 19404567-9 2010 We also observed that Rac1 activation leads to increased endothelial permeability through tyrosine phosphorylation of occludin. Tyrosine 90-98 Rac family small GTPase 1 Homo sapiens 22-26 19366706-7 2009 Hyperoxia caused rapid activation and redistribution of Rac1, and IQGAP1 to cell periphery, and down-regulation of Rac1, and IQGAP1 attenuated hyperoxia-induced tyrosine phosphorylation of Src and cortactin and ROS generation. Tyrosine 161-169 Rac family small GTPase 1 Homo sapiens 115-119 19366706-10 2009 These results demonstrate a role of PLD in hyperoxia-mediated IQGAP1 activation through Rac1 in tyrosine phosphorylation of Src and cortactin, as well as in p47(phox) translocation and ROS formation in human lung endothelial cells. Tyrosine 96-104 Rac family small GTPase 1 Homo sapiens 88-92 18172037-3 2008 METHODS AND RESULTS: In cultured atrial myocytes and fibroblasts, Ang II induced tyrosine phosphorylation of STAT3 through a Rac1-dependent mechanism, which was inhibited by dominant-negative Rac1, losartan, and simvastatin. Tyrosine 81-89 Rac family small GTPase 1 Homo sapiens 125-129 18172037-3 2008 METHODS AND RESULTS: In cultured atrial myocytes and fibroblasts, Ang II induced tyrosine phosphorylation of STAT3 through a Rac1-dependent mechanism, which was inhibited by dominant-negative Rac1, losartan, and simvastatin. Tyrosine 81-89 Rac family small GTPase 1 Homo sapiens 192-196 17854274-4 2007 To this end, we searched for binding partners of Rac1 and identified a tyrosine-phosphorylated fragment of MKK6 that bound to Rac1 under redox-stress conditions. Tyrosine 71-79 Rac family small GTPase 1 Homo sapiens 126-130 17854274-5 2007 Constitutively active MKK6 interacted directly with Rac1 in vitro, and this interaction was enhanced when MKK6 was phosphorylated on tyrosine 219. Tyrosine 133-141 Rac family small GTPase 1 Homo sapiens 52-56