PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
11487585-7	2001	Our data are consistent with a model in which full activation of HPK1 requires its own phosphorylation on tyrosine and subsequent interaction with adaptors of the SLP family, providing a mechanistic basis for the integration of this kinase into antigen receptor signaling cascades.	Tyrosine	106-114	mitogen-activated protein kinase kinase kinase kinase 1	Homo sapiens	65-69	
11279207-4	2001	Co-expression of protein-tyrosine kinases, Lck and Zap70, with HPK1 led to HPK1 activation and tyrosine phosphorylation in transfected mammalian cells.	Tyrosine	25-33	mitogen-activated protein kinase kinase kinase kinase 1	Homo sapiens	63-67	
11279207-4	2001	Co-expression of protein-tyrosine kinases, Lck and Zap70, with HPK1 led to HPK1 activation and tyrosine phosphorylation in transfected mammalian cells.	Tyrosine	25-33	mitogen-activated protein kinase kinase kinase kinase 1	Homo sapiens	75-79	
10233887-7	1999	We found HPK1 constitutively associated with HS1 and that HS1 was tyrosine-phosphorylated in response to cellular stresses as well as Epo stimulation.	Tyrosine	66-74	mitogen-activated protein kinase kinase kinase kinase 1	Homo sapiens	9-13	
11487585-4	2001	This interaction requires Tyr(379) of HPK1 and the Src homology 2 (SH2) domain of BLNK/SLP-76.	Tyrosine	26-29	mitogen-activated protein kinase kinase kinase kinase 1	Homo sapiens	38-42	
11514608-4	2001	BCR ligation induced rapid tyrosine-phosphorylation of HPK1 mainly by Syk and Lyn, resulting in its association with BASH and catalytic activation.	Tyrosine	27-35	mitogen-activated protein kinase kinase kinase kinase 1	Homo sapiens	55-59	
11514608-6	2001	The functional SH2 domain of BASH and Tyr-379 within HPK1 which we identified as a Syk-phosphorylation site were both necessary for interaction of both proteins and efficient HPK1 activation after BCR stimulation.	Tyrosine	38-41	mitogen-activated protein kinase kinase kinase kinase 1	Homo sapiens	53-57	
11514608-6	2001	The functional SH2 domain of BASH and Tyr-379 within HPK1 which we identified as a Syk-phosphorylation site were both necessary for interaction of both proteins and efficient HPK1 activation after BCR stimulation.	Tyrosine	38-41	mitogen-activated protein kinase kinase kinase kinase 1	Homo sapiens	175-179	
11514608-8	2001	These results reveal a novel BCR signaling pathway leading to the activation of HPK1 and subsequently IKKbeta, in which BASH recruits tyrosine-phosphorylated HPK1 into the BCR signaling complex.	Tyrosine	134-142	mitogen-activated protein kinase kinase kinase kinase 1	Homo sapiens	80-84	
11514608-8	2001	These results reveal a novel BCR signaling pathway leading to the activation of HPK1 and subsequently IKKbeta, in which BASH recruits tyrosine-phosphorylated HPK1 into the BCR signaling complex.	Tyrosine	134-142	mitogen-activated protein kinase kinase kinase kinase 1	Homo sapiens	158-162	
9346925-8	1997	Several activated receptor and cytoplasmic tyrosine kinases, including the EGF receptor, stimulated the tyrosine phosphorylation of the HPK1 serine/threonine kinase.	Tyrosine	43-51	mitogen-activated protein kinase kinase kinase kinase 1	Homo sapiens	136-140	
17353368-5	2007	Interestingly, either S376A mutation or HPK-1 knockdown resulted in increased TCR-induced tyrosine phosphorylation of SLP-76 and phospholipase C-gamma1.	Tyrosine	90-98	mitogen-activated protein kinase kinase kinase kinase 1	Homo sapiens	40-45	
31959629-0	2020	Hematopoietic progenitor kinase 1 down-regulates the oncogenic receptor tyrosine kinase AXL in pancreatic cancer.	Tyrosine	72-80	mitogen-activated protein kinase kinase kinase kinase 1	Homo sapiens	0-33	
15770651-4	2005	HPK1 tyrosine phosphorylation and kinase activation depend on the presence of adaptor proteins.	Tyrosine	5-13	mitogen-activated protein kinase kinase kinase kinase 1	Homo sapiens	0-4	
15743830-3	2005	Here we demonstrate the capacity of the Src family kinase Lck and the SLP-76 family adaptor protein Clnk (cytokine-dependent hematopoietic cell linker) to induce HPK1 tyrosine phosphorylation and relocation to the plasma membrane, which in lymphocytes results in recruitment of HPK1 to the contact site of antigen-presenting cell (APC)-T-cell conjugates.	Tyrosine	167-175	mitogen-activated protein kinase kinase kinase kinase 1	Homo sapiens	162-166